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  1. Original research

    I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma

    I-124 codrituzumab (aka GC33), an antibody directed at Glypican 3, was evaluated in patients with hepatocellular carcinoma (HCC). Fourteen patients with HCC underwent baseline imaging with I-124 codrituzumab (...

    Jorge A. Carrasquillo, Joseph A. O’Donoghue, Volkan Beylergil, Shutian Ruan, Neeta Pandit-Taskar, Steven M. Larson, Peter M. Smith-Jones, Serge K. Lyashchenko, Norihisa Ohishi, Toshihiko Ohtomo and Ghassan K. Abou-Alfa

    EJNMMI Research 2018 8:20

    Published on: 5 March 2018

  2. Original research

    Imaging Aβ and tau in early stage Alzheimer’s disease with [18F]AV45 and [18F]AV1451

    AD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate th...

    Azadeh Firouzian, Alex Whittington, Graham E. Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone and Roger N. Gunn

    EJNMMI Research 2018 8:19

    Published on: 2 March 2018

  3. Original research

    Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis

    Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has...

    Christian H. Pfob, Matthias Eiber, Peter Luppa, Florian Maurer, Tobias Maurer, Robert Tauber, Calogero D’Alessandria, Benedikt Feuerecker, Klemens Scheidhauer, Armin Ott, Uwe Heemann, Markus Schwaiger and Christoph Schmaderer

    EJNMMI Research 2018 8:17

    Published on: 27 February 2018

  4. Original research

    Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging

    In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DO...

    Elisabeth Eppard, Ana de la Fuente, Nicole Mohr, Mareli Allmeroth, Rudolf Zentel, Matthias Miederer, Stefanie Pektor and Frank Rösch

    EJNMMI Research 2018 8:16

    Published on: 27 February 2018

  5. Preliminary research

    Feasibility of intraoperative detection of sentinel lymph nodes with 89-zirconium-labelled nanocolloidal albumin PET-CT and a handheld high-energy gamma probe

    PET/CT lymphoscintigraphy using 89Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary t...

    Derrek A. Heuveling, K. Hakki Karagozoglu, Arthur Van Lingen, Otto S. Hoekstra, Guus A. M. S. Van Dongen and Remco De Bree

    EJNMMI Research 2018 8:15

    Published on: 14 February 2018

  6. Original research

    A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases

    xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images wit...

    Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis and Solène Querellou

    EJNMMI Research 2018 8:14

    Published on: 12 February 2018

  7. Original research

    Statistical evaluation of test-retest studies in PET brain imaging

    Positron emission tomography (PET) is a molecular imaging technology that enables in vivo quantification of metabolic activity or receptor density, among other applications. Examples of applications of PET ima...

    Richard Baumgartner, Aniket Joshi, Dai Feng, Francesca Zanderigo and R. Todd Ogden

    EJNMMI Research 2018 8:13

    Published on: 12 February 2018

  8. Original research

    Subcellular storage and release mode of the novel 18F-labeled sympathetic nerve PET tracer LMI1195

    18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural up...

    Xinyu Chen, Rudolf A. Werner, Constantin Lapa, Naoko Nose, Mitsuru Hirano, Mehrbod S. Javadi, Simon Robinson and Takahiro Higuchi

    EJNMMI Research 2018 8:12

    Published on: 6 February 2018

  9. Original research

    Feasibility of 15O-water PET studies of auditory system activation during general anesthesia in children

    15O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic r....

    Martin Mamach, Florian Wilke, Martin Durisin, Frank A. Beger, Mareike Finke, Andreas Büchner, Barbara Schultz, Arthur Schultz, Lilli Geworski, Frank M. Bengel, Thomas Lenarz, Anke Lesinski-Schiedat and Georg Berding

    EJNMMI Research 2018 8:11

    Published on: 5 February 2018

  10. Original research

    Biokinetics, dosimetry, and radiation risk in infants after 99mTc-MAG3 scans

    Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochas...

    J. Soares Machado, J. Tran-Gia, S. Schlögl, A. K. Buck and M. Lassmann

    EJNMMI Research 2018 8:10

    Published on: 2 February 2018

  11. Letter to the Editor

    It is time to move forward into the era of Theranostics

    Radionuclide therapy, which until 15 years ago included only a few approved therapies, is gaining importance in the treatment of various malignancies. The future of oncology will not be limited to surgery, che...

    Hojjat Ahmadzadehfar and Markus Essler

    EJNMMI Research 2018 8:9

    Published on: 30 January 2018

  12. Original research

    Renal sympathetic nerve activity after catheter-based renal denervation

    Catheter-based renal sympathetic denervation (RDN) has been considered a potential treatment for therapy resistant hypertension (RHT). However, in a randomized placebo-controlled trial, RDN did not lead to a s...

    Linn C. Dobrowolski, Daan W. Eeftinck Schattenkerk, C. T. Paul Krediet, Peter M. Van Brussel, Liffert Vogt, Frederike J. Bemelman, Jim A. Reekers, Bert-Jan H. Van Den Born and Hein J. Verberne

    EJNMMI Research 2018 8:8

    Published on: 26 January 2018

  13. Original research

    Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody

    Ideally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development....

    Yvonne W. S. Jauw, Marc C. Huisman, Tapan K. Nayak, Danielle J. Vugts, Randolph Christen, Valerie Meresse Naegelen, Dominik Ruettinger, Florian Heil, Adriaan A. Lammertsma, Henk M. W. Verheul, Otto S. Hoekstra, Guus A. M. S. van Dongen and C. Willemien Menke-van der Houven van Oordt

    EJNMMI Research 2018 8:6

    Published on: 22 January 2018

  14. Original research

    Phantom and clinical evaluation of the effect of full Monte Carlo collimator modelling in post-SIRT yttrium-90 Bremsstrahlung SPECT imaging

    Post-therapy SPECT/CT imaging of 90Y microspheres delivered to hepatic malignancies is difficult, owing to the continuous, high-energy Bremsstrahlung spectrum emitted by 90Y. This study aimed to evaluate the util...

    Charlotte A. Porter, Kevin M. Bradley, Eero T. Hippeläinen, Matthew D. Walker and Daniel R. McGowan

    EJNMMI Research 2018 8:7

    Published on: 22 January 2018

  15. Original research

    A novel genomic signature predicting FDG uptake in diverse metastatic tumors

    Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requir...

    Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J. Garcia-Cases, Ramon Gonzalez Manzano and Antonio Brugarolas

    EJNMMI Research 2018 8:4

    Published on: 18 January 2018

  16. Original research

    Diagnostic implications of a small-voxel reconstruction for loco-regional lymph node characterization in breast cancer patients using FDG-PET/CT

    We evaluated the diagnostic implications of a small-voxel reconstruction for lymph node characterization in breast cancer patients, using state-of-the-art FDG-PET/CT. We included 69 FDG-PET/CT scans from breas...

    Daniëlle Koopman, Jorn A. van Dalen, Hester Arkies, Ad H. J. Oostdijk, Anne Brecht Francken, Jos Bart, Cornelis H. Slump, Siert Knollema and Pieter L. Jager

    EJNMMI Research 2018 8:3

    Published on: 16 January 2018

  17. Original research

    Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

    The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for t...

    Yong-il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee and June-Key Chung

    EJNMMI Research 2018 8:2

    Published on: 10 January 2018

  18. Preliminary research

    Positron emission tomography-magnetic resonance imaging (PET-MRI) for response assessment after radiation therapy of cervical carcinoma: a pilot study

    Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control is a prerequisite for cure. Imaging after treatment is controversial. Positron emission tomography (PET) combined with c...

    J. E. Mongula, F. C. H. Bakers, S. Vöö, L. Lutgens, T. van Gorp, R. F. P. M. Kruitwagen and B. F. M. Slangen

    EJNMMI Research 2018 8:1

    Published on: 2 January 2018

  19. Original research

    The effect of selective internal radiation therapy with yttrium-90 resin microspheres on lung carbon monoxide diffusion capacity

    Selective internal radiation therapy (SIRT) with embolization of branches of the hepatic artery is a valuable therapeutic tool for patients with hepatic malignancies; however, it is also associated with lung i...

    Tunc Ones, Emel Eryuksel, Feyyaz Baltacioglu, Berrin Ceyhan and Tanju Yusuf Erdil

    EJNMMI Research 2017 7:103

    Published on: 29 December 2017

  20. Original research

    Impact of tissue transport on PET hypoxia quantification in pancreatic tumours

    The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate ...

    Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C. Dhani, Iram Siddiqui, David W. Hedley and David A. Jaffray

    EJNMMI Research 2017 7:101

    Published on: 22 December 2017

  21. Original research

    Quantitative pulmonary blood flow measurement using 15O-H2O PET with and without tissue fraction correction: a comparison study

    Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpreta...

    Keiko Matsunaga, Masahiro Yanagawa, Tomoyuki Otsuka, Haruhiko Hirata, Takashi Kijima, Atsushi Kumanogoh, Noriyuki Tomiyama, Eku Shimosegawa and Jun Hatazawa

    EJNMMI Research 2017 7:102

    Published on: 22 December 2017

  22. Original research

    Improved visualization of breast tissue on a dedicated breast PET system through ergonomic redesign of the imaging table

    Breast lesions closer than 2 cm to the chest wall are difficult to position in the field of view of dedicated breast PET (db-PET) systems. This inability to detect such lesions is a significant limitation of t...

    Michael K. O’Connor, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Katie N. Hunt and Dana H. Whaley

    EJNMMI Research 2017 7:100

    Published on: 19 December 2017

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