Articles

Predicting the nature of pleural effusion in patients with lung adenocarcinoma based on ¹⁸F-FDG PET/CT

This study aims to establish a predictive model on the basis of ¹⁸F-FDG PET/CT for diagnosing the nature of pleural effusion (PE) in patients with lung adenocarcinoma.

Authors: Yi Li, Wei Mu, Yuan Li, Xiao Song, Yan Huang and Lei Jiang

Short-duration dynamic [¹⁸F]DCFPyL PET and CT perfusion imaging to localize dominant intraprostatic lesions in prostate cancer: validation against digital histopathology and comparison to [¹⁸F]DCFPyL PET/MR at 120 minutes

Localized prostate cancer (PCa) in patients is characterized by a dominant focus in the gland (dominant intraprostatic lesion, DIL). Accurate DIL identification may enable more accurate diagnosis and therapy t...

Authors: Dae-Myoung Yang, Ryan Alfano, Glenn Bauman, Jonathan D. Thiessen, Joseph Chin, Stephen Pautler, Madeleine Moussa, Jose A. Gomez, Irina Rachinsky, Mena Gaed, Kevin J. Chung, Aaron Ward and Ting-Yim Lee

There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography

In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there a...

Authors: Katja Steiger, Neil Gerard Quigley, Tanja Groll, Frauke Richter, Maximilian Alexander Zierke, Ambros Johannes Beer, Wilko Weichert, Markus Schwaiger, Susanne Kossatz and Johannes Notni

Convolutional neural network-based automatic heart segmentation and quantitation in ¹²³I-metaiodobenzylguanidine SPECT imaging

Since three-dimensional segmentation of cardiac region in ¹²³I-metaiodobenzylguanidine (MIBG) study has not been established, this study aimed to achieve organ segmentation using a convolutional neural network (C...

Authors: Shintaro Saito, Kenichi Nakajima, Lars Edenbrandt, Olof Enqvist, Johannes Ulén and Seigo Kinuya

Rationale for MYC imaging and targeting in pancreatic cancer

The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The d...

Authors: Günter Schneider, Matthias Wirth, Ulrich Keller and Dieter Saur

Alteration of neuroinflammation detected by ¹⁸F-GE180 PET imaging in place-conditioned rats with morphine withdrawal

Accumulating evidence indicates that neuroinflammation (NI) significantly contributes to drug addiction, but the conversion of NI after drug withdrawal is not clear. Here, we conducted ¹⁸F-flutriciclamide (GE180)...

Authors: Junpeng Li, Da Shao, Donglang Jiang, Qi Huang, Yihui Guan, Bin Lai, Jun Zhao, Fengchun Hua and Fang Xie

Retraction Note to: Inter- and intraobserver agreement of the quantitative assessment of [^99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer

Authors: Daniel Johnathan Hughes, Gitasha Chand, Vicky Goh and Gary J. R. Cook

Correction to: Biokinetics, dosimetry and radiation risk in infants after ^99mTc-MAG3 scans

Authors: J. Soares Machado, J. Tran-Gia, S. Schlögl, A. K. Buck and M. Lassmann

The prognostic significance of [¹⁸F]FDG PET/CT in multiple myeloma according to novel interpretation criteria (IMPeTUs)

[¹⁸F]FDG PET/CT is the elective imaging modality for treatment monitoring in multiple myeloma (MM). However, MM is a heterogeneous disease from an imaging point of view, raising challenges in interpretation of PE...

Authors: Christos Sachpekidis, Maximilian Merz, Marc-Steffen Raab, Uta Bertsch, Vivienn Weru, Annette Kopp-Schneider, Anna Jauch, Hartmut Goldschmidt and Antonia Dimitrakopoulou-Strauss

Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity

Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation a...

Authors: Rie Hosoi, Yuka Fujii, Ohba Hiroyuki, Miho Shukuri, Shingo Nishiyama, Masakatsu Kanazawa, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hideo Tsukada and Osamu Inoue

Automated liver lesion detection in ⁶⁸Ga DOTATATE PET/CT using a deep fully convolutional neural network

Gastroenteropancreatic neuroendocrine tumors most commonly metastasize to the liver; however, high normal background ⁶⁸Ga-DOTATATE activity and high image noise make metastatic lesions difficult to detect. The pu...

Authors: Jonathan Wehrend, Michael Silosky, Fuyong Xing and Bennett B. Chin

In vivo quantitative assessment of therapeutic response to bortezomib therapy in disseminated animal models of multiple myeloma with [¹⁸F]FDG and [⁶⁴Cu]Cu-LLP2A PET

Multiple myeloma (MM) is a disease of cancerous plasma cells in the bone marrow. Imaging-based timely determination of therapeutic response is critical for improving outcomes in MM patients. Very late antigen-...

Authors: Anchal Ghai, Nikki Fettig, Francesca Fontana, John DiPersio, Mike Rettig, Julie O. Neal, Samuel Achilefu, Kooresh I. Shoghi and Monica Shokeen

Lung shunt fraction calculation using ^99mTc-MAA SPECT/CT imaging for ⁹⁰Y microsphere selective internal radiation therapy of liver tumors

^99mTc-macroaggregated albumin (^99mTc-MAA) scintigraphy is utilized in treatment planning for Yttrium-90 (⁹⁰Y) Selective Internal Radiation Therapy (SIRT) of liver tumors to evaluate hepatopulmonary shunting by ca...

Authors: Mike F. Georgiou, Russ A. Kuker, Matthew T. Studenski, Preeti P. Ahlman, Megan Witte and Lorraine Portelance

The effect of eating on the uptake of PSMA ligands in the salivary glands

PSMA-directed therapy for metastatic prostate cancer is gaining adoption as a treatment option. However, accumulation of ¹⁷⁷Lu/²²⁵Ac-PSMA in the salivary glands remains a problem, with risk of dose-limiting xeros...

Authors: V. Mohan, N. M. Bruin, J. B. van de Kamer, J.-J. Sonke and W. V. Vogel

Imaging modalities for diagnosis and monitoring of cancer cachexia

Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily imp...

Authors: Jessie Han, Luke Harrison, Lisa Patzelt, Mingming Wu, Daniela Junker, Stephan Herzig, Mauricio Berriel Diaz and Dimitrios C. Karampinos

Benefits and harms of implementing [¹⁸F]FDG-PET/CT for diagnosing recurrent breast cancer: a prospective clinical study

[¹⁸F]-fluorodeoxyglucose-positron emission tomography/computed tomography ([¹⁸F]FDG-PET/CT) has been implemented sporadically in hospital settings as the standard of care examination for recurrent breast cancer. ...

Authors: Marianne Vogsen, Jeanette Dupont Jensen, Oke Gerke, Anne Marie Bak Jylling, Jon Thor Asmussen, Ivar Yannick Christensen, Poul-Erik Braad, Peter Thye-Rønn, Katrine Lydolph Søe, Marianne Ewertz and Malene Grubbe Hildebrandt

[¹²³I]MIBG is a better early marker of anthracycline cardiotoxicity than [¹⁸F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study

During anthracycline treatment of cancer, there is a lack for biomarkers of cardiotoxicity besides the cardiac dysfunction. The objective of the present study was to compare [¹⁸F]FDG and [¹²³I]MIBG (metaiodobenzy...

Authors: Alexandra Oudot, Alan Courteau, Mélanie Guillemin, Jean-Marc Vrigneaud, Paul Michael Walker, François Brunotte, Alexandre Cochet and Bertrand Collin

CERMEP-IDB-MRXFDG: a database of 37 normal adult human brain [¹⁸F]FDG PET, T1 and FLAIR MRI, and CT images available for research

We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent static [¹⁸F]FDG PET/CT and MRI, resulting in [¹⁸F]FDG PET, T...

Authors: Inés Mérida, Julien Jung, Sandrine Bouvard, Didier Le Bars, Sophie Lancelot, Franck Lavenne, Caroline Bouillot, Jérôme Redouté, Alexander Hammers and Nicolas Costes

Quantitative evaluation of interim positron emission tomography in peripheral T-cell lymphoma

Interim [¹⁸F]fluoro-deoxyglucose-positron emission tomography predicts outcome in peripheral T-cell lymphoma (PTCL). We compared two quantitative evaluation methods.

Authors: Lars Kurch, Ulrich Dührsen, Andreas Hüttmann, Thomas W. Georgi, Osama Sabri, Regine Kluge and Dirk Hasenclever

Assessment of early metabolic progression in melanoma patients under immunotherapy: an ¹⁸F-FDG PET/CT study

The usage of immune checkpoint inhibitors (ICIs) is the standard practice for the treatment of metastatic melanoma. However, a significant amount of patients show no response to immunotherapy, while issues on ...

Authors: Christos Sachpekidis, Annette Kopp-Schneider, Jessica C. Hassel and Antonia Dimitrakopoulou-Strauss

The effects of molar activity on [¹⁸F]FDOPA uptake in patients with neuroendocrine tumors

6-[¹⁸F]fluoro-l-3,4-dihydroxyphenyl alanine ([¹⁸F]FDOPA) is a commonly used PET tracer for the detection and staging of neuroendocrine tumors. In neuroendocrine tumors, [¹⁸F]FDOPA is decarboxylated to [¹⁸F]dopami...

Authors: Gilles N. Stormezand, Romano S. B. H. Schreuder, Adrienne H. Brouwers, Riemer H. J. A. Slart, Philip H. Elsinga, Annemiek M. E. Walenkamp, R. A. J. O. Dierckx, Andor W. J. M. Glaudemans and Gert Luurtsema

The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis

A combination of positron emission tomography and computed tomography (PET/CT) is an important modality for the diagnosis of carcinoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been ...

Authors: Hidenori Kido, Shunsuke Kato, Kimihiko Funahashi, Kazutoshi Shibuya, Yousuke Sasaki, Yoshihisa Urita, Masaaki Hori and Sunao Mizumura

Quantitative SPECT/CT parameters of myocardial ^99mTechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) uptake in suspected cardiac transthyretin amyloidosis

^99mTc-labelled bisphosphonates are used for imaging assessment of patients with transthyretin cardiac amyloidosis (ATTR). Present study evaluates whether quantitative SPECT/CT measurement of absolute myocardial ^9...

Authors: Simona Ben-Haim, A. Chicheportiche, E. Goshen, M. Arad, M. Smekhov, L. J. Menezes, P. M. Elliott, E. O’Mahoney, E. Stern, Bella Yuzefovich and J. B. Bomanji

EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases

Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and...

Authors: Erik H. J. G. Aarntzen, Edel Noriega-Álvarez, Vera Artiko, André H. Dias, Olivier Gheysens, Andor W. J. M. Glaudemans, Chiara Lauri, Giorgio Treglia, Tim van den Wyngaert, Fijs W. B. van Leeuwen and Samantha Y. A. Terry

A novel read methodology to evaluate the optimal dose of ⁶⁸Ga-satoreotide trizoxetan as a PET imaging agent in patients with gastroenteropancreatic neuroendocrine tumours: a phase II clinical trial

⁶⁸Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist exhibiting higher tumour-to-background ratios and sensitivity compared to ⁶⁸Ga-DOTATOC. This randomised, 2 × 3 factorial, phase II study aim...

Authors: Colin G. Miller, Henning Grønbæk, Irene Virgolini, Andreas Kjaer, Pierre Terve, Shadfar Bahri, Peter Iversen, Hanna Svirydenka, Thomas Rohban and Sandy McEwan

Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted

Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is ...

Authors: Simone Ballke, Irina Heid, Carolin Mogler, Rickmer Braren, Markus Schwaiger, Wilko Weichert and Katja Steiger

Sex correction improves the accuracy of clinical dopamine transporter imaging

In clinical diagnostic imaging, dopamine transporter (DAT) SPECT scans are commonly evaluated using automated semiquantitative analysis software. Age correction is routinely implemented, but usually no sex cor...

Authors: Emma A. Honkanen, Tommi Noponen, Risto Hirvilammi, Kari Lindholm, Riitta Parkkola, Juho Joutsa, Andrea Varrone and Valtteri Kaasinen

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes

The therapeutic use of [¹³¹I]meta-iodobenzylguanidine ([¹³¹I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is cause...

Authors: Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen and Godelieve A. M. Tytgat

Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review

Although volumetric imaging by computed tomography (CT) is the gold standard for preoperative assessment of the future liver remnant, nuclear imaging studies have shown promising data. This systematic review s...

Authors: Caroline Espersen, Lise Borgwardt, Peter Nørgaard Larsen, Trine Borup Andersen, Louise Stenholt and Lars J. Petersen

Preselection of robust radiomic features does not improve outcome modelling in non-small cell lung cancer based on clinical routine FDG-PET imaging

Radiomics is a promising tool for identifying imaging-based biomarkers. Radiomics-based models are often trained on single-institution datasets; however, multi-centre imaging datasets are preferred for externa...

Authors: Carol Oliveira, Florian Amstutz, Diem Vuong, Marta Bogowicz, Martin Hüllner, Robert Foerster, Lucas Basler, Christina Schröder, Eric I. Eboulet, Miklos Pless, Sandra Thierstein, Solange Peters, Sven Hillinger, Stephanie Tanadini-Lang and Matthias Guckenberger

[¹⁸F]FDG-PET/CT in prone compared to supine position for optimal axillary staging and treatment in clinically node-positive breast cancer patients with neoadjuvant systemic therapy

Axillary staging before neoadjuvant systemic therapy in clinically node-positive breast cancer patients with tailored axillary treatment according to the Marking Axillary lymph nodes with radioactive iodine se...

Authors: Ariane A. van Loevezijn, Marcel P. M. Stokkel, Maarten L. Donswijk, Erik D. van Werkhoven, Marieke E. M. van der Noordaa, Frederieke H. van Duijnhoven and Marie-Jeanne T. F. D. Vrancken Peeters

Investigation of spleen CXCR4 expression by [⁶⁸Ga]Pentixafor PET in a cohort of 145 solid cancer patients

The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

Authors: Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter, Caroline Anna Peuker, Rudolf Werner, Valëza Ademaj-Kospiri, Alexander Gäble, Wolfgang Weber, Hans-Jürgen Wester, Andreas Buck, Peter Herhaus, Constantin Lapa and Ulrich Keller

PSMA-ligand uptake can serve as a novel biomarker in primary prostate cancer to predict outcome after radical prostatectomy

The prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer, and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is incre...

Authors: Hui Wang, Thomas Amiel, Christoph Würnschimmel, Thomas Langbein, Katja Steiger, Isabel Rauscher, Thomas Horn, Tobias Maurer, Wolfgang Weber, Hans-Juergen Wester, Karina Knorr and Matthias Eiber

An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [^64/67Cu]Cu-SARTATE

In a preclinical model of neuroblastoma, Dearling et al. recently demonstrated the potential interest for a theranostic approach of [⁶⁴/⁶⁷Cu]Cu-SARTATE for the detection and treatment of SSTR2-positive neuroblast...

Authors: Eric Laffon, Henri de Clermont and Roger Marthan

Potential and pitfalls of ⁸⁹Zr-immuno-PET to assess target status: ⁸⁹Zr-trastuzumab as an example

⁸⁹Zirconium-immuno-positron emission tomography (⁸⁹Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target...

Authors: Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah and Yvonne W. S. Jauw

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of ⁶⁸Ga-DOTATATE in patients without neuroendocrine tumors

Physiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at the organism level. Whole-body PBPK models contain an explicit repres...

Authors: H. Siebinga, B. J. de Wit-van der Veen, J. H. Beijnen, M. P. M. Stokkel, T. P. C. Dorlo, A. D. R. Huitema and J. J. M. A. Hendrikx

Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging

Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are ref...

Authors: Friederike Liesche-Starnecker, Georg Prokop, Igor Yakushev, Christine Preibisch, Claire Delbridge, Hanno S. Meyer, Kaywan Aftahy, Melanie Barz, Bernhard Meyer, Claus Zimmer, Jürgen Schlegel, Benedikt Wiestler and Jens Gempt

Imaging angiogenesis in atherosclerosis in large arteries with ⁶⁸Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease

Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The a...

Authors: Matthieu Dietz, Christel H. Kamani, Emmanuel Deshayes, Vincent Dunet, Periklis Mitsakis, George Coukos, Marie Nicod Lalonde, Niklaus Schaefer and John O. Prior

[¹⁸F]FDG PET/MRI enables early chemotherapy response prediction in pancreatic ductal adenocarcinoma

In this prospective exploratory study, we evaluated the feasibility of [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon thera...

Authors: Felix N. Harder, Friederike Jungmann, Georgios A. Kaissis, Fabian K. Lohöfer, Sebastian Ziegelmayer, Daniel Havel, Michael Quante, Maximillian Reichert, Roland M. Schmid, Ihsan Ekin Demir, Helmut Friess, Moritz Wildgruber, Jens Siveke, Alexander Muckenhuber, Katja Steiger, Wilko Weichert…

Automated procedure assessing the accuracy of HRCT–PET registration applied in functional virtual bronchoscopy

Bronchoscopy serves as direct visualisation of the airway. Virtual bronchoscopy provides similar visual information using a non-invasive imaging procedure(s). Early and accurate image-guided diagnosis requires...

Authors: Gábor Opposits, Marianna Nagy, Zoltán Barta, Csaba Aranyi, Dániel Szabó, Attila Makai, Imre Varga, László Galuska, Lajos Trón, László Balkay and Miklós Emri

N-staging in large cell neuroendocrine carcinoma of the lung: diagnostic value of [¹⁸F]FDG PET/CT compared to the histopathology reference standard

Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare entity occurring in less than 4% of all lung cancers. Due to its low differentiation and high glucose transporter 1 (GLUT1) expression, LCNEC d...

Authors: Hubertus Hautzel, Yazan Alnajdawi, Wolfgang P. Fendler, Christoph Rischpler, Kaid Darwiche, Wilfried E. Eberhardt, Lale Umutlu, Dirk Theegarten, Martin Stuschke, Martin Schuler, Clemens Aigner, Ken Herrmann and Till Plönes

Hypoxia and glucose metabolism assessed by FMISO and FDG PET for predicting IDH1 mutation and 1p/19q codeletion status in newly diagnosed malignant gliomas

Tumor hypoxia and glycolysis have been recognized as determinant factors characterizing tumor aggressiveness in malignant gliomas. To clarify in vivo hypoxia and glucose metabolism in relation to isocitrate dehyd...

Authors: Kenta Suzuki, Nobuyuki Kawai, Tomoya Ogawa, Keisuke Miyake, Aya Shinomiya, Yuka Yamamoto, Yoshihiro Nishiyama and Takashi Tamiya

Competitive blocking of salivary gland [¹⁸F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radion...

Authors: Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke and Frank I. Lin

A dedicated paediatric [¹⁸F]FDG PET/CT dosage regimen

The role of 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiati...

Authors: Christina P. W. Cox, Daniëlle M. E. van Assema, Frederik A. Verburg, Tessa Brabander, Mark Konijnenberg and Marcel Segbers

Prognostic value of baseline total metabolic tumour volume of ¹⁸F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma

The aim of this study was to explore the prognostic value of baseline metabolic parameters of ¹⁸F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).

Authors: Huanyu Gong, Tiannv Li, Jianyong Li, Lijun Tang and Chongyang Ding

In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201

Auger electron-emitting radionuclides have potential in targeted treatment of small tumors. Thallium-201 (²⁰¹Tl), a gamma-emitting radionuclide used in myocardial perfusion scintigraphy, decays by electron captur...

Authors: Katarzyna M. Osytek, Philip J. Blower, Ines M. Costa, Gareth E. Smith, Vincenzo Abbate and Samantha Y. A. Terry

Whole-body [¹⁸F]-FDG-PET/MRI for staging of pediatric non-Hodgkin lymphoma: first results from a single-center evaluation

In 2015, the revised International Pediatric Non-Hodgkin Lymphoma Staging System was published. It mentions [¹⁸F]-FDG-PET/MRI as the latest method to perform whole-body imaging. However, supporting data are pendi...

Authors: L. Kurch, R. Kluge, O. Sabri, L. Fischer, S. Wendt, H. Graf Einsiedel, S. Starke, J.-S. Kühl, H. Christiansen, F. W. Hirsch, I. Sorge and C. Roth

Hematologic safety of ¹⁷⁷Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer

Myelosuppression is a potential dose-limiting factor in radioligand therapy (RLT). This study aims to investigate occurrence, severity and reversibility of hematotoxic adverse events in patients undergoing RLT...

Authors: Daniel Groener, Cam Tu Nguyen, Justus Baumgarten, Benjamin Bockisch, Karen Davis, Christian Happel, Nicolai Mader, Christina Nguyen Ngoc, Jennifer Wichert, Severine Banek, Philipp Mandel, Felix K. H. Chun, Nikolaos Tselis, Frank Grünwald and Amir Sabet

Accuracy comparison of various quantitative [^99mTc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses

There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different ^99mTc-dicarboxypropandiphosphate ([^99mTc]Tc-DPD) SPECT/CT quantificati...

Authors: Martin Braun, Michal Cachovan, Felix Kaul, Federico Caobelli, Markus Bäumer, A. Hans Vija, Geert Pagenstert, Damian Wild and Martin Kretzschmar

[^99mTc]Tc-Galacto-RGD₂ integrin α_vβ₃-targeted imaging as a surrogate for molecular phenotyping in lung cancer: real-world data

Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of [^99mTc]Tc-Galacto-RGD₂ single-photon emission computed tomography ...

Authors: Jingjing Fu, Yan Xie, Tong Fu, Fan Qiu, Fei Yu, Wei Qu, Xiaochen Yao, Aiping Zhang, Zhenhua Yang, Guoqiang Shao, Qingle Meng, Xiumin Shi, Yue Huang, Wei Gu and Feng Wang