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  1. In this prospective exploratory study, we evaluated the feasibility of [18F]fluorodeoxyglucose ([18F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon thera...

    Authors: Felix N. Harder, Friederike Jungmann, Georgios A. Kaissis, Fabian K. Lohöfer, Sebastian Ziegelmayer, Daniel Havel, Michael Quante, Maximillian Reichert, Roland M. Schmid, Ihsan Ekin Demir, Helmut Friess, Moritz Wildgruber, Jens Siveke, Alexander Muckenhuber, Katja Steiger, Wilko Weichert…

    Citation: EJNMMI Research 2021 11:70

    Content type: Original research

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  2. Bronchoscopy serves as direct visualisation of the airway. Virtual bronchoscopy provides similar visual information using a non-invasive imaging procedure(s). Early and accurate image-guided diagnosis requires...

    Authors: Gábor Opposits, Marianna Nagy, Zoltán Barta, Csaba Aranyi, Dániel Szabó, Attila Makai, Imre Varga, László Galuska, Lajos Trón, László Balkay and Miklós Emri

    Citation: EJNMMI Research 2021 11:69

    Content type: Original research

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  3. Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare entity occurring in less than 4% of all lung cancers. Due to its low differentiation and high glucose transporter 1 (GLUT1) expression, LCNEC d...

    Authors: Hubertus Hautzel, Yazan Alnajdawi, Wolfgang P. Fendler, Christoph Rischpler, Kaid Darwiche, Wilfried E. Eberhardt, Lale Umutlu, Dirk Theegarten, Martin Stuschke, Martin Schuler, Clemens Aigner, Ken Herrmann and Till Plönes

    Citation: EJNMMI Research 2021 11:68

    Content type: Original research

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  4. Tumor hypoxia and glycolysis have been recognized as determinant factors characterizing tumor aggressiveness in malignant gliomas. To clarify in vivo hypoxia and glucose metabolism in relation to isocitrate dehyd...

    Authors: Kenta Suzuki, Nobuyuki Kawai, Tomoya Ogawa, Keisuke Miyake, Aya Shinomiya, Yuka Yamamoto, Yoshihiro Nishiyama and Takashi Tamiya

    Citation: EJNMMI Research 2021 11:67

    Content type: Original research

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  5. PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radion...

    Authors: Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke and Frank I. Lin

    Citation: EJNMMI Research 2021 11:66

    Content type: Original research

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  6. The role of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiati...

    Authors: Christina P. W. Cox, Daniëlle M. E. van Assema, Frederik A. Verburg, Tessa Brabander, Mark Konijnenberg and Marcel Segbers

    Citation: EJNMMI Research 2021 11:65

    Content type: Original research

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  7. The aim of this study was to explore the prognostic value of baseline metabolic parameters of 18F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).

    Authors: Huanyu Gong, Tiannv Li, Jianyong Li, Lijun Tang and Chongyang Ding

    Citation: EJNMMI Research 2021 11:64

    Content type: Original research

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  8. Auger electron-emitting radionuclides have potential in targeted treatment of small tumors. Thallium-201 (201Tl), a gamma-emitting radionuclide used in myocardial perfusion scintigraphy, decays by electron captur...

    Authors: Katarzyna M. Osytek, Philip J. Blower, Ines M. Costa, Gareth E. Smith, Vincenzo Abbate and Samantha Y. A. Terry

    Citation: EJNMMI Research 2021 11:63

    Content type: Original research

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  9. In 2015, the revised International Pediatric Non-Hodgkin Lymphoma Staging System was published. It mentions [18F]-FDG-PET/MRI as the latest method to perform whole-body imaging. However, supporting data are pendi...

    Authors: L. Kurch, R. Kluge, O. Sabri, L. Fischer, S. Wendt, H. Graf Einsiedel, S. Starke, J.-S. Kühl, H. Christiansen, F. W. Hirsch, I. Sorge and C. Roth

    Citation: EJNMMI Research 2021 11:62

    Content type: Original research

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  10. Myelosuppression is a potential dose-limiting factor in radioligand therapy (RLT). This study aims to investigate occurrence, severity and reversibility of hematotoxic adverse events in patients undergoing RLT...

    Authors: Daniel Groener, Cam Tu Nguyen, Justus Baumgarten, Benjamin Bockisch, Karen Davis, Christian Happel, Nicolai Mader, Christina Nguyen Ngoc, Jennifer Wichert, Severine Banek, Philipp Mandel, Felix K. H. Chun, Nikolaos Tselis, Frank Grünwald and Amir Sabet

    Citation: EJNMMI Research 2021 11:61

    Content type: Original research

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  11. There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different 99mTc-dicarboxypropandiphosphate ([99mTc]Tc-DPD) SPECT/CT quantificati...

    Authors: Martin Braun, Michal Cachovan, Felix Kaul, Federico Caobelli, Markus Bäumer, A. Hans Vija, Geert Pagenstert, Damian Wild and Martin Kretzschmar

    Citation: EJNMMI Research 2021 11:60

    Content type: Original research

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  12. Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of [99mTc]Tc-Galacto-RGD2 single-photon emission computed tomography ...

    Authors: Jingjing Fu, Yan Xie, Tong Fu, Fan Qiu, Fei Yu, Wei Qu, Xiaochen Yao, Aiping Zhang, Zhenhua Yang, Guoqiang Shao, Qingle Meng, Xiumin Shi, Yue Huang, Wei Gu and Feng Wang

    Citation: EJNMMI Research 2021 11:59

    Content type: Original research

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  13. DNA methylation inhibits gene expression by preventing transcription factors from binding to DNA. Functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (...

    Authors: Kyoungjune Pak, Ju Won Seok, Hyun-Yeol Nam, Seongho Seo, Myung Jun Lee, Keunyoung Kim and In Joo Kim

    Citation: EJNMMI Research 2021 11:58

    Content type: Original research

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  14. The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imagin...

    Authors: Marion Chomet, Maxime Schreurs, Ricardo Vos, Mariska Verlaan, Esther J. Kooijman, Alex J. Poot, Ronald Boellaard, Albert D. Windhorst, Guus AMS van Dongen, Danielle J. Vugts, Marc C. Huisman and Wissam Beaino

    Citation: EJNMMI Research 2021 11:57

    Content type: Original research

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  15. Considering the limited accessibility of amyloid position emission tomography (PET) in patients with dementia, we proposed a deep learning (DL)-based amyloid PET positivity classification model from PET images...

    Authors: Suhong Kim, Peter Lee, Kyeong Taek Oh, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Yu Kyeong Kim, Byoung Seok Ye, Mi Jin Yun, Dong Young Lee and Yong Jeong

    Citation: EJNMMI Research 2021 11:56

    Content type: Original research

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  16. Accurate sentinel lymph node (SLN) staging is essential for both prognosis and treatment in patients with breast cancer. However, the preoperative lymphoscintigraphy may fail to visualize the SLN in some patie...

    Authors: Youssef Chahid, Xinbo Qiu, Ewoudt M. W. van de Garde, Hein J. Verberne and Jan Booij

    Citation: EJNMMI Research 2021 11:54

    Content type: Original research

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  17. In this work, we address image segmentation in the scope of dosimetry using deep learning and make three main contributions: (a) to extend and optimize the architecture of an existing convolutional neural netw...

    Authors: Mahmood Nazari, Luis David Jiménez-Franco, Michael Schroeder, Andreas Kluge, Marcus Bronzel and Sharok Kimiaei

    Citation: EJNMMI Research 2021 11:53

    Content type: Original research

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  18. Diagnosis of Parkinson’s disease (PD) is informed by the presence of progressive motor and non-motor symptoms and by imaging dopamine transporter with [123I]ioflupane (DaTscan). Deep learning and ensemble methods...

    Authors: Kevin H. Leung, Steven P. Rowe, Martin G. Pomper and Yong Du

    Citation: EJNMMI Research 2021 11:52

    Content type: Original research

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  19. To confirm the prognostic value of previously published baseline interleukin 6 (IL6) and IL8 cutoff values in survival and liver dysfunction in patients with advanced HCC undergoing 90Y radioembolization.

    Authors: Osman Öcal, Juozas Kupčinskas, Egidijus Morkunas, Holger Amthauer, Kerstin Schütte, Peter Malfertheiner, Heinz Josef Klümpen, Christian Sengel, Julia Benckert, Ricarda Seidensticker, Bruno Sangro, Moritz Wildgruber, Maciej Pech, Peter Bartenstein, Jens Ricke and Max Seidensticker

    Citation: EJNMMI Research 2021 11:51

    Content type: Original research

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  20. Surgically induced nerve damage is a common but debilitating side effect in oncological surgery. With the aim to use fluorescence guidance to enable nerve-sparing interventions in future surgery, a fluorescent...

    Authors: Tessa Buckle, Albertus. W. Hensbergen, Danny M. van Willigen, Frank Bosse, Kevin Bauwens, Rob C. M. Pelger and Fijs W. B. van Leeuwen

    Citation: EJNMMI Research 2021 11:50

    Content type: Original research

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  21. [18F]MK-6240 is a PET tracer with sub-nanomolar affinity for neurofibrillary tangles. Therefore, tau quantification is possible with [18F]MK-6240 PET/CT scans, and it can be used for assessment of Alzheimer’s dis...

    Authors: Guilherme D. Kolinger, David Vállez García, Talakad G. Lohith, Eric D. Hostetler, Cyrille Sur, Arie Struyk, Ronald Boellaard and Michel Koole

    Citation: EJNMMI Research 2021 11:49

    Content type: Original research

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  22. There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surgery. New contrast agents are obtained by substituting the radioactive tag with, or adding a fluorescent cyanin...

    Authors: Marcus C. M. Stroet, Bianca M. Dijkstra, Sebastiaan E. Dulfer, Schelto Kruijff, Wilfred F. A. den Dunnen, Frank A. E. Kruyt, Rob J. M. Groen, Yann Seimbille, Kranthi M. Panth, Laura Mezzanotte, Clemens W. G. M. Lowik and Marion de Jong

    Citation: EJNMMI Research 2021 11:47

    Content type: Original research

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  23. Animal brain functions evaluated by in vivo imaging under anesthesia can be affected by anesthetic agents, resulting in incorrect assessment of physiological brain function. We therefore performed dynamic posi...

    Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata

    Citation: EJNMMI Research 2021 11:46

    Content type: Original research

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  24. Inflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image in...

    Authors: Romain Schollhammer, Sébastien Lepreux, Nicole Barthe, Delphine Vimont, Anne Rullier, Igor Sibon, Xavier Berard, Andrea Zhang, Yasuyuki Kimura, Masahiro Fujita, Robert B. Innis, Paolo Zanotti-Fregonara and Clément Morgat

    Citation: EJNMMI Research 2021 11:45

    Content type: Original research

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  25. High-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability for rapid data acquisition while preserving diagnostic image quality. However, determining a reliable and cl...

    Authors: Julia Pilz, Lukas Hehenwarter, Georg Zimmermann, Gundula Rendl, Gregor Schweighofer-Zwink, Mohsen Beheshti and Christian Pirich

    Citation: EJNMMI Research 2021 11:44

    Content type: Original research

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  26. 99mTc-tricarbonyl-nitrilotriacetic acid, [99mTc]Tc(CO)3(NTA), is a new 99mTc-renal radiopharmaceutical with a clearance equal to that of 131I-ortho-iodohippuran, [131I]I-OIH. Our purpose was to compare the perfor...

    Authors: Andrew T. Taylor, Malgorzata Lipowska and Raghuveer K. Halkar

    Citation: EJNMMI Research 2021 11:43

    Content type: Original research

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  27. To elucidate the biological association between tumor proliferation, tumor infiltration and neovascularization, we analyzed the association between volumetric information of 4′-[methyl-11C]thiothymidine (4DST) po...

    Authors: Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kenichi Tanaka, Tetsuhiro Hatakeyama, Keisuke Miyake, Jun Toyohara and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2021 11:42

    Content type: Original research

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  28. Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate...

    Authors: Niloefar Ahmadi Bidakhvidi, Annouschka Laenen, Sander Jentjens, Christophe M. Deroose, Koen Van Laere, Liesbeth De Wever, Cindy Mai, Charlien Berghen, Gert De Meerleer, Karin Haustermans, Steven Joniau, Wouter Everaerts and Karolien Goffin

    Citation: EJNMMI Research 2021 11:41

    Content type: Original research

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  29. When Alzheimer’s disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in the case of a late onset. We aim at identifying [ ...

    Authors: Jing Li, Emanuele Antonecchia, Marco Camerlenghi, Agostino Chiaravalloti, Qian Chu, Alfonso Di Costanzo, Zhen Li, Lin Wan, Xiangsong Zhang, Nicola D’Ascenzo, Orazio Schillaci and Qingguo Xie

    Citation: EJNMMI Research 2021 11:40

    Content type: Original research

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  30. Glycolysis is increased by hypoxia, suggesting a possible correlation between the accumulation of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in malignant tumors and regional hypoxia defined by 1H-1-(3-[18F]fluoro-2-hy...

    Authors: Sadek A. Nehmeh, Mohamed B. Moussa, Nancy Lee, Pat Zanzonico, Mithat Gönen, John L. Humm and Heiko Schöder

    Citation: EJNMMI Research 2021 11:38

    Content type: Original research

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  31. Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [18F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography–computed tomography (PET) on ...

    Authors: David Tonnelet, M. D. Pierre Bohn, Stephanie Becker, Pierre Decazes, Vincent Camus, Sebastien Thureau, Hervé Tilly, Fabrice Jardin and Pierre Vera

    Citation: EJNMMI Research 2021 11:37

    Content type: Original research

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  32. Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used i...

    Authors: Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret and Nadja Van Camp

    Citation: EJNMMI Research 2021 11:36

    Content type: Original research

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  33. Previous studies found that the positron emission tomography (PET) radioligand [18F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to as...

    Authors: Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Mohammad B. Haskali, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis and Paolo Zanotti-Fregonara

    Citation: EJNMMI Research 2021 11:35

    Content type: Original research

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  34. The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membr...

    Authors: Yohji Matsusaka, Tomohiko Yamane, Kenji Fukushima, Akira Seto, Ichiro Matsunari and Ichiei Kuji

    Citation: EJNMMI Research 2021 11:34

    Content type: Original research

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  35. The aim of this prospective study was to evaluate a data-driven gating software’s performance, in terms of identifying the respiratory signal, comparing [68Ga]Ga-DOTATOC and [18F]FDG examinations. In addition, fo...

    Authors: Jonathan Sigfridsson, Elin Lindström, Victor Iyer, Maria Holstensson, Irina Velikyan, Anders Sundin and Mark Lubberink

    Citation: EJNMMI Research 2021 11:33

    Content type: Original research

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  36. Identifying the correct location of a parathyroid adenoma in patients with primary hyperparathyroidism (pHPT) is crucial as it can guide surgical treatment. This study aimed to determine the diagnostic perform...

    Authors: M. E. Noltes, S. Kruijff, L. Jansen, H. E. Westerlaan, W. T. Zandee, R. A. J. O. Dierckx and A. H. Brouwers

    Citation: EJNMMI Research 2021 11:32

    Content type: Original research

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  37. The objective of the study is to define the most appropriate region for intensity normalization in brain 18FDG PET semi-quantitative analysis. The best option could be based on previous absolute quantification st...

    Authors: A. Verger, M. Doyen, J. Y. Campion and Eric Guedj

    Citation: EJNMMI Research 2021 11:31

    Content type: Short communication

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  38. Atherosclerotic plaque vulnerability is comprised by plaque composition driven by inflammatory activity and these features can be depicted with 3D ultrasound and 2-[18F]FDG-PET, respectively. The study investi...

    Authors: Laerke Urbak, Rasmus S. Ripa, Benjamin V. Sandholt, Andreas Kjaer, Henrik Sillesen and Martin Graebe

    Citation: EJNMMI Research 2021 11:30

    Content type: Original research

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  39. Post-transplant lymphoproliferative disorders (PTLDs) are a spectrum of hematological malignancies occurring after solid organ and hematopoietic stem cell transplantation. [18F]FDG PET/CT is routinely performed a...

    Authors: F. Montes de Jesus, D. Dierickx, V. Vergote, W. Noordzij, R. A. J. O. Dierckx, C. M. Deroose, A. W. J. M. Glaudemans, O. Gheysens and T. C. Kwee

    Citation: EJNMMI Research 2021 11:29

    Content type: Original research

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  40. In women undergoing breast-conserving surgery (BCS), 20–25% require a re-operation as a result of incomplete tumour resection. An intra-operative technique to assess tumour margins accurately would be a major ...

    Authors: Patriek A. G. T. Jurrius, Maarten R. Grootendorst, Marika Krotewicz, Massimiliano Cariati, Ashutosh Kothari, Neill Patani, Paulina Karcz, Monika Nagadowska, Kunal N. Vyas, Arnie Purushotham and Maria Turska-d’Amico

    Citation: EJNMMI Research 2021 11:28

    Content type: Original research

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  41. Many radioligands have been developed for the visualization of atherosclerosis by targeting inflammation. However, interpretation of in vivo signals is often limited to plaque identification. We evaluated bind...

    Authors: Eric J. Meester, Erik de Blois, Boudewijn J. Krenning, Antonius F. W. van der Steen, Jeff P. Norenberg, Kim van Gaalen, Monique R. Bernsen, Marion de Jong and Kim van der Heiden

    Citation: EJNMMI Research 2021 11:27

    Content type: Original research

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  42. Expression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with neuroinflammation. The second-generation PET ligand [18F]FEPPA specifically binds T...

    Authors: Chi-Wei Chang, Chuang-Hsin Chiu, Ming-Hsien Lin, Hung-Ming Wu, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Ya-Yao Huang, Chyng-Yann Shiue, Wen-Sheng Huang and Skye Hsin-Hsien Yeh

    Citation: EJNMMI Research 2021 11:26

    Content type: Original research

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  43. Salivary glands are highly perfused and express the prostate-specific membrane antigen (PSMA) receptor as well as the sodium—iodide symporter. As a consequence, treatment with 177Lu/225Ac-PSMA for prostate cancer...

    Authors: V. Mohan, N. M. Bruin, M. E. T. Tesselaar, J. P. de Boer, E. Vegt, J. J. M. A. Hendrikx, A. Al-Mamgani, J. B. van de Kamer, J.-J. Sonke and W. V. Vogel

    Citation: EJNMMI Research 2021 11:25

    Content type: Original research

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  44. The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosim...

    Authors: Guillaume Nodari, Romain Popoff, Jean Marc Riedinger, Olivier Lopez, Julie Pellegrinelli, Inna Dygai-Cochet, Claire Tabouret-Viaud, Benoit Presles, Olivier Chevallier, Sophie Gehin, Matthieu Gallet, Marianne Latournerie, Sylvain Manfredi, Romaric Loffroy, Jean Marc Vrigneaud and Alexandre Cochet

    Citation: EJNMMI Research 2021 11:24

    Content type: Original research

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  45. To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target vol...

    Authors: Macarena Rodríguez-Fraile, Ana Ezponda, Fabiana Grisanti, Verónica Morán, Marta Calvo, Pablo Berián, Antonio Martínez de la Cuesta, Lidia Sancho, Mercedes Iñarrairaegui, Bruno Sangro and José Ignacio Bilbao

    Citation: EJNMMI Research 2021 11:23

    Content type: Original research

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  46. Intraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier...

    Authors: Michael Mix, Wolfgang Schultze-Seemann, Moritz von Büren, August Sigle, Mohamed A. Omrane, Markus T. Grabbert, Martin Werner, Christian Gratzke, Philipp T. Meyer and Cordula A. Jilg

    Citation: EJNMMI Research 2021 11:22

    Content type: Original research

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  47. [68Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context of a low tumor burden. Digital PET/CT bears the potential of reducing scan time duration/administered t...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Maurizio Conti, Axel Wetter, David Kersting, Christoph Rischpler and Pedro Fragoso Costa

    Citation: EJNMMI Research 2021 11:21

    Content type: Original research

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