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  1. Content type: Original research

    The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this differen...

    Authors: Julien Salvadori, Laetitia Imbert, Mathieu Perrin, Gilles Karcher, Zohra Lamiral, Pierre-Yves Marie and Antoine Verger

    Citation: EJNMMI Research 2019 9:61

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  2. Content type: Original research

    To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[18F]-fluoropropyl)-2-nitroimidazole ([18F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity ...

    Authors: Shiro Watanabe, Tohru Shiga, Kenji Hirata, Keiichi Magota, Shozo Okamoto, Takuya Toyonaga, Kei Higashikawa, Hironobu Yasui, Jun Kobayashi, Ken-ichi Nishijima, Ken Iseki, Hiroki Matsumoto, Yuji Kuge and Nagara Tamaki

    Citation: EJNMMI Research 2019 9:60

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  3. Content type: Original research

    In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer’s disease (AD) through 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) s...

    Authors: Débora E. Peretti, David Vállez García, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard

    Citation: EJNMMI Research 2019 9:59

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  4. Content type: Original research

    Non-invasive tumor blood flow (TBF) quantification is a candidate approach for risk stratification and monitoring of prostate cancer patients. Validation data have recently been published on prostate TBF measu...

    Authors: Mads Ryø Jochumsen, Kirsten Bouchelouche, Katrine Bødkergaard Nielsen, Jørgen Frøkiær, Michael Borre, Jens Sörensen and Lars Poulsen Tolbod

    Citation: EJNMMI Research 2019 9:58

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  5. Content type: Original research

    Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[18F]...

    Authors: Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Lothar A. Schwarte, Frederik Barkhof, Petra J. W. Pouwels, Jan J. Heimans, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, William P. Vandertop, Pieter Wesseling, Ronald Boellaard and Philip C. de Witt Hamer

    Citation: EJNMMI Research 2019 9:57

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  6. Content type: Original research

    (E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising re...

    Authors: Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock and Simon M. Ametamey

    Citation: EJNMMI Research 2019 9:56

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  7. Content type: Original research

    This study investigated the noninvasive assessment of tumor vascularization with clinical F-18-fluorodeoxyglucose positron emission tomography/computed tomography and contrast-enhanced computed tomography ([18...

    Authors: Martin Mirus, Sergey V. Tokalov, Andrij Abramyuk, Jessica Heinold, Vincent Prochnow, Klaus Zöphel, Jörg Kotzerke and Nasreddin Abolmaali

    Citation: EJNMMI Research 2019 9:55

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  8. Content type: Original research

    18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, q....

    Authors: Milou C. Schimmelpennink, Adriane D. M. Vorselaars, Marcel Veltkamp and Ruth G. M. Keijsers

    Citation: EJNMMI Research 2019 9:54

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  9. Content type: Original research

    Biodistribution studies based on organ harvesting represent the gold standard pre-clinical technique for dose extrapolations. However, sequential imaging is becoming increasingly popular as it allows the extra...

    Authors: Francesco Cicone, Silvano Gnesin, Thibaut Denoël, Thierry Stora, Nicholas P. van der Meulen, Cristina Müller, Christiaan Vermeulen, Martina Benešová, Ulli Köster, Karl Johnston, Ernesto Amato, Lucrezia Auditore, George Coukos, Michael Stabin, Niklaus Schaefer, David Viertl…

    Citation: EJNMMI Research 2019 9:53

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  10. Content type: Original research

    Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRP-R) are expressed in prostate cancer and can be targeted with radiolabeled inhibitors and antagonists. Their performances fo...

    Authors: Romain Schollhammer, Henri De Clermont Gallerande, Mokrane Yacoub, Marie-Laure Quintyn Ranty, Nicole Barthe, Delphine Vimont, Elif Hindié, Philippe Fernandez and Clément Morgat

    Citation: EJNMMI Research 2019 9:52

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  11. Content type: Original research

    Eribulin, an inhibitor of microtubule dynamics, shows antitumor potency against a variety of solid cancers through its antivascular activity and remodeling of tumor vasculature. 18F-Fluoromisonidazole (18F-FMISO)...

    Authors: Songji Zhao, Wenwen Yu, Naoyuki Ukon, Chengbo Tan, Ken-ichi Nishijima, Yoichi Shimizu, Kei Higashikawa, Tohru Shiga, Hiroko Yamashita, Nagara Tamaki and Yuji Kuge

    Citation: EJNMMI Research 2019 9:51

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  12. Content type: Original research

    To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of 18F-1-amino-3-fluorocyclobutane-1-carbo...

    Authors: Irena Saarinen, Ivan Jambor, Mai Kim, Anna Kuisma, Jukka Kemppainen, Harri Merisaari, Olli Eskola, Anna-Riina Koskenniemi, Ileana Montoya Perez, Peter Boström, Pekka Taimen and Heikki Minn

    Citation: EJNMMI Research 2019 9:50

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  13. Content type: Original research

    Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten ...

    Authors: Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch and Matthias M. Herth

    Citation: EJNMMI Research 2019 9:49

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  14. Content type: Original research

    The widespread use of 68Ga for positron emission tomography (PET) relies on the development of radiopharmaceutical precursors that can be radiolabelled and dispensed in a simple, quick, and convenient manner. The...

    Authors: Jean-Philippe Sinnes, Johannes Nagel, Bradley P. Waldron, Theodosia Maina, Berthold A. Nock, Ralf K. Bergmann, Martin Ullrich, Jens Pietzsch, Michael Bachmann, Richard P. Baum and Frank Rösch

    Citation: EJNMMI Research 2019 9:48

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  15. Content type: Original research

    [11C]methionine ([11C]Met) was used for cancer imaging based on upregulated amino acid transport and protein synthesis in different tumor types. However, the short half-life of 11C decay limited further clinical ...

    Authors: Olga Sergeeva, Yifan Zhang, Jonathan D. Kenyon, Galen A. Miller-Atkins, Chunying Wu, Renuka Iyer, Sandra Sexton, Patrick Wojtylak, Amad Awadallah, Wei Xin, E. Ricky Chan, James K. O’Donnel and Zhenghong Lee

    Citation: EJNMMI Research 2019 9:47

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  16. Content type: Original research

    Liposomes are drug nano-carriers that are capable of targeting therapeutics to tumor sites because of enhanced permeability retention (EPR). In several preclinical studies with various tumor-bearing mice models,

    Authors: Shyh-Jen Wang, Wen-Sheng Huang, Chi-Mu Chuang, Chih-Hsien Chang, Te-Wei Lee, Gann Ting, Ming-Huang Chen, Peter Mu-Hsin Chang, Ta-Chung Chao, Hao-Wei Teng, Yee Chao, Yuh-Min Chen, Tzu-Ping Lin, Ya-Jen Chang, Su-Jung Chen, Yuan-Ruei Huang…

    Citation: EJNMMI Research 2019 9:46

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  17. Content type: Original research

    Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. To understand...

    Authors: Kevin S. Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J. Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers, Andor W. J. M. Glaudemans, Veena Vincent, Jessica Renaux, Matt Szapacs, Mary Birchler, Matthew Cleveland…

    Citation: EJNMMI Research 2019 9:45

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  18. Content type: Correction

    Following publication of the original article [1], the authors flagged the that the Kaplan-Meier curve in Fig. 6 is a duplication of the Kaplan-Meier curve in Fig. 5, which is not correct.

    Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh

    Citation: EJNMMI Research 2019 9:44

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    The original article was published in EJNMMI Research 2017 7:15

  19. Content type: Preliminary research

    Reactive oxygen species (ROS)-induced oxidative stress damages many cellular components such as fatty acids, DNA, and proteins. This damage is implicated in many disease pathologies including cancer and neurod...

    Authors: Kiran Kumar Solingapuram Sai, Nagaraju Bashetti, Xiaofei Chen, Skylar Norman, Justin W. Hines, Omsai Meka, J. V. Shanmukha Kumar, Sriram Devanathan, Gagan Deep, Cristina M. Furdui and Akiva Mintz

    Citation: EJNMMI Research 2019 9:43

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  20. Content type: Original research

    In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued...

    Authors: C. Shaun Loveless, Lauren L. Radford, Samuel J. Ferran, Stacy L. Queern, Matthew R. Shepherd and Suzanne E. Lapi

    Citation: EJNMMI Research 2019 9:42

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  21. Content type: Preliminary research

    Acute allograft rejection is one of the major complications after lung transplantation, and adequate and early recognition is important. Till now, the reference standard to detect acute rejection is the histop...

    Authors: Eef D. Telenga, Wim van der Bij, Erik F. J. de Vries, Erik A. M. Verschuuren, Wim Timens, Gert Luurtsema, Riemer H. J. A. Slart, Alberto Signore and Andor W. J. M. Glaudemans

    Citation: EJNMMI Research 2019 9:41

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  22. Content type: Original research

    Positron emission tomography (PET) imaging of 90Y following selective internal radiation therapy (SIRT) is possible, but image quality is poor, and therefore, accurate quantification and dosimetry are challenging...

    Authors: Nathaniel P. Scott and Daniel R. McGowan

    Citation: EJNMMI Research 2019 9:40

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  23. Content type: Original research

    While [18F]fluoromisonidazole (FMISO), a representative PET tracer to detect hypoxia, is reported to be able to prospect the prognosis after treatment for various types of cancers, the relation is unclear for pan...

    Authors: Tomohiko Yamane, Masayasu Aikawa, Masanori Yasuda, Kenji Fukushima, Akira Seto, Koujun Okamoto, Isamu Koyama and Ichiei Kuji

    Citation: EJNMMI Research 2019 9:39

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  24. Content type: Original research

    Positron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protei...

    Authors: S. K. Vainio, A. M. Dickens, J. Tuisku, O. Eskola, O. Solin, E. Löyttyniemi, D. C. Anthony, J. O. Rinne, L. Airas and M. Haaparanta-Solin

    Citation: EJNMMI Research 2019 9:38

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  25. Content type: Original research

    The specific uptake size index (SUSI) of striatal FP-CIT uptake is independent of spatial resolution in the SPECT image, in contrast to the specific binding ratio (SBR). This suggests that the SUSI is particul...

    Authors: Ralph Buchert, Catharina Lange, Timo S. Spehl, Ivayla Apostolova, Lars Frings, Cathrine Jonsson, Philipp T. Meyer and Sabine Hellwig

    Citation: EJNMMI Research 2019 9:37

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  26. Content type: Original research

    Semi-automated quantitative measurement of metabolic tumor volume (MTV) for prognosis in diffuse large B-Cell lymphoma (DLBCL) has gained considerable interest lately. However, simple tumor volume measures may...

    Authors: Lars C. Gormsen, Mikkel H. Vendelbo, Mette Abildgaard Pedersen, Ate Haraldsen, Karin Hjorthaug, Trond Velde Bogsrud, Lars J. Petersen, Karen Juul Jensen, Rasmus Brøndum and Tarec C. El-Galaly

    Citation: EJNMMI Research 2019 9:36

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  27. Content type: Original research

    The goal of targeted radiotherapy (TRT) is to administer radionuclides to tumor cells, while limiting radiation exposure to normal tissues. 3′-Deoxy-3′-[18F]-fluorothymidine (18F-FLT) is able to target tumor cell...

    Authors: Thititip Tippayamontri, Brigitte Guérin, René Ouellet, Otman Sarrhini, Jacques Rousseau, Roger Lecomte, Benoit Paquette and Léon Sanche

    Citation: EJNMMI Research 2019 9:33

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  28. Content type: Original research

    A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to stat...

    Authors: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley and Adriaan A. Lammertsma

    Citation: EJNMMI Research 2019 9:32

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  29. Content type: Original research

    [11C]-acetate positron emission tomography is used to assess oxidative metabolism in various tissues including the heart, tumor, and brown adipose tissue. For brown adipose tissue, a monoexponential decay model i...

    Authors: Marie Anne Richard, Denis P. Blondin, Christophe Noll, Réjean Lebel, Martin Lepage and André C. Carpentier

    Citation: EJNMMI Research 2019 9:31

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  30. Content type: Correction

    Following publication of the original article [1], the authors flagged that the author affiliations detailed in the article are incorrect for the authors M. L. Calcagni and A. Giordano.

    Authors: E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan and L. Indovina

    Citation: EJNMMI Research 2019 9:30

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    The original article was published in EJNMMI Research 2018 8:24

  31. Content type: Original research

    177Lu-octreotate is used for therapy of somatostatin receptor expressing neuroendocrine tumors with promising results, although complete tumor remission is rarely seen. Previous studies on nude mice bearing the h...

    Authors: Johan Spetz, Britta Langen, Nils-Petter Rudqvist, Toshima Z. Parris, Emman Shubbar, Johanna Dalmo, Bo Wängberg, Ola Nilsson, Khalil Helou and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2019 9:28

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  32. Content type: Original research

    Evidence has shown the clinical usefulness of measuring the metastatic tumor burden of bone for prognostic assessment especially in prostate cancer; quantitative evaluation by dedicated SPECT is difficult due ...

    Authors: Tadaki Nakahara, Yoshiki Owaki, Tsubasa Shindou, Kiyotaka Nakajima and Masahiro Jinzaki

    Citation: EJNMMI Research 2019 9:27

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  33. Content type: Original research

    Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been us...

    Authors: Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino, Ken-Ichiro Kikuta, Tetsuya Mori, Akira Makino and Yasushi Kiyono

    Citation: EJNMMI Research 2019 9:26

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  34. Content type: Original research

    Among the many peptide receptor systems, gastrin-releasing-peptide (GRP) receptors, the mammalian equivalent of bombesin (BN) receptors, are potential targets for diagnosis and therapy of breast tumors due to ...

    Authors: Kakali De, Dibyanti Mukherjee, Samarendu Sinha and Shantanu Ganguly

    Citation: EJNMMI Research 2019 9:25

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  35. Content type: Original research

    Metabolic parameters are increasingly being used to characterize tumors. Motion artifacts due to patient respiration introduce uncertainties in quantification of metabolic parameters during positron emission t...

    Authors: Esther M. M. Smeets, Dominique S. Withaar, Willem Grootjans, John J. Hermans, Kees van Laarhoven, Lioe-Fee de Geus-Oei, Martin Gotthardt and Erik H. J. G. Aarntzen

    Citation: EJNMMI Research 2019 9:24

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  36. Content type: Original research

    Today, the standardized uptake value (SUV) is essentially the only means for quantitative evaluation of static [18F-]fluorodeoxyglucose (FDG) positron emission tomography (PET) investigations. However, the SUV ap...

    Authors: Frank Hofheinz, Jens Maus, Sebastian Zschaeck, Julian Rogasch, Georg Schramm, Liane Oehme, Ivayla Apostolova, Jörg Kotzerke and Jörg van den Hoff

    Citation: EJNMMI Research 2019 9:23

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  37. Content type: Original research

    The heart-to-mediastinum ratio (HMR) obtained in myocardial sympathetic innervation imaging using 123I-metaiodobenzylguanidine (MIBG) is used for heart failure or Lewy body diseases (LBD). Discovery NM/CT 670 CZT...

    Authors: Nanami Okano, Iichiro Osawa, Saki Tsuchihashi, Masafumi Takahashi, Mamoru Niitsu and Ichiro Matsunari

    Citation: EJNMMI Research 2019 9:22

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  38. Content type: Original research

    Hybrid positron emission tomography and magnetic resonance imaging (PET/MRI) scanners are increasingly used for both clinical and preclinical imaging. Especially functional MRI sequences such as diffusion-weig...

    Authors: Jakob Albrecht, Dietrich Polenz, Anja A. Kühl, Julian M. M. Rogasch, Annekatrin Leder, Igor M. Sauer, Magor Babos, Gabor Mócsai, Nicola Beindorff, Ingo G. Steffen, Winfried Brenner and Eva J. Koziolek

    Citation: EJNMMI Research 2019 9:21

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  39. Content type: Original research

    223Ra imaging is crucial to evaluate the successfulness of the therapy of bone metastasis of castration-resistant prostate cancer (CRPC). The goals of this study were to establish a quantitative tomographic 223Ra...

    Authors: Nadia Benabdallah, Michela Bernardini, Marta Bianciardi, Claire de Labriolle-Vaylet, Didier Franck and Aurélie Desbrée

    Citation: EJNMMI Research 2019 9:20

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  40. Content type: Original research

    We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and v...

    Authors: Esmaeel Jafargholi Rangraz, Walter Coudyzer, Geert Maleux, Kristof Baete, Christophe M. Deroose and Johan Nuyts

    Citation: EJNMMI Research 2019 9:19

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  41. Content type: Original research

    We have previously developed the caspase-based radiotracer, 18F-ICMT-11, for PET imaging to monitor treatment response. We further validated 18F-ICMT-11 specificity in a murine melanoma death-switch tumour model ...

    Authors: Vessela Vassileva, Stephen M. Stribbling, Chris Barnes, Laurence Carroll, Marta Braga, Joel Abrahams, Kathrin Heinzmann, Caroline Haegeman, Marion MacFarlane, Kathryn L. Simpson, Caroline Dive, Jamie Honeychurch, Timothy M. Illidge and Eric O. Aboagye

    Citation: EJNMMI Research 2019 9:18

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  42. Content type: Original research

    The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However,...

    Authors: Irina Velikyan, Torsten Haack, Martin Bossart, Andreas Evers, Iina Laitinen, Philip Larsen, Oliver Plettenburg, Lars Johansson, Stefan Pierrou, Michael Wagner and Olof Eriksson

    Citation: EJNMMI Research 2019 9:17

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  43. Content type: Original research

    Bone marrow failure syndrome (BMFS) is a heterogeneous group of disorders associated with single- or multiple-lineage cytopenia and failure of normal hematopoiesis. We assessed the feasibility of integrated PE...

    Authors: Tetsuya Tsujikawa, Toshiki Tasaki, Naoko Hosono, Tetsuya Mori, Akira Makino, Yasushi Kiyono, Paolo Zanotti-Fregonara, Takahiro Yamauchi and Hidehiko Okazawa

    Citation: EJNMMI Research 2019 9:16

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  44. Content type: Original research

    Hyperglycaemia can influence 18F-fluorodeoxyglucose (FDG) uptake due to competition for glucose transport and phosphorylation by hexokinase. Major international nuclear medicine societies recommend blood glucose ...

    Authors: David A. Pattison, Lisa L. MacFarlane, Jason Callahan, Emma L. Kane, Timothy Akhurst and Rodney J. Hicks

    Citation: EJNMMI Research 2019 9:15

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  45. Content type: Original research

    Total metabolic active tumour volume (TMATV) and total tumour burden (TTB) are increasingly studied as prognostic and predictive factors in non-small cell lung cancer (NSCLC) patients. In this study, we invest...

    Authors: Guilherme D. Kolinger, David Vállez García, Gerbrand M. Kramer, Virginie Frings, Egbert F. Smit, Adrianus J. de Langen, Rudi A. J. O. Dierckx, Otto S. Hoekstra and Ronald Boellaard

    Citation: EJNMMI Research 2019 9:14

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  46. Content type: Original research

    Partial-volume effects generally result in an underestimation of tumor tracer uptake on PET-CT for small lesions, necessitating partial-volume correction (PVC) for accurate quantification. However, investigati...

    Authors: M. C. F. Cysouw, S. V. S. Golla, V. Frings, E. F. Smit, O. S. Hoekstra, G. M. Kramer and R. Boellaard

    Citation: EJNMMI Research 2019 9:12

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  47. Content type: Original research

    Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is commonly used to assess patients with cardiovascular disease. However, in certain scenarios, it may have limited sp...

    Authors: John P. Bois, Chris Scott, Panithaya Chareonthaitawee, Raymond J. Gibbons and Martin Rodriguez-Porcel

    Citation: EJNMMI Research 2019 9:11

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