Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) i...
Authors: Wen-Sheng Huang, Guann-Juh Chen, Tung-Han Tsai, Chen-Yi Cheng, Chyng-Yann Shiue, Kuo-Hsing Ma and Skye Hsin-Hsien Yeh
Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical st...
Authors: Go Akamatsu, Yasuhiko Ikari, Akihito Ohnishi, Keiichi Matsumoto, Hiroyuki Nishida, Yasuji Yamamoto and Michio Senda
Overall, 40% of patients with a locally advanced head and neck cancer (LAHNC) treated by chemoradiotherapy (CRT) present local recurrence within 2 years after the treatment. The aims of this study were to char...
Authors: J. Beaumont, O. Acosta, A. Devillers, X. Palard-Novello, E. Chajon, R. de Crevoisier and J. Castelli
The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/com...
Authors: Wen-Jie Wu, Zhen-Yu Li, Shuang Dong, Shu-Ming Liu, Lei Zheng, Ming-Wei Huang and Jian-Guo Zhang
An efficient and cost-effective synthesis of the metal chelating agents that couple to tumor-targeting peptides is required to enhance the process of preclinical research toward the clinical translation of mol...
Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ l...
Authors: Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier and Melanie A. Kimm
Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is re...
Authors: Johan Economou Lundeberg, Jenny Oddstig, Ulrika Bitzén and Elin Trägårdh
Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcino...
Authors: Fortuné M. K. Elekonawo, Susanne Lütje, Gerben M. Franssen, Desirée L. Bos, David M. Goldenberg, Otto C. Boerman and Mark Rijpkema
A cerebrospinal fluid (CSF)-mask algorithm has been developed to reduce the adverse influence of CSF-low-counts on the diagnostic utility of the specific binding ratio (SBR) index calculated with Southampton m...
The aim of the current study was to assess whether and to what extent monitoring response to treatment using prostate-specific membrane antigen (PSMA)-based positron-emitting tomography/computerized tomography...
Authors: Jonathan Kuten, David Sarid, Ofer Yossepowitch, Nicola J. Mabjeesh and Einat Even-Sapir
Positron emission tomography/magnetic resonance imaging (PET/MRI) is a promising diagnostic imaging tool for the diagnosis of dementia, as PET can add complementary information to the routine imaging examinati...
Authors: Silje Kjærnes Øen, Thomas Morten Keil, Erik Magnus Berntsen, Joel Fredrik Aanerud, Thomas Schwarzlmüller, Claes Nøhr Ladefoged, Anna Maria Karlberg and Live Eikenes
The use of 16α-[18F]fluoro-17β-estradiol (FES) positron emission tomography (PET) in clinical dilemmas and for therapy decision-making in lesions expressing estrogen receptors is growing. However, on a considerab...
Authors: C. M. Venema, E. F. J. de Vries, S. J. van der Veen, M. D. Dorrius, M. van Kruchten, C. P. Schröder, G. A. P. Hospers and A. W. J. M. Glaudemans
Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) v...
Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce.
Authors: Guillaume Rucher, Lucie Cameliere, Jihene Fendri, Antoine Anfray, Ahmed Abbas, Saïd Kamel, Quentin Dupas, Nicolas Delcroix, Ludovic Berger and Alain Manrique
(1) To perform a comprehensive analysis of the time elapsed between the last G-CSF injection and the PET/CT examination on the biodistribution of 18F-FDG, with emphasis on liver, spleen, and bone marrow uptake, a...
Authors: Magno Oliveira, Charline Lasnon, Catherine Nganoa, Anne-Claire Gac, Gandhi Damaj and Nicolas Aide
Immunotherapies that employ immune checkpoint modulators (ICMs) have emerged as an effective treatment for a variety of solid cancers, as well as a paradigm shift in the treatment of cancers. Despite this brea...
Authors: Mathieu Sinigaglia, Tarek Assi, Florent L. Besson, Samy Ammari, Myriam Edjlali, Whitney Feltus, Laura Rozenblum-Beddok, Binsheng Zhao, Lawrence H. Schwartz, Fatima-Zohra Mokrane and Laurent Dercle
PET (positron emission tomography) biokinetic modelling relies on accurate quantitative data. One of the main corrections required in PET imaging to obtain high quantitative accuracy is tissue attenuation corr...
Authors: Jorge Cabello, Mihai Avram, Felix Brandl, Mona Mustafa, Martin Scherr, Claudia Leucht, Stefan Leucht, Christian Sorg and Sibylle I. Ziegler
The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed f...
Authors: Astrid Gosewisch, Harun Ilhan, Sebastian Tattenberg, Andrea Mairani, Katia Parodi, Julia Brosch, Lena Kaiser, Franz Josef Gildehaus, Andrei Todica, Sibylle Ziegler, Peter Bartenstein and Guido Böning
The development and clinical translation of [68Ga] Pentixafor has substantially promoted the relevance of non-invasive PET imaging of CXCR4 expression in a broad spectrum of diseases, including cancer and inflamm...
Authors: Margret Schottelius, Marina Ludescher, Frauke Richter, Tobias G. Kapp, Horst Kessler and Hans-Jürgen Wester
In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed ...
Authors: Sven De Bruycker, Christel Vangestel, Steven Staelens, Leonie wyffels, Jan Detrez, Marlies Verschuuren, Winnok H. De Vos, Patrick Pauwels, Tim Van den Wyngaert and Sigrid Stroobants
To evaluate the optimal tracer uptake time, the minimal amount of radioactivity and the inter-observer agreement for 11C-choline positron emission tomography/computed tomography (PET/CT) in patients with primary ...
Authors: Milou E. Noltes, Schelto Kruijff, Walter Noordzij, Eef D. Telenga, David Vállez García, Malgorzata Trofimiuk-Müldner, Marta Opalińska, Alicja Hubalewska-Dydejczyk, Gert Luurtsema, Rudi A. J. O. Dierckx, Mostafa El Moumni, Ronald Boellaard and Adrienne H. Brouwers
18F-fluorocholine (FCH) PET/CT is a promising technique for visualizing hyperfunctioning parathyroid glands in hyperparathyroidism. It is still under debate whether to use this technique as a first-line imaging ....
Authors: Wouter A. M. Broos, Maurits Wondergem, Remco J. J. Knol and Friso M. van der Zant
Cimbi-36 can be 11C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT2A receptor in the brain. In its non-labeled form (25B-NBOMe), it is used as a recreationa...
Authors: Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen and Hanne D. Hansen
Whole body [18F]-fluorodihydrotestosterone positron emission tomography ([18F]FDHT PET) imaging directly targets the androgen receptor and is a promising prognostic and predictive biomarker in metastatic castrati...
Authors: Matthijs C. F. Cysouw, Gerbrand M. Kramer, Dennis Heijtel, Robert C. Schuit, Michael J. Morris, Alfons J. M. van den Eertwegh, Jens Voortman, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard
Orbital inflammatory diseases are a heterogenic group of conditions that often entail a difficult diagnostic process and many patients are treatment resistant. Inflammatory diseases can be visualized by Zircon...
Authors: Kamil G. Laban, Rachel Kalmann, Roos J. Leguit and Bart de Keizer
For almost a decade, terbium radioisotopes have been explored for their potential theragnostic application in nuclear medicine: 152Tb and 155Tb are the radioisotopes identified for PET or SPECT imaging, while 149
Authors: Cristina Müller, Aviral Singh, Christoph A. Umbricht, Harshad R. Kulkarni, Karl Johnston, Martina Benešová, Stefan Senftleben, Dirk Müller, Christiaan Vermeulen, Roger Schibli, Ulli Köster, Nicholas P. van der Meulen and Richard P. Baum
Our aim was to present a new data analysis technique for the early detection of tumorous lesions using single-photon emission computed tomography (SPECT) imaging. Beyond standardized uptake value (SUV) and sta...
Authors: Dániel S. Veres, Domokos Máthé, Nikolett Hegedűs, Ildikó Horváth, Fanni J. Kiss, Gabriella Taba, Edit Tóth-Bodrogi, Tibor Kovács and Krisztián Szigeti
We investigated the whole-body distribution and the radiation dosimetry of [18F]-JK-PSMA-7, a novel 18F-labeled PSMA-ligand for PET/CT imaging of prostate cancer.
Authors: Melanie Hohberg, Carsten Kobe, Philipp Krapf, Philipp Täger, Jochen Hammes, Felix Dietlein, Boris D. Zlatopolskiy, Heike Endepols, Markus Wild, Stephan Neubauer, Axel Heidenreich, Bernd Neumaier, Alexander Drzezga and Markus Dietlein
The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting t...
Authors: John Ly, David Minarik, Lars Edenbrandt, Per Wollmer and Elin Trägårdh
Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstructi...
Authors: Elin Trägårdh, David Minarik, Helén Almquist, Ulrika Bitzén, Sabine Garpered, Erland Hvittfelt, Berit Olsson and Jenny Oddstig
To determine the reliability of visual assessment of [123I]FP-CIT SPECT imaging by non-experts in dopamine transporter (DAT) SPECT imaging in patients with early drug-naive Parkinson’s disease (PD). Also, we expl...
Authors: Sven R. Suwijn, Constant V. M. Verschuur, Marleen A. Slim, Jan Booij and Rob M. A. de Bie
The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interven...
Authors: Marilyne Kafrouni, Carole Allimant, Marjolaine Fourcade, Sébastien Vauclin, Boris Guiu, Denis Mariano-Goulart and Fayçal Ben Bouallègue
The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this differen...
Authors: Julien Salvadori, Laetitia Imbert, Mathieu Perrin, Gilles Karcher, Zohra Lamiral, Pierre-Yves Marie and Antoine Verger
To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[18F]-fluoropropyl)-2-nitroimidazole ([18F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity ...
Authors: Shiro Watanabe, Tohru Shiga, Kenji Hirata, Keiichi Magota, Shozo Okamoto, Takuya Toyonaga, Kei Higashikawa, Hironobu Yasui, Jun Kobayashi, Ken-ichi Nishijima, Ken Iseki, Hiroki Matsumoto, Yuji Kuge and Nagara Tamaki
In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer’s disease (AD) through 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) s...
Authors: Débora E. Peretti, David Vállez García, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard
Non-invasive tumor blood flow (TBF) quantification is a candidate approach for risk stratification and monitoring of prostate cancer patients. Validation data have recently been published on prostate TBF measu...
Authors: Mads Ryø Jochumsen, Kirsten Bouchelouche, Katrine Bødkergaard Nielsen, Jørgen Frøkiær, Michael Borre, Jens Sörensen and Lars Poulsen Tolbod
Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[18F]...
Authors: Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Lothar A. Schwarte, Frederik Barkhof, Petra J. W. Pouwels, Jan J. Heimans, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, William P. Vandertop, Pieter Wesseling, Ronald Boellaard and Philip C. de Witt Hamer
(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising re...
Authors: Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock and Simon M. Ametamey
This study investigated the noninvasive assessment of tumor vascularization with clinical F-18-fluorodeoxyglucose positron emission tomography/computed tomography and contrast-enhanced computed tomography ([18...
Authors: Martin Mirus, Sergey V. Tokalov, Andrij Abramyuk, Jessica Heinold, Vincent Prochnow, Klaus Zöphel, Jörg Kotzerke and Nasreddin Abolmaali
18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, q....
Authors: Milou C. Schimmelpennink, Adriane D. M. Vorselaars, Marcel Veltkamp and Ruth G. M. Keijsers
Biodistribution studies based on organ harvesting represent the gold standard pre-clinical technique for dose extrapolations. However, sequential imaging is becoming increasingly popular as it allows the extra...
Authors: Francesco Cicone, Silvano Gnesin, Thibaut Denoël, Thierry Stora, Nicholas P. van der Meulen, Cristina Müller, Christiaan Vermeulen, Martina Benešová, Ulli Köster, Karl Johnston, Ernesto Amato, Lucrezia Auditore, George Coukos, Michael Stabin, Niklaus Schaefer, David Viertl…
Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRP-R) are expressed in prostate cancer and can be targeted with radiolabeled inhibitors and antagonists. Their performances fo...
Authors: Romain Schollhammer, Henri De Clermont Gallerande, Mokrane Yacoub, Marie-Laure Quintyn Ranty, Nicole Barthe, Delphine Vimont, Elif Hindié, Philippe Fernandez and Clément Morgat
Eribulin, an inhibitor of microtubule dynamics, shows antitumor potency against a variety of solid cancers through its antivascular activity and remodeling of tumor vasculature. 18F-Fluoromisonidazole (18F-FMISO)...
To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of 18F-1-amino-3-fluorocyclobutane-1-carbo...
Authors: Irena Saarinen, Ivan Jambor, Mai Kim, Anna Kuisma, Jukka Kemppainen, Harri Merisaari, Olli Eskola, Anna-Riina Koskenniemi, Ileana Montoya Perez, Peter Boström, Pekka Taimen and Heikki Minn
Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten ...
Authors: Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch and Matthias M. Herth
The widespread use of 68Ga for positron emission tomography (PET) relies on the development of radiopharmaceutical precursors that can be radiolabelled and dispensed in a simple, quick, and convenient manner. The...
Authors: Jean-Philippe Sinnes, Johannes Nagel, Bradley P. Waldron, Theodosia Maina, Berthold A. Nock, Ralf K. Bergmann, Martin Ullrich, Jens Pietzsch, Michael Bachmann, Richard P. Baum and Frank Rösch
[11C]methionine ([11C]Met) was used for cancer imaging based on upregulated amino acid transport and protein synthesis in different tumor types. However, the short half-life of 11C decay limited further clinical ...
Authors: Olga Sergeeva, Yifan Zhang, Jonathan D. Kenyon, Galen A. Miller-Atkins, Chunying Wu, Renuka Iyer, Sandra Sexton, Patrick Wojtylak, Amad Awadallah, Wei Xin, E. Ricky Chan, James K. O’Donnel and Zhenghong Lee
Liposomes are drug nano-carriers that are capable of targeting therapeutics to tumor sites because of enhanced permeability retention (EPR). In several preclinical studies with various tumor-bearing mice models,
Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. To understand...
Authors: Kevin S. Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J. Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers, Andor W. J. M. Glaudemans, Veena Vincent, Jessica Renaux, Matt Szapacs, Mary Birchler, Matthew Cleveland…
Following publication of the original article [1], the authors flagged the that the Kaplan-Meier curve in Fig. 6 is a duplication of the Kaplan-Meier curve in Fig. 5, which is not correct.
Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh
