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  1. [68Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context of a low tumor burden. Digital PET/CT bears the potential of reducing scan time duration/administered t...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Maurizio Conti, Axel Wetter, David Kersting, Christoph Rischpler and Pedro Fragoso Costa

    Citation: EJNMMI Research 2021 11:21

    Content type: Original research

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  2. A major challenge to the long-term success of neuroblastoma therapy is widespread metastases that survive initial therapy as minimal residual disease (MRD). The SSTR2 receptor is expressed by most neuroblastom...

    Authors: Jason L. J. Dearling, Ellen M. van Dam, Matthew J. Harris and Alan B. Packard

    Citation: EJNMMI Research 2021 11:20

    Content type: Original research

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  3. To develop and validate a machine learning model based on radiomic features derived from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) images to preoperatively predict...

    Authors: Haiqun Xing, Zhixin Hao, Wenjia Zhu, Dehui Sun, Jie Ding, Hui Zhang, Yu Liu and Li Huo

    Citation: EJNMMI Research 2021 11:19

    Content type: Original research

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  4. Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. While most of the existing literature has been focussed on t...

    Authors: Paul Windisch, Daniel R. Zwahlen, Frederik L. Giesel, Eberhard Scholz, Patrick Lugenbiel, Jürgen Debus, Uwe Haberkorn and Sebastian Adeberg

    Citation: EJNMMI Research 2021 11:18

    Content type: Review

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  5. Adrenocortical carcinoma (ACC) is an uncommon malignancy with an estimated 15,400 new cases annually across the globe. The prognosis is generally poor as the disease is often already advanced at initial diagno...

    Authors: Sen Lu, Jasreman Dhillon, Julie Hallanger Johnson and Ghassan El-Haddad

    Citation: EJNMMI Research 2021 11:17

    Content type: Case report

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  6. The functional 6-[18F]FDOPA positron emission tomography (PET) can be a helpful tool in differentiating parkinsonism with dopaminergic deficiency from clinically similar differential diagnoses. Furthermore, in T2...

    Authors: Enrico Michler, Daniel Kaiser, Kiriaki Eleftheriadou, Björn Falkenburger, Jörg Kotzerke and Sebastian Hoberück

    Citation: EJNMMI Research 2021 11:16

    Content type: Original research

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  7. The aim of this study was to assess the reader variability in quantitatively assessing pre- and post-treatment 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) sc...

    Authors: Joo Hyun O, Su Jin Lim, Hao Wang, Jeffrey P. Leal, Hui-Kuo G. Shu and Richard L. Wahl

    Citation: EJNMMI Research 2021 11:15

    Content type: Original research

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  8. RNA-based vaccination strategies tailoring immune response to specific reactions have become an important pillar for a broad range of applications. Recently, the use of lipid-based nanoparticles opened the pos...

    Authors: Matthias Miederer, Stefanie Pektor, Isabelle Miederer, Nicole Bausbacher, Isabell Sofia Keil, Hossam Hefesha, Heinrich Haas, Ugur Sahin and Mustafa Diken

    Citation: EJNMMI Research 2021 11:14

    Content type: Original research

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  9. We investigated the potential of interim 4′-[methyl-11C]thiothymidine ([11C]4DST) PET for predicting the chemoradiotherapeutic response for head and neck squamous cell carcinoma (HNSCC), in comparison with 2-deox...

    Authors: Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto, Kengo Fujimoto, Yasukage Takami, Hiroshi Hoshikawa, Jun Toyohara and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2021 11:13

    Content type: Original research

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  10. Both prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressive...

    Authors: Mads Ryø Jochumsen, Jens Sörensen, Lars Poulsen Tolbod, Bodil Ginnerup Pedersen, Jørgen Frøkiær, Michael Borre and Kirsten Bouchelouche

    Citation: EJNMMI Research 2021 11:12

    Content type: Original research

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  11. Until now, results evaluating the expression of PSMA in ovarian cancer were sparse and contradictory. The aim was to reinvestigate the feasibility of a PSMA targeted theranostic approach in epithelial ovarian ...

    Authors: Nicolas Aide, Laurent Poulain, Nicolas Elie, Mélanie Briand, Florence Giffard, Cécile Blanc-Fournier, Florence Joly and Charline Lasnon

    Citation: EJNMMI Research 2021 11:11

    Content type: Short communication

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  12. To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[18F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep...

    Authors: Zongyao Li, Kazuhiro Kitajima, Kenji Hirata, Ren Togo, Junki Takenaka, Yasuo Miyoshi, Kohsuke Kudo, Takahiro Ogawa and Miki Haseyama

    Citation: EJNMMI Research 2021 11:10

    Content type: Original research

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  13. [18F]Fluoromisonidazole ([18F]FMISO) is a PET imaging probe widely used for the detection of hypoxia. We previously reported that [18F]FMISO is metabolized to the glutathione conjugate of the reduced form in hypo...

    Authors: Yoichi Shimizu, Yukihiro Nakai, Hiroyuki Watanabe, Shimpei Iikuni, Masahiro Ono, Hideo Saji, Yuji Kuge, Tsuneo Saga and Yuji Nakamoto

    Citation: EJNMMI Research 2021 11:9

    Content type: Preliminary research

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  14. The purpose of this study was to evaluate both the biodistribution and safety of 64Cu-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-Trastuzumab, a novel 64Cu-labeled positron emission tomography (PET) trace...

    Authors: Inki Lee, Ilhan Lim, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang-Keun Woo, Kwang Il Kim, Kyo Chul Lee, Joo Hyun Kang, Min-Ki Seong, Hyun-Ah Kim, Woo Chul Noh and Sang Moo Lim

    Citation: EJNMMI Research 2021 11:8

    Content type: Original research

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  15. In this descriptive study of male and female mice at different weeks of age, we use serial non-invasive cardiac 18F-FDG-PET scans to follow up on metabolic alterations, heart function parameters, and the ECG o...

    Authors: Maximilian Fischer, Mathias J. Zacherl, Tobias Weinberger, Ludwig Weckbach, Bruno Huber, Christian Schulz, Steffen Massberg, Peter Bartenstein, Sebastian Lehner and Andrei Todica

    Citation: EJNMMI Research 2021 11:7

    Content type: Original research

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  16. [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor r...

    Authors: Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher…

    Citation: EJNMMI Research 2021 11:5

    Content type: Original research

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  17. Positron emission tomography (PET) is routinely used for cancer staging and treatment follow-up. Metabolic active tumor volume (MATV) as well as total MATV (TMATV—including primary tumor, lymph nodes and metas...

    Authors: Elisabeth Pfaehler, Liesbet Mesotten, Gem Kramer, Michiel Thomeer, Karolien Vanhove, Johan de Jong, Peter Adriaensens, Otto S. Hoekstra and Ronald Boellaard

    Citation: EJNMMI Research 2021 11:4

    Content type: Original research

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  18. Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)–targeted positron emission...

    Authors: Jonathan Kuten, Snir Dekalo, Ishai Mintz, Ofer Yossepowitch, Roy Mano and Einat Even-Sapir

    Citation: EJNMMI Research 2021 11:3

    Content type: Original research

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  19. Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-...

    Authors: Dae-Myoung Yang, Fiona Li, Glenn Bauman, Joseph Chin, Stephen Pautler, Madeleine Moussa, Irina Rachinsky, John Valliant and Ting-Yim Lee

    Citation: EJNMMI Research 2021 11:2

    Content type: Original research

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  20. The aim of this study was to compare a commercial dosimetry workstation (PLANET® Dose) and the dosimetry approach (GE Dosimetry Toolkit® and OLINDA/EXM® V1.0) currently used in our department for quantificatio...

    Authors: Lore Santoro, L. Pitalot, D. Trauchessec, E. Mora-Ramirez, P. O. Kotzki, M. Bardiès and E. Deshayes

    Citation: EJNMMI Research 2021 11:1

    Content type: Original research

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  21. We investigated the image quality of 11C, 68Ga, 18F and 89Zr, which have different positron fractions, physical half-lifes and positron ranges. Three small animal positron emission tomography/computed tomography ...

    Authors: Jarmo Teuho, Leon Riehakainen, Aake Honkaniemi, Olli Moisio, Chunlei Han, Marko Tirri, Shihao Liu, Tove J. Grönroos, Jie Liu, Lin Wan, Xiao Liang, Yiqing Ling, Yuexuan Hua, Anne Roivainen, Juhani Knuuti, Qingguo Xie…

    Citation: EJNMMI Research 2020 10:155

    Content type: Original research

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  22. 2-deoxy-2-[18F]fluoro-d-glucose’s (FDG) biodistribution limits the evaluation of cardiac sarcoidosis (CS) and neurosarcoidosis (NS). While protocols for cardiac suppression exist, they can be inconvenient for pat...

    Authors: Patrick Martineau, Matthieu Pelletier-Galarneau, Daniel Juneau, Eugene Leung, Pablo Nery, Rob deKemp, Rob Beanlands and David Birnie

    Citation: EJNMMI Research 2020 10:154

    Content type: Original research

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  23. The efficiency of [18F]FDG PET/CT using volume-based indices was evaluated to assess the disease activity and response to therapy in patients with immunoglobulin G4-related disease (IgG4-RD).

    Authors: Katsuya Mitamura, Hanae Arai-Okuda, Yuka Yamamoto, Takashi Norikane, Yasukage Takami, Kengo Fujimoto, Risa Wakiya, Hiroki Ozaki, Hiroaki Dobashi and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2020 10:153

    Content type: Original research

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  24. Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype ...

    Authors: Mohammed Shahid, Juha O. Rinne, Mika Scheinin, Jere Virta, Päivi Marjamäki, Olof Solin, Eveliina Arponen, Jukka Sallinen, Katja Kuokkanen and Juha Rouru

    Citation: EJNMMI Research 2020 10:152

    Content type: Original research

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  25. Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treat...

    Authors: Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian. J. Leeper, Kevin M. Brindle and André A. Neves

    Citation: EJNMMI Research 2020 10:151

    Content type: Original research

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  26. Deriving links between imaging and genomic markers is an evolving field. 2-[18F]FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography–computed tomography) is commonly used for cancer imaging, with maxim...

    Authors: Amin Haghighat Jahromi, Donald A. Barkauskas, Matthew Zabel, Aaron M. Goodman, Garret Frampton, Mina Nikanjam, Carl K. Hoh and Razelle Kurzrock

    Citation: EJNMMI Research 2020 10:150

    Content type: Original research

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  27. Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68G...

    Authors: Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo and Hans-Jürgen Wester

    Citation: EJNMMI Research 2020 10:149

    Content type: Original research

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  28. Stereotactic radiosurgery (SRS) is often the primary treatment modality for patients with intracranial metastatic disease. Despite advances in magnetic resonance imaging, including use of perfusion and diffusi...

    Authors: Ephraim E. Parent, Dhruv Patel, Jonathon A. Nye, Zhuo Li, Jeffrey J. Olson, David M. Schuster and Mark M. Goodman

    Citation: EJNMMI Research 2020 10:148

    Content type: Original research

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  29. Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity...

    Authors: Yusuf Helo, Graham E. Searle, Federica Borghese, Sonya Abraham and Azeem Saleem

    Citation: EJNMMI Research 2020 10:147

    Content type: Short communication

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  30. The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalys...

    Authors: Alice Egerton, Joel T. Dunn, Nisha Singh, Zilin Yu, Jim O’Doherty, Ivan Koychev, Jessica Webb, Simon Claridge, Federico E. Turkheimer, Paul K. Marsden, Alexander Hammers and Antony Gee

    Citation: EJNMMI Research 2020 10:146

    Content type: Original research

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  31. Checkpoint inhibition therapy using monoclonal antibodies against programmed cell death protein 1 (PD-1) or its ligand (PD-L1) is now standard management of non-small cell lung cancer (NSCLC). PD-L1 expression...

    Authors: Daniel Johnathan Hughes, Gitasha Chand, Vicky Goh and Gary J. R. Cook

    Citation: EJNMMI Research 2020 10:145

    Content type: Original research

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  32. Digital PET cameras markedly improve sensitivity and spatial resolution of brain 18F-FDG PET images compared to conventional cameras. Our study aimed to assess whether specific control databases are required to i...

    Authors: Elise Mairal, Matthieu Doyen, Thérèse Rivasseau-Jonveaux, Catherine Malaplate, Eric Guedj and Antoine Verger

    Citation: EJNMMI Research 2020 10:144

    Content type: Original research

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  33. Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following AD...

    Authors: Gaurav Malviya, Rachana Patel, Mark Salji, Rafael S. Martinez, Peter Repiscak, Ernest Mui, Susan Champion, Agata Mrowinska, Emma Johnson, Maha AlRasheedi, Sally Pimlott, David Lewis and Hing Y. Leung

    Citation: EJNMMI Research 2020 10:143

    Content type: Original research

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  34. Deriving individual tumor genomic characteristics from patient imaging analysis is desirable. We explore the predictive value of 2-[18F]FDG uptake with regard to the KRAS mutational status of colorectal adenocarc...

    Authors: M. Popovic, O. Talarico, J. van den Hoff, H. Kunin, Z. Zhang, D. Lafontaine, S. Dogan, J. Leung, E. Kaye, C. Czmielewski, M. E. Mayerhoefer, P. Zanzonico, R. Yaeger, H. Schöder, J. L. Humm, S. B. Solomon…

    Citation: EJNMMI Research 2020 10:142

    Content type: Original research

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  35. In molecular imaging with dynamic PET, the binding and dissociation of a targeted tracer is characterized by kinetics modeling which requires the arterial concentration of the tracer to be measured accurately....

    Authors: Fiona Li, Justin W. Hicks, Lihai Yu, Lise Desjardin, Laura Morrison, Jennifer Hadway and Ting-Yim Lee

    Citation: EJNMMI Research 2020 10:141

    Content type: Original research

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  36. Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1...

    Authors: Dorien Glorie, Jeroen Verhaeghe, Alan Miranda, Stef De Lombaerde, Sigrid Stroobants and Steven Staelens

    Citation: EJNMMI Research 2020 10:140

    Content type: Original research

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  37. Assessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar sci...

    Authors: Annie K. Kogler, Andrew M. Polemi, Surabhi Nair, Stanislaw Majewski, Lynn T. Dengel, Craig L. Slingluff Jr, Brian Kross, S. J. Lee, J. E. McKisson, John McKisson, Andrew G. Weisenberger, Benjamin L. Welch, Thomas Wendler, Philipp Matthies, Joerg Traub, Michael Witt…

    Citation: EJNMMI Research 2020 10:139

    Content type: Original research

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  38. Clinical management decisions on prostate cancer (PCa) are often based on a determination of risk. 68Ga-prostate-specific membrane antigen (PSMA)-11-positron emission tomography (PET)/computer tomography (CT) is ...

    Authors: Jun-jie Hong, Bo-le Liu, Zhi-qiang Wang, Kun Tang, Xiao-wei Ji, Wei-wei Yin, Jie Lin and Xiang-wu Zheng

    Citation: EJNMMI Research 2020 10:138

    Content type: Original research

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  39. Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts.

    Authors: Silvia Morbelli, Dario Arnaldi, Eugenia Cella, Stefano Raffa, Maria Isabella Donegani, Selene Capitanio, Federico Massa, Alberto Miceli, Laura Filippi, Andrea Chincarini and Flavio Nobili

    Citation: EJNMMI Research 2020 10:137

    Content type: Short communication

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  40. Brown adipose tissue (BAT) is a fat tissue found in most mammals that helps regulate energy balance and core body temperature through a sympathetic process known as non-shivering thermogenesis. BAT activity is...

    Authors: Christian T. McHugh, John Garside, Jared Barkes, Jonathan Frank, Constance Dragicevich, Hong Yuan and Rosa T. Branca

    Citation: EJNMMI Research 2020 10:136

    Content type: Original research

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  41. The study aimed to evaluate the effect of androgen deprivation therapy (ADT) on PSMA imaging and its correlation to the PSA concentration by comparing qualitative and quantitative parameters: SUVmax, SUVmean, PSM...

    Authors: Sebastian Hoberück, Steffen Löck, Robert Winzer, Klaus Zöphel, Michael Froehner, Dieter Fedders, Jörg Kotzerke and Tobias Hölscher

    Citation: EJNMMI Research 2020 10:135

    Content type: Original research

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  42. Asphericity (ASP) of the primary tumor’s metabolic tumor volume (MTV) in FDG-PET/CT is independently predictive for survival in patients with non-small cell lung cancer (NSCLC). However, comparability between ...

    Authors: Julian M. M. Rogasch, Christian Furth, Stephanie Bluemel, Piotr Radojewski, Holger Amthauer and Frank Hofheinz

    Citation: EJNMMI Research 2020 10:134

    Content type: Original research

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  43. As a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemore...

    Authors: Neil Gerard Quigley, Katja Steiger, Frauke Richter, Wilko Weichert, Sebastian Hoberück, Jörg Kotzerke and Johannes Notni

    Citation: EJNMMI Research 2020 10:133

    Content type: Original research

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  44. Prostate-specific membrane antigen (PSMA) agents, such as [68Ga]Ga-PSMA-11, have an unprecedented accuracy in staging prostate cancer (PCa) and detecting disease recurrence. PSMA PET/CT may also be used for respo...

    Authors: Judith olde Heuvel, Berlinda J. de Wit-van der Veen, Maarten L. Donswijk, Cornelis H. Slump and Marcel P. M. Stokkel

    Citation: EJNMMI Research 2020 10:132

    Content type: Original research

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  45. With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson’s disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. ...

    Authors: Jingjie Ge, Min Wang, Wei Lin, Ping Wu, Yihui Guan, Huiwei Zhang, Zhemin Huang, Likun Yang, Chuantao Zuo, Jiehui Jiang, Axel Rominger and Kuangyu Shi

    Citation: EJNMMI Research 2020 10:131

    Content type: Original research

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  46. [177Lu]Lu-DOTA-ZOL has shown promising results from the dosimetry and preclinical aspects, but data on its role in the clinical efficacy are limited. The objective of this study is to evaluate the efficacy and sa...

    Authors: Madhav Prasad Yadav, Sanjana Ballal, Marian Meckel, Frank Roesch and Chandrasekhar Bal

    Citation: EJNMMI Research 2020 10:130

    Content type: Original research

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  47. Prostate-specific membrane antigen (PSMA) is expressed in the microvasculature of thyroid cancer. This suggests the potential use of PSMA as a diagnostic agent in patients with aggressive forms of thyroid canc...

    Authors: Courtney Lawhn-Heath, Sue S. Yom, Chienying Liu, Javier E. Villanueva-Meyer, Maya Aslam, Raven Smith, Manpreet Narwal, Roxanna Juarez, Spencer C. Behr, Miguel Hernandez Pampaloni, Jason W. Chan, Christine M. Glastonbury, Thomas A. Hope and Robert R. Flavell

    Citation: EJNMMI Research 2020 10:128

    Content type: Original research

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  48. In vivo imaging of glucose analogue 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) via positron emission tomography (PET) is the current gold standard to visualize and assess brown adipose tissue (BAT) activity. Howe...

    Authors: Andreas Paulus, Natascha Drude, Wouter van Marken Lichtenbelt, Felix M. Mottaghy and Matthias Bauwens

    Citation: EJNMMI Research 2020 10:127

    Content type: Original research

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