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  1. The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet been reported. This work repor...

    Authors: Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu, Jürgen Einsiedel, Patrick Riss, Nora Vogg, Jörg König, Martin F. Fromm, Harald Hübner, Peter Gmeiner and Olaf Prante
    Citation: EJNMMI Research 2024 14:80
    Content type: Original research Published on:

  2. Neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (SN) pars compacta, and can be detected by magnetic resonance imaging (MRI). It is a promising imaging-base biomarker for neurolog...

    Authors: Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng and Lihong Bu
    Citation: EJNMMI Research 2024 14:79
    Content type: Original research Published on:

  3. Parkinson’s disease (PD) is a prevalent neurodegenerative disorder worldwide, diagnosed based on classic symptoms like motor dysfunction and cognitive impairments. With the development of various radioactive l...

    Authors: Jie Tang, Congjin Liu, Chunyi Liu, Qianyue Hu, Yi Fang and Zhengping Chen
    Citation: EJNMMI Research 2024 14:78
    Content type: Original research Published on:

  4. CXCR3 is expressed on activated T cells and plays a crucial role in T-cell recruitment to the tumor microenvironment (TME) during cell-based and immune checkpoint inhibitor (ICI) immunotherapy. This study util...

    Authors: Sebastian Martin, Lennard Wendlinger, Béatrice Zitti, Mehdi Hicham, Viktoriia Postupalenko, Léo Marx, Greta Giordano-Attianese, Elisabetta Cribioli, Melita Irving, Alexandra Litvinenko, Radmila Faizova, David Viertl and Margret Schottelius
    Citation: EJNMMI Research 2024 14:77
    Content type: Original research Published on:

  5. Reactive microglia and recruited peripheral macrophages contribute to the pathogenesis of Alzheimer’s dementia (AD). Monocytes, macrophages and microglia all express the marker colony-stimulating factor 1 rece...

    Authors: Catherine A. Foss, Ravi Naik, Deepankar Das, Hyojin Cha, Il Minn, Andrew Hall, Paige Finley, Sophia Jiang Wu, Yong Du, Robert F. Dannals, Martin G. Pomper and Andrew G. Horti
    Citation: EJNMMI Research 2024 14:76
    Content type: Original research Published on:

  6. Serum bone turnover markers offer limited insight into metabolic activity at the individual vertebra level in osteoporosis. This study introduces a novel image-derived bone turnover marker for individual verte...

    Authors: Dong Yun Lee, Jungsu S. Oh, Ji Wan Kim, Seung Hun Lee, Beom-Jun Kim, Jung-Min Koh, Jae Seung Kim and Jin-Sook Ryu
    Citation: EJNMMI Research 2024 14:75
    Content type: Original research Published on:

  8. Peptide receptor radionuclide therapy (PRRT) uses [177Lu]Lu-[DOTA0-Tyr3]octreotate ([177Lu]Lu-DOTA-TATE) to treat patients with neuroendocrine tumours (NETs) overexpressing the somatostatin receptor 2A (SSTR2A). ...

    Authors: Jordan Cheng, Joke Zink, Edward O’Neill, Bart Cornelissen, Julie Nonnekens, Lefteris Livieratos and Samantha Y. A. Terry
    Citation: EJNMMI Research 2024 14:73
    Content type: Original research Published on:

  9. [18F]FDG PET denoising by SubtlePET™ using deep learning artificial intelligence (AI) was previously found to induce slight modifications in lesion and reference organs’ quantification and in lesion detection. As...

    Authors: Kathleen Weyts, Justine Lequesne, Alison Johnson, Hubert Curcio, Aurélie Parzy, Elodie Coquan and Charline Lasnon
    Citation: EJNMMI Research 2024 14:72
    Content type: Original research Published on:

  10. Relapsing Polychondritis(RP) is a rare rheumatic immune disease. As with most diseases, if intervention is delayed, the patient’s prognosis is worse. Currently, the diagnostic criteria used in clinical practic...

    Authors: Zilin Wang, Yihan Tian, Yanhui Ji, Tong Liu, Shiqi Wen, Peng Wang, Jie Hu and Wei Li
    Citation: EJNMMI Research 2024 14:71
    Content type: Case report Published on:

  11. Radiolabeled antibody 131I-omburtamab was administered intraventricularly in patients with leptomeningeal disease under an institutionally approved study (#NCT03275402). Radiation safety precautions were tailored...

    Authors: Kavya Prasad, Brian E. Serencsits, Bae P. Chu, Lawrence T. Dauer, Maria Donzelli, Ellen Basu, Kim Kramer and Neeta Pandit-Taskar
    Citation: EJNMMI Research 2024 14:70
    Content type: Original research Published on:

  12. This study aims to evaluate the effect of various background reference regions on spinal 18F-FET PET imaging, with a focus on distinguishing between spinal tumors and myelitis. To enhance diagnostic accuracy, we ...

    Authors: Jing Huang, Jiyuan Wang, Bixiao Cui, Hongwei Yang, Defeng Tian, Jie Ma, Wanru Duan, Zan Chen and Jie Lu
    Citation: EJNMMI Research 2024 14:69
    Content type: Original research Published on:

  14. 123I-meta-iodobenzylguanidine (mIBG) has been applied to patients with chronic heart failure (CHF). However, the relationship between 123I-mIBG activity and lethal arrhythmic events (ArE) is not well defined. Thi...

    Authors: Kenichi Nakajima, Tomoaki Nakata, Takahiro Doi, Derk O. Verschure, Viviana Frantellizzi, Maria Silvia De Feo, Hayato Tada and Hein J. Verberne
    Citation: EJNMMI Research 2024 14:67
    Content type: Original research Published on:

  15. Radiolabelled fibroblast activation protein inhibitors (FAPIs) are becoming increasingly important for imaging various tumour diseases. However, it is essential to be aware of potential pitfalls. Here, we inve...

    Authors: Kim M. Pabst, Lukas Kessler, Justin Ferdinandus, Rainer Hamacher, Timo Bartel, Jens T. Siveke, Michael Nader, Tim Brandenburg, Mélanie Desaulniers, Ken Herrmann and Wolfgang P. Fendler
    Citation: EJNMMI Research 2024 14:66
    Content type: Short communication Published on:

  16. Dual-phase fluorine-18 labeled N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) scans could be used to support disorders like Parkinson’s disease (PD)....

    Authors: Ji-Young Kim, Seo Young Kang, Byung Seok Moon, Bom Sahn Kim, Jee Hyang Jeong and Hai-Jeon Yoon
    Citation: EJNMMI Research 2024 14:65
    Content type: Original research Published on:

  18. Positron emission tomography (PET) is now an established diagnostic method for myocardial perfusion imaging (MPI) in coronary artery disease, which is the main cause of death globally. The available tracers sh...

    Authors: Seweryn Krajewski, Lukasz Steczek, Karina Gotowicz, Urszula Karczmarczyk, Joanna Towpik, Ewa Witkowska-Patena, Krzysztof Łyczko, Maciej Mazur, Przemysław Kozanecki, Joanna Włostowska, Juhani Knuuti, Mirosław Dziuk, Piotr Garnuszek and Cezary Kozanecki
    Citation: EJNMMI Research 2024 14:63
    Content type: Original research Published on:

  19. Uveal melanoma (UM) is the most common primary intraocular tumor in adults, and early detection is critical to improve the clinical outcome of this disease. In this study, the diagnostic effectiveness of [18F]AlF...

    Authors: Ling Wang, Xue Zhu, Yan Xue, Zhihong Huang, Wenjun Zou, Zhengwei Zhang, Mengxi Yu, Donghui Pan and Ke Wang
    Citation: EJNMMI Research 2024 14:62
    Content type: Original research Published on:

  20. Subtype diagnosis of primary aldosteronism (PA) is used to determine treatment, and the potential utility of 68Ga-pentixafor PET/CT for investigation of PA has long been recognized. The study aimed to evaluate th...

    Authors: Rui Zuo, Shuang Liu, Wenbo Li, Zhu Xia, Lu Xu and Hua Pang
    Citation: EJNMMI Research 2024 14:61
    Content type: Original research Published on:

  21. The aim of this study is to investigate the added value of combining tumour blood flow (BF) and metabolism parameters, including texture features, with clinical parameters to predict, at baseline, the patholog...

    Authors: Neree Payan, Benoit Presles, Charles Coutant, Isabelle Desmoulins, Sylvain Ladoire, Françoise Beltjens, François Brunotte, Jean-Marc Vrigneaud and Alexandre Cochet
    Citation: EJNMMI Research 2024 14:60
    Content type: Original research Published on:

  22. N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of P.....

    Authors: Jae Hun Ahn, Min Hwan Kim, Kyongkyu Lee, Keumrok Oh, Hyunwoo Lim, Hee Seup Kil, Soon Jeong Kwon, Jae Yong Choi, Dae Yoon Chi and Yong Jin Lee
    Citation: EJNMMI Research 2024 14:59
    Content type: Original research Published on:

  23. O-(2-[18F]fluoroethyl)-l-tyrosine positron emission tomography ([18F]FET PET) scanning is used in routine clinical management and evaluation of gliomas with a recommended 4 h prior fasting. Knowledge of test–rete...

    Authors: Sarah Chehri, Otto Mølby Henriksen, Lisbeth Marner, Mette Christensen, Aida Muhic, Hans Skovgaard Poulsen and Ian Law
    Citation: EJNMMI Research 2024 14:58
    Content type: Original research Published on:

  24. Paraquat (PQ) -induced pulmonary fibrosis poses a significant medical challenge due to limited treatment options and high mortality rates. Consequently, there is an urgent need for early diagnosis and accurate...

    Authors: Dimei Zhang, Yusheng Shi, Jiangwei Kong, Na Chen, Guiting Li, Mingfang Wang, Guoxia Zhang and Chuangyan Zhai
    Citation: EJNMMI Research 2024 14:57
    Content type: Original research Published on:

  25. In preclinical studies, the positron emission tomography (PET) imaging with [11C]UCB-A provided promising results for imaging synaptic vesicle protein 2A (SV2A) as a proxy for synaptic density. This paper reports...

    Authors: Mengfei Xiong, Mark Lubberink, Lieuwe Appel, Xiaotian Tsong Fang, Torsten Danfors, Eva Kumlien and Gunnar Antoni
    Citation: EJNMMI Research 2024 14:56
    Content type: Original research Published on:

  26. Studies on single-target PET imaging of gastrin-releasing peptide receptor (GRPR), prostate-specific membrane antigen (PSMA), or neurotensin receptor 1(NTR1) have been reported. However, the performance of the...

    Authors: Ling Xiao, Zhihui Fang, Yongxiang Tang, Yanyan Sun, Zehua Zhu, Jian Li, Ming Zhou, Nengan Yang, Kai Zheng and Shuo Hu
    Citation: EJNMMI Research 2024 14:55
    Content type: Original research Published on:

  27. Neuroblastoma is the most common extra-cranial pediatric solid tumor. 131I-metaiodobenzylguanidine (MIBG) is a targeted radiopharmaceutical highly specific for neuroblastoma tumors, providing potent radiotherapy ...

    Authors: Prerna Kumar, Jessica Koach, Erin Nekritz, Sucheta Mukherjee, Benjamin S. Braun, Steven G. DuBois, Nicole Nasholm, Daphne Haas-Kogan, Katherine K. Matthay, William A. Weiss, Clay Gustafson and Youngho Seo
    Citation: EJNMMI Research 2024 14:54
    Content type: Original research Published on:

  28. Fatty acid uptake can be measured using PET and 14-(R,S)‐[18F]fluoro‐6‐thia‐heptadecanoic acid ([18F]FTHA). However, the relatively rapid rate of [18F]FTHA metabolism significantly affects kinetic modeling of tis...

    Authors: Richard Aarnio, Anna Kirjavainen, Johan Rajander, Sarita Forsback, Kari Kalliokoski, Pirjo Nuutila, Zvonko Milicevic, Tamer Coskun, Axel Haupt, Iina Laitinen and Merja Haaparanta-Solin
    Citation: EJNMMI Research 2024 14:53
    Content type: Original research Published on:

  29. F-18-flurodeoxyglucose (FDG) PET/CT is routinely used for staging, evaluation of response to treatment and follow-up of most pediatric malignancies. Cervical lymph nodes can be involved in some pediatric malig...

    Authors: Jeremy Godefroy, Raphael Godefroy, Koral Vedder, Yair Altura, Alexandre Chicheportiche, Simona Ben-Haim and Gal Goldstein
    Citation: EJNMMI Research 2024 14:52
    Content type: Original research Published on:

  30. 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography combined with low-dose computed tomography (PET/CT) can be used at diagnosis to identify myeloma-defining events and also provides prognosti...

    Authors: Silvano Marchiori, François Cousin, Iraklis Papadopoulos, Claire Bernard, Marie Thys, Bernard De Prijck, Michelle Pirotte, Anne-Françoise Donneau, Roland Hustinx, Jo Caers and Nadia Withofs
    Citation: EJNMMI Research 2024 14:51
    Content type: Original research Published on:

  31. Exploring the relationship between oxygen supply and myelin damage would benefit from a simultaneous quantification of myelin and cerebral blood flow (CBF) in the brain’s white matter (WM). To validate an anal...

    Authors: Arya Yazdan-Panah, Benedetta Bodini, Théodore Soulier, Mattia Veronese, Michel Bottlaender, Matteo Tonietto and Bruno Stankoff
    Citation: EJNMMI Research 2024 14:50
    Content type: Original research Published on:

  32. Besides International Prognostic Index (IPI) score, baseline prognostic factors of post-transplant lymphoproliferative disorders (PTLD) are poorly identified due to the rarity of the disease. New indexes deriv...

    Authors: David Morland, Lukshe Kanagaratnam, Fabrice Hubelé, Elise Toussaint, Sylvain Choquet, Aurélie Kas, Pierre-Ambroise Caquot, Corinne Haioun, Emmanuel Itti, Stéphane Leprêtre, Pierre Decazes, Fontanet Bijou, Paul Schwartz, Caroline Jacquet, Adrien Chauchet, Julien Matuszak…
    Citation: EJNMMI Research 2024 14:49
    Content type: Original research Published on:

  33. [11C]metomidate, a methyl ester analogue of etomidate, is used for positron emission tomography of adrenocortical cancer, and has been tested in recent clinical trials for lateralization in primary aldosteronism ...

    Authors: Isabella Silins, Adrian Moreno, Anders Wall, Franklin Aigbirhio, Mark Gurnell, Morris Brown, Sara Roslin, Gunnar Antoni, Per Hellman, Anders Sundin and Mark Lubberink
    Citation: EJNMMI Research 2024 14:48
    Content type: Original research Published on:

  34. Indocyanine green (ICG)-guided surgery has proven effective in the identification of neoplastic tissues. The effect of radiation therapy (RT) on lymph node fluorescence after intravenous injection of ICG has n...

    Authors: Antoine Digonnet, Sophie Vankerkhove, Michel Moreau, Cécile Dekeyser, Marie Quiriny, Esther Willemse, Nicolas de saint Aubain, Matteo Cappello, Vincent Donckier and Pierre Bourgeois
    Citation: EJNMMI Research 2024 14:47
    Content type: Original research Published on:

  35. Approaches targeting the sodium-glucose cotransporter (SGLT) could represent a promising future therapeutic strategy for numerous oncological and metabolic diseases. In this study, we evaluated the safety, bio...

    Authors: Barbara Katharina Geist, Juan Carlos Ramirez, Patrick Binder, Holger Einspieler, Harald Ibeschitz, Werner Langsteger, Lukas Nics, Ivo Rausch, Markus Diemling, Antti Sohlberg, Marcus Hacker and Sazan Rasul
    Citation: EJNMMI Research 2024 14:46
    Content type: Original research Published on:

  36. Thymic cysts are a rare benign disease that needs to be distinguished from low-risk thymoma. [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is a non-invasive imaging tec...

    Authors: Sunju Choi, Yong-il Kim, Sangwon Han, Jae Kwang Yun, Geun Dong Lee, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park and Jin-Sook Ryu
    Citation: EJNMMI Research 2024 14:45
    Content type: Original research Published on:

  37. Authors: Obada M. Alzghool, Richard Aarnio, Jatta S. Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J. Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O. Rinne and Merja Haaparanta‑Solin
    Citation: EJNMMI Research 2024 14:44
    Content type: Correction Published on:

    The original article was published in EJNMMI Research 2024 14:25

  38. 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [11C]3MeO4AP has sho...

    Authors: Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin and Pedro Brugarolas
    Citation: EJNMMI Research 2024 14:43
    Content type: Original research Published on:

  39. In patients with prostate cancer (PCa), imaging with gastrin-releasing peptide receptor (GRPR) ligands is an alternative to PSMA-targeted tracers, particularly if PSMA expression is low or absent. [99mTc]Tc-N4-BT...

    Authors: Andreas Rinscheid, Alexander Gäble, Georgine Wienand, Alexander Dierks, Malte Kircher, Thomas Günther, Marianne Patt, Ralph A. Bundschuh, Constantin Lapa and Christian H. Pfob
    Citation: EJNMMI Research 2024 14:42
    Content type: Original research Published on:

  40. Mitochondrial function plays a key role in regulating neurotransmission and may contribute to general intelligence. Mitochondrial complex I (MC-I) is the largest enzyme of the respiratory chain. Recently, it h...

    Authors: Ekaterina Shatalina, Thomas S. Whitehurst, Ellis Chika Onwordi, Barnabas J. Gilbert, Gaia Rizzo, Alex Whittington, Ayla Mansur, Hideo Tsukada, Tiago Reis Marques, Sridhar Natesan, Eugenii A. Rabiner, Matthew B. Wall and Oliver D. Howes
    Citation: EJNMMI Research 2024 14:41
    Content type: Original research Published on:

  41. The aim of this study was to assess the impact of the post-injection electrical seizure duration on the identification of the seizure onset zone (SOZ) in ictal brain perfusion SPECT in presurgical evaluation o...

    Authors: Amir Karimzadeh, Kian Baradaran-Salimi, Berthold Voges, Ivayla Apostolova, Thomas Sauvigny, Michael Lanz, Susanne Klutmann, Stefan Stodieck, Philipp T. Meyer and Ralph Buchert
    Citation: EJNMMI Research 2024 14:40
    Content type: Original research Published on:

  42. Kinetic modeling of 18F-florbetaben provides important quantification of brain amyloid deposition in research and clinical settings but its use is limited by the requirement of arterial blood data for quantitativ...

    Authors: Emily Nicole Holy, Elizabeth Li, Anjan Bhattarai, Evan Fletcher, Evelyn R. Alfaro, Danielle J. Harvey, Benjamin A. Spencer, Simon R. Cherry, Charles S. DeCarli and Audrey P. Fan
    Citation: EJNMMI Research 2024 14:39
    Content type: Original research Published on:

  44. A new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to less enzymatic degradation. Nevertheless, relatively low tumor radiation...

    Authors: Christof Rottenburger, Michael Hentschel, Markus Fürstner, Lisa McDougall, Danijela Kottoros, Felix Kaul, Rosalba Mansi, Melpomeni Fani, A. Hans Vija, Roger Schibli, Susanne Geistlich, Martin Behe, Emanuel R. Christ and Damian Wild
    Citation: EJNMMI Research 2024 14:37
    Content type: Original research Published on:

  45. Liver uptake in [68Ga]Ga-PSMA-11 PET is used as an internal reference in addition to clinical parameters to select patients for [177Lu]Lu-PSMA-617 radioligand therapy (RLT). Due to increased demand, [68Ga]Ga-PSMA...

    Authors: Cristina E. Popescu, Boya Zhang, Thomas Sartoretti, Noel Spielhofer, Stephan Skawran, Jakob Heimer, Michael Messerli, Alexander Sauter, Martin W. Huellner, Philipp A. Kaufmann, Irene A. Burger and Alexander Maurer
    Citation: EJNMMI Research 2024 14:36
    Content type: Original research Published on:

  47. In juvenile systemic lupus erythematosus (j-SLE) with neuropsychiatric (NP) symptoms, there is a lack of diagnostic biomarkers. Thus, we study whether PET-FDG may identify any metabolic dysfunction in j-NPSLE.

    Authors: Sebastian Rodrigo, Stefania Costi, Pierre Ellul, Melodie Aubart, Nathalie Boddaert, Stephane Auvin, Monique Elmaleh, Alexandra Ntorkou, Brigitte Bader-Meunier, Vincent Lebon, Isabelle Melki and Catherine Chiron
    Citation: EJNMMI Research 2024 14:34
    Content type: Original research Published on:

  48. Accurate measurement of the arterial input function (AIF) is crucial for parametric PET studies, but the AIF is commonly derived from invasive arterial blood sampling. It is possible to use an image-derived in...

    Authors: Hamed Moradi, Rajat Vashistha, Soumen Ghosh, Kieran O’Brien, Amanda Hammond, Axel Rominger, Hasan Sari, Kuangyu Shi, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:33
    Content type: Original research Published on:

  49. Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinic...

    Authors: Mark Muzi, Lanell M. Peterson, Jennifer M. Specht, Daniel S. Hippe, Alena Novakova-Jiresova, Jean H. Lee, Brenda F. Kurland, David A. Mankoff, Nancy Obuchowski, Hannah M. Linden and Paul E. Kinahan
    Citation: EJNMMI Research 2024 14:32
    Content type: Original research Published on:

  50. Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variab...

    Authors: Mette Abildgaard Pedersen, André H. Dias, Karin Hjorthaug, Lars C. Gormsen, Joan Fledelius, Anna Lyhne Johnsson, Signe Borgquist, Trine Tramm, Ole Lajord Munk and Mikkel Holm Vendelbo
    Citation: EJNMMI Research 2024 14:31
    Content type: Original research Published on:

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  • ISSN: 2191-219X (electronic)