Articles

CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett’s esophagus

Near-infrared (NIR) fluorescence imaging has been emerging as a promising strategy to overcome the high number of early esophageal adenocarcinomas missed by white light endoscopy and random biopsy collection. ...

Authors: Sabrina Marcazzan, Marcos J. Braz Carvalho, Matthias Konrad, Julia Strangmann, Anna Tenditnaya, Theresa Baumeister, Roland M. Schmid, Hans-Jürgen Wester, Vasilis Ntziachristos, Dimitris Gorpas, Timothy C. Wang, Margret Schottelius and Michael Quante

Whole-body biodistribution and radiation dosimetry of [¹⁸F]PR04.MZ: a new PET radiotracer for clinical management of patients with movement disorders

[¹⁸F]PR04.MZ is a new PET imaging agent for dopamine transporters, providing excellent image quality and allowing for the evaluation of patients with movement disorders such as Parkinson’s disease. The objective ...

Authors: Wencke Lehnert, Patrick J. Riss, Ana Hurtado de Mendoza, Sandra Lopez, Gonzalo Fernandez, Marcelo Ilheu, Horacio Amaral and Vasko Kramer

Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

Tumour hypoxia promotes an aggressive tumour phenotype and enhances resistance to anticancer treatments. Following the recent observation that the mitochondrial inhibitor atovaquone increases tumour oxygenatio...

Authors: Pauline Bourigault, Michael Skwarski, Ruth E. Macpherson, Geoff S. Higgins and Daniel R. McGowan

The usefulness of repeated CMR and FDG PET/CT in the diagnosis of patients with initial possible cardiac sarcoidosis

Cardiac sarcoidosis (CS) diagnosis is usually based on advanced imaging techniques and multidisciplinary evaluation. Diagnosis is classified as definite, probable, possible or unlikely. If diagnostic confidenc...

Authors: H. Mathijssen, T. W. H. Tjoeng, R. G. M. Keijsers, A. L. M. Bakker, F. Akdim, H. W. van Es, F. T. van Beek, M. V. Veltkamp, J. C. Grutters and M. C. Post

Risk of metastatic disease using [¹⁸F]PSMA-1007 PET/CT for primary prostate cancer staging

Accurate prostate cancer imaging is critical for patient management. Multiple studies have demonstrated superior diagnostic accuracy of [⁶⁸Ga]-PSMA-11 PET/CT over conventional imaging for disease detection, with ...

Authors: Venkata Avinash Chikatamarla, Satomi Okano, Peter Jenvey, Alexander Ansaldo, Matthew J. Roberts, Stuart C. Ramsay, Paul A. Thomas and David A. Pattison

Magnetic nanoparticles in theranostics of malignant melanoma

Malignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure a...

Authors: Maxim Shevtsov, Susanne Kaesler, Christian Posch, Gabriele Multhoff and Tilo Biedermann

First experiences with ¹⁷⁷Lu-PSMA-617 therapy for recurrent or metastatic salivary gland cancer

Advanced salivary gland cancers become difficult to treat when they are technically irresectable and radiotherapy limits are exceeded. There is also an unmet need to improve palliative systemic therapy. Saliva...

Authors: Thomas J. W. Klein Nulent, Robert J. J. van Es, Stefan M. Willems, Arthur. J. A. T. Braat, Lot A. Devriese, Remco de Bree and Bart de Keizer

Amyloid PET quantification using low-dose CT-guided anatomic standardization

Centiloid (CL) scaling has become a standardized quantitative measure in amyloid PET because it facilitates the direct comparison of results across institutions, even when different analytical methods or trace...

Authors: Hiroshi Matsuda, Tensho Yamao, Mitsuru Shakado, Yoko Shigemoto, Kyoji Okita and Noriko Sato

L-type amino acid transporter (LAT) 1 expression in ¹⁸F-FET-negative gliomas

O-(2-[¹⁸F]-fluoroethyl)-L-tyrosine (¹⁸F-FET) is a highly sensitive PET tracer for glioma imaging, and its uptake is suggested to be driven by an overexpression of the L-type amino-acid transporter 1 (LAT1). Howev...

Authors: Franziska J. Vettermann, Caroline Diekmann, Lorraine Weidner, Marcus Unterrainer, Bogdana Suchorska, Viktoria Ruf, Mario Dorostkar, Vera Wenter, Jochen Herms, Jörg-Christian Tonn, Peter Bartenstein, Markus J. Riemenschneider and Nathalie L. Albert

Detection of the sentinel lymph node with hybrid tracer (ICG-[^99mTc]Tc-albumin nanocolloid) in intermediate- and high-risk endometrial cancer: a feasibility study

Indocyanine green (ICG) is frequently used for the detection of the sentinel lymph node (SLN) in gynecology, but it carries the loss of the presurgical SLN mapping provided by [^99mTc]-based colloids. Hybrid trace...

Authors: Nuria Sánchez-Izquierdo, Sergi Vidal-Sicart, Francisco Campos, Aureli Torné, Martina Aida Angeles, Federico Migliorelli, Meritxell Munmany, Adela Saco, Berta Diaz-Feijoo, Ariel Glickman, Jaume Ordi, Andrés Perissinotti, Marta del Pino and Pilar Paredes

Dynamic planar scintigraphy for the rapid kinetic measurement of myocardial ¹²³I-MIBG turnover can identify Lewy body disease

Using two static scans for ¹²³I-meta-iodobenzyl-guanidine (¹²³I-MIBG) myocardial scintigraphy ignores the dynamic response from vesicular trapping in nerve terminals. Moreover, the long pause between scans is imp...

Authors: Yoshitaka Kumakura, Yuji Shimizu, Masatsugu Hariu, Ken-ichi Ichikawa, Norihito Yoshida, Masato Suzuki, Satoru Oji, Shinya Narukawa, Haruo Yoshimasu and Kyoichi Nomura

Imaging pheochromocytoma in small animals: preclinical models to improve diagnosis and treatment

Pheochromocytomas (PCCs) and paragangliomas (PGLs), together referred to as PPGLs, are rare chromaffin cell-derived tumors. They require timely diagnosis as this is the only way to achieve a cure through surge...

Authors: Hermine Mohr, Alessia Foscarini, Katja Steiger, Simone Ballke, Christoph Rischpler, Franz Schilling and Natalia S. Pellegata

Native glycan fragments detected by MALDI mass spectrometry imaging are independent prognostic factors in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies to date. The impressively developed stroma that surrounds and modulates the behavior of cancer cells is one of the main factors...

Authors: Na Sun, Marija Trajkovic-Arsic, Fengxia Li, Yin Wu, Corinna Münch, Thomas Kunzke, Annette Feuchtinger, Katja Steiger, Anna Melissa Schlitter, Wilko Weichert, Irene Esposito, Jens T. Siveke and Axel Walch

[¹⁸F]FMCH PET/CT biomarkers and similarity analysis to refine the definition of oligometastatic prostate cancer

The role of image-derived biomarkers in recurrent oligometastatic Prostate Cancer (PCa) is unexplored. This paper aimed to evaluate [¹⁸F]FMCH PET/CT radiomic analysis in patients with recurrent PCa after primary ...

Authors: Martina Sollini, Francesco Bartoli, Lara Cavinato, Francesca Ieva, Alessandra Ragni, Andrea Marciano, Roberta Zanca, Luca Galli, Fabiola Paiar, Francesco Pasqualetti and Paola Anna Erba

Receptor depletion and recovery in small-intestinal neuroendocrine tumors and normal tissues after administration of a single intravenous dose of octreotide measured by ⁶⁸Ga-DOTATOC PET/CT

Low-grade neuroendocrine tumors (NETs) are characterized by an abundance of somatostatin receptors (SSTR) that can be targeted with somatostatin analogs (SSA). When activated with a single dose of SSA, the rec...

Authors: Ulrika Jahn, Ezgi Ilan, Irina Velikyan, Katarzyna Fröss-Baron, Mark Lubberink and Anders Sundin

Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder

The purpose of this study is to compare dynamic and static whole-body (WB) [¹⁸F]NaF PET/CT scan methods used for analysis of bone plasma clearance in patients with chronic kidney disease-mineral and bone disorder...

Authors: M. H. Vrist, J. N. Bech, T. G. Lauridsen, C. A. Fynbo and J. Theil

Value of ¹⁸F-FDG PET/CT for predicting axillary pathologic complete response following neoadjuvant systemic therapy in breast cancer patients: emphasis on breast cancer subtype

Neoadjuvant systemic therapy (NST) is a widely accepted initial treatment modality that can lead to pathologic downstaging of the axillary disease burden in breast cancer patients. Axillary response as well as...

Authors: Cornelis M. de Mooij, Cristina Mitea, Felix M. Mottaghy, Marjolein L. Smidt and Thiemo J. A. van Nijnatten

Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer

Recent advancements in the field of immune-oncology have led to a significant increase in life expectancy of patients with diverse forms of cancer, such as hematologic malignancies, melanoma and lung cancer. U...

Authors: Q. Lecocq, P. Debie, J. Puttemans, R. M. Awad, L. De Beck, T. Ertveldt, Y. De Vlaeminck, C. Goyvaerts, G. Raes, M. Keyaerts, K. Breckpot and N. Devoogdt

[⁶⁸Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation

Imaging diagnosis of inflammation has been challenging for many years. Inflammation imaging agents commonly used in nuclear medicine, such as [⁶⁷Ga]Ga-citrate and 2-deoxy-2-[¹⁸F]fluoro-d-glucose ([¹⁸F]FDG) showed...

Authors: Shigufa Kahn Ali, Samia Ait-Mohand, Véronique Dumulon-Perreault and Brigitte Guérin

Dose escalation biodistribution, positron emission tomography/computed tomography imaging and dosimetry of a highly specific radionuclide-labeled non-blocking nanobody

Immunotherapy is a valuable option for cancer treatment, and the curative effect of anti-PD-1/PD-L1 therapy correlates closely with PD-L1 expression levels. Positron emission tomography (PET) imaging of PD-L1 ...

Authors: Yanling Yang, Chao Wang, Yan Wang, Yan Sun, Xing Huang, Minzhou Huang, Hui Xu, Huaying Fan, Daquan Chen and Feng Zhao

More fat, less migration: breast density as a predictor of sentinel lymph node non-visualization in breast cancer

Authors: Elske Quak, Grégoire Braux, Kathleen Weyts and Charline Lasnon

Response to letter: More fat, less migration: breast density as a predictor of sentinel lymph node non-visualization in breast cancer

Authors: Youssef Chahid, Hein J. Verberne and Jan Booij

Semi-quantitative measurements of chemokine receptor 4-targeted ⁶⁸Ga-pentixafor PET/CT in response assessment of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma

⁶⁸Ga-pentixafor PET/CT was reported to have a high sensitivity in detecting tumor involvement of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) in our previous study. We aimed to further inves....

Authors: Qingqing Pan, Xinxin Cao, Yaping Luo, Jian Li and Fang Li

Intraindividual comparison of [⁶⁸ Ga]-Ga-PSMA-11 and [¹⁸F]-F-PSMA-1007 in prostate cancer patients: a retrospective single-center analysis

The analysis aimed to compare the radiotracers [⁶⁸Ga]-Ga-PSMA-11 and [¹⁸F]-F-PSMA-1007 intraindividually in terms of malignant lesions, mi(molecular-imaging)TNM staging and presumable unspecific lesions retrospec...

Authors: Sebastian Hoberück, Steffen Löck, Angelika Borkowetz, Ulrich Sommer, Robert Winzer, Klaus Zöphel, Dieter Fedders, Enrico Michler, Jörg Kotzerke, Klaus Kopka, Tobias Hölscher and Anja Braune

Predicting the nature of pleural effusion in patients with lung adenocarcinoma based on ¹⁸F-FDG PET/CT

This study aims to establish a predictive model on the basis of ¹⁸F-FDG PET/CT for diagnosing the nature of pleural effusion (PE) in patients with lung adenocarcinoma.

Authors: Yi Li, Wei Mu, Yuan Li, Xiao Song, Yan Huang and Lei Jiang

Short-duration dynamic [¹⁸F]DCFPyL PET and CT perfusion imaging to localize dominant intraprostatic lesions in prostate cancer: validation against digital histopathology and comparison to [¹⁸F]DCFPyL PET/MR at 120 minutes

Localized prostate cancer (PCa) in patients is characterized by a dominant focus in the gland (dominant intraprostatic lesion, DIL). Accurate DIL identification may enable more accurate diagnosis and therapy t...

Authors: Dae-Myoung Yang, Ryan Alfano, Glenn Bauman, Jonathan D. Thiessen, Joseph Chin, Stephen Pautler, Madeleine Moussa, Jose A. Gomez, Irina Rachinsky, Mena Gaed, Kevin J. Chung, Aaron Ward and Ting-Yim Lee

There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography

In the context of nuclear medicine and theranostics, integrin-related research and development was, for most of the time, focused predominantly on 'RGD peptides' and the subtype αvβ3-integrin. However, there a...

Authors: Katja Steiger, Neil Gerard Quigley, Tanja Groll, Frauke Richter, Maximilian Alexander Zierke, Ambros Johannes Beer, Wilko Weichert, Markus Schwaiger, Susanne Kossatz and Johannes Notni

Convolutional neural network-based automatic heart segmentation and quantitation in ¹²³I-metaiodobenzylguanidine SPECT imaging

Since three-dimensional segmentation of cardiac region in ¹²³I-metaiodobenzylguanidine (MIBG) study has not been established, this study aimed to achieve organ segmentation using a convolutional neural network (C...

Authors: Shintaro Saito, Kenichi Nakajima, Lars Edenbrandt, Olof Enqvist, Johannes Ulén and Seigo Kinuya

Rationale for MYC imaging and targeting in pancreatic cancer

The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The d...

Authors: Günter Schneider, Matthias Wirth, Ulrich Keller and Dieter Saur

Alteration of neuroinflammation detected by ¹⁸F-GE180 PET imaging in place-conditioned rats with morphine withdrawal

Accumulating evidence indicates that neuroinflammation (NI) significantly contributes to drug addiction, but the conversion of NI after drug withdrawal is not clear. Here, we conducted ¹⁸F-flutriciclamide (GE180)...

Authors: Junpeng Li, Da Shao, Donglang Jiang, Qi Huang, Yihui Guan, Bin Lai, Jun Zhao, Fengchun Hua and Fang Xie

Retraction Note to: Inter- and intraobserver agreement of the quantitative assessment of [^99mTc]-labelled anti-programmed death-ligand 1 (PD-L1) SPECT/CT in non-small cell lung cancer

Authors: Daniel Johnathan Hughes, Gitasha Chand, Vicky Goh and Gary J. R. Cook

Correction to: Biokinetics, dosimetry and radiation risk in infants after ^99mTc-MAG3 scans

Authors: J. Soares Machado, J. Tran-Gia, S. Schlögl, A. K. Buck and M. Lassmann

The prognostic significance of [¹⁸F]FDG PET/CT in multiple myeloma according to novel interpretation criteria (IMPeTUs)

[¹⁸F]FDG PET/CT is the elective imaging modality for treatment monitoring in multiple myeloma (MM). However, MM is a heterogeneous disease from an imaging point of view, raising challenges in interpretation of PE...

Authors: Christos Sachpekidis, Maximilian Merz, Marc-Steffen Raab, Uta Bertsch, Vivienn Weru, Annette Kopp-Schneider, Anna Jauch, Hartmut Goldschmidt and Antonia Dimitrakopoulou-Strauss

Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity

Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation a...

Authors: Rie Hosoi, Yuka Fujii, Ohba Hiroyuki, Miho Shukuri, Shingo Nishiyama, Masakatsu Kanazawa, Kenichiro Todoroki, Yasushi Arano, Toshihiro Sakai, Hideo Tsukada and Osamu Inoue

Automated liver lesion detection in ⁶⁸Ga DOTATATE PET/CT using a deep fully convolutional neural network

Gastroenteropancreatic neuroendocrine tumors most commonly metastasize to the liver; however, high normal background ⁶⁸Ga-DOTATATE activity and high image noise make metastatic lesions difficult to detect. The pu...

Authors: Jonathan Wehrend, Michael Silosky, Fuyong Xing and Bennett B. Chin

In vivo quantitative assessment of therapeutic response to bortezomib therapy in disseminated animal models of multiple myeloma with [¹⁸F]FDG and [⁶⁴Cu]Cu-LLP2A PET

Multiple myeloma (MM) is a disease of cancerous plasma cells in the bone marrow. Imaging-based timely determination of therapeutic response is critical for improving outcomes in MM patients. Very late antigen-...

Authors: Anchal Ghai, Nikki Fettig, Francesca Fontana, John DiPersio, Mike Rettig, Julie O. Neal, Samuel Achilefu, Kooresh I. Shoghi and Monica Shokeen

Lung shunt fraction calculation using ^99mTc-MAA SPECT/CT imaging for ⁹⁰Y microsphere selective internal radiation therapy of liver tumors

^99mTc-macroaggregated albumin (^99mTc-MAA) scintigraphy is utilized in treatment planning for Yttrium-90 (⁹⁰Y) Selective Internal Radiation Therapy (SIRT) of liver tumors to evaluate hepatopulmonary shunting by ca...

Authors: Mike F. Georgiou, Russ A. Kuker, Matthew T. Studenski, Preeti P. Ahlman, Megan Witte and Lorraine Portelance

The effect of eating on the uptake of PSMA ligands in the salivary glands

PSMA-directed therapy for metastatic prostate cancer is gaining adoption as a treatment option. However, accumulation of ¹⁷⁷Lu/²²⁵Ac-PSMA in the salivary glands remains a problem, with risk of dose-limiting xeros...

Authors: V. Mohan, N. M. Bruin, J. B. van de Kamer, J.-J. Sonke and W. V. Vogel

Imaging modalities for diagnosis and monitoring of cancer cachexia

Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight in cancer cachexia primarily imp...

Authors: Jessie Han, Luke Harrison, Lisa Patzelt, Mingming Wu, Daniela Junker, Stephan Herzig, Mauricio Berriel Diaz and Dimitrios C. Karampinos

Benefits and harms of implementing [¹⁸F]FDG-PET/CT for diagnosing recurrent breast cancer: a prospective clinical study

[¹⁸F]-fluorodeoxyglucose-positron emission tomography/computed tomography ([¹⁸F]FDG-PET/CT) has been implemented sporadically in hospital settings as the standard of care examination for recurrent breast cancer. ...

Authors: Marianne Vogsen, Jeanette Dupont Jensen, Oke Gerke, Anne Marie Bak Jylling, Jon Thor Asmussen, Ivar Yannick Christensen, Poul-Erik Braad, Peter Thye-Rønn, Katrine Lydolph Søe, Marianne Ewertz and Malene Grubbe Hildebrandt

[¹²³I]MIBG is a better early marker of anthracycline cardiotoxicity than [¹⁸F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study

During anthracycline treatment of cancer, there is a lack for biomarkers of cardiotoxicity besides the cardiac dysfunction. The objective of the present study was to compare [¹⁸F]FDG and [¹²³I]MIBG (metaiodobenzy...

Authors: Alexandra Oudot, Alan Courteau, Mélanie Guillemin, Jean-Marc Vrigneaud, Paul Michael Walker, François Brunotte, Alexandre Cochet and Bertrand Collin

CERMEP-IDB-MRXFDG: a database of 37 normal adult human brain [¹⁸F]FDG PET, T1 and FLAIR MRI, and CT images available for research

We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent static [¹⁸F]FDG PET/CT and MRI, resulting in [¹⁸F]FDG PET, T...

Authors: Inés Mérida, Julien Jung, Sandrine Bouvard, Didier Le Bars, Sophie Lancelot, Franck Lavenne, Caroline Bouillot, Jérôme Redouté, Alexander Hammers and Nicolas Costes

Quantitative evaluation of interim positron emission tomography in peripheral T-cell lymphoma

Interim [¹⁸F]fluoro-deoxyglucose-positron emission tomography predicts outcome in peripheral T-cell lymphoma (PTCL). We compared two quantitative evaluation methods.

Authors: Lars Kurch, Ulrich Dührsen, Andreas Hüttmann, Thomas W. Georgi, Osama Sabri, Regine Kluge and Dirk Hasenclever

Assessment of early metabolic progression in melanoma patients under immunotherapy: an ¹⁸F-FDG PET/CT study

The usage of immune checkpoint inhibitors (ICIs) is the standard practice for the treatment of metastatic melanoma. However, a significant amount of patients show no response to immunotherapy, while issues on ...

Authors: Christos Sachpekidis, Annette Kopp-Schneider, Jessica C. Hassel and Antonia Dimitrakopoulou-Strauss

The effects of molar activity on [¹⁸F]FDOPA uptake in patients with neuroendocrine tumors

6-[¹⁸F]fluoro-l-3,4-dihydroxyphenyl alanine ([¹⁸F]FDOPA) is a commonly used PET tracer for the detection and staging of neuroendocrine tumors. In neuroendocrine tumors, [¹⁸F]FDOPA is decarboxylated to [¹⁸F]dopami...

Authors: Gilles N. Stormezand, Romano S. B. H. Schreuder, Adrienne H. Brouwers, Riemer H. J. A. Slart, Philip H. Elsinga, Annemiek M. E. Walenkamp, R. A. J. O. Dierckx, Andor W. J. M. Glaudemans and Gert Luurtsema

The metabolic parameters based on volume in PET/CT are associated with clinicopathological N stage of colorectal cancer and can predict prognosis

A combination of positron emission tomography and computed tomography (PET/CT) is an important modality for the diagnosis of carcinoma. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have been ...

Authors: Hidenori Kido, Shunsuke Kato, Kimihiko Funahashi, Kazutoshi Shibuya, Yousuke Sasaki, Yoshihisa Urita, Masaaki Hori and Sunao Mizumura

Quantitative SPECT/CT parameters of myocardial ^99mTechnetium-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) uptake in suspected cardiac transthyretin amyloidosis

^99mTc-labelled bisphosphonates are used for imaging assessment of patients with transthyretin cardiac amyloidosis (ATTR). Present study evaluates whether quantitative SPECT/CT measurement of absolute myocardial ^9...

Authors: Simona Ben-Haim, A. Chicheportiche, E. Goshen, M. Arad, M. Smekhov, L. J. Menezes, P. M. Elliott, E. O’Mahoney, E. Stern, Bella Yuzefovich and J. B. Bomanji

EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases

Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and...

Authors: Erik H. J. G. Aarntzen, Edel Noriega-Álvarez, Vera Artiko, André H. Dias, Olivier Gheysens, Andor W. J. M. Glaudemans, Chiara Lauri, Giorgio Treglia, Tim van den Wyngaert, Fijs W. B. van Leeuwen and Samantha Y. A. Terry

A novel read methodology to evaluate the optimal dose of ⁶⁸Ga-satoreotide trizoxetan as a PET imaging agent in patients with gastroenteropancreatic neuroendocrine tumours: a phase II clinical trial

⁶⁸Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist exhibiting higher tumour-to-background ratios and sensitivity compared to ⁶⁸Ga-DOTATOC. This randomised, 2 × 3 factorial, phase II study aim...

Authors: Colin G. Miller, Henning Grønbæk, Irene Virgolini, Andreas Kjaer, Pierre Terve, Shadfar Bahri, Peter Iversen, Hanna Svirydenka, Thomas Rohban and Sandy McEwan

Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted

Correlation of in vivo imaging to histomorphological pathology in animal models requires comparative interdisciplinary expertise of different fields of medicine. From the morphological point of view, there is ...

Authors: Simone Ballke, Irina Heid, Carolin Mogler, Rickmer Braren, Markus Schwaiger, Wilko Weichert and Katja Steiger