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  1. Localized prostate cancer (PCa) in patients is characterized by a dominant focus in the gland (dominant intraprostatic lesion, DIL). Accurate DIL identification may enable more accurate diagnosis and therapy t...

    Authors: Dae-Myoung Yang, Ryan Alfano, Glenn Bauman, Jonathan D. Thiessen, Joseph Chin, Stephen Pautler, Madeleine Moussa, Jose A. Gomez, Irina Rachinsky, Mena Gaed, Kevin J. Chung, Aaron Ward and Ting-Yim Lee

    Citation: EJNMMI Research 2021 11:107

    Content type: Original research

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  2. In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there a...

    Authors: Katja Steiger, Neil Gerard Quigley, Tanja Groll, Frauke Richter, Maximilian Alexander Zierke, Ambros Johannes Beer, Wilko Weichert, Markus Schwaiger, Susanne Kossatz and Johannes Notni

    Citation: EJNMMI Research 2021 11:106

    Content type: Review

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  3. Since three-dimensional segmentation of cardiac region in 123I-metaiodobenzylguanidine (MIBG) study has not been established, this study aimed to achieve organ segmentation using a convolutional neural network (C...

    Authors: Shintaro Saito, Kenichi Nakajima, Lars Edenbrandt, Olof Enqvist, Johannes Ulén and Seigo Kinuya

    Citation: EJNMMI Research 2021 11:105

    Content type: Original research

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  4. The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The d...

    Authors: Günter Schneider, Matthias Wirth, Ulrich Keller and Dieter Saur

    Citation: EJNMMI Research 2021 11:104

    Content type: Review

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  5. Accumulating evidence indicates that neuroinflammation (NI) significantly contributes to drug addiction, but the conversion of NI after drug withdrawal is not clear. Here, we conducted 18F-flutriciclamide (GE180)...

    Authors: Junpeng Li, Da Shao, Donglang Jiang, Qi Huang, Yihui Guan, Bin Lai, Jun Zhao, Fengchun Hua and Fang Xie

    Citation: EJNMMI Research 2021 11:103

    Content type: Original research

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  6. [18F]FDG PET/CT is the elective imaging modality for treatment monitoring in multiple myeloma (MM). However, MM is a heterogeneous disease from an imaging point of view, raising challenges in interpretation of PE...

    Authors: Christos Sachpekidis, Maximilian Merz, Marc-Steffen Raab, Uta Bertsch, Vivienn Weru, Annette Kopp-Schneider, Anna Jauch, Hartmut Goldschmidt and Antonia Dimitrakopoulou-Strauss

    Citation: EJNMMI Research 2021 11:100

    Content type: Original research

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  7. Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation a...

    Authors: Rie Hosoi, Yuka Fujii, Ohba Hiroyuki, Miho Shukuri, Shingo Nishiyama, Masakatsu Kanazawa, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hideo Tsukada and Osamu Inoue

    Citation: EJNMMI Research 2021 11:99

    Content type: Original research

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  8. Gastroenteropancreatic neuroendocrine tumors most commonly metastasize to the liver; however, high normal background 68Ga-DOTATATE activity and high image noise make metastatic lesions difficult to detect. The pu...

    Authors: Jonathan Wehrend, Michael Silosky, Fuyong Xing and Bennett B. Chin

    Citation: EJNMMI Research 2021 11:98

    Content type: Original research

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  9. Multiple myeloma (MM) is a disease of cancerous plasma cells in the bone marrow. Imaging-based timely determination of therapeutic response is critical for improving outcomes in MM patients. Very late antigen-...

    Authors: Anchal Ghai, Nikki Fettig, Francesca Fontana, John DiPersio, Mike Rettig, Julie O. Neal, Samuel Achilefu, Kooresh I. Shoghi and Monica Shokeen

    Citation: EJNMMI Research 2021 11:97

    Content type: Original research

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  10. 99mTc-macroaggregated albumin (99mTc-MAA) scintigraphy is utilized in treatment planning for Yttrium-90 (90Y) Selective Internal Radiation Therapy (SIRT) of liver tumors to evaluate hepatopulmonary shunting by ca...

    Authors: Mike F. Georgiou, Russ A. Kuker, Matthew T. Studenski, Preeti P. Ahlman, Megan Witte and Lorraine Portelance

    Citation: EJNMMI Research 2021 11:96

    Content type: Original research

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  11. PSMA-directed therapy for metastatic prostate cancer is gaining adoption as a treatment option. However, accumulation of 177Lu/225Ac-PSMA in the salivary glands remains a problem, with risk of dose-limiting xeros...

    Authors: V. Mohan, N. M. Bruin, J. B. van de Kamer, J.-J. Sonke and W. V. Vogel

    Citation: EJNMMI Research 2021 11:95

    Content type: Original research

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  12. Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily imp...

    Authors: Jessie Han, Luke Harrison, Lisa Patzelt, Mingming Wu, Daniela Junker, Stephan Herzig, Mauricio Berriel Diaz and Dimitrios C. Karampinos

    Citation: EJNMMI Research 2021 11:94

    Content type: Review

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  13. [18F]-fluorodeoxyglucose-positron emission tomography/computed tomography ([18F]FDG-PET/CT) has been implemented sporadically in hospital settings as the standard of care examination for recurrent breast cancer. ...

    Authors: Marianne Vogsen, Jeanette Dupont Jensen, Oke Gerke, Anne Marie Bak Jylling, Jon Thor Asmussen, Ivar Yannick Christensen, Poul-Erik Braad, Peter Thye-Rønn, Katrine Lydolph Søe, Marianne Ewertz and Malene Grubbe Hildebrandt

    Citation: EJNMMI Research 2021 11:93

    Content type: Original research

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  14. During anthracycline treatment of cancer, there is a lack for biomarkers of cardiotoxicity besides the cardiac dysfunction. The objective of the present study was to compare [18F]FDG and [123I]MIBG (metaiodobenzy...

    Authors: Alexandra Oudot, Alan Courteau, Mélanie Guillemin, Jean-Marc Vrigneaud, Paul Michael Walker, François Brunotte, Alexandre Cochet and Bertrand Collin

    Citation: EJNMMI Research 2021 11:92

    Content type: Original research

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  15. We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent static [18F]FDG PET/CT and MRI, resulting in [18F]FDG PET, T...

    Authors: Inés Mérida, Julien Jung, Sandrine Bouvard, Didier Le Bars, Sophie Lancelot, Franck Lavenne, Caroline Bouillot, Jérôme Redouté, Alexander Hammers and Nicolas Costes

    Citation: EJNMMI Research 2021 11:91

    Content type: Original research

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  16. Interim [18F]fluoro-deoxyglucose-positron emission tomography predicts outcome in peripheral T-cell lymphoma (PTCL). We compared two quantitative evaluation methods.

    Authors: Lars Kurch, Ulrich Dührsen, Andreas Hüttmann, Thomas W. Georgi, Osama Sabri, Regine Kluge and Dirk Hasenclever

    Citation: EJNMMI Research 2021 11:90

    Content type: Short communication

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  17. The usage of immune checkpoint inhibitors (ICIs) is the standard practice for the treatment of metastatic melanoma. However, a significant amount of patients show no response to immunotherapy, while issues on ...

    Authors: Christos Sachpekidis, Annette Kopp-Schneider, Jessica C. Hassel and Antonia Dimitrakopoulou-Strauss

    Citation: EJNMMI Research 2021 11:89

    Content type: Original research

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  18. 6-[18F]fluoro-l-3,4-dihydroxyphenyl alanine ([18F]FDOPA) is a commonly used PET tracer for the detection and staging of neuroendocrine tumors. In neuroendocrine tumors, [18F]FDOPA is decarboxylated to [18F]dopami...

    Authors: Gilles N. Stormezand, Romano S. B. H. Schreuder, Adrienne H. Brouwers, Riemer H. J. A. Slart, Philip H. Elsinga, Annemiek M. E. Walenkamp, R. A. J. O. Dierckx, Andor W. J. M. Glaudemans and Gert Luurtsema

    Citation: EJNMMI Research 2021 11:88

    Content type: Original research

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  19. A combination of positron emission tomography and computed tomography (PET/CT) is an important modality for the diagnosis of carcinoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been ...

    Authors: Hidenori Kido, Shunsuke Kato, Kimihiko Funahashi, Kazutoshi Shibuya, Yousuke Sasaki, Yoshihisa Urita, Masaaki Hori and Sunao Mizumura

    Citation: EJNMMI Research 2021 11:87

    Content type: Original research

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  20. 99mTc-labelled bisphosphonates are used for imaging assessment of patients with transthyretin cardiac amyloidosis (ATTR). Present study evaluates whether quantitative SPECT/CT measurement of absolute myocardial 9...

    Authors: Simona Ben-Haim, A. Chicheportiche, E. Goshen, M. Arad, M. Smekhov, L. J. Menezes, P. M. Elliott, E. O’Mahoney, E. Stern, Bella Yuzefovich and J. B. Bomanji

    Citation: EJNMMI Research 2021 11:86

    Content type: Original research

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  21. Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and...

    Authors: Erik H. J. G. Aarntzen, Edel Noriega-Álvarez, Vera Artiko, André H. Dias, Olivier Gheysens, Andor W. J. M. Glaudemans, Chiara Lauri, Giorgio Treglia, Tim van den Wyngaert, Fijs W. B. van Leeuwen and Samantha Y. A. Terry

    Citation: EJNMMI Research 2021 11:85

    Content type: Guideline

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  22. 68Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist exhibiting higher tumour-to-background ratios and sensitivity compared to 68Ga-DOTATOC. This randomised, 2 × 3 factorial, phase II study aim...

    Authors: Colin G. Miller, Henning Grønbæk, Irene Virgolini, Andreas Kjaer, Pierre Terve, Shadfar Bahri, Peter Iversen, Hanna Svirydenka, Thomas Rohban and Sandy McEwan

    Citation: EJNMMI Research 2021 11:84

    Content type: Original research

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  23. Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is ...

    Authors: Simone Ballke, Irina Heid, Carolin Mogler, Rickmer Braren, Markus Schwaiger, Wilko Weichert and Katja Steiger

    Citation: EJNMMI Research 2021 11:83

    Content type: Short communication

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  24. In clinical diagnostic imaging, dopamine transporter (DAT) SPECT scans are commonly evaluated using automated semiquantitative analysis software. Age correction is routinely implemented, but usually no sex cor...

    Authors: Emma A. Honkanen, Tommi Noponen, Risto Hirvilammi, Kari Lindholm, Riitta Parkkola, Juho Joutsa, Andrea Varrone and Valtteri Kaasinen

    Citation: EJNMMI Research 2021 11:82

    Content type: Original research

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  25. The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is cause...

    Authors: Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen and Godelieve A. M. Tytgat

    Citation: EJNMMI Research 2021 11:81

    Content type: Original research

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  26. Although volumetric imaging by computed tomography (CT) is the gold standard for preoperative assessment of the future liver remnant, nuclear imaging studies have shown promising data. This systematic review s...

    Authors: Caroline Espersen, Lise Borgwardt, Peter Nørgaard Larsen, Trine Borup Andersen, Louise Stenholt and Lars J. Petersen

    Citation: EJNMMI Research 2021 11:80

    Content type: Review

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  27. Radiomics is a promising tool for identifying imaging-based biomarkers. Radiomics-based models are often trained on single-institution datasets; however, multi-centre imaging datasets are preferred for externa...

    Authors: Carol Oliveira, Florian Amstutz, Diem Vuong, Marta Bogowicz, Martin Hüllner, Robert Foerster, Lucas Basler, Christina Schröder, Eric I. Eboulet, Miklos Pless, Sandra Thierstein, Solange Peters, Sven Hillinger, Stephanie Tanadini-Lang and Matthias Guckenberger

    Citation: EJNMMI Research 2021 11:79

    Content type: Original research

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  28. Axillary staging before neoadjuvant systemic therapy in clinically node-positive breast cancer patients with tailored axillary treatment according to the Marking Axillary lymph nodes with radioactive iodine se...

    Authors: Ariane A. van Loevezijn, Marcel P. M. Stokkel, Maarten L. Donswijk, Erik D. van Werkhoven, Marieke E. M. van der Noordaa, Frederieke H. van Duijnhoven and Marie-Jeanne T. F. D. Vrancken Peeters

    Citation: EJNMMI Research 2021 11:78

    Content type: Original research

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  29. The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

    Authors: Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter, Caroline Anna Peuker, Rudolf Werner, Valëza Ademaj-Kospiri, Alexander Gäble, Wolfgang Weber, Hans-Jürgen Wester, Andreas Buck, Peter Herhaus, Constantin Lapa and Ulrich Keller

    Citation: EJNMMI Research 2021 11:77

    Content type: Original research

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  30. The prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer, and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is incre...

    Authors: Hui Wang, Thomas Amiel, Christoph Würnschimmel, Thomas Langbein, Katja Steiger, Isabel Rauscher, Thomas Horn, Tobias Maurer, Wolfgang Weber, Hans-Juergen Wester, Karina Knorr and Matthias Eiber

    Citation: EJNMMI Research 2021 11:76

    Content type: Original research

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  31. 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target...

    Authors: Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah and Yvonne W. S. Jauw

    Citation: EJNMMI Research 2021 11:74

    Content type: Short communication

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  32. Physiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at the organism level. Whole-body PBPK models contain an explicit repres...

    Authors: H. Siebinga, B. J. de Wit-van der Veen, J. H. Beijnen, M. P. M. Stokkel, T. P. C. Dorlo, A. D. R. Huitema and J. J. M. A. Hendrikx

    Citation: EJNMMI Research 2021 11:73

    Content type: Original research

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  33. Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are ref...

    Authors: Friederike Liesche-Starnecker, Georg Prokop, Igor Yakushev, Christine Preibisch, Claire Delbridge, Hanno S. Meyer, Kaywan Aftahy, Melanie Barz, Bernhard Meyer, Claus Zimmer, Jürgen Schlegel, Benedikt Wiestler and Jens Gempt

    Citation: EJNMMI Research 2021 11:72

    Content type: Original research

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  34. Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The a...

    Authors: Matthieu Dietz, Christel H. Kamani, Emmanuel Deshayes, Vincent Dunet, Periklis Mitsakis, George Coukos, Marie Nicod Lalonde, Niklaus Schaefer and John O. Prior

    Citation: EJNMMI Research 2021 11:71

    Content type: Original research

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  35. In this prospective exploratory study, we evaluated the feasibility of [18F]fluorodeoxyglucose ([18F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon thera...

    Authors: Felix N. Harder, Friederike Jungmann, Georgios A. Kaissis, Fabian K. Lohöfer, Sebastian Ziegelmayer, Daniel Havel, Michael Quante, Maximillian Reichert, Roland M. Schmid, Ihsan Ekin Demir, Helmut Friess, Moritz Wildgruber, Jens Siveke, Alexander Muckenhuber, Katja Steiger, Wilko Weichert…

    Citation: EJNMMI Research 2021 11:70

    Content type: Original research

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  36. Bronchoscopy serves as direct visualisation of the airway. Virtual bronchoscopy provides similar visual information using a non-invasive imaging procedure(s). Early and accurate image-guided diagnosis requires...

    Authors: Gábor Opposits, Marianna Nagy, Zoltán Barta, Csaba Aranyi, Dániel Szabó, Attila Makai, Imre Varga, László Galuska, Lajos Trón, László Balkay and Miklós Emri

    Citation: EJNMMI Research 2021 11:69

    Content type: Original research

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  37. Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare entity occurring in less than 4% of all lung cancers. Due to its low differentiation and high glucose transporter 1 (GLUT1) expression, LCNEC d...

    Authors: Hubertus Hautzel, Yazan Alnajdawi, Wolfgang P. Fendler, Christoph Rischpler, Kaid Darwiche, Wilfried E. Eberhardt, Lale Umutlu, Dirk Theegarten, Martin Stuschke, Martin Schuler, Clemens Aigner, Ken Herrmann and Till Plönes

    Citation: EJNMMI Research 2021 11:68

    Content type: Original research

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  38. Tumor hypoxia and glycolysis have been recognized as determinant factors characterizing tumor aggressiveness in malignant gliomas. To clarify in vivo hypoxia and glucose metabolism in relation to isocitrate dehyd...

    Authors: Kenta Suzuki, Nobuyuki Kawai, Tomoya Ogawa, Keisuke Miyake, Aya Shinomiya, Yuka Yamamoto, Yoshihiro Nishiyama and Takashi Tamiya

    Citation: EJNMMI Research 2021 11:67

    Content type: Original research

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  39. PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radion...

    Authors: Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke and Frank I. Lin

    Citation: EJNMMI Research 2021 11:66

    Content type: Original research

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  40. The role of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiati...

    Authors: Christina P. W. Cox, Daniëlle M. E. van Assema, Frederik A. Verburg, Tessa Brabander, Mark Konijnenberg and Marcel Segbers

    Citation: EJNMMI Research 2021 11:65

    Content type: Original research

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  41. The aim of this study was to explore the prognostic value of baseline metabolic parameters of 18F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).

    Authors: Huanyu Gong, Tiannv Li, Jianyong Li, Lijun Tang and Chongyang Ding

    Citation: EJNMMI Research 2021 11:64

    Content type: Original research

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  42. Auger electron-emitting radionuclides have potential in targeted treatment of small tumors. Thallium-201 (201Tl), a gamma-emitting radionuclide used in myocardial perfusion scintigraphy, decays by electron captur...

    Authors: Katarzyna M. Osytek, Philip J. Blower, Ines M. Costa, Gareth E. Smith, Vincenzo Abbate and Samantha Y. A. Terry

    Citation: EJNMMI Research 2021 11:63

    Content type: Original research

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  43. In 2015, the revised International Pediatric Non-Hodgkin Lymphoma Staging System was published. It mentions [18F]-FDG-PET/MRI as the latest method to perform whole-body imaging. However, supporting data are pendi...

    Authors: L. Kurch, R. Kluge, O. Sabri, L. Fischer, S. Wendt, H. Graf Einsiedel, S. Starke, J.-S. Kühl, H. Christiansen, F. W. Hirsch, I. Sorge and C. Roth

    Citation: EJNMMI Research 2021 11:62

    Content type: Original research

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  44. Myelosuppression is a potential dose-limiting factor in radioligand therapy (RLT). This study aims to investigate occurrence, severity and reversibility of hematotoxic adverse events in patients undergoing RLT...

    Authors: Daniel Groener, Cam Tu Nguyen, Justus Baumgarten, Benjamin Bockisch, Karen Davis, Christian Happel, Nicolai Mader, Christina Nguyen Ngoc, Jennifer Wichert, Severine Banek, Philipp Mandel, Felix K. H. Chun, Nikolaos Tselis, Frank Grünwald and Amir Sabet

    Citation: EJNMMI Research 2021 11:61

    Content type: Original research

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  45. There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different 99mTc-dicarboxypropandiphosphate ([99mTc]Tc-DPD) SPECT/CT quantificati...

    Authors: Martin Braun, Michal Cachovan, Felix Kaul, Federico Caobelli, Markus Bäumer, A. Hans Vija, Geert Pagenstert, Damian Wild and Martin Kretzschmar

    Citation: EJNMMI Research 2021 11:60

    Content type: Original research

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  46. Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of [99mTc]Tc-Galacto-RGD2 single-photon emission computed tomography ...

    Authors: Jingjing Fu, Yan Xie, Tong Fu, Fan Qiu, Fei Yu, Wei Qu, Xiaochen Yao, Aiping Zhang, Zhenhua Yang, Guoqiang Shao, Qingle Meng, Xiumin Shi, Yue Huang, Wei Gu and Feng Wang

    Citation: EJNMMI Research 2021 11:59

    Content type: Original research

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