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  1. [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor r...

    Authors: Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher…

    Citation: EJNMMI Research 2021 11:5

    Content type: Original research

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  2. Positron emission tomography (PET) is routinely used for cancer staging and treatment follow-up. Metabolic active tumor volume (MATV) as well as total MATV (TMATV—including primary tumor, lymph nodes and metas...

    Authors: Elisabeth Pfaehler, Liesbet Mesotten, Gem Kramer, Michiel Thomeer, Karolien Vanhove, Johan de Jong, Peter Adriaensens, Otto S. Hoekstra and Ronald Boellaard

    Citation: EJNMMI Research 2021 11:4

    Content type: Original research

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  3. Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)–targeted positron emission...

    Authors: Jonathan Kuten, Snir Dekalo, Ishai Mintz, Ofer Yossepowitch, Roy Mano and Einat Even-Sapir

    Citation: EJNMMI Research 2021 11:3

    Content type: Original research

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  4. Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-...

    Authors: Dae-Myoung Yang, Fiona Li, Glenn Bauman, Joseph Chin, Stephen Pautler, Madeleine Moussa, Irina Rachinsky, John Valliant and Ting-Yim Lee

    Citation: EJNMMI Research 2021 11:2

    Content type: Original research

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  5. The aim of this study was to compare a commercial dosimetry workstation (PLANET® Dose) and the dosimetry approach (GE Dosimetry Toolkit® and OLINDA/EXM® V1.0) currently used in our department for quantificatio...

    Authors: Lore Santoro, L. Pitalot, D. Trauchessec, E. Mora-Ramirez, P. O. Kotzki, M. Bardiès and E. Deshayes

    Citation: EJNMMI Research 2021 11:1

    Content type: Original research

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  6. We investigated the image quality of 11C, 68Ga, 18F and 89Zr, which have different positron fractions, physical half-lifes and positron ranges. Three small animal positron emission tomography/computed tomography ...

    Authors: Jarmo Teuho, Leon Riehakainen, Aake Honkaniemi, Olli Moisio, Chunlei Han, Marko Tirri, Shihao Liu, Tove J. Grönroos, Jie Liu, Lin Wan, Xiao Liang, Yiqing Ling, Yuexuan Hua, Anne Roivainen, Juhani Knuuti, Qingguo Xie…

    Citation: EJNMMI Research 2020 10:155

    Content type: Original research

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  7. 2-deoxy-2-[18F]fluoro-d-glucose’s (FDG) biodistribution limits the evaluation of cardiac sarcoidosis (CS) and neurosarcoidosis (NS). While protocols for cardiac suppression exist, they can be inconvenient for pat...

    Authors: Patrick Martineau, Matthieu Pelletier-Galarneau, Daniel Juneau, Eugene Leung, Pablo Nery, Rob deKemp, Rob Beanlands and David Birnie

    Citation: EJNMMI Research 2020 10:154

    Content type: Original research

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  8. The efficiency of [18F]FDG PET/CT using volume-based indices was evaluated to assess the disease activity and response to therapy in patients with immunoglobulin G4-related disease (IgG4-RD).

    Authors: Katsuya Mitamura, Hanae Arai-Okuda, Yuka Yamamoto, Takashi Norikane, Yasukage Takami, Kengo Fujimoto, Risa Wakiya, Hiroki Ozaki, Hiroaki Dobashi and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2020 10:153

    Content type: Original research

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  9. Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype ...

    Authors: Mohammed Shahid, Juha O. Rinne, Mika Scheinin, Jere Virta, Päivi Marjamäki, Olof Solin, Eveliina Arponen, Jukka Sallinen, Katja Kuokkanen and Juha Rouru

    Citation: EJNMMI Research 2020 10:152

    Content type: Original research

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  10. Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treat...

    Authors: Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian. J. Leeper, Kevin M. Brindle and André A. Neves

    Citation: EJNMMI Research 2020 10:151

    Content type: Original research

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  11. Deriving links between imaging and genomic markers is an evolving field. 2-[18F]FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography–computed tomography) is commonly used for cancer imaging, with maxim...

    Authors: Amin Haghighat Jahromi, Donald A. Barkauskas, Matthew Zabel, Aaron M. Goodman, Garret Frampton, Mina Nikanjam, Carl K. Hoh and Razelle Kurzrock

    Citation: EJNMMI Research 2020 10:150

    Content type: Original research

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  12. Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68G...

    Authors: Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo and Hans-Jürgen Wester

    Citation: EJNMMI Research 2020 10:149

    Content type: Original research

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  13. Stereotactic radiosurgery (SRS) is often the primary treatment modality for patients with intracranial metastatic disease. Despite advances in magnetic resonance imaging, including use of perfusion and diffusi...

    Authors: Ephraim E. Parent, Dhruv Patel, Jonathon A. Nye, Zhuo Li, Jeffrey J. Olson, David M. Schuster and Mark M. Goodman

    Citation: EJNMMI Research 2020 10:148

    Content type: Original research

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  14. Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity...

    Authors: Yusuf Helo, Graham E. Searle, Federica Borghese, Sonya Abraham and Azeem Saleem

    Citation: EJNMMI Research 2020 10:147

    Content type: Short communication

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  15. The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalys...

    Authors: Alice Egerton, Joel T. Dunn, Nisha Singh, Zilin Yu, Jim O’Doherty, Ivan Koychev, Jessica Webb, Simon Claridge, Federico E. Turkheimer, Paul K. Marsden, Alexander Hammers and Antony Gee

    Citation: EJNMMI Research 2020 10:146

    Content type: Original research

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  16. Checkpoint inhibition therapy using monoclonal antibodies against programmed cell death protein 1 (PD-1) or its ligand (PD-L1) is now standard management of non-small cell lung cancer (NSCLC). PD-L1 expression...

    Authors: Daniel Johnathan Hughes, Gitasha Chand, Vicky Goh and Gary J. R. Cook

    Citation: EJNMMI Research 2020 10:145

    Content type: Original research

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  17. Digital PET cameras markedly improve sensitivity and spatial resolution of brain 18F-FDG PET images compared to conventional cameras. Our study aimed to assess whether specific control databases are required to i...

    Authors: Elise Mairal, Matthieu Doyen, Thérèse Rivasseau-Jonveaux, Catherine Malaplate, Eric Guedj and Antoine Verger

    Citation: EJNMMI Research 2020 10:144

    Content type: Original research

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  18. Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following AD...

    Authors: Gaurav Malviya, Rachana Patel, Mark Salji, Rafael S. Martinez, Peter Repiscak, Ernest Mui, Susan Champion, Agata Mrowinska, Emma Johnson, Maha AlRasheedi, Sally Pimlott, David Lewis and Hing Y. Leung

    Citation: EJNMMI Research 2020 10:143

    Content type: Original research

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  19. Deriving individual tumor genomic characteristics from patient imaging analysis is desirable. We explore the predictive value of 2-[18F]FDG uptake with regard to the KRAS mutational status of colorectal adenocarc...

    Authors: M. Popovic, O. Talarico, J. van den Hoff, H. Kunin, Z. Zhang, D. Lafontaine, S. Dogan, J. Leung, E. Kaye, C. Czmielewski, M. E. Mayerhoefer, P. Zanzonico, R. Yaeger, H. Schöder, J. L. Humm, S. B. Solomon…

    Citation: EJNMMI Research 2020 10:142

    Content type: Original research

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  20. In molecular imaging with dynamic PET, the binding and dissociation of a targeted tracer is characterized by kinetics modeling which requires the arterial concentration of the tracer to be measured accurately....

    Authors: Fiona Li, Justin W. Hicks, Lihai Yu, Lise Desjardin, Laura Morrison, Jennifer Hadway and Ting-Yim Lee

    Citation: EJNMMI Research 2020 10:141

    Content type: Original research

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  21. Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1...

    Authors: Dorien Glorie, Jeroen Verhaeghe, Alan Miranda, Stef De Lombaerde, Sigrid Stroobants and Steven Staelens

    Citation: EJNMMI Research 2020 10:140

    Content type: Original research

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  22. Assessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar sci...

    Authors: Annie K. Kogler, Andrew M. Polemi, Surabhi Nair, Stanislaw Majewski, Lynn T. Dengel, Craig L. Slingluff Jr, Brian Kross, S. J. Lee, J. E. McKisson, John McKisson, Andrew G. Weisenberger, Benjamin L. Welch, Thomas Wendler, Philipp Matthies, Joerg Traub, Michael Witt…

    Citation: EJNMMI Research 2020 10:139

    Content type: Original research

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  23. Clinical management decisions on prostate cancer (PCa) are often based on a determination of risk. 68Ga-prostate-specific membrane antigen (PSMA)-11-positron emission tomography (PET)/computer tomography (CT) is ...

    Authors: Jun-jie Hong, Bo-le Liu, Zhi-qiang Wang, Kun Tang, Xiao-wei Ji, Wei-wei Yin, Jie Lin and Xiang-wu Zheng

    Citation: EJNMMI Research 2020 10:138

    Content type: Original research

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  24. Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts.

    Authors: Silvia Morbelli, Dario Arnaldi, Eugenia Cella, Stefano Raffa, Maria Isabella Donegani, Selene Capitanio, Federico Massa, Alberto Miceli, Laura Filippi, Andrea Chincarini and Flavio Nobili

    Citation: EJNMMI Research 2020 10:137

    Content type: Short communication

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  25. Brown adipose tissue (BAT) is a fat tissue found in most mammals that helps regulate energy balance and core body temperature through a sympathetic process known as non-shivering thermogenesis. BAT activity is...

    Authors: Christian T. McHugh, John Garside, Jared Barkes, Jonathan Frank, Constance Dragicevich, Hong Yuan and Rosa T. Branca

    Citation: EJNMMI Research 2020 10:136

    Content type: Original research

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  26. The study aimed to evaluate the effect of androgen deprivation therapy (ADT) on PSMA imaging and its correlation to the PSA concentration by comparing qualitative and quantitative parameters: SUVmax, SUVmean, PSM...

    Authors: Sebastian Hoberück, Steffen Löck, Robert Winzer, Klaus Zöphel, Michael Froehner, Dieter Fedders, Jörg Kotzerke and Tobias Hölscher

    Citation: EJNMMI Research 2020 10:135

    Content type: Original research

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  27. Asphericity (ASP) of the primary tumor’s metabolic tumor volume (MTV) in FDG-PET/CT is independently predictive for survival in patients with non-small cell lung cancer (NSCLC). However, comparability between ...

    Authors: Julian M. M. Rogasch, Christian Furth, Stephanie Bluemel, Piotr Radojewski, Holger Amthauer and Frank Hofheinz

    Citation: EJNMMI Research 2020 10:134

    Content type: Original research

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  28. As a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemore...

    Authors: Neil Gerard Quigley, Katja Steiger, Frauke Richter, Wilko Weichert, Sebastian Hoberück, Jörg Kotzerke and Johannes Notni

    Citation: EJNMMI Research 2020 10:133

    Content type: Original research

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  29. Prostate-specific membrane antigen (PSMA) agents, such as [68Ga]Ga-PSMA-11, have an unprecedented accuracy in staging prostate cancer (PCa) and detecting disease recurrence. PSMA PET/CT may also be used for respo...

    Authors: Judith olde Heuvel, Berlinda J. de Wit-van der Veen, Maarten L. Donswijk, Cornelis H. Slump and Marcel P. M. Stokkel

    Citation: EJNMMI Research 2020 10:132

    Content type: Original research

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  30. With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson’s disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. ...

    Authors: Jingjie Ge, Min Wang, Wei Lin, Ping Wu, Yihui Guan, Huiwei Zhang, Zhemin Huang, Likun Yang, Chuantao Zuo, Jiehui Jiang, Axel Rominger and Kuangyu Shi

    Citation: EJNMMI Research 2020 10:131

    Content type: Original research

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  31. [177Lu]Lu-DOTA-ZOL has shown promising results from the dosimetry and preclinical aspects, but data on its role in the clinical efficacy are limited. The objective of this study is to evaluate the efficacy and sa...

    Authors: Madhav Prasad Yadav, Sanjana Ballal, Marian Meckel, Frank Roesch and Chandrasekhar Bal

    Citation: EJNMMI Research 2020 10:130

    Content type: Original research

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  32. Prostate-specific membrane antigen (PSMA) is expressed in the microvasculature of thyroid cancer. This suggests the potential use of PSMA as a diagnostic agent in patients with aggressive forms of thyroid canc...

    Authors: Courtney Lawhn-Heath, Sue S. Yom, Chienying Liu, Javier E. Villanueva-Meyer, Maya Aslam, Raven Smith, Manpreet Narwal, Roxanna Juarez, Spencer C. Behr, Miguel Hernandez Pampaloni, Jason W. Chan, Christine M. Glastonbury, Thomas A. Hope and Robert R. Flavell

    Citation: EJNMMI Research 2020 10:128

    Content type: Original research

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  33. In vivo imaging of glucose analogue 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) via positron emission tomography (PET) is the current gold standard to visualize and assess brown adipose tissue (BAT) activity. Howe...

    Authors: Andreas Paulus, Natascha Drude, Wouter van Marken Lichtenbelt, Felix M. Mottaghy and Matthias Bauwens

    Citation: EJNMMI Research 2020 10:127

    Content type: Original research

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  34. Some neuropsychological diseases are associated with abnormal thiamine metabolism, including Korsakoff–Wernicke syndrome and Alzheimer’s disease. However, in vivo detection of the status of brain thiamine meta...

    Authors: Changpeng Wang, Siwei Zhang, Yuefei Zou, Hongzhao Ma, Donglang Jiang, Lei Sheng, Shaoming Sang, Lirong Jin, Yihui Guan, Yuan Gui, Zhihong Xu and Chunjiu Zhong

    Citation: EJNMMI Research 2020 10:126

    Content type: Original research

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  35. To analyze the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional ...

    Authors: Amalia Peix, Kenia Padrón, Lázaro O. Cabrera, Osmín Castañeda, Danet Milán, Jesús Castro, Roylan Falcón, Frank Martínez, Lydia Rodríguez, Jesús Sánchez, Erick Mena, Regla Carrillo, Yoel Fernández, Ricardo Escarano, Diana Páez and Maurizio Dondi

    Citation: EJNMMI Research 2020 10:125

    Content type: Original research

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  36. Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodent...

    Authors: Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Nakul R. Raval, Ida V. Andersen, Fraser G. Edgar, Nikolaj R. Speth, Simone L. Baerentzen, Hanne D. Hansen, Lene L. Donovan, Arafat Nasser, Siv T. Peitersen, Andreas Kjaer, Gitte M. Knudsen, Stina Syvänen, Mikael Palner…

    Citation: EJNMMI Research 2020 10:124

    Content type: Original research

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  37. The standard reference region (RR) for amyloid-beta (Aβ) PET studies is the cerebellar grey matter (GMCB), while alternative RRs have mostly been utilized without prior validation against the gold standard. Th...

    Authors: Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Rik Ossenkoppele, Nelleke Tolboom, Bart N. M. van Berckel, Adriaan A. Lammertsma and Maqsood Yaqub

    Citation: EJNMMI Research 2020 10:123

    Content type: Original research

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  38. This is a prospective, single-center trial in pediatric patients with sarcoma aiming to evaluate [18F]FDG PET/CT as a tool for early response assessment to neoadjuvant chemotherapy (neo-CTX).

    Authors: Giulia Polverari, Francesco Ceci, Roberto Passera, Jacquelyn Crane, Lin Du, Gang Li, Stefano Fanti, Nicholas Bernthal, Fritz C. Eilber, Martin Allen-Auerbach, Johannes Czernin, Jeremie Calais and Noah Federman

    Citation: EJNMMI Research 2020 10:122

    Content type: Original research

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  39. Brain SPECT perfusion and PET metabolism have been, most often interchangeably, proposed to study the underlying pathological process in major depressive disorder (MDD). The objective of this study was to spec...

    Authors: Maud Tastevin, Laurent Boyer, Theo Korchia, Guillaume Fond, Christophe Lançon, Raphaëlle Richieri and Eric Guedj

    Citation: EJNMMI Research 2020 10:121

    Content type: Preliminary research

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  40. 18F-FDG PET/CT is a standard for many B cell malignancies, while blood DNA measurements are emerging tools. Our objective was to evaluate the correlations between baseline PET parameters and circulating DNA in d....

    Authors: Pierre Decazes, Vincent Camus, Elodie Bohers, Pierre-Julien Viailly, Hervé Tilly, Philippe Ruminy, Mathieu Viennot, Sébastien Hapdey, Isabelle Gardin, Stéphanie Becker, Pierre Vera and Fabrice Jardin

    Citation: EJNMMI Research 2020 10:120

    Content type: Original research

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  41. Strong line of evidence suggests that the increased risk to develop AD may at least be partly mediated by cholesterol metabolism. A key regulator of cholesterol transport is the Apolipoprotein E4 (ApoE4), whic...

    Authors: Angela Kuhla, Lou Meuth, Jan Stenzel, Tobias Lindner, Chris Lappe, Jens Kurth, Bernd J. Krause, Stefan Teipel, Änne Glass, Guenther Kundt and Brigitte Vollmar

    Citation: EJNMMI Research 2020 10:119

    Content type: Original research

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  42. Integrin αvβ3, which are expressed by activated hepatic stellate cells in non-alcoholic steatohepatitis (NASH), play an important role in the fibrosis. Recently, we reported that an RGD peptide positron emission ...

    Authors: Shuichi Hiroyama, Takemi Rokugawa, Miwa Ito, Hitoshi Iimori, Ippei Morita, Hiroki Maeda, Kae Fujisawa, Keiko Matsunaga, Eku Shimosegawa and Kohji Abe

    Citation: EJNMMI Research 2020 10:118

    Content type: Original research

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  43. Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiol...

    Authors: Yo-Han Joo, Yun-Kwan Kim, In-Gyu Choi, Hyeon-Jin Kim, Young-Don Son, Hang-Keun Kim, Paul Cumming and Jong-Hoon Kim

    Citation: EJNMMI Research 2020 10:116

    Content type: Original research

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  44. Increases in fasting plasma glucose (PG) levels lead to a decrease in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) uptake in the normal brain, especially in the precuneus, resulting in an Alzheimer’s disease (AD)-l...

    Authors: Jun Toyohara, Norihiro Harada, Takeharu Kakiuchi, Hiroyuki Ohba, Masakatsu Kanazawa, Tetsuro Tago, Muneyuki Sakata and Kiichi Ishiwata

    Citation: EJNMMI Research 2020 10:115

    Content type: Original research

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  45. Clinical positron emission tomography (PET) imaging of the presynaptic norepinephrine transporter (NET) function provides valuable diagnostic information on sympathetic outflow and neuronal status. As data on ...

    Authors: Linjing Mu, Stefanie D. Krämer, Geoffrey I. Warnock, Ahmed Haider, Susan Bengs, Giovanni Cartolano, Dominic S. Bräm, Claudia Keller, Roger Schibli, Simon M. Ametamey, Philipp A. Kaufmann and Catherine Gebhard

    Citation: EJNMMI Research 2020 10:114

    Content type: Original research

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  46. Accurate and sensitive imaging biomarkers are required to study the progression of white matter (WM) inflammation in neurodegenerative diseases. Radioligands targeting the translocator protein (TSPO) are consi...

    Authors: Nassir U. Al-Khishman, Qi Qi, Austyn D. Roseborough, Alexander Levit, Brian L. Allman, Udunna C. Anazodo, Matthew S. Fox, Shawn N. Whitehead and Jonathan D. Thiessen

    Citation: EJNMMI Research 2020 10:113

    Content type: Original research

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  47. Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alteratio...

    Authors: Verena Buchecker, Ann-Marie Waldron, R. Maarten van Dijk, Ines Koska, Matthias Brendel, Barbara von Ungern-Sternberg, Simon Lindner, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein and Heidrun Potschka

    Citation: EJNMMI Research 2020 10:112

    Content type: Short communication

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  48. The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag tech...

    Authors: Frans V. Suurs, Si-Qi Qiu, Joshua J. Yim, Carolien P. Schröder, Hetty Timmer-Bosscha, Eric S. Bensen, John T. Santini Jr, Elisabeth G. E. de Vries, Matthew Bogyo and Gooitzen M. van Dam

    Citation: EJNMMI Research 2020 10:111

    Content type: Original research

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