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  1. Dosimetry for diagnostic agents is performed to assess the risk of radiation detriment (e.g., cancer) associated with the imaging agent and the risk is assessed by computing the effective dose coefficient, e. Sty...

    Authors: Anders Josefsson, Klaikangwol Siritantikorn, Sagar Ranka, Jose Willegaignon de Amorim de Carvalho, Carlos Alberto Buchpiguel, Marcelo Tatit Sapienza, Wesley E. Bolch and George Sgouros

    Citation: EJNMMI Research 2020 10:26

    Content type: Original research

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  2. [18F]AmBF3-TATE is a somatostatin agonist that selectively binds to somatostatin receptor subtype 2 (SSTR2). For clinical translation, pharmacokinetics, radiation dosimetry, and acute toxicity of [18F]AmBF3-TATE ...

    Authors: Joseph Lau, Jinhe Pan, Etienne Rousseau, Carlos F. Uribe, Sudhakara Reddy Seelam, Brent W. Sutherland, David M. Perrin, Kuo-Shyan Lin and François Bénard

    Citation: EJNMMI Research 2020 10:25

    Content type: Original research

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  3. It is well known that a severe cell injury after exposure to ionizing radiation is the induction of DNA double-strand breaks (DSBs). After exposure, an early response to DSBs is the phosphorylation of the hist...

    Authors: Anna Stenvall, Erik Larsson, Bo Holmqvist, Sven-Erik Strand and Bo-Anders Jönsson

    Citation: EJNMMI Research 2020 10:22

    Content type: Original research

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  4. Previous studies found that [18F]LSN3316612 was a promising positron emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and human volunteers. This study sought to further evaluate ...

    Authors: Jae-Hoon Lee, Jeih-San Liow, Soumen Paul, Cheryl L. Morse, Mohammad B. Haskali, Lester Manly, Sergey Shcherbinin, J. Craig Ruble, Nancy Kant, Emily C. Collins, Hugh N. Nuthall, Paolo Zanotti-Fregonara, Sami S. Zoghbi, Victor W. Pike and Robert B. Innis

    Citation: EJNMMI Research 2020 10:20

    Content type: Original research

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  5. Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients be...

    Authors: Lisa H. de Vries, Lutske Lodewijk, Arthur J. A. T. Braat, Gerard C. Krijger, Gerlof D. Valk, Marnix G. E. H. Lam, Inne H. M. Borel Rinkes, Menno R. Vriens and Bart de Keizer

    Citation: EJNMMI Research 2020 10:18

    Content type: Preliminary research

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  6. Identification of suspicious PSMA-PET/CT-positive lymph node (LN) metastases (LNM) from prostate cancer (PCa) during lymphadenectomy (LA) is challenging. We evaluated an 111In-labelled PSMA ligand (DKFZ-617, refe...

    Authors: Cordula A. Jilg, Kathrin Reichel, Christian Stoykow, H. Christian Rischke, Mark Bartholomä, Vanessa Drendel, Moritz von Büren, Wolfgang Schultze-Seemann, Philipp T. Meyer and Michael Mix

    Citation: EJNMMI Research 2020 10:17

    Content type: Original research

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  7. Targeting G protein-coupled receptors on the surface of cancer cells with peptide ligands is a promising concept for the selective tumor delivery of therapeutically active cargos, including radiometals for tar...

    Authors: Adrien Chastel, Dennis J. Worm, Isabel D. Alves, Delphine Vimont, Melina Petrel, Samantha Fernandez, Philippe Garrigue, Philippe Fernandez, Elif Hindié, Annette G. Beck-Sickinger and Clément Morgat

    Citation: EJNMMI Research 2020 10:16

    Content type: Original research

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  8. Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aim...

    Authors: Céline Derwael, Olivier Lavergne, Pierre Lovinfosse, Vlad Nechifor, Mallory Salvé, David Waltregny, Roland Hustinx and Nadia Withofs

    Citation: EJNMMI Research 2020 10:15

    Content type: Original research

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  9. Several scan parameters for PET imaging with 18F-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide admi...

    Authors: Sarah Piron, Kathia De Man, Vanessa Schelfhout, Nick Van Laeken, Ken Kersemans, Eric Achten, Filip De Vos and Piet Ost

    Citation: EJNMMI Research 2020 10:14

    Content type: Original research

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  10. Cancer stem cells (CSCs) are involved in drug resistance, metastasis, and relapse of cancers, which can significantly affect tumor therapy. Hence, to develop specifically therapeutic target probe at CSCs for i...

    Authors: Siao-Syun Guan, Cheng-Tien Wu, Tse-Zung Liao, Tsai-Yueh Luo, Kun-Liang Lin and Shing-Hwa Liu

    Citation: EJNMMI Research 2020 10:13

    Content type: Original research

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  11. The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET i...

    Authors: Anna Ringheim, Guilherme de Carvalho Campos Neto, Udunna Anazodo, Lumeng Cui, Marcelo Livorsi da Cunha, Taise Vitor, Karine Minaif Martins, Ana Cláudia Camargo Miranda, Marycel Figols de Barboza, Leonardo Lima Fuscaldi, Gustavo Caserta Lemos, José Roberto Colombo Junior and Ronaldo Hueb Baroni

    Citation: EJNMMI Research 2020 10:12

    Content type: Original research

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  12. The undifferentiated embryonic sarcoma of the liver (UESL) is a rare, aggressive tumor mainly affecting children. Since UESL has no specific clinical symptoms or imaging characteristics, many cases of UESL are...

    Authors: Regine Mariette Perl, Almut Häring, Marius Stefan Horger, Christina Pfannenberg and Sergios Gatidis

    Citation: EJNMMI Research 2020 10:11

    Content type: Case report

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  13. Targeted alpha therapy (TAT) is a promising treatment for micrometastatic and minimal residual cancer. We evaluated systemic α-radioimmunotherapy (α-RIT) of metastatic castration-resistant prostate cancer (mCR...

    Authors: Tom A. Bäck, Karin Jennbacken, Malin Hagberg Thulin, Sture Lindegren, Holger Jensen, Tove Olafsen, Paul J. Yazaki, Stig Palm, Per Albertsson, Jan-Erik Damber, Anna M. Wu and Karin Welén

    Citation: EJNMMI Research 2020 10:10

    Content type: Original research

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  14. Chronic kidney disease (CKD) is associated with endothelial dysfunction and increased cardiovascular mortality. Endothelial dysfunction can be studied measuring myocardial perfusion reserve (MPR). MPR is the r...

    Authors: Johanna Päivärinta, Kaj Metsärinne, Eliisa Löyttyniemi, Jarmo Teuho, Tuula Tolvanen, Juhani Knuuti and Niina Koivuviita

    Citation: EJNMMI Research 2020 10:9

    Content type: Original research

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  15. There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and per...

    Authors: Stephanus T. Malherbe, Ray Y. Chen, Patrick Dupont, Ilse Kant, Magdalena Kriel, André G. Loxton, Bronwyn Smith, Caroline G. G. Beltran, Susan van Zyl, Shirely McAnda, Charmaine Abrahams, Elizna Maasdorp, Alex Doruyter, Laura E. Via, Clifton E. Barry III, David Alland…

    Citation: EJNMMI Research 2020 10:8

    Content type: Original research

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  16. Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of ...

    Authors: Mohamed Altai, Javad Garousi, Sara S. Rinne, Alexey Schulga, Sergey Deyev and Anzhelika Vorobyeva

    Citation: EJNMMI Research 2020 10:7

    Content type: Original research

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  17. The aim of this study was the validation of a recently established comprehensive and compact prediction model for 68Ga-PSMA-11-ligand positron-emission tomography (PET) positivity with an independent subsequent p...

    Authors: Pia Kraft, Tobias Maurer, Andrei Gafita, Markus Krönke, Bernhard Haller, Wolfgang A. Weber, Matthias Eiber and Isabel Rauscher

    Citation: EJNMMI Research 2020 10:6

    Content type: Original research

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  18. Positron emission tomography (PET) is increasingly applied for in vivo brown adipose tissue (BAT) research in healthy volunteers. To limit the radiation exposure, the injected 18F-FDG tracer dose should be as low...

    Authors: Edwin E. G. W. ter Voert, Hanna Svirydenka, Julian Müller, Anton S. Becker, Miroslav Balaz, Vissarion Efthymiou, Claudia Irene Maushart, Gani Gashi, Christian Wolfrum, Matthias J. Betz and Irene A. Burger

    Citation: EJNMMI Research 2020 10:5

    Content type: Original research

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  19. 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated at the γ-glutamyl residue with fluorophores and radio-isotopes is able to image dead and dying cells in vitro and in vivo by binding...

    Authors: Ivan Ho Shon, Divesh Kumar, Chithradevi Sathiakumar, Paula Berghofer, Khang Van, Andrew Chicco and Philip J. Hogg

    Citation: EJNMMI Research 2020 10:4

    Content type: Original research

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  20. Patients with atrial fibrillation (AF) and dementia experience reduced quality of life and increased mortality. Technetium 99m ECD brain perfusion single-photon emission computed tomography (99mTc-ECD brain perfu...

    Authors: Hidenobu Hashimoto, Rine Nakanishi, Sunao Mizumura, Yukiko Hashimoto, Yuriko Okamura, Kyoko Yamanaka and Takanori Ikeda

    Citation: EJNMMI Research 2020 10:3

    Content type: Original research

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  21. Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still ne...

    Authors: Elodie Jouberton, Sébastien Schmitt, Emmanuel Chautard, Aurélie Maisonial-Besset, Marie Roy, Nina Radosevic-Robin, Jean-Michel Chezal, Elisabeth Miot-Noirault, Yann Bouvet and Florent Cachin

    Citation: EJNMMI Research 2020 10:2

    Content type: Original research

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  22. To propose a personalized therapeutic approach in osteosarcoma treatment, we assessed whether sequential [18F]FDG PET/CT (PET/CT) could predict the outcome of patients with osteosarcoma of the extremities after o...

    Authors: Inki Lee, Byung Hyun Byun, Ilhan Lim, Byung Il Kim, Chang Woon Choi, Jae-Soo Koh, Won Seok Song, Wan Hyeong Cho, Chang-Bae Kong and Sang Moo Lim

    Citation: EJNMMI Research 2020 10:1

    Content type: Original research

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  23. The aim of this study was to evaluate the diagnostic efficacy of 18F-fluorocholine (18F-FCH) PET/CT for uremic hyperparathyroidism (uHPT) compared to 99mTc-sestaMIBI SPECT/CT and ultrasonography (US).

    Authors: Yu Xue, Wenbo Li, Zhu Xia, Chengming Lei, Yiyi Cao, Zhengjie Wang and Hua Pang

    Citation: EJNMMI Research 2019 9:118

    Content type: Original research

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  24. We aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR).

    Authors: Alain Manrique, David Dudoignon, Stéphanie Brun, Catherine N’Ganoa, Emmanuelle Cassol, Damien Legallois, Yoan Lavie-Badie, Denis Agostini and Olivier Lairez

    Citation: EJNMMI Research 2019 9:117

    Content type: Original research

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  25. Predicting the aggressive behavior of non-functional pancreatic neuroendocrine tumors (NF-PNET) remains controversial. We wanted to explore, in a prospective setting, whether the diagnostic accuracy can be imp...

    Authors: Susanna Majala, Hanna Seppänen, Jukka Kemppainen, Jari Sundström, Camilla Schalin-Jäntti, Risto Gullichsen, Jukka Schildt, Harri Mustonen, Tiina Vesterinen, Johanna Arola and Saila Kauhanen

    Citation: EJNMMI Research 2019 9:116

    Content type: Original research

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  26. In clinical routine, SUVmax and SUVpeak are most often used to determine the glucose metabolism in tumours by 18F-FDG PET/CT. Both metrics can be further normalised to SUVs in reference regions resulting in a SUV...

    Authors: Janusch Blautzik, Leonie Grelich, Nicolai Schramm, Rebecca Henkel, Peter Bartenstein and Thomas Pfluger

    Citation: EJNMMI Research 2019 9:115

    Content type: Original research

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  27. Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may...

    Authors: Elodie A. Pérès, Jérôme Toutain, Louis-Paul Paty, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Louisa Barré, Aurélien Vidal, Michel Cherel, Mickaël Bourgeois, Myriam Bernaudin and Samuel Valable

    Citation: EJNMMI Research 2019 9:114

    Content type: Original research

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  28. While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...

    Authors: Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer and Pilar Jimenez-Royo

    Citation: EJNMMI Research 2019 9:113

    Content type: Original research

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  29. Radiation pneumonitis is a common and potentially fatal complication of radiotherapy (RT). Some patients with radiation pneumonitis show increases in uptake of fluorodeoxyglucose (FDG) on positron emission tom...

    Authors: Meiying Guo, Liang Qi, Yun Zhang, Dongping Shang, Jinming Yu and Jinbo Yue

    Citation: EJNMMI Research 2019 9:112

    Content type: Original research

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  30. Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance in the preclinical stage of iNPH remains unknown. Herein, we evalua...

    Authors: Koichi Miyazaki, Kohei Hanaoka, Hayato Kaida, Yasutaka Chiba and Kazunari Ishii

    Citation: EJNMMI Research 2019 9:111

    Content type: Original research

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  31. P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which effectively restrict the brain distribution of the majority of current...

    Authors: Beatrix Wulkersdorfer, Martin Bauer, Rudolf Karch, Harald Stefanits, Cécile Philippe, Maria Weber, Thomas Czech, Marie-Claude Menet, Xavier Declèves, Johannes A. Hainfellner, Matthias Preusser, Marcus Hacker, Markus Zeitlinger, Markus Müller and Oliver Langer

    Citation: EJNMMI Research 2019 9:110

    Content type: Original research

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  32. For differentiating tumor from inflammation and normal tissues, fluorodeoxyglucose ([18F]FDG) dual time point PET could be helpful. Albeit [18F]FLT is more specific for tumors than [18F]FDG; we explored the role ...

    Authors: Pierre Lovinfosse, Caroline Rousseau, Jean-Yves Pierga, Francis Bouchet, Alexandre Cochet, Jean-Louis Alberini, Sylvie Girault, Pierre Vera, Pierre Olivier, Lionel Uwer, Florent Cachin, Benoit Scarwell, Jérome Lemonnier, Emmanuelle Fourme, Christel Mesleard, Anne-Laure Martin…

    Citation: EJNMMI Research 2019 9:109

    Content type: Original research

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  33. In colorectal cancer, survival of patients is drastically reduced when complete resection is hampered by involvement of critical structures. Targeted photodynamic therapy (tPDT) is a local and targeted therapy...

    Authors: Fortuné M. K. Elekonawo, Desirée L. Bos, David M. Goldenberg, Otto C. Boerman and Mark Rijpkema

    Citation: EJNMMI Research 2019 9:108

    Content type: Original research

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  34. Following publication of the original article [1], the authors have reported an error in the ‘Histopathology’ (under ‘Materials and methods’) section of the article that compromises the reproducibility of the ...

    Authors: Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier and Melanie A. Kimm

    Citation: EJNMMI Research 2019 9:107

    Content type: Correction

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    The original article was published in EJNMMI Research 2019 9:87

  35. A high SUV-reproducibility is crucial when different PET scanners are in use. We evaluated the SUV variability in whole-body FDG-PET scans of patients with suspected or proven cancer using an EARL-accredited c...

    Authors: Daniëlle Koopman, Pieter L. Jager, Cornelis H. Slump, Siert Knollema and Jorn A. van Dalen

    Citation: EJNMMI Research 2019 9:106

    Content type: Original research

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  36. In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and ...

    Authors: Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Marta Cvijic, Georg Schramm, Johan Nuyts, Jens-Uwe Voigt and Olivier Gheysens

    Citation: EJNMMI Research 2019 9:105

    Content type: Original research

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  37. We investigated the prognostic predictive value of the combination of fluorodeoxyglucose (FDG)- and fluoromisonidazole (FMISO)-PET in patients with non-small cell lung carcinoma (NSCLC) treated with stereotact...

    Authors: Shiro Watanabe, Tetsuya Inoue, Shozo Okamoto, Keiichi Magota, Ayumi Takayanagi, Jun Sakakibara-Konishi, Norio Katoh, Kenji Hirata, Osamu Manabe, Takuya Toyonaga, Yuji Kuge, Hiroki Shirato, Nagara Tamaki and Tohru Shiga

    Citation: EJNMMI Research 2019 9:104

    Content type: Original research

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  38. The aim of this analysis was to investigate whether the standardized uptake value (SUV) normalized by lean body mass (SUL) is a more appropriate quantitative parameter compared to the commonly used SUV normali...

    Authors: Andrei Gafita, Jeremie Calais, Charlott Franz, Isabel Rauscher, Hui Wang, Andrew Roberstson, Johannes Czernin, Wolfgang A. Weber and Matthias Eiber

    Citation: EJNMMI Research 2019 9:103

    Content type: Original research

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  39. Preclinical biodistribution and dosimetric analysis of [177Lu]Lu-DOTAZOL suggest the bisphosphonate zoledronate as a promising new radiopharmaceutical for therapy of bone metastases. We evaluated biodistribution ...

    Authors: Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian. C. Gaertner, Markus Essler and Ralph. A. Bundschuh

    Citation: EJNMMI Research 2019 9:102

    Content type: Original research

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  40. Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake.

    Authors: Ellen Boswijk, Renee Franssen, Guy H. E. J. Vijgen, Roel Wierts, Jochem A. J. van der Pol, Alma M. A. Mingels, Erwin M. J. Cornips, Marian H. J. M. Majoie, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Joachim E. Wildberger and Jan Bucerius

    Citation: EJNMMI Research 2019 9:101

    Content type: Original research

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  41. Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity sta...

    Authors: Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike and Christer Halldin

    Citation: EJNMMI Research 2019 9:100

    Content type: Original research

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  42. Despite the widespread use of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the diagnosis and response assessment of patients with lymphoma, few studies have assessed...

    Authors: Hye Lim Park, Joo Hyun O, Sonya Youngju Park, Seung-Eun Jung, Gyeongsin Park, Byung-Ock Choi, Sung Hoon Kim, Young-Woo Jeon, Seok-Goo Cho and Suk-Woo Yang

    Citation: EJNMMI Research 2019 9:99

    Content type: Original research

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  43. Combining modalities using dual-labeled antibodies may allow preoperative and intraoperative tumor localization and could be used in image-guided surgery to improve complete tumor resection. Trastuzumab is a m...

    Authors: Marion M. Deken, Desirée L. Bos, Willemieke S. F. J. Tummers, Taryn L. March, Cornelis J. H. van de Velde, Mark Rijpkema and Alexander L. Vahrmeijer

    Citation: EJNMMI Research 2019 9:98

    Content type: Original research

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  44. The linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic heterogeneity features of the tumor are associ...

    Authors: Jinyeong Choi, Jeong-An Gim, Chiwoo Oh, Seunggyun Ha, Howard Lee, Hongyoon Choi and Hyung-Jun Im

    Citation: EJNMMI Research 2019 9:97

    Content type: Original research

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  45. This letter aims at explaining that adjusting the performance of PET/CT systems to a new standard also requires updating of interpretation criteria. Simply changing one aspect of the imaging procedure, i.e., P...

    Authors: Ronald Boellaard, Terez Sera, Andres Kaalep, Otto S. Hoekstra, Sally F. Barrington and Josée M. Zijlstra

    Citation: EJNMMI Research 2019 9:95

    Content type: Letter to the Editor

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  46. Selective removal of initially tumor-positive axillary lymph nodes in breast cancer patients who underwent neoadjuvant systemic treatment (NST) improves the accuracy of nodal staging and provides the opportuni...

    Authors: Daan Hellingman, Maarten L. Donswijk, Gonneke A. O. Winter-Warnars, Petra de Koekkoek-Doll, Marilyn Pinas, Yvonne Budde-van Namen, Johan Westerga, Marie-Jeanne T. F. D. Vrancken Peeters, Nikola Kimmings and Marcel P. M. Stokkel

    Citation: EJNMMI Research 2019 9:94

    Content type: Original research

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  47. Prostate-specific membrane antigen (PSMA) is overexpressed on the endothelial cells of tumor neo-vessels of several solid malignancies, including differentiated thyroid cancer (DTC). We aimed to test the poten...

    Authors: Martina Sollini, Luca di Tommaso, Margarita Kirienko, Chiara Piombo, Marco Erreni, Andrea Gerardo Lania, Paola Anna Erba, Lidija Antunovic and Arturo Chiti

    Citation: EJNMMI Research 2019 9:93

    Content type: Original research

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  48. Overall, 40% of patients with a locally advanced head and neck cancer (LAHNC) treated by chemoradiotherapy (CRT) present local recurrence within 2 years after the treatment. The aims of this study were to char...

    Authors: J. Beaumont, O. Acosta, A. Devillers, X. Palard-Novello, E. Chajon, R. de Crevoisier and J. Castelli

    Citation: EJNMMI Research 2019 9:90

    Content type: Original research

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