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  1. Original research

    A novel genomic signature predicting FDG uptake in diverse metastatic tumors

    Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requir...

    Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J. Garcia-Cases, Ramon Gonzalez Manzano and Antonio Brugarolas

    EJNMMI Research 2018 8:4

    Published on: 18 January 2018

  2. Original research

    Diagnostic implications of a small-voxel reconstruction for loco-regional lymph node characterization in breast cancer patients using FDG-PET/CT

    We evaluated the diagnostic implications of a small-voxel reconstruction for lymph node characterization in breast cancer patients, using state-of-the-art FDG-PET/CT. We included 69 FDG-PET/CT scans from breas...

    Daniëlle Koopman, Jorn A. van Dalen, Hester Arkies, Ad H. J. Oostdijk, Anne Brecht Francken, Jos Bart, Cornelis H. Slump, Siert Knollema and Pieter L. Jager

    EJNMMI Research 2018 8:3

    Published on: 16 January 2018

  3. Original research

    Prognostic value of simultaneous 18F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

    The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous 18F-fluorodeoxyglucose (FDG) PET/MRI for t...

    Yong-il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee and June-Key Chung

    EJNMMI Research 2018 8:2

    Published on: 10 January 2018

  4. Preliminary research

    Positron emission tomography-magnetic resonance imaging (PET-MRI) for response assessment after radiation therapy of cervical carcinoma: a pilot study

    Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control is a prerequisite for cure. Imaging after treatment is controversial. Positron emission tomography (PET) combined with c...

    J. E. Mongula, F. C. H. Bakers, S. Vöö, L. Lutgens, T. van Gorp, R. F. P. M. Kruitwagen and B. F. M. Slangen

    EJNMMI Research 2018 8:1

    Published on: 2 January 2018

  5. Original research

    The effect of selective internal radiation therapy with yttrium-90 resin microspheres on lung carbon monoxide diffusion capacity

    Selective internal radiation therapy (SIRT) with embolization of branches of the hepatic artery is a valuable therapeutic tool for patients with hepatic malignancies; however, it is also associated with lung i...

    Tunc Ones, Emel Eryuksel, Feyyaz Baltacioglu, Berrin Ceyhan and Tanju Yusuf Erdil

    EJNMMI Research 2017 7:103

    Published on: 29 December 2017

  6. Original research

    Impact of tissue transport on PET hypoxia quantification in pancreatic tumours

    The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate ...

    Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C. Dhani, Iram Siddiqui, David W. Hedley and David A. Jaffray

    EJNMMI Research 2017 7:101

    Published on: 22 December 2017

  7. Original research

    Quantitative pulmonary blood flow measurement using 15O-H2O PET with and without tissue fraction correction: a comparison study

    Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpreta...

    Keiko Matsunaga, Masahiro Yanagawa, Tomoyuki Otsuka, Haruhiko Hirata, Takashi Kijima, Atsushi Kumanogoh, Noriyuki Tomiyama, Eku Shimosegawa and Jun Hatazawa

    EJNMMI Research 2017 7:102

    Published on: 22 December 2017

  8. Original research

    Improved visualization of breast tissue on a dedicated breast PET system through ergonomic redesign of the imaging table

    Breast lesions closer than 2 cm to the chest wall are difficult to position in the field of view of dedicated breast PET (db-PET) systems. This inability to detect such lesions is a significant limitation of t...

    Michael K. O’Connor, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Katie N. Hunt and Dana H. Whaley

    EJNMMI Research 2017 7:100

    Published on: 19 December 2017

  9. Correction

    Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models

    Unfortunately, the original version of Figs. 4, 5 and 6b in the article [1] contained errors in the n numbers as indicated on the columns. Please note that column heights and error bars in the original figures an...

    Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths and Kevin Michael Brindle

    EJNMMI Research 2017 7:99

    Published on: 15 December 2017

    The original article was published in EJNMMI Research 2016 6:63

  10. Original research

    Biodistribution and radiation dosimetry of [64Cu]copper dichloride: first-in-human study in healthy volunteers

    In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper tran...

    M.A. Avila-Rodriguez, C. Rios, J. Carrasco-Hernandez, J. C. Manrique-Arias, R. Martinez-Hernandez, F. O. García-Pérez, A. R. Jalilian, E. Martinez-Rodriguez, M. E. Romero-Piña and A. Diaz-Ruiz

    EJNMMI Research 2017 7:98

    Published on: 12 December 2017

  11. Original research

    Quantitative 3D scintigraphy shows increased muscular uptake of pyrophosphate in idiopathic inflammatory myopathy

    Nuclear imaging is increasingly being used in the diagnostic work-up of idiopathic inflammatory myopathy (IIM). Increased muscular uptake of technetium-99m-pyrophosphate (99mTc-PYP) has hitherto been assessed qua...

    Karin Folmer Thøgersen, Jane Angel Simonsen, Svend Hvidsten, Oke Gerke, Søren Jacobsen, Poul Flemming Høilund-Carlsen, Karen Middelbo Buch-Olsen and Louise Pyndt Diederichsen

    EJNMMI Research 2017 7:97

    Published on: 8 December 2017

  12. Original research

    [18F]-BMS-747158-02PET imaging for evaluating hepatic mitochondrial complex 1dysfunction in a mouse model of non-alcoholic fatty liver disease

    Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to...

    Takemi Rokugawa, Sotaro Momosaki, Miwa Ito, Hitoshi Iimori, Yuki Kato and Kohji Abe

    EJNMMI Research 2017 7:96

    Published on: 6 December 2017

  13. Original research

    Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

    Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived r...

    Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis and Mirkka Sarparanta

    EJNMMI Research 2017 7:95

    Published on: 2 December 2017

  14. Original research

    Phantom validation of quantitative Y-90 PET/CT-based dosimetry in liver radioembolization

    PET/CT has recently been shown to be a viable alternative to traditional post-infusion imaging methods providing good quality images of 90Y-laden microspheres after selective internal radiation therapy (SIRT). In...

    Marco D’Arienzo, Maria Pimpinella, Marco Capogni, Vanessa De Coste, Luca Filippi, Emiliano Spezi, Nick Patterson, Francesca Mariotti, Paolo Ferrari, Paola Chiaramida, Michael Tapner, Alexander Fischer, Timo Paulus, Roberto Pani, Giuseppe Iaccarino, Marco D’Andrea…

    EJNMMI Research 2017 7:94

    Published on: 28 November 2017

  15. Original research

    Evaluation of the novel TSPO radiotracer [18F] VUIIS1008 in a preclinical model of cerebral ischemia in rats

    In vivo positron-emission tomography (PET) imaging of transporter protein (TSPO) expression is an attractive and indispensable tool for the diagnosis and therapy evaluation of neuroinflammation after cerebral ...

    Krishna R. Pulagam, Lorena Colás, Daniel Padro, Sandra Plaza-García, Vanessa Gómez-Vallejo, Makoto Higuchi, Jordi Llop and Abraham Martín

    EJNMMI Research 2017 7:93

    Published on: 25 November 2017

  16. Original research

    Diagnostic accuracy of coronary opacification derived from coronary computed tomography angiography to detect ischemia: first validation versus single-photon emission computed tomography

    Estimation of functional relevance of a coronary stenosis by fractional flow reserve (FFR) from coronary computed tomography angiography (CCTA) has recently provided encouraging results. Due to its limited ava...

    Dominik C. Benz, Fran Mikulicic, Christoph Gräni, Marvin Grossmann, Andreas A. Giannopoulos, Michael Messerli, Catherine Gebhard, Oliver Gaemperli, Ronny R. Buechel, Philipp A. Kaufmann and Aju P. Pazhenkottil

    EJNMMI Research 2017 7:92

    Published on: 25 November 2017

  17. Original research

    Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects

    18F-Tetrafluoroborate (18F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The ai...

    Huailei Jiang, Nicholas R. Schmit, Alex R. Koenen, Aditya Bansal, Mukesh K. Pandey, Robert B. Glynn, Bradley J. Kemp, Kera L. Delaney, Angela Dispenzieri, Jamie N. Bakkum-Gamez, Kah-Whye Peng, Stephen J. Russell, Tina M. Gunderson, Val J. Lowe and Timothy R. DeGrado

    EJNMMI Research 2017 7:90

    Published on: 27 October 2017

  18. Original research

    Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

    Positron emission tomography (PET) studies using 15O-labeled CO2, O2, and CO have been used in humans to evaluate cerebral blood flow (CBF), the cerebral oxygen extraction fraction (OEF), and the cerebral metabol...

    Genki Horitsugi, Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Hiroki Kato, Sadahiro Naka, Mana Ishibashi, Keiko Matsunaga, Kayako Isohashi, Eku Shimosegawa and Jun Hatazawa

    EJNMMI Research 2017 7:91

    Published on: 27 October 2017

  19. Original research

    TSPO imaging using the novel PET ligand [18F]GE-180: quantification approaches in patients with multiple sclerosis

    PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [

    Lena Vomacka, Nathalie Lisa Albert, Simon Lindner, Marcus Unterrainer, Christoph Mahler, Matthias Brendel, Larissa Ermoschkin, Astrid Gosewisch, Anika Brunegraf, Christopher Buckley, Tania Kümpfel, Rainer Rupprecht, Sibylle Ziegler, Martin Kerschensteiner, Peter Bartenstein and Guido Böning

    EJNMMI Research 2017 7:89

    Published on: 26 October 2017

  20. Original research

    Simple, mild, one-step labelling of proteins with gallium-68 using a tris(hydroxypyridinone) bifunctional chelator: a 68Ga-THP-scFv targeting the prostate-specific membrane antigen

    Labelling proteins with gallium-68 using bifunctional chelators is often problematic because of unsuitably harsh labelling conditions such as low pH or high temperature and may entail post-labelling purificati...

    Saima Nawaz, Gregory E. D. Mullen, Kavitha Sunassee, Jayanta Bordoloi, Philip J. Blower and James R. Ballinger

    EJNMMI Research 2017 7:86

    Published on: 25 October 2017

  21. Original research

    Potential of asphericity as a novel diagnostic parameter in the evaluation of patients with 68Ga-PSMA-HBED-CC PET-positive prostate cancer lesions

    The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients ...

    Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Frank Hofheinz and Marcus R. Makowski

    EJNMMI Research 2017 7:85

    Published on: 23 October 2017

  22. Commentary

    Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

    Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands—(R)-PK1119...

    Masahiro Fujita, Masato Kobayashi, Masamichi Ikawa, Roger N. Gunn, Eugenii A. Rabiner, David R. Owen, Sami S. Zoghbi, Mohamad B. Haskali, Sanjay Telu, Victor W. Pike and Robert B. Innis

    EJNMMI Research 2017 7:84

    Published on: 16 October 2017

  23. Original research

    Initial evaluation of the Celesteion large-bore PET/CT scanner in accordance with the NEMA NU2-2012 standard and the Japanese guideline for oncology FDG PET/CT data acquisition protocol version 2.0

    The goal of this study was to evaluate the performance of the Celesteion positron emission tomography/computed tomography (PET/CT) scanner, which is characterized by a large-bore and time-of-flight (TOF) funct...

    Tomohiro Kaneta, Matsuyoshi Ogawa, Nobutoku Motomura, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida and Tomio Inoue

    EJNMMI Research 2017 7:83

    Published on: 11 October 2017

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