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  1. Accurate prostate cancer imaging is critical for patient management. Multiple studies have demonstrated superior diagnostic accuracy of [68Ga]-PSMA-11 PET/CT over conventional imaging for disease detection, with ...

    Authors: Venkata Avinash Chikatamarla, Satomi Okano, Peter Jenvey, Alexander Ansaldo, Matthew J. Roberts, Stuart C. Ramsay, Paul A. Thomas and David A. Pattison
    Citation: EJNMMI Research 2021 11:128
  2. Malignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure a...

    Authors: Maxim Shevtsov, Susanne Kaesler, Christian Posch, Gabriele Multhoff and Tilo Biedermann
    Citation: EJNMMI Research 2021 11:127
  3. Advanced salivary gland cancers become difficult to treat when they are technically irresectable and radiotherapy limits are exceeded. There is also an unmet need to improve palliative systemic therapy. Saliva...

    Authors: Thomas J. W. Klein Nulent, Robert J. J. van Es, Stefan M. Willems, Arthur. J. A. T. Braat, Lot A. Devriese, Remco de Bree and Bart de Keizer
    Citation: EJNMMI Research 2021 11:126
  4. Centiloid (CL) scaling has become a standardized quantitative measure in amyloid PET because it facilitates the direct comparison of results across institutions, even when different analytical methods or trace...

    Authors: Hiroshi Matsuda, Tensho Yamao, Mitsuru Shakado, Yoko Shigemoto, Kyoji Okita and Noriko Sato
    Citation: EJNMMI Research 2021 11:125
  5. O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) is a highly sensitive PET tracer for glioma imaging, and its uptake is suggested to be driven by an overexpression of the L-type amino-acid transporter 1 (LAT1). Howev...

    Authors: Franziska J. Vettermann, Caroline Diekmann, Lorraine Weidner, Marcus Unterrainer, Bogdana Suchorska, Viktoria Ruf, Mario Dorostkar, Vera Wenter, Jochen Herms, Jörg-Christian Tonn, Peter Bartenstein, Markus J. Riemenschneider and Nathalie L. Albert
    Citation: EJNMMI Research 2021 11:124
  6. Indocyanine green (ICG) is frequently used for the detection of the sentinel lymph node (SLN) in gynecology, but it carries the loss of the presurgical SLN mapping provided by [99mTc]-based colloids. Hybrid trace...

    Authors: Nuria Sánchez-Izquierdo, Sergi Vidal-Sicart, Francisco Campos, Aureli Torné, Martina Aida Angeles, Federico Migliorelli, Meritxell Munmany, Adela Saco, Berta Diaz-Feijoo, Ariel Glickman, Jaume Ordi, Andrés Perissinotti, Marta del Pino and Pilar Paredes
    Citation: EJNMMI Research 2021 11:123
  7. Using two static scans for 123I-meta-iodobenzyl-guanidine (123I-MIBG) myocardial scintigraphy ignores the dynamic response from vesicular trapping in nerve terminals. Moreover, the long pause between scans is imp...

    Authors: Yoshitaka Kumakura, Yuji Shimizu, Masatsugu Hariu, Ken-ichi Ichikawa, Norihito Yoshida, Masato Suzuki, Satoru Oji, Shinya Narukawa, Haruo Yoshimasu and Kyoichi Nomura
    Citation: EJNMMI Research 2021 11:122
  8. Pheochromocytomas (PCCs) and paragangliomas (PGLs), together referred to as PPGLs, are rare chromaffin cell-derived tumors. They require timely diagnosis as this is the only way to achieve a cure through surge...

    Authors: Hermine Mohr, Alessia Foscarini, Katja Steiger, Simone Ballke, Christoph Rischpler, Franz Schilling and Natalia S. Pellegata
    Citation: EJNMMI Research 2021 11:121
  9. Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies to date. The impressively developed stroma that surrounds and modulates the behavior of cancer cells is one of the main factors...

    Authors: Na Sun, Marija Trajkovic-Arsic, Fengxia Li, Yin Wu, Corinna Münch, Thomas Kunzke, Annette Feuchtinger, Katja Steiger, Anna Melissa Schlitter, Wilko Weichert, Irene Esposito, Jens T. Siveke and Axel Walch
    Citation: EJNMMI Research 2021 11:120
  10. The role of image-derived biomarkers in recurrent oligometastatic Prostate Cancer (PCa) is unexplored. This paper aimed to evaluate [18F]FMCH PET/CT radiomic analysis in patients with recurrent PCa after primary ...

    Authors: Martina Sollini, Francesco Bartoli, Lara Cavinato, Francesca Ieva, Alessandra Ragni, Andrea Marciano, Roberta Zanca, Luca Galli, Fabiola Paiar, Francesco Pasqualetti and Paola Anna Erba
    Citation: EJNMMI Research 2021 11:119
  11. Low-grade neuroendocrine tumors (NETs) are characterized by an abundance of somatostatin receptors (SSTR) that can be targeted with somatostatin analogs (SSA). When activated with a single dose of SSA, the rec...

    Authors: Ulrika Jahn, Ezgi Ilan, Irina Velikyan, Katarzyna Fröss-Baron, Mark Lubberink and Anders Sundin
    Citation: EJNMMI Research 2021 11:118
  12. The purpose of this study is to compare dynamic and static whole-body (WB) [18F]NaF PET/CT scan methods used for analysis of bone plasma clearance in patients with chronic kidney disease-mineral and bone disorder...

    Authors: M. H. Vrist, J. N. Bech, T. G. Lauridsen, C. A. Fynbo and J. Theil
    Citation: EJNMMI Research 2021 11:117
  13. Neoadjuvant systemic therapy (NST) is a widely accepted initial treatment modality that can lead to pathologic downstaging of the axillary disease burden in breast cancer patients. Axillary response as well as...

    Authors: Cornelis M. de Mooij, Cristina Mitea, Felix M. Mottaghy, Marjolein L. Smidt and Thiemo J. A. van Nijnatten
    Citation: EJNMMI Research 2021 11:116
  14. Recent advancements in the field of immune-oncology have led to a significant increase in life expectancy of patients with diverse forms of cancer, such as hematologic malignancies, melanoma and lung cancer. U...

    Authors: Q. Lecocq, P. Debie, J. Puttemans, R. M. Awad, L. De Beck, T. Ertveldt, Y. De Vlaeminck, C. Goyvaerts, G. Raes, M. Keyaerts, K. Breckpot and N. Devoogdt
    Citation: EJNMMI Research 2021 11:115
  15. Imaging diagnosis of inflammation has been challenging for many years. Inflammation imaging agents commonly used in nuclear medicine, such as [67Ga]Ga-citrate and 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) showed...

    Authors: Shigufa Kahn Ali, Samia Ait-Mohand, Véronique Dumulon-Perreault and Brigitte Guérin
    Citation: EJNMMI Research 2021 11:114
  16. Immunotherapy is a valuable option for cancer treatment, and the curative effect of anti-PD-1/PD-L1 therapy correlates closely with PD-L1 expression levels. Positron emission tomography (PET) imaging of PD-L1 ...

    Authors: Yanling Yang, Chao Wang, Yan Wang, Yan Sun, Xing Huang, Minzhou Huang, Hui Xu, Huaying Fan, Daquan Chen and Feng Zhao
    Citation: EJNMMI Research 2021 11:113
  17. 68Ga-pentixafor PET/CT was reported to have a high sensitivity in detecting tumor involvement of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in our previous study. We aimed to further inves....

    Authors: Qingqing Pan, Xinxin Cao, Yaping Luo, Jian Li and Fang Li
    Citation: EJNMMI Research 2021 11:110
  18. The analysis aimed to compare the radiotracers [68Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 intraindividually in terms of malignant lesions, mi(molecular-imaging)TNM staging and presumable unspecific lesions retrospec...

    Authors: Sebastian Hoberück, Steffen Löck, Angelika Borkowetz, Ulrich Sommer, Robert Winzer, Klaus Zöphel, Dieter Fedders, Enrico Michler, Jörg Kotzerke, Klaus Kopka, Tobias Hölscher and Anja Braune
    Citation: EJNMMI Research 2021 11:109
  19. Localized prostate cancer (PCa) in patients is characterized by a dominant focus in the gland (dominant intraprostatic lesion, DIL). Accurate DIL identification may enable more accurate diagnosis and therapy t...

    Authors: Dae-Myoung Yang, Ryan Alfano, Glenn Bauman, Jonathan D. Thiessen, Joseph Chin, Stephen Pautler, Madeleine Moussa, Jose A. Gomez, Irina Rachinsky, Mena Gaed, Kevin J. Chung, Aaron Ward and Ting-Yim Lee
    Citation: EJNMMI Research 2021 11:107
  20. In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there a...

    Authors: Katja Steiger, Neil Gerard Quigley, Tanja Groll, Frauke Richter, Maximilian Alexander Zierke, Ambros Johannes Beer, Wilko Weichert, Markus Schwaiger, Susanne Kossatz and Johannes Notni
    Citation: EJNMMI Research 2021 11:106
  21. Since three-dimensional segmentation of cardiac region in 123I-metaiodobenzylguanidine (MIBG) study has not been established, this study aimed to achieve organ segmentation using a convolutional neural network (C...

    Authors: Shintaro Saito, Kenichi Nakajima, Lars Edenbrandt, Olof Enqvist, Johannes Ulén and Seigo Kinuya
    Citation: EJNMMI Research 2021 11:105
  22. The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The d...

    Authors: Günter Schneider, Matthias Wirth, Ulrich Keller and Dieter Saur
    Citation: EJNMMI Research 2021 11:104
  23. Accumulating evidence indicates that neuroinflammation (NI) significantly contributes to drug addiction, but the conversion of NI after drug withdrawal is not clear. Here, we conducted 18F-flutriciclamide (GE180)...

    Authors: Junpeng Li, Da Shao, Donglang Jiang, Qi Huang, Yihui Guan, Bin Lai, Jun Zhao, Fengchun Hua and Fang Xie
    Citation: EJNMMI Research 2021 11:103
  24. [18F]FDG PET/CT is the elective imaging modality for treatment monitoring in multiple myeloma (MM). However, MM is a heterogeneous disease from an imaging point of view, raising challenges in interpretation of PE...

    Authors: Christos Sachpekidis, Maximilian Merz, Marc-Steffen Raab, Uta Bertsch, Vivienn Weru, Annette Kopp-Schneider, Anna Jauch, Hartmut Goldschmidt and Antonia Dimitrakopoulou-Strauss
    Citation: EJNMMI Research 2021 11:100
  25. Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation a...

    Authors: Rie Hosoi, Yuka Fujii, Ohba Hiroyuki, Miho Shukuri, Shingo Nishiyama, Masakatsu Kanazawa, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hideo Tsukada and Osamu Inoue
    Citation: EJNMMI Research 2021 11:99
  26. Gastroenteropancreatic neuroendocrine tumors most commonly metastasize to the liver; however, high normal background 68Ga-DOTATATE activity and high image noise make metastatic lesions difficult to detect. The pu...

    Authors: Jonathan Wehrend, Michael Silosky, Fuyong Xing and Bennett B. Chin
    Citation: EJNMMI Research 2021 11:98
  27. Multiple myeloma (MM) is a disease of cancerous plasma cells in the bone marrow. Imaging-based timely determination of therapeutic response is critical for improving outcomes in MM patients. Very late antigen-...

    Authors: Anchal Ghai, Nikki Fettig, Francesca Fontana, John DiPersio, Mike Rettig, Julie O. Neal, Samuel Achilefu, Kooresh I. Shoghi and Monica Shokeen
    Citation: EJNMMI Research 2021 11:97
  28. 99mTc-macroaggregated albumin (99mTc-MAA) scintigraphy is utilized in treatment planning for Yttrium-90 (90Y) Selective Internal Radiation Therapy (SIRT) of liver tumors to evaluate hepatopulmonary shunting by ca...

    Authors: Mike F. Georgiou, Russ A. Kuker, Matthew T. Studenski, Preeti P. Ahlman, Megan Witte and Lorraine Portelance
    Citation: EJNMMI Research 2021 11:96
  29. PSMA-directed therapy for metastatic prostate cancer is gaining adoption as a treatment option. However, accumulation of 177Lu/225Ac-PSMA in the salivary glands remains a problem, with risk of dose-limiting xeros...

    Authors: V. Mohan, N. M. Bruin, J. B. van de Kamer, J.-J. Sonke and W. V. Vogel
    Citation: EJNMMI Research 2021 11:95
  30. Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily imp...

    Authors: Jessie Han, Luke Harrison, Lisa Patzelt, Mingming Wu, Daniela Junker, Stephan Herzig, Mauricio Berriel Diaz and Dimitrios C. Karampinos
    Citation: EJNMMI Research 2021 11:94
  31. [18F]-fluorodeoxyglucose-positron emission tomography/computed tomography ([18F]FDG-PET/CT) has been implemented sporadically in hospital settings as the standard of care examination for recurrent breast cancer. ...

    Authors: Marianne Vogsen, Jeanette Dupont Jensen, Oke Gerke, Anne Marie Bak Jylling, Jon Thor Asmussen, Ivar Yannick Christensen, Poul-Erik Braad, Peter Thye-Rønn, Katrine Lydolph Søe, Marianne Ewertz and Malene Grubbe Hildebrandt
    Citation: EJNMMI Research 2021 11:93
  32. During anthracycline treatment of cancer, there is a lack for biomarkers of cardiotoxicity besides the cardiac dysfunction. The objective of the present study was to compare [18F]FDG and [123I]MIBG (metaiodobenzy...

    Authors: Alexandra Oudot, Alan Courteau, Mélanie Guillemin, Jean-Marc Vrigneaud, Paul Michael Walker, François Brunotte, Alexandre Cochet and Bertrand Collin
    Citation: EJNMMI Research 2021 11:92
  33. We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent static [18F]FDG PET/CT and MRI, resulting in [18F]FDG PET, T...

    Authors: Inés Mérida, Julien Jung, Sandrine Bouvard, Didier Le Bars, Sophie Lancelot, Franck Lavenne, Caroline Bouillot, Jérôme Redouté, Alexander Hammers and Nicolas Costes
    Citation: EJNMMI Research 2021 11:91
  34. Interim [18F]fluoro-deoxyglucose-positron emission tomography predicts outcome in peripheral T-cell lymphoma (PTCL). We compared two quantitative evaluation methods.

    Authors: Lars Kurch, Ulrich Dührsen, Andreas Hüttmann, Thomas W. Georgi, Osama Sabri, Regine Kluge and Dirk Hasenclever
    Citation: EJNMMI Research 2021 11:90
  35. The usage of immune checkpoint inhibitors (ICIs) is the standard practice for the treatment of metastatic melanoma. However, a significant amount of patients show no response to immunotherapy, while issues on ...

    Authors: Christos Sachpekidis, Annette Kopp-Schneider, Jessica C. Hassel and Antonia Dimitrakopoulou-Strauss
    Citation: EJNMMI Research 2021 11:89
  36. 6-[18F]fluoro-l-3,4-dihydroxyphenyl alanine ([18F]FDOPA) is a commonly used PET tracer for the detection and staging of neuroendocrine tumors. In neuroendocrine tumors, [18F]FDOPA is decarboxylated to [18F]dopami...

    Authors: Gilles N. Stormezand, Romano S. B. H. Schreuder, Adrienne H. Brouwers, Riemer H. J. A. Slart, Philip H. Elsinga, Annemiek M. E. Walenkamp, R. A. J. O. Dierckx, Andor W. J. M. Glaudemans and Gert Luurtsema
    Citation: EJNMMI Research 2021 11:88
  37. A combination of positron emission tomography and computed tomography (PET/CT) is an important modality for the diagnosis of carcinoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been ...

    Authors: Hidenori Kido, Shunsuke Kato, Kimihiko Funahashi, Kazutoshi Shibuya, Yousuke Sasaki, Yoshihisa Urita, Masaaki Hori and Sunao Mizumura
    Citation: EJNMMI Research 2021 11:87
  38. 99mTc-labelled bisphosphonates are used for imaging assessment of patients with transthyretin cardiac amyloidosis (ATTR). Present study evaluates whether quantitative SPECT/CT measurement of absolute myocardial 9...

    Authors: Simona Ben-Haim, A. Chicheportiche, E. Goshen, M. Arad, M. Smekhov, L. J. Menezes, P. M. Elliott, E. O’Mahoney, E. Stern, Bella Yuzefovich and J. B. Bomanji
    Citation: EJNMMI Research 2021 11:86
  39. Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and...

    Authors: Erik H. J. G. Aarntzen, Edel Noriega-Álvarez, Vera Artiko, André H. Dias, Olivier Gheysens, Andor W. J. M. Glaudemans, Chiara Lauri, Giorgio Treglia, Tim van den Wyngaert, Fijs W. B. van Leeuwen and Samantha Y. A. Terry
    Citation: EJNMMI Research 2021 11:85
  40. 68Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist exhibiting higher tumour-to-background ratios and sensitivity compared to 68Ga-DOTATOC. This randomised, 2 × 3 factorial, phase II study aim...

    Authors: Colin G. Miller, Henning Grønbæk, Irene Virgolini, Andreas Kjaer, Pierre Terve, Shadfar Bahri, Peter Iversen, Hanna Svirydenka, Thomas Rohban and Sandy McEwan
    Citation: EJNMMI Research 2021 11:84
  41. Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is ...

    Authors: Simone Ballke, Irina Heid, Carolin Mogler, Rickmer Braren, Markus Schwaiger, Wilko Weichert and Katja Steiger
    Citation: EJNMMI Research 2021 11:83
  42. In clinical diagnostic imaging, dopamine transporter (DAT) SPECT scans are commonly evaluated using automated semiquantitative analysis software. Age correction is routinely implemented, but usually no sex cor...

    Authors: Emma A. Honkanen, Tommi Noponen, Risto Hirvilammi, Kari Lindholm, Riitta Parkkola, Juho Joutsa, Andrea Varrone and Valtteri Kaasinen
    Citation: EJNMMI Research 2021 11:82
  43. The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is cause...

    Authors: Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen and Godelieve A. M. Tytgat
    Citation: EJNMMI Research 2021 11:81
  44. 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target...

    Authors: Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah and Yvonne W. S. Jauw
    Citation: EJNMMI Research 2021 11:74