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  1. Dosimetry in [177Lu]Lu-PSMA therapy is a valuable tool to assess treatment efficacy and toxicity. This study aims to develop a clinically implementable protocol to determine the absorbed dose in organs and tumor ...

    Authors: Steffie M. B. Peters, Maaike C. T. Mink, Bastiaan M. Privé, Maarten de Bakker, Frank de Lange, Constantijn H. J. Muselaers, Niven Mehra, J. Alfred Witjes, Martin Gotthardt, James Nagarajah and Mark W. Konijnenberg
    Citation: EJNMMI Research 2023 13:6
  2. To quantify the relationship between [18F]FDG uptake of the primary tumour measured by PET-imaging with immunohistochemical (IHC) expression of ER, PR, HER2, Ki-67, and clinical subtypes based on these markers...

    Authors: Cornelis M. de Mooij, Roxanne A. W. Ploumen, Patty J. Nelemans, Felix M. Mottaghy, Marjolein L. Smidt and Thiemo J. A. van Nijnatten
    Citation: EJNMMI Research 2023 13:5
  3. In recent years, immune checkpoint inhibitor (ICI) therapy has greatly changed the treatment prospects of patients with non-small cell lung cancer (NSCLC). Among the available ICI therapy strategies, programme...

    Authors: Xiaoqian Zhao, Yan Zhao, Jingmian Zhang, Zhaoqi Zhang, Lihua Liu and Xinming Zhao
    Citation: EJNMMI Research 2023 13:4
  4. Positron emission tomography (PET)/computed tomography (CT) imaging with fluorine-18 (18F)-sodium fluoride (NaF) provides assessment of active vascular microcalcification, but its utility for evaluating diabetes ...

    Authors: Ting-Heng Chou, Eleanor T. Rimmerman, Surina Patel, Molly K. Wynveen, Susan N. Eisert, Kumudha Narayana Musini, Sarah A. Janse, Adam J. Bobbey, Timur P. Sarac, Said A. Atway, Michael R. Go and Mitchel R. Stacy
    Citation: EJNMMI Research 2023 13:3
  5. Radioguided surgery (RGS) has recently emerged as a valuable new tool in the management of recurrent prostate cancer (PCa). After preoperative injection of a 99mTc-labeled prostate-specific membrane antigen (PSMA...

    Authors: Jan-Philip Kunert, Max Müller, Thomas Günther, León Stopper, Nicole Urtz-Urban, Roswitha Beck and Hans-Jürgen Wester
    Citation: EJNMMI Research 2023 13:2
  6. The purpose of this study was to assess the feasibility of using a minimally invasive simultaneous estimation method (SIME) to quantify the binding of the 18-kDa translocator protein tracer [18F]FEPPA. Arterial s...

    Authors: Praveen Dassanayake, Udunna C. Anazodo, Linshan Liu, Lucas Narciso, Maryssa Iacobelli, Justin Hicks, Pablo Rusjan, Elizabeth Finger and Keith St Lawrence
    Citation: EJNMMI Research 2023 13:1
  7. Visual snow syndrome (VSS) is a recently recognized chronic neurologic condition characterized by the constant perceiving of tiny flickering dots throughout the entire visual field. Metabolic overactivity and ...

    Authors: Koen Van Laere, Jenny Ceccarini, Juanito Gebruers, Karolien Goffin and Elizabet Boon
    Citation: EJNMMI Research 2022 12:77
  8. Accurate classification of sites of interest on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) images is an important diagnostic requirement for the differentiation of prostate ca...

    Authors: Kevin H. Leung, Steven P. Rowe, Jeffrey P. Leal, Saeed Ashrafinia, Mohammad S. Sadaghiani, Hyun Woo Chung, Pejman Dalaie, Rima Tulbah, Yafu Yin, Ryan VanDenBerg, Rudolf A. Werner, Kenneth J. Pienta, Michael A. Gorin, Yong Du and Martin G. Pomper
    Citation: EJNMMI Research 2022 12:76
  9. Somatostatin receptor 68Ga PET imaging is standard for evaluation of a patient’s suitability for 177Lu peptide receptor radionuclide therapy of neuroendocrine tumours (NETs). The 68Ga PET serves to ensure suffici...

    Authors: Anna Stenvall, Johan Gustafsson, Erik Larsson, Daniel Roth, Anna Sundlöv, Lena Jönsson, Cecilia Hindorf, Tomas Ohlsson and Katarina Sjögreen Gleisner
    Citation: EJNMMI Research 2022 12:75
  10. Receptor saturation during peptide receptor radionuclide therapy (PRRT) could result in altered [177Lu]Lu-HA-DOTATATE uptake in tumors and organs. Therefore, receptor expression status and effects of different (u...

    Authors: Hinke Siebinga, Chayenne H. A. M. Veerman, Linda de Wit-van der Veen, Marcel P. M. Stokkel, Jeroen J. M. A. Hendrikx and Else A. Aalbersberg
    Citation: EJNMMI Research 2022 12:74
  11. Bayesian penalized likelihood (BPL) algorithm is an effective way to suppress noise in the process of positron emission tomography (PET) image reconstruction by incorporating a smooth penalty. The strength of ...

    Authors: Lei Xu, Can Cui, Rushuai Li, Rui Yang, Rencong Liu, Qingle Meng and Feng Wang
    Citation: EJNMMI Research 2022 12:73
  12. Dopamine transporter (DAT) imaging is used in the diagnostic work-up in suspected parkinsonian syndromes and dementia with Lewy bodies but cannot differentiate between these syndromes, and an extra brain imagi...

    Authors: Susanna Jakobson Mo, Jan Axelsson, Lars Stiernman and Katrine Riklund
    Citation: EJNMMI Research 2022 12:72
  13. Antiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure activity, speed of brain entry may be an important factor. BRV showed fas...

    Authors: Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, Ralph Paul Maguire, Joël Mercier, Nabeel B. Nabulsi, Sophie Kervyn, Shannan Henry, Jean-Marie Nicolas, Yiyun Huang, Ming-Kai Chen, Jonas Hannestad, Henrik Klitgaard, Armel Stockis and Richard E. Carson
    Citation: EJNMMI Research 2022 12:71
  14. Programmed cell death 1 ligand 1(PD-L1) is overexpressed in many tumors. The radionuclide-labeled anti-PD-L1 monoclonal antibody can be used for imaging and therapy of PD-L1 overexpressing cancer. Here, we des...

    Authors: Linhan Zhang, Sheng Zhao, Huijie Jiang, Rongjun Zhang, Mingyu Zhang, Wenbin Pan, Zhongqi Sun, Dandan Wang and Jinping Li
    Citation: EJNMMI Research 2022 12:70
  15. This study aims to analyze the 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) characteristics of different causes of fever of unknown origin (FUO) and identify independen...

    Authors: Jia Chen, MingYou Xing, Dong Xu, NaNa Xie, WenCong Zhang, QiuRong Ruan and JianXin Song
    Citation: EJNMMI Research 2022 12:69
  16. Two commonly used imaging techniques to aid in the diagnosis of neurodegenerative parkinsonian syndromes are dopamine transporter (DAT) imaging with [123I]-FP-CIT single-photon emission computed tomography (DAT-S...

    Authors: Elon Wallert, Erwann Letort, Friso van der Zant, Ania Winogrodzka, Henk Berendse, Martijn Beudel, Rob de Bie, Jan Booij, Pieter Raijmakers and Elsmarieke van de Giessen
    Citation: EJNMMI Research 2022 12:68
  17. Radiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous and normal tissue. Hence, the i...

    Authors: Chung Ying Chan, Samantha L. Hopkins, Florian Guibbal, Anna Pacelli, Julia Baguña Torres, Michael Mosley, Doreen Lau, Patrick Isenegger, Zijun Chen, Thomas C. Wilson, Gemma Dias, Rebekka Hueting, Véronique Gouverneur and Bart Cornelissen
    Citation: EJNMMI Research 2022 12:67
  18. PSMA PET/CT is the recommended imaging test in cases with prostate-specific antigen (PSA) recurrence after primary therapy of prostate cancer (PCa). However, imaging protocols remain a topic of active research...

    Authors: Daniel Koehler, Markus Sauer, Amir Karimzadeh, Ivayla Apostolova, Susanne Klutmann, Gerhard Adam, Sophie Knipper, Tobias Maurer and Christoph Berliner
    Citation: EJNMMI Research 2022 12:66
  19. PSMA-TO-1 (“Tumor-Optimized-1”) is a novel PSMA ligand with longer circulation time than PSMA-617. We compared the biodistribution in subcutaneous tumor-bearing mice of PSMA-TO-1, PSMA-617 and PSMA-11 when lab...

    Authors: Catherine Meyer, Vikas Prasad, Andreea Stuparu, Peter Kletting, Gerhard Glatting, Jonathan Miksch, Christoph Solbach, Katharina Lueckerath, Lea Nyiranshuti, Shaojun Zhu, Johannes Czernin, Ambros J. Beer, Roger Slavik, Jeremie Calais and Magnus Dahlbom
    Citation: EJNMMI Research 2022 12:65
  20. Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions out...

    Authors: Jennifer M. Coughlin, Yong Du, Wojciech G. Lesniak, Courtney K. Harrington, Mary Katherine Brosnan, Riley O’Toole, Adeline Zandi, Shannon Eileen Sweeney, Rehab Abdallah, Yunkou Wu, Daniel P. Holt, Andrew W. Hall, Robert F. Dannals, Lilja Solnes, Andrew G. Horti and Martin G. Pomper
    Citation: EJNMMI Research 2022 12:64
  21. This study aimed to develop a novel analytic approach based on a radiomics model derived from 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT for predicting intraprostatic lesions in patients with prosta...

    Authors: Shiming Zang, Shuyue Ai, Rui Yang, Pengjun Zhang, Wenyu Wu, Zhenyu Zhao, Yudan Ni, Qing Zhang, Hongbin Sun, Hongqian Guo, Ruipeng Jia and Feng Wang
    Citation: EJNMMI Research 2022 12:63
  22. CD4+ T cells are central inflammatory mediators in the pathogenesis of autoimmune rheumatoid arthritis (RA), as they are one of the dominating cell types in synovial inflammation. Molecular imaging of CD4+ T cell...

    Authors: Anne Skovsbo Clausen, Camilla Christensen, Esben Christensen, Sigrid Cold, Lotte Kellemann Kristensen, Anders Elias Hansen and Andreas Kjaer
    Citation: EJNMMI Research 2022 12:62
  23. Elastic motion correction in PET has been shown to increase image quality and quantitative measurements of PET datasets affected by respiratory motion. However, little is known on the impact of respiratory mot...

    Authors: Benjamin Noto, Wolfgang Roll, Laura Zinken, Robert Rischen, Laura Kerschke, Georg Evers, Walter Heindel, Michael Schäfers and Florian Büther
    Citation: EJNMMI Research 2022 12:61
  24. Triple-negative breast cancer (TNBC) lacks biomarkers for targeted therapy. Auger emitters display the best therapeutic effect, if delivered directly into the nucleus proximal to DNA. The nuclear protein Poly ...

    Authors: Ramya Ambur Sankaranarayana, Alexandru Florea, Susanne Allekotte, Andreas T. J. Vogg, Jochen Maurer, Laura Schäfer, Carsten Bolm, Steven Terhorst, Arno Classen, Matthias Bauwens, Agnieszka Morgenroth and Felix M. Mottaghy
    Citation: EJNMMI Research 2022 12:60
  25. Aggressive B cell lymphoma often requires prompt steroid treatment, even before baseline 18f-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and definitive treatment, to allevia...

    Authors: Karyn Revital Geiger, Oren Pasvolsky, Tamar Berger, Pia Raanani, Tzippy Shochat, Ronit Gurion, Tamer Anati, David Groshar, Anat Gafter-Gvili and Hanna Bernstine
    Citation: EJNMMI Research 2022 12:59
  26. Clinical prediction models need to be validated. In this study, we used simulation data to compare various internal and external validation approaches to validate models.

    Authors: Jakoba J. Eertink, Martijn W. Heymans, Gerben J. C. Zwezerijnen, Josée M. Zijlstra, Henrica C. W. de Vet and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:58
  27. To explore the feasibility of short-time-window Ki imaging using a population-based arterial input function (IF) and optimized Bayesian penalized likelihood (BPL) reconstruction as a practical alternative to l...

    Authors: Takato Tanaka, Masatoyo Nakajo, Hirofumi Kawakami, Eriko Motomura, Tomofumi Fujisaka, Satoko Ojima, Yasumasa Saigo and Takashi Yoshiura
    Citation: EJNMMI Research 2022 12:57
  28. Dopamine transporter (DAT) imaging of striatum is clinically used in Parkinson’s disease (PD) and neurodegenerative parkinsonian syndromes (PS) especially in the early disease stages. The aim of the present st...

    Authors: Lisbeth Marner, Kirsten Korsholm, Lasse Anderberg, Markus N. Lonsdale, Mads Radmer Jensen, Eva Brødsgaard, Charlotte L. Denholt, Nic Gillings, Ian Law and Lars Friberg
    Citation: EJNMMI Research 2022 12:56
  29. Our aim was to investigate the discriminative value of 18F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudin...

    Authors: Elina Rauhala, Jarkko Johansson, Mira Karrasch, Olli Eskola, Tuula Tolvanen, Riitta Parkkola, Kirsi A. Virtanen and Juha O. Rinne
    Citation: EJNMMI Research 2022 12:55
  30. Zirconium-89-immuno-positron emission tomography (89Zr-immuno-PET) has enabled visualization of zirconium-89 labelled monoclonal antibody (89Zr-mAb) uptake in organs and tumors in vivo. Patlak linearization of 89

    Authors: Jessica E. Wijngaarden, Marc C. Huisman, Johanna E. E. Pouw, C. Willemien Menke-van der Houven van Oordt, Yvonne W. S. Jauw and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:54
  31. The NMDA receptor (NMDAR) plays a key role in the central nervous system, e.g., for synaptic transmission. While synaptic NMDARs are thought to have protective characteristics, activation of extrasynaptic NMDA...

    Authors: Lucas Rischka, Matej Murgaš, Verena Pichler, Chrysoula Vraka, Ivo Rausch, Dietmar Winkler, Lukas Nics, Sazan Rasul, Leo Robert Silberbauer, Murray Bruce Reed, Godber Mathis Godbersen, Jakob Unterholzner, Patricia Handschuh, Gregor Gryglewski, Thomas Mindt, Markus Mitterhauser…
    Citation: EJNMMI Research 2022 12:53
  32. This pilot study was designed to evaluate the diagnostic value of 68 Ga-PSMA-617 and 18F-FDG PET/CT in adenoid cystic carcinoma (ACC) and to assess the safety and therapeutic response to PSMA radioligand therapy ...

    Authors: Guochang Wang, Mengjiao Zhou, Jie Zang, Yuanyuan Jiang, Xiaohong Chen, Zhaohui Zhu and Xiaoyuan Chen
    Citation: EJNMMI Research 2022 12:52
  33. Multiple-pinhole (MPH) collimators improve the resolution–sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, ...

    Authors: Franziska Mathies, Ivayla Apostolova, Lena Dierck, Janin Jacobi, Katja Kuen, Markus Sauer, Michael Schenk, Susanne Klutmann, Attila Forgács and Ralph Buchert
    Citation: EJNMMI Research 2022 12:51
  34. Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabe...

    Authors: Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting and Bart Cornelissen
    Citation: EJNMMI Research 2022 12:50
  35. Cervical dystonia is considered as a network disorder affecting various brain regions in recent days. Presumably, deep brain stimulation (DBS) of the internal segment of globus pallidus (GPi) may exert therape...

    Authors: Sungjin Park, Hyeonseok Jeong, Yong-An Chung, Ilhyang Kang, Seunghee Kim, In-Uk Song and Ryoong Huh
    Citation: EJNMMI Research 2022 12:47
  36. Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in mul...

    Authors: Melinda Wuest, Justin J. Bailey, Jennifer Dufour, Darryl Glubrecht, Vanessa Omana, Tom H. Johnston, Jonathan M. Brotchie and Ralf Schirrmacher
    Citation: EJNMMI Research 2022 12:46
  37. Differentiated thyroid carcinoma (DTC) originates from abnormal follicular cells and accounts for approximately 90–95% of thyroid malignancies. The diagnosis of radioiodine refractory DTC (RR-DTC) is based on ...

    Authors: Ye Liu, Yuhua Wang and Wanchun Zhang
    Citation: EJNMMI Research 2022 12:45
  38. [18F]FDG PET-based metabolic tumor volume (MTV) is a promising prognostic marker for lymphoma patients. The aim of this study is to assess the sensitivity of several MTV segmentation methods to variations in imag...

    Authors: Maria C. Ferrández, Jakoba J. Eertink, Sandeep S. V. Golla, Sanne E. Wiegers, Gerben J. C. Zwezerijnen, Simone Pieplenbosch, Josée M. Zijlstra and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:44
  39. Oxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s disease (AD). However, tracking oxidative stress in the brain has proven difficult and impe...

    Authors: Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus and Robert H. Mach
    Citation: EJNMMI Research 2022 12:43
  40. High urinary activity in urinary bladder and ureters may hamper interpretation of prostate cancer and regional nodal metastases in prostate-specific membrane antigen (PSMA) PET/CT. The goal of this study was t...

    Authors: Maarten L. Donswijk, Maurits Wondergem, Linda de Wit - van der Veen, Natascha M. Bruin, Pim J. van Leeuwen, Henk G. van der Poel, Marcel P. M. Stokkel and Wouter V. Vogel
    Citation: EJNMMI Research 2022 12:42
  41. Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis as evidenced by persistent negative regulation (phosphorylatio...

    Authors: Naresh Damuka, Miranda E. Orr, Avinash H. Bansode, Ivan Krizan, Mack Miller, Jillian Lee, Shannon L. Macauley, Christopher T. Whitlow, Akiva Mintz, Suzanne Craft and Kiran Kumar Solingapuram Sai
    Citation: EJNMMI Research 2022 12:41
  42. Tumor equivalent uniform dose (EUD) is proposed as a predictor of patient outcome after liver radioembolization (RE) of hepatocellular carcinoma (HCC) and can be evaluated with 90Y-TOF-PET. The aim is to evaluate...

    Authors: Philippe d’Abadie, Stephan Walrand, Michel Hesse, Ivan Borbath, Renaud Lhommel and François Jamar
    Citation: EJNMMI Research 2022 12:40
  43. We hypothesised that the radiomics signature, which includes texture information of dopamine transporter single-photon emission computed tomography (DAT-SPECT) images for Parkinson’s disease (PD), may assist s...

    Authors: Takuro Shiiba, Kazuki Takano, Akihiro Takaki and Shugo Suwazono
    Citation: EJNMMI Research 2022 12:39
  44. High levels of 18F-fluorodeoxyglucose (18F-FDG) tumor uptake are associated with worse prognosis in patients with non-small cell lung cancer (NSCLC). Meanwhile, high levels of immune cell infiltration in primary ...

    Authors: Jinyeong Choi, Azmal Sarker, Hongyoon Choi, Dong Soo Lee and Hyung-Jun Im
    Citation: EJNMMI Research 2022 12:38
  45. 2-Deoxy-2-[18F]fluoroglucose (FDG) PET is an important tool for the identification of Alzheimer’s disease (AD) patients through the characteristic neurodegeneration pattern that these patients present. Regional c...

    Authors: Débora E. Peretti, David Vállez García, Remco J. Renken, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:37
  46. Minimally invasive radioguided sentinel lymph node (SLN) procedures, increasingly performed with robot-assisted laparoscopy, can benefit from using a drop-in γ-probe instead of the conventional rigid laparosco...

    Authors: Ilse G. T. Baeten, Jacob P. Hoogendam, Arthur J. A. T. Braat, Ronald P. Zweemer and Cornelis G. Gerestein
    Citation: EJNMMI Research 2022 12:36
  47. Adnectin is a protein family derived from the 10th type III domain of human fibronectin (10Fn3) with high-affinity targeting capabilities. Positron emission tomography (PET) probes derived from anti-programmed de...

    Authors: Huimin Zhou, Guangfa Bao, Ziqiang Wang, Buchuan Zhang, Dan Li, Lixing Chen, Xiaoyun Deng, Bo Yu, Jun Zhao and Xiaohua Zhu
    Citation: EJNMMI Research 2022 12:35
  48. FDG-PET/CT has a high negative predictive value to detect residual nodal disease in patients with locally advanced squamous cell head and neck cancer after completing concurrent chemoradiotherapy (CCRT). Howev...

    Authors: Frederik Soffers, Nils Helsen, Tim Van den Wyngaert, Laurens Carp, Otto S. Hoekstra, Laurence Goethals, Michel Martens, Kristof Deben, Karoline Spaepen, Remco De Bree, Frank De Geeter, G. J. C. Zwezerijnen, Carl Van Laer, Alex Maes, Olivier Lenssen and Sigrid Stroobants
    Citation: EJNMMI Research 2022 12:34