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  1. When Alzheimer’s disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in the case of a late onset. We aim at identifying [ ...

    Authors: Jing Li, Emanuele Antonecchia, Marco Camerlenghi, Agostino Chiaravalloti, Qian Chu, Alfonso Di Costanzo, Zhen Li, Lin Wan, Xiangsong Zhang, Nicola D’Ascenzo, Orazio Schillaci and Qingguo Xie

    Citation: EJNMMI Research 2021 11:40

    Content type: Original research

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  2. Glycolysis is increased by hypoxia, suggesting a possible correlation between the accumulation of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in malignant tumors and regional hypoxia defined by 1H-1-(3-[18F]fluoro-2-hy...

    Authors: Sadek A. Nehmeh, Mohamed B. Moussa, Nancy Lee, Pat Zanzonico, Mithat Gönen, John L. Humm and Heiko Schöder

    Citation: EJNMMI Research 2021 11:38

    Content type: Original research

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  3. Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [18F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography–computed tomography (PET) on ...

    Authors: David Tonnelet, M. D. Pierre Bohn, Stephanie Becker, Pierre Decazes, Vincent Camus, Sebastien Thureau, Hervé Tilly, Fabrice Jardin and Pierre Vera

    Citation: EJNMMI Research 2021 11:37

    Content type: Original research

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  4. Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used i...

    Authors: Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret and Nadja Van Camp

    Citation: EJNMMI Research 2021 11:36

    Content type: Original research

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  5. Previous studies found that the positron emission tomography (PET) radioligand [18F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to as...

    Authors: Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Mohammad B. Haskali, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis and Paolo Zanotti-Fregonara

    Citation: EJNMMI Research 2021 11:35

    Content type: Original research

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  6. The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membr...

    Authors: Yohji Matsusaka, Tomohiko Yamane, Kenji Fukushima, Akira Seto, Ichiro Matsunari and Ichiei Kuji

    Citation: EJNMMI Research 2021 11:34

    Content type: Original research

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  7. The aim of this prospective study was to evaluate a data-driven gating software’s performance, in terms of identifying the respiratory signal, comparing [68Ga]Ga-DOTATOC and [18F]FDG examinations. In addition, fo...

    Authors: Jonathan Sigfridsson, Elin Lindström, Victor Iyer, Maria Holstensson, Irina Velikyan, Anders Sundin and Mark Lubberink

    Citation: EJNMMI Research 2021 11:33

    Content type: Original research

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  8. Identifying the correct location of a parathyroid adenoma in patients with primary hyperparathyroidism (pHPT) is crucial as it can guide surgical treatment. This study aimed to determine the diagnostic perform...

    Authors: M. E. Noltes, S. Kruijff, L. Jansen, H. E. Westerlaan, W. T. Zandee, R. A. J. O. Dierckx and A. H. Brouwers

    Citation: EJNMMI Research 2021 11:32

    Content type: Original research

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  9. The objective of the study is to define the most appropriate region for intensity normalization in brain 18FDG PET semi-quantitative analysis. The best option could be based on previous absolute quantification st...

    Authors: A. Verger, M. Doyen, J. Y. Campion and Eric Guedj

    Citation: EJNMMI Research 2021 11:31

    Content type: Short communication

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  10. Atherosclerotic plaque vulnerability is comprised by plaque composition driven by inflammatory activity and these features can be depicted with 3D ultrasound and 2-[18F]FDG-PET, respectively. The study investi...

    Authors: Laerke Urbak, Rasmus S. Ripa, Benjamin V. Sandholt, Andreas Kjaer, Henrik Sillesen and Martin Graebe

    Citation: EJNMMI Research 2021 11:30

    Content type: Original research

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  11. Post-transplant lymphoproliferative disorders (PTLDs) are a spectrum of hematological malignancies occurring after solid organ and hematopoietic stem cell transplantation. [18F]FDG PET/CT is routinely performed a...

    Authors: F. Montes de Jesus, D. Dierickx, V. Vergote, W. Noordzij, R. A. J. O. Dierckx, C. M. Deroose, A. W. J. M. Glaudemans, O. Gheysens and T. C. Kwee

    Citation: EJNMMI Research 2021 11:29

    Content type: Original research

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  12. In women undergoing breast-conserving surgery (BCS), 20–25% require a re-operation as a result of incomplete tumour resection. An intra-operative technique to assess tumour margins accurately would be a major ...

    Authors: Patriek A. G. T. Jurrius, Maarten R. Grootendorst, Marika Krotewicz, Massimiliano Cariati, Ashutosh Kothari, Neill Patani, Paulina Karcz, Monika Nagadowska, Kunal N. Vyas, Arnie Purushotham and Maria Turska-d’Amico

    Citation: EJNMMI Research 2021 11:28

    Content type: Original research

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  13. Many radioligands have been developed for the visualization of atherosclerosis by targeting inflammation. However, interpretation of in vivo signals is often limited to plaque identification. We evaluated bind...

    Authors: Eric J. Meester, Erik de Blois, Boudewijn J. Krenning, Antonius F. W. van der Steen, Jeff P. Norenberg, Kim van Gaalen, Monique R. Bernsen, Marion de Jong and Kim van der Heiden

    Citation: EJNMMI Research 2021 11:27

    Content type: Original research

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  14. Expression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with neuroinflammation. The second-generation PET ligand [18F]FEPPA specifically binds T...

    Authors: Chi-Wei Chang, Chuang-Hsin Chiu, Ming-Hsien Lin, Hung-Ming Wu, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Ya-Yao Huang, Chyng-Yann Shiue, Wen-Sheng Huang and Skye Hsin-Hsien Yeh

    Citation: EJNMMI Research 2021 11:26

    Content type: Original research

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  15. Salivary glands are highly perfused and express the prostate-specific membrane antigen (PSMA) receptor as well as the sodium—iodide symporter. As a consequence, treatment with 177Lu/225Ac-PSMA for prostate cancer...

    Authors: V. Mohan, N. M. Bruin, M. E. T. Tesselaar, J. P. de Boer, E. Vegt, J. J. M. A. Hendrikx, A. Al-Mamgani, J. B. van de Kamer, J.-J. Sonke and W. V. Vogel

    Citation: EJNMMI Research 2021 11:25

    Content type: Original research

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  16. The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosim...

    Authors: Guillaume Nodari, Romain Popoff, Jean Marc Riedinger, Olivier Lopez, Julie Pellegrinelli, Inna Dygai-Cochet, Claire Tabouret-Viaud, Benoit Presles, Olivier Chevallier, Sophie Gehin, Matthieu Gallet, Marianne Latournerie, Sylvain Manfredi, Romaric Loffroy, Jean Marc Vrigneaud and Alexandre Cochet

    Citation: EJNMMI Research 2021 11:24

    Content type: Original research

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  17. To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target vol...

    Authors: Macarena Rodríguez-Fraile, Ana Ezponda, Fabiana Grisanti, Verónica Morán, Marta Calvo, Pablo Berián, Antonio Martínez de la Cuesta, Lidia Sancho, Mercedes Iñarrairaegui, Bruno Sangro and José Ignacio Bilbao

    Citation: EJNMMI Research 2021 11:23

    Content type: Original research

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  18. Intraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier...

    Authors: Michael Mix, Wolfgang Schultze-Seemann, Moritz von Büren, August Sigle, Mohamed A. Omrane, Markus T. Grabbert, Martin Werner, Christian Gratzke, Philipp T. Meyer and Cordula A. Jilg

    Citation: EJNMMI Research 2021 11:22

    Content type: Original research

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  19. [68Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context of a low tumor burden. Digital PET/CT bears the potential of reducing scan time duration/administered t...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Maurizio Conti, Axel Wetter, David Kersting, Christoph Rischpler and Pedro Fragoso Costa

    Citation: EJNMMI Research 2021 11:21

    Content type: Original research

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  20. A major challenge to the long-term success of neuroblastoma therapy is widespread metastases that survive initial therapy as minimal residual disease (MRD). The SSTR2 receptor is expressed by most neuroblastom...

    Authors: Jason L. J. Dearling, Ellen M. van Dam, Matthew J. Harris and Alan B. Packard

    Citation: EJNMMI Research 2021 11:20

    Content type: Original research

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  21. To develop and validate a machine learning model based on radiomic features derived from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) images to preoperatively predict...

    Authors: Haiqun Xing, Zhixin Hao, Wenjia Zhu, Dehui Sun, Jie Ding, Hui Zhang, Yu Liu and Li Huo

    Citation: EJNMMI Research 2021 11:19

    Content type: Original research

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  22. Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. While most of the existing literature has been focussed on t...

    Authors: Paul Windisch, Daniel R. Zwahlen, Frederik L. Giesel, Eberhard Scholz, Patrick Lugenbiel, Jürgen Debus, Uwe Haberkorn and Sebastian Adeberg

    Citation: EJNMMI Research 2021 11:18

    Content type: Review

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  23. Adrenocortical carcinoma (ACC) is an uncommon malignancy with an estimated 15,400 new cases annually across the globe. The prognosis is generally poor as the disease is often already advanced at initial diagno...

    Authors: Sen Lu, Jasreman Dhillon, Julie Hallanger Johnson and Ghassan El-Haddad

    Citation: EJNMMI Research 2021 11:17

    Content type: Case report

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  24. The functional 6-[18F]FDOPA positron emission tomography (PET) can be a helpful tool in differentiating parkinsonism with dopaminergic deficiency from clinically similar differential diagnoses. Furthermore, in T2...

    Authors: Enrico Michler, Daniel Kaiser, Kiriaki Eleftheriadou, Björn Falkenburger, Jörg Kotzerke and Sebastian Hoberück

    Citation: EJNMMI Research 2021 11:16

    Content type: Original research

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  25. The aim of this study was to assess the reader variability in quantitatively assessing pre- and post-treatment 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) sc...

    Authors: Joo Hyun O, Su Jin Lim, Hao Wang, Jeffrey P. Leal, Hui-Kuo G. Shu and Richard L. Wahl

    Citation: EJNMMI Research 2021 11:15

    Content type: Original research

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  26. RNA-based vaccination strategies tailoring immune response to specific reactions have become an important pillar for a broad range of applications. Recently, the use of lipid-based nanoparticles opened the pos...

    Authors: Matthias Miederer, Stefanie Pektor, Isabelle Miederer, Nicole Bausbacher, Isabell Sofia Keil, Hossam Hefesha, Heinrich Haas, Ugur Sahin and Mustafa Diken

    Citation: EJNMMI Research 2021 11:14

    Content type: Original research

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  27. We investigated the potential of interim 4′-[methyl-11C]thiothymidine ([11C]4DST) PET for predicting the chemoradiotherapeutic response for head and neck squamous cell carcinoma (HNSCC), in comparison with 2-deox...

    Authors: Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto, Kengo Fujimoto, Yasukage Takami, Hiroshi Hoshikawa, Jun Toyohara and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2021 11:13

    Content type: Original research

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  28. Both prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressive...

    Authors: Mads Ryø Jochumsen, Jens Sörensen, Lars Poulsen Tolbod, Bodil Ginnerup Pedersen, Jørgen Frøkiær, Michael Borre and Kirsten Bouchelouche

    Citation: EJNMMI Research 2021 11:12

    Content type: Original research

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  29. Until now, results evaluating the expression of PSMA in ovarian cancer were sparse and contradictory. The aim was to reinvestigate the feasibility of a PSMA targeted theranostic approach in epithelial ovarian ...

    Authors: Nicolas Aide, Laurent Poulain, Nicolas Elie, Mélanie Briand, Florence Giffard, Cécile Blanc-Fournier, Florence Joly and Charline Lasnon

    Citation: EJNMMI Research 2021 11:11

    Content type: Short communication

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  30. To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[18F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep...

    Authors: Zongyao Li, Kazuhiro Kitajima, Kenji Hirata, Ren Togo, Junki Takenaka, Yasuo Miyoshi, Kohsuke Kudo, Takahiro Ogawa and Miki Haseyama

    Citation: EJNMMI Research 2021 11:10

    Content type: Original research

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  31. [18F]Fluoromisonidazole ([18F]FMISO) is a PET imaging probe widely used for the detection of hypoxia. We previously reported that [18F]FMISO is metabolized to the glutathione conjugate of the reduced form in hypo...

    Authors: Yoichi Shimizu, Yukihiro Nakai, Hiroyuki Watanabe, Shimpei Iikuni, Masahiro Ono, Hideo Saji, Yuji Kuge, Tsuneo Saga and Yuji Nakamoto

    Citation: EJNMMI Research 2021 11:9

    Content type: Preliminary research

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  32. The purpose of this study was to evaluate both the biodistribution and safety of 64Cu-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-Trastuzumab, a novel 64Cu-labeled positron emission tomography (PET) trace...

    Authors: Inki Lee, Ilhan Lim, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang-Keun Woo, Kwang Il Kim, Kyo Chul Lee, Joo Hyun Kang, Min-Ki Seong, Hyun-Ah Kim, Woo Chul Noh and Sang Moo Lim

    Citation: EJNMMI Research 2021 11:8

    Content type: Original research

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  33. In this descriptive study of male and female mice at different weeks of age, we use serial non-invasive cardiac 18F-FDG-PET scans to follow up on metabolic alterations, heart function parameters, and the ECG o...

    Authors: Maximilian Fischer, Mathias J. Zacherl, Tobias Weinberger, Ludwig Weckbach, Bruno Huber, Christian Schulz, Steffen Massberg, Peter Bartenstein, Sebastian Lehner and Andrei Todica

    Citation: EJNMMI Research 2021 11:7

    Content type: Original research

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  34. [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor r...

    Authors: Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher…

    Citation: EJNMMI Research 2021 11:5

    Content type: Original research

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  35. Positron emission tomography (PET) is routinely used for cancer staging and treatment follow-up. Metabolic active tumor volume (MATV) as well as total MATV (TMATV—including primary tumor, lymph nodes and metas...

    Authors: Elisabeth Pfaehler, Liesbet Mesotten, Gem Kramer, Michiel Thomeer, Karolien Vanhove, Johan de Jong, Peter Adriaensens, Otto S. Hoekstra and Ronald Boellaard

    Citation: EJNMMI Research 2021 11:4

    Content type: Original research

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  36. Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)–targeted positron emission...

    Authors: Jonathan Kuten, Snir Dekalo, Ishai Mintz, Ofer Yossepowitch, Roy Mano and Einat Even-Sapir

    Citation: EJNMMI Research 2021 11:3

    Content type: Original research

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  37. Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-...

    Authors: Dae-Myoung Yang, Fiona Li, Glenn Bauman, Joseph Chin, Stephen Pautler, Madeleine Moussa, Irina Rachinsky, John Valliant and Ting-Yim Lee

    Citation: EJNMMI Research 2021 11:2

    Content type: Original research

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  38. The aim of this study was to compare a commercial dosimetry workstation (PLANET® Dose) and the dosimetry approach (GE Dosimetry Toolkit® and OLINDA/EXM® V1.0) currently used in our department for quantificatio...

    Authors: Lore Santoro, L. Pitalot, D. Trauchessec, E. Mora-Ramirez, P. O. Kotzki, M. Bardiès and E. Deshayes

    Citation: EJNMMI Research 2021 11:1

    Content type: Original research

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  39. We investigated the image quality of 11C, 68Ga, 18F and 89Zr, which have different positron fractions, physical half-lifes and positron ranges. Three small animal positron emission tomography/computed tomography ...

    Authors: Jarmo Teuho, Leon Riehakainen, Aake Honkaniemi, Olli Moisio, Chunlei Han, Marko Tirri, Shihao Liu, Tove J. Grönroos, Jie Liu, Lin Wan, Xiao Liang, Yiqing Ling, Yuexuan Hua, Anne Roivainen, Juhani Knuuti, Qingguo Xie…

    Citation: EJNMMI Research 2020 10:155

    Content type: Original research

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  40. 2-deoxy-2-[18F]fluoro-d-glucose’s (FDG) biodistribution limits the evaluation of cardiac sarcoidosis (CS) and neurosarcoidosis (NS). While protocols for cardiac suppression exist, they can be inconvenient for pat...

    Authors: Patrick Martineau, Matthieu Pelletier-Galarneau, Daniel Juneau, Eugene Leung, Pablo Nery, Rob deKemp, Rob Beanlands and David Birnie

    Citation: EJNMMI Research 2020 10:154

    Content type: Original research

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  41. The efficiency of [18F]FDG PET/CT using volume-based indices was evaluated to assess the disease activity and response to therapy in patients with immunoglobulin G4-related disease (IgG4-RD).

    Authors: Katsuya Mitamura, Hanae Arai-Okuda, Yuka Yamamoto, Takashi Norikane, Yasukage Takami, Kengo Fujimoto, Risa Wakiya, Hiroki Ozaki, Hiroaki Dobashi and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2020 10:153

    Content type: Original research

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  42. Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype ...

    Authors: Mohammed Shahid, Juha O. Rinne, Mika Scheinin, Jere Virta, Päivi Marjamäki, Olof Solin, Eveliina Arponen, Jukka Sallinen, Katja Kuokkanen and Juha Rouru

    Citation: EJNMMI Research 2020 10:152

    Content type: Original research

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  43. Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treat...

    Authors: Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian. J. Leeper, Kevin M. Brindle and André A. Neves

    Citation: EJNMMI Research 2020 10:151

    Content type: Original research

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  44. Deriving links between imaging and genomic markers is an evolving field. 2-[18F]FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography–computed tomography) is commonly used for cancer imaging, with maxim...

    Authors: Amin Haghighat Jahromi, Donald A. Barkauskas, Matthew Zabel, Aaron M. Goodman, Garret Frampton, Mina Nikanjam, Carl K. Hoh and Razelle Kurzrock

    Citation: EJNMMI Research 2020 10:150

    Content type: Original research

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  45. Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68G...

    Authors: Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo and Hans-Jürgen Wester

    Citation: EJNMMI Research 2020 10:149

    Content type: Original research

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  46. Stereotactic radiosurgery (SRS) is often the primary treatment modality for patients with intracranial metastatic disease. Despite advances in magnetic resonance imaging, including use of perfusion and diffusi...

    Authors: Ephraim E. Parent, Dhruv Patel, Jonathon A. Nye, Zhuo Li, Jeffrey J. Olson, David M. Schuster and Mark M. Goodman

    Citation: EJNMMI Research 2020 10:148

    Content type: Original research

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  47. Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity...

    Authors: Yusuf Helo, Graham E. Searle, Federica Borghese, Sonya Abraham and Azeem Saleem

    Citation: EJNMMI Research 2020 10:147

    Content type: Short communication

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  48. The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalys...

    Authors: Alice Egerton, Joel T. Dunn, Nisha Singh, Zilin Yu, Jim O’Doherty, Ivan Koychev, Jessica Webb, Simon Claridge, Federico E. Turkheimer, Paul K. Marsden, Alexander Hammers and Antony Gee

    Citation: EJNMMI Research 2020 10:146

    Content type: Original research

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