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  1. Dopamine transporter (DAT) imaging is used in the diagnostic work-up in suspected parkinsonian syndromes and dementia with Lewy bodies but cannot differentiate between these syndromes, and an extra brain imagi...

    Authors: Susanna Jakobson Mo, Jan Axelsson, Lars Stiernman and Katrine Riklund
    Citation: EJNMMI Research 2022 12:72
  2. Antiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure activity, speed of brain entry may be an important factor. BRV showed fas...

    Authors: Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, Ralph Paul Maguire, Joël Mercier, Nabeel B. Nabulsi, Sophie Kervyn, Shannan Henry, Jean-Marie Nicolas, Yiyun Huang, Ming-Kai Chen, Jonas Hannestad, Henrik Klitgaard, Armel Stockis and Richard E. Carson
    Citation: EJNMMI Research 2022 12:71
  3. Programmed cell death 1 ligand 1(PD-L1) is overexpressed in many tumors. The radionuclide-labeled anti-PD-L1 monoclonal antibody can be used for imaging and therapy of PD-L1 overexpressing cancer. Here, we des...

    Authors: Linhan Zhang, Sheng Zhao, Huijie Jiang, Rongjun Zhang, Mingyu Zhang, Wenbin Pan, Zhongqi Sun, Dandan Wang and Jinping Li
    Citation: EJNMMI Research 2022 12:70
  4. This study aims to analyze the 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) characteristics of different causes of fever of unknown origin (FUO) and identify independen...

    Authors: Jia Chen, MingYou Xing, Dong Xu, NaNa Xie, WenCong Zhang, QiuRong Ruan and JianXin Song
    Citation: EJNMMI Research 2022 12:69
  5. Two commonly used imaging techniques to aid in the diagnosis of neurodegenerative parkinsonian syndromes are dopamine transporter (DAT) imaging with [123I]-FP-CIT single-photon emission computed tomography (DAT-S...

    Authors: Elon Wallert, Erwann Letort, Friso van der Zant, Ania Winogrodzka, Henk Berendse, Martijn Beudel, Rob de Bie, Jan Booij, Pieter Raijmakers and Elsmarieke van de Giessen
    Citation: EJNMMI Research 2022 12:68
  6. Radiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous and normal tissue. Hence, the i...

    Authors: Chung Ying Chan, Samantha L. Hopkins, Florian Guibbal, Anna Pacelli, Julia Baguña Torres, Michael Mosley, Doreen Lau, Patrick Isenegger, Zijun Chen, Thomas C. Wilson, Gemma Dias, Rebekka Hueting, Véronique Gouverneur and Bart Cornelissen
    Citation: EJNMMI Research 2022 12:67
  7. PSMA PET/CT is the recommended imaging test in cases with prostate-specific antigen (PSA) recurrence after primary therapy of prostate cancer (PCa). However, imaging protocols remain a topic of active research...

    Authors: Daniel Koehler, Markus Sauer, Amir Karimzadeh, Ivayla Apostolova, Susanne Klutmann, Gerhard Adam, Sophie Knipper, Tobias Maurer and Christoph Berliner
    Citation: EJNMMI Research 2022 12:66
  8. PSMA-TO-1 (“Tumor-Optimized-1”) is a novel PSMA ligand with longer circulation time than PSMA-617. We compared the biodistribution in subcutaneous tumor-bearing mice of PSMA-TO-1, PSMA-617 and PSMA-11 when lab...

    Authors: Catherine Meyer, Vikas Prasad, Andreea Stuparu, Peter Kletting, Gerhard Glatting, Jonathan Miksch, Christoph Solbach, Katharina Lueckerath, Lea Nyiranshuti, Shaojun Zhu, Johannes Czernin, Ambros J. Beer, Roger Slavik, Jeremie Calais and Magnus Dahlbom
    Citation: EJNMMI Research 2022 12:65
  9. Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions out...

    Authors: Jennifer M. Coughlin, Yong Du, Wojciech G. Lesniak, Courtney K. Harrington, Mary Katherine Brosnan, Riley O’Toole, Adeline Zandi, Shannon Eileen Sweeney, Rehab Abdallah, Yunkou Wu, Daniel P. Holt, Andrew W. Hall, Robert F. Dannals, Lilja Solnes, Andrew G. Horti and Martin G. Pomper
    Citation: EJNMMI Research 2022 12:64
  10. This study aimed to develop a novel analytic approach based on a radiomics model derived from 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT for predicting intraprostatic lesions in patients with prosta...

    Authors: Shiming Zang, Shuyue Ai, Rui Yang, Pengjun Zhang, Wenyu Wu, Zhenyu Zhao, Yudan Ni, Qing Zhang, Hongbin Sun, Hongqian Guo, Ruipeng Jia and Feng Wang
    Citation: EJNMMI Research 2022 12:63
  11. CD4+ T cells are central inflammatory mediators in the pathogenesis of autoimmune rheumatoid arthritis (RA), as they are one of the dominating cell types in synovial inflammation. Molecular imaging of CD4+ T cell...

    Authors: Anne Skovsbo Clausen, Camilla Christensen, Esben Christensen, Sigrid Cold, Lotte Kellemann Kristensen, Anders Elias Hansen and Andreas Kjaer
    Citation: EJNMMI Research 2022 12:62
  12. Elastic motion correction in PET has been shown to increase image quality and quantitative measurements of PET datasets affected by respiratory motion. However, little is known on the impact of respiratory mot...

    Authors: Benjamin Noto, Wolfgang Roll, Laura Zinken, Robert Rischen, Laura Kerschke, Georg Evers, Walter Heindel, Michael Schäfers and Florian Büther
    Citation: EJNMMI Research 2022 12:61
  13. Triple-negative breast cancer (TNBC) lacks biomarkers for targeted therapy. Auger emitters display the best therapeutic effect, if delivered directly into the nucleus proximal to DNA. The nuclear protein Poly ...

    Authors: Ramya Ambur Sankaranarayana, Alexandru Florea, Susanne Allekotte, Andreas T. J. Vogg, Jochen Maurer, Laura Schäfer, Carsten Bolm, Steven Terhorst, Arno Classen, Matthias Bauwens, Agnieszka Morgenroth and Felix M. Mottaghy
    Citation: EJNMMI Research 2022 12:60
  14. Aggressive B cell lymphoma often requires prompt steroid treatment, even before baseline 18f-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and definitive treatment, to allevia...

    Authors: Karyn Revital Geiger, Oren Pasvolsky, Tamar Berger, Pia Raanani, Tzippy Shochat, Ronit Gurion, Tamer Anati, David Groshar, Anat Gafter-Gvili and Hanna Bernstine
    Citation: EJNMMI Research 2022 12:59
  15. Clinical prediction models need to be validated. In this study, we used simulation data to compare various internal and external validation approaches to validate models.

    Authors: Jakoba J. Eertink, Martijn W. Heymans, Gerben J. C. Zwezerijnen, Josée M. Zijlstra, Henrica C. W. de Vet and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:58
  16. To explore the feasibility of short-time-window Ki imaging using a population-based arterial input function (IF) and optimized Bayesian penalized likelihood (BPL) reconstruction as a practical alternative to l...

    Authors: Takato Tanaka, Masatoyo Nakajo, Hirofumi Kawakami, Eriko Motomura, Tomofumi Fujisaka, Satoko Ojima, Yasumasa Saigo and Takashi Yoshiura
    Citation: EJNMMI Research 2022 12:57
  17. Dopamine transporter (DAT) imaging of striatum is clinically used in Parkinson’s disease (PD) and neurodegenerative parkinsonian syndromes (PS) especially in the early disease stages. The aim of the present st...

    Authors: Lisbeth Marner, Kirsten Korsholm, Lasse Anderberg, Markus N. Lonsdale, Mads Radmer Jensen, Eva Brødsgaard, Charlotte L. Denholt, Nic Gillings, Ian Law and Lars Friberg
    Citation: EJNMMI Research 2022 12:56
  18. Our aim was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudin...

    Authors: Elina Rauhala, Jarkko Johansson, Mira Karrasch, Olli Eskola, Tuula Tolvanen, Riitta Parkkola, Kirsi A. Virtanen and Juha O. Rinne
    Citation: EJNMMI Research 2022 12:55
  19. Zirconium-89-immuno-positron emission tomography (89Zr-immuno-PET) has enabled visualization of zirconium-89 labelled monoclonal antibody (89Zr-mAb) uptake in organs and tumors in vivo. Patlak linearization of 89

    Authors: Jessica E. Wijngaarden, Marc C. Huisman, Johanna E. E. Pouw, C. Willemien Menke-van der Houven van Oordt, Yvonne W. S. Jauw and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:54
  20. The NMDA receptor (NMDAR) plays a key role in the central nervous system, e.g., for synaptic transmission. While synaptic NMDARs are thought to have protective characteristics, activation of extrasynaptic NMDA...

    Authors: Lucas Rischka, Matej Murgaš, Verena Pichler, Chrysoula Vraka, Ivo Rausch, Dietmar Winkler, Lukas Nics, Sazan Rasul, Leo Robert Silberbauer, Murray Bruce Reed, Godber Mathis Godbersen, Jakob Unterholzner, Patricia Handschuh, Gregor Gryglewski, Thomas Mindt, Markus Mitterhauser…
    Citation: EJNMMI Research 2022 12:53
  21. This pilot study was designed to evaluate the diagnostic value of 68 Ga-PSMA-617 and 18F-FDG PET/CT in adenoid cystic carcinoma (ACC) and to assess the safety and therapeutic response to PSMA radioligand therapy ...

    Authors: Guochang Wang, Mengjiao Zhou, Jie Zang, Yuanyuan Jiang, Xiaohong Chen, Zhaohui Zhu and Xiaoyuan Chen
    Citation: EJNMMI Research 2022 12:52
  22. Multiple-pinhole (MPH) collimators improve the resolution–sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, ...

    Authors: Franziska Mathies, Ivayla Apostolova, Lena Dierck, Janin Jacobi, Katja Kuen, Markus Sauer, Michael Schenk, Susanne Klutmann, Attila Forgács and Ralph Buchert
    Citation: EJNMMI Research 2022 12:51
  23. Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabe...

    Authors: Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting and Bart Cornelissen
    Citation: EJNMMI Research 2022 12:50
  24. Cervical dystonia is considered as a network disorder affecting various brain regions in recent days. Presumably, deep brain stimulation (DBS) of the internal segment of globus pallidus (GPi) may exert therape...

    Authors: Sungjin Park, Hyeonseok Jeong, Yong-An Chung, Ilhyang Kang, Seunghee Kim, In-Uk Song and Ryoong Huh
    Citation: EJNMMI Research 2022 12:47
  25. Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in mul...

    Authors: Melinda Wuest, Justin J. Bailey, Jennifer Dufour, Darryl Glubrecht, Vanessa Omana, Tom H. Johnston, Jonathan M. Brotchie and Ralf Schirrmacher
    Citation: EJNMMI Research 2022 12:46
  26. Differentiated thyroid carcinoma (DTC) originates from abnormal follicular cells and accounts for approximately 90–95% of thyroid malignancies. The diagnosis of radioiodine refractory DTC (RR-DTC) is based on ...

    Authors: Ye Liu, Yuhua Wang and Wanchun Zhang
    Citation: EJNMMI Research 2022 12:45
  27. [18F]FDG PET-based metabolic tumor volume (MTV) is a promising prognostic marker for lymphoma patients. The aim of this study is to assess the sensitivity of several MTV segmentation methods to variations in imag...

    Authors: Maria C. Ferrández, Jakoba J. Eertink, Sandeep S. V. Golla, Sanne E. Wiegers, Gerben J. C. Zwezerijnen, Simone Pieplenbosch, Josée M. Zijlstra and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:44
  28. Oxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s disease (AD). However, tracking oxidative stress in the brain has proven difficult and impe...

    Authors: Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus and Robert H. Mach
    Citation: EJNMMI Research 2022 12:43
  29. High urinary activity in urinary bladder and ureters may hamper interpretation of prostate cancer and regional nodal metastases in prostate-specific membrane antigen (PSMA) PET/CT. The goal of this study was t...

    Authors: Maarten L. Donswijk, Maurits Wondergem, Linda de Wit - van der Veen, Natascha M. Bruin, Pim J. van Leeuwen, Henk G. van der Poel, Marcel P. M. Stokkel and Wouter V. Vogel
    Citation: EJNMMI Research 2022 12:42
  30. Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis as evidenced by persistent negative regulation (phosphorylatio...

    Authors: Naresh Damuka, Miranda E. Orr, Avinash H. Bansode, Ivan Krizan, Mack Miller, Jillian Lee, Shannon L. Macauley, Christopher T. Whitlow, Akiva Mintz, Suzanne Craft and Kiran Kumar Solingapuram Sai
    Citation: EJNMMI Research 2022 12:41
  31. Tumor equivalent uniform dose (EUD) is proposed as a predictor of patient outcome after liver radioembolization (RE) of hepatocellular carcinoma (HCC) and can be evaluated with 90Y-TOF-PET. The aim is to evaluate...

    Authors: Philippe d’Abadie, Stephan Walrand, Michel Hesse, Ivan Borbath, Renaud Lhommel and François Jamar
    Citation: EJNMMI Research 2022 12:40
  32. We hypothesised that the radiomics signature, which includes texture information of dopamine transporter single-photon emission computed tomography (DAT-SPECT) images for Parkinson’s disease (PD), may assist s...

    Authors: Takuro Shiiba, Kazuki Takano, Akihiro Takaki and Shugo Suwazono
    Citation: EJNMMI Research 2022 12:39
  33. High levels of 18F-fluorodeoxyglucose (18F-FDG) tumor uptake are associated with worse prognosis in patients with non-small cell lung cancer (NSCLC). Meanwhile, high levels of immune cell infiltration in primary ...

    Authors: Jinyeong Choi, Azmal Sarker, Hongyoon Choi, Dong Soo Lee and Hyung-Jun Im
    Citation: EJNMMI Research 2022 12:38
  34. 2-Deoxy-2-[18F]fluoroglucose (FDG) PET is an important tool for the identification of Alzheimer’s disease (AD) patients through the characteristic neurodegeneration pattern that these patients present. Regional c...

    Authors: Débora E. Peretti, David Vállez García, Remco J. Renken, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:37
  35. Minimally invasive radioguided sentinel lymph node (SLN) procedures, increasingly performed with robot-assisted laparoscopy, can benefit from using a drop-in γ-probe instead of the conventional rigid laparosco...

    Authors: Ilse G. T. Baeten, Jacob P. Hoogendam, Arthur J. A. T. Braat, Ronald P. Zweemer and Cornelis G. Gerestein
    Citation: EJNMMI Research 2022 12:36
  36. Adnectin is a protein family derived from the 10th type III domain of human fibronectin (10Fn3) with high-affinity targeting capabilities. Positron emission tomography (PET) probes derived from anti-programmed de...

    Authors: Huimin Zhou, Guangfa Bao, Ziqiang Wang, Buchuan Zhang, Dan Li, Lixing Chen, Xiaoyun Deng, Bo Yu, Jun Zhao and Xiaohua Zhu
    Citation: EJNMMI Research 2022 12:35
  37. FDG-PET/CT has a high negative predictive value to detect residual nodal disease in patients with locally advanced squamous cell head and neck cancer after completing concurrent chemoradiotherapy (CCRT). Howev...

    Authors: Frederik Soffers, Nils Helsen, Tim Van den Wyngaert, Laurens Carp, Otto S. Hoekstra, Laurence Goethals, Michel Martens, Kristof Deben, Karoline Spaepen, Remco De Bree, Frank De Geeter, G. J. C. Zwezerijnen, Carl Van Laer, Alex Maes, Olivier Lenssen and Sigrid Stroobants
    Citation: EJNMMI Research 2022 12:34
  38. Aortic microcalcification activity is a recently described method of measuring aortic sodium [18F]fluoride uptake in the thoracic aorta on positron emission tomography. In this study, we aimed to compare and to m...

    Authors: Samuel Debono, Jennifer Nash, Alexander J. Fletcher, Maaz B. J. Syed, Scott I. Semple, Edwin J. R. van Beek, Alison Fletcher, Sebastien Cadet, Michelle C. Williams, Damini Dey, Piotr J. Slomka, Rachael O. Forsythe, Marc R. Dweck and David E. Newby
    Citation: EJNMMI Research 2022 12:33
  39. Hand automatisms (HA) are common clinical manifestations in mesial temporal lobe epilepsy. However, the location of the symptomatogenic zone (EZ) in HA as well as the networks involved, are still unclear. To h...

    Authors: Jiajie Mo, Yao Wang, Jianguo Zhang, Lixin Cai, Qingzhu Liu, Wenhan Hu, Lin Sang, Chao Zhang, Xiu Wang, Xiaoqiu Shao and Kai Zhang
    Citation: EJNMMI Research 2022 12:32
  40. Segmentation of neuroendocrine neoplasms (NENs) in [64Cu]Cu-DOTATATE positron emission tomography makes it possible to extract quantitative measures useable for prognostication of patients. However, manual tumor ...

    Authors: Esben Andreas Carlsen, Kristian Lindholm, Amalie Hindsholm, Mathias Gæde, Claes Nøhr Ladefoged, Mathias Loft, Camilla Bardram Johnbeck, Seppo Wang Langer, Peter Oturai, Ulrich Knigge, Andreas Kjaer and Flemming Littrup Andersen
    Citation: EJNMMI Research 2022 12:30
  41. Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in cere...

    Authors: Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Bart N. M. van Berckel, Lyduine E. Collij, Katherine R. Gray, Richard Manber, Robin Wolz, Valentina Garibotto, Catriona Wimberley, Craig Ritchie, Frederik Barkhof, Juan Domingo Gispert, David Vállez García, Isadora Lopes Alves and Adriaan A. Lammertsma
    Citation: EJNMMI Research 2022 12:29
  42. Although most guidelines suggest performing a positron emission tomography/computed tomography (PET/CT) with somatostatin receptor (SSTR) ligands for staging of pulmonary carcinoid tumours (PC), only a limited...

    Authors: Anne-Leen Deleu, Annouschka Laenen, Herbert Decaluwé, Birgit Weynand, Christophe Dooms, Walter De Wever, Sander Jentjens, Karolien Goffin, Johan Vansteenkiste, Koen Van Laere, Paul De Leyn, Kristiaan Nackaerts and Christophe M. Deroose
    Citation: EJNMMI Research 2022 12:28
  43. Transthyretin amyloidosis (ATTR) is a progressive disease which can be diagnosed non-invasively using bone avid [99mTc]-labeled radiotracers. Thus, ATTR is also an occasional incidental finding on bone scintigrap...

    Authors: Hanna-Leena Halme, Toni Ihalainen, Olli Suomalainen, Antti Loimaala, Sorjo Mätzke, Valtteri Uusitalo, Outi Sipilä and Eero Hippeläinen
    Citation: EJNMMI Research 2022 12:27
  44. Pituitary adenomas (PA) affect ~ 1:1200 of the population and can cause a wide range of symptoms due to hormone over-secretion, loss of normal pituitary gland function and/or compression of visual pathways, re...

    Authors: Daniel Gillett, Russell Senanayake, James MacFarlane, Merel van der Meulen, Olympia Koulouri, Andrew S. Powlson, Rosy Crawford, Bethany Gillett, Nick Bird, Sarah Heard, Angelos Kolias, Richard Mannion, Luigi Aloj, Iosif A. Mendichovszky, Heok Cheow, Waiel A. Bashari…
    Citation: EJNMMI Research 2022 12:26
  45. Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in n...

    Authors: Carolin Kitzberger, Rebekka Spellerberg, Volker Morath, Nathalie Schwenk, Kathrin A. Schmohl, Christina Schug, Sarah Urnauer, Mariella Tutter, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Sibylle Ziegler, Peter Bartenstein, Ernst Wagner, Peter J. Nelson and Christine Spitzweg
    Citation: EJNMMI Research 2022 12:25
  46. Hyperpolarization enhances the sensitivity of nuclear magnetic resonance experiments by between four and five orders of magnitude. Several hyperpolarized sensor molecules have been introduced that enable high ...

    Authors: Wai-Yan Ryana Fok, Martin Grashei, Jason G. Skinner, Bjoern H. Menze and Franz Schilling
    Citation: EJNMMI Research 2022 12:24
  47. To investigate the value of 18F-FDG PET/CT molecular radiomics combined with a clinical model in predicting thoracic lymph node metastasis (LNM) in invasive lung adenocarcinoma (≤ 3 cm).

    Authors: Cheng Chang, Maomei Ruan, Bei Lei, Hong Yu, Wenlu Zhao, Yaqiong Ge, Shaofeng Duan, Wenjing Teng, Qianfu Wu, Xiaohua Qian, Lihua Wang, Hui Yan, Ciyi Liu, Liu Liu, Jian Feng and Wenhui Xie
    Citation: EJNMMI Research 2022 12:23