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  1. Original research

    Motor impairment and compensation in a hemiparkinsonian rat model: correlation between dopamine depletion severity, cerebral metabolism and gait patterns

    In Parkinson’s disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment...

    Elena Kordys, Nadine Apetz, Katharina Schneider, Eilidh Duncan, Beatriz Büschbell, Cathrin Rohleder, Michael Sué, Alexander Drzezga, Bernd Neumaier, Lars Timmermann and Heike Endepols

    EJNMMI Research 2017 7:68

    Published on: 23 August 2017

  2. Original research

    Revisiting the Logan plot to account for non-negligible blood volume in brain tissue

    Reference tissue-based quantification of brain PET data does not typically include correction for signal originating from blood vessels, which is known to result in biased outcome measures. The bias extent dep...

    Martin Schain, Patrik Fazio, Ladislav Mrzljak, Nahid Amini, Nabil Al-Tawil, Cheryl Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Christina Sampaio, Christer Halldin and Andrea Varrone

    EJNMMI Research 2017 7:66

    Published on: 18 August 2017

  3. Preliminary research

    Semi-quantitative metabolic values on FDG PET/CT including extracardiac sites of disease as a predictor of treatment course in patients with cardiac sarcoidosis

    Cardiac sarcoidosis is associated with major adverse cardiac events including cardiac arrest, for which anti-inflammatory treatment is indicated. Oral corticosteroid is the mainstay among treatment options; ho...

    Mitsutomi Ishiyama, Laurie A. Soine and Hubert J. Vesselle

    EJNMMI Research 2017 7:67

    Published on: 18 August 2017

  4. Original research

    Introducing navigation during melanoma-related sentinel lymph node procedures in the head-and-neck region

    Intraoperative sentinel node (SN) identification in patients with head-and-neck malignancies can be challenging due to unexpected drainage patterns and anatomical complexity. Here, intraoperative navigation-ba...

    Gijs H. KleinJan, Baris Karakullukçu, W. Martin C. Klop, Thijs Engelen, Nynke S. van den Berg and Fijs W. B. van Leeuwen

    EJNMMI Research 2017 7:65

    Published on: 17 August 2017

  5. Original research

    A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors

    α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We ...

    Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma…

    EJNMMI Research 2017 7:63

    Published on: 16 August 2017

  6. Original research

    O-(2-[18F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres

    PET using O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) is an established method for brain tumour diagnostics, but data processing varies in different centres. This study analyses the influence of methodological di...

    Christian P. Filss, Nathalie L. Albert, Guido Böning, Elena Rota Kops, Bogdana Suchorska, Gabriele Stoffels, Norbert Galldiks, Nadim J. Shah, Felix M. Mottaghy, Peter Bartenstein, Jörg C. Tonn and Karl-Josef Langen

    EJNMMI Research 2017 7:64

    Published on: 16 August 2017

  7. Original research

    Selective targeting of melanoma using N-(2-diethylaminoethyl) 4-[18F]fluoroethoxy benzamide (4-[18F]FEBZA): a novel PET imaging probe

    The purpose of this study was to develop a positron emission tomography (PET) imaging probe that is easy to synthesize and selectively targets melanoma in vivo. Herein, we report the synthesis and preclinical ...

    Pradeep K. Garg, Rachid Nazih, Yanjun Wu, Vladimir P. Grinevich and Sudha Garg

    EJNMMI Research 2017 7:61

    Published on: 8 August 2017

  8. Original research

    The effects of segmentation algorithms on the measurement of 18F-FDG PET texture parameters in non-small cell lung cancer

    Measures of tumour heterogeneity derived from 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans are increasingly reported as potential biomarkers of non-small cell l...

    Usman Bashir, Gurdip Azad, Muhammad Musib Siddique, Saana Dhillon, Nikheel Patel, Paul Bassett, David Landau, Vicky Goh and Gary Cook

    EJNMMI Research 2017 7:60

    Published on: 26 July 2017

  9. Preliminary research

    Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates

    The 18-kDa translocator protein (TSPO) is an important target for assessing neuroimmune function in brain with positron-emission tomography (PET) imaging. The goal of this work was to assess two [11C]PBR28 imagin...

    Ansel T. Hillmer, Daniel Holden, Krista Fowles, Nabeel Nabulsi, Brian L. West, Richard E. Carson and Kelly P. Cosgrove

    EJNMMI Research 2017 7:59

    Published on: 24 July 2017

  10. Short communication

    Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data

    Kinetic modelling with metabolite-corrected arterial plasma is considered the gold standard for quantification of [11C]PBR28 binding to the translocator protein (TSPO), since there is no brain region devoid of TS...

    Granville J. Matheson, Pontus Plavén-Sigray, Anton Forsberg, Andrea Varrone, Lars Farde and Simon Cervenka

    EJNMMI Research 2017 7:58

    Published on: 21 July 2017

  11. Original research

    Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

    Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted deli...

    Jessie R. Nedrow, Anders Josefsson, Sunju Park, Tom Bäck, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern and George Sgouros

    EJNMMI Research 2017 7:57

    Published on: 18 July 2017

  12. Original research

    FLT-PET for early response evaluation of colorectal cancer patients with liver metastases: a prospective study

    Fluoro-L-thymidine (FLT) is a positron emission tomography/computed tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main objective of this prospective explorative study...

    Marie Benzon Mogensen, Annika Loft, Marianne Aznar, Thomas Axelsen, Ben Vainer, Kell Osterlind and Andreas Kjaer

    EJNMMI Research 2017 7:56

    Published on: 10 July 2017

  13. Preliminary Research

    Use of a digital phantom developed by QIBA for harmonizing SUVs obtained from the state-of-the-art SPECT/CT systems: a multicenter study

    Although quantitative analysis using standardized uptake value (SUV) becomes realistic in clinical single-photon emission computed tomography/computed tomography (SPECT/CT) imaging, reconstruction parameter se...

    Tadaki Nakahara, Hiromitsu Daisaki, Yasushi Yamamoto, Takashi Iimori, Kazuyuki Miyagawa, Tomoya Okamoto, Yoshiki Owaki, Nobuhiro Yada, Koichi Sawada, Ryotaro Tokorodani and Masahiro Jinzaki

    EJNMMI Research 2017 7:53

    Published on: 20 June 2017

  14. Original research

    PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease

    The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). 15O-water positron emission tomogra...

    Osamu Manabe, Masanao Naya, Tadao Aikawa, Masahiko Obara, Keiichi Magota, Markus Kroenke, Noriko Oyama-Manabe, Kenji Hirata, Daiki Shinyama, Chietsugu Katoh and Nagara Tamaki

    EJNMMI Research 2017 7:52

    Published on: 5 June 2017

  15. Short communication

    Response assessment with the CXCR4-directed positron emission tomography tracer [68Ga]Pentixafor in a patient with extranodal marginal zone lymphoma of the orbital cavities

    CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is over...

    Peter Herhaus, Stefan Habringer, Tibor Vag, Katja Steiger, Julia Slotta-Huspenina, Carlos Gerngroß, Benedikt Wiestler, Hans-Jürgen Wester, Markus Schwaiger and Ulrich Keller

    EJNMMI Research 2017 7:51

    Published on: 2 June 2017

  16. Original research

    Clinical value of fluorine-18α-methyltyrosine PET in patients with gliomas: comparison with fluorine-18 fluorodeoxyglucose PET

    We investigated the relationship between metabolic activity and histological features of gliomas using fluorine-18α-methyltyrosine (18F-FAMT) positron emission tomography (PET) compared with fluorine-18 fluorodeo...

    Keishi Horiguchi, Masahiko Tosaka, Tetsuya Higuchi, Yukiko Arisaka, Kenichi Sugawara, Junko Hirato, Hideaki Yokoo, Yoshito Tsushima and Yuhei Yoshimoto

    EJNMMI Research 2017 7:50

    Published on: 31 May 2017

  17. Original research

    Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab

    The ability to image vascular endothelial growth factor (VEGF) could enable prospective, non-invasive monitoring of patients receiving anti-angiogenic therapy. This study investigates the specificity and pharm...

    Neel Patel, Sarah Able, Danny Allen, Emmanouil Fokas, Bart Cornelissen, Fergus V. Gleeson, Adrian L. Harris and Katherine A. Vallis

    EJNMMI Research 2017 7:49

    Published on: 30 May 2017

  18. Original research

    Towards standardization of 18F-FET PET imaging: do we need a consistent method of background activity assessment?

    PET with O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) has reached increasing clinical significance for patients with brain neoplasms. For quantification of standard PET-derived parameters such as the tumor-to-backg...

    Marcus Unterrainer, Franziska Vettermann, Matthias Brendel, Adrien Holzgreve, Michael Lifschitz, Matthias Zähringer, Bogdana Suchorska, Vera Wenter, Ben M. Illigens, Peter Bartenstein and Nathalie L. Albert

    EJNMMI Research 2017 7:48

    Published on: 30 May 2017

  19. Original research

    Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

    An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fl...

    Christopher Coello, Marie Fisk, Divya Mohan, Frederick J. Wilson, Andrew P. Brown, Michael I. Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S. Murphy, Joseph Cheriyan and Roger N. Gunn

    EJNMMI Research 2017 7:47

    Published on: 25 May 2017

  20. Original Research

    Clinical and imaging-based prognostic factors in radioembolisation of liver metastases from colorectal cancer: a retrospective exploratory analysis

    The aim of this study was to investigate the relationship between absorbed dose and response of colorectal cancer liver metastases treated with [90Y]-resin microspheres and to explore possible clinical and imagin...

    Kathy P. Willowson, Aimee R. Hayes, David L. H. Chan, Michael Tapner, Elizabeth J. Bernard, Richard Maher, Nick Pavlakis, Stephen J. Clarke and Dale L. Bailey

    EJNMMI Research 2017 7:46

    Published on: 23 May 2017

  21. Original research

    Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected 11C-methionine uptake

    Tumor to normal tissue ratio (T/N ratio) on 11C-methionine (11C-MET) positron emission tomography/computed tomography (PET/CT) is affected by variable factors. We investigated whether T/N ratio cutoff values corr...

    Tae-Young Jung, In-Young Kim, Sa-Hoe Lim, Ki Seong Park, Dong-Yeon Kim, Shin Jung, Kyung-Sub Moon, Woo-Youl Jang, Sae-Ryung Kang, Sang-Geon Cho, Jung-Joon Min, Hee-Seung Bom and Seong Young Kwon

    EJNMMI Research 2017 7:45

    Published on: 23 May 2017

  22. Original research

    First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK

    Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RG...

    Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F. Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl and John O. Prior

    EJNMMI Research 2017 7:43

    Published on: 18 May 2017

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