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  1. Multiple-pinhole (MPH) collimators improve the resolution–sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, ...

    Authors: Franziska Mathies, Ivayla Apostolova, Lena Dierck, Janin Jacobi, Katja Kuen, Markus Sauer, Michael Schenk, Susanne Klutmann, Attila Forgács and Ralph Buchert
    Citation: EJNMMI Research 2022 12:51
  2. Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabe...

    Authors: Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting and Bart Cornelissen
    Citation: EJNMMI Research 2022 12:50
  3. Cervical dystonia is considered as a network disorder affecting various brain regions in recent days. Presumably, deep brain stimulation (DBS) of the internal segment of globus pallidus (GPi) may exert therape...

    Authors: Sungjin Park, Hyeonseok Jeong, Yong-An Chung, Ilhyang Kang, Seunghee Kim, In-Uk Song and Ryoong Huh
    Citation: EJNMMI Research 2022 12:47
  4. Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in mul...

    Authors: Melinda Wuest, Justin J. Bailey, Jennifer Dufour, Darryl Glubrecht, Vanessa Omana, Tom H. Johnston, Jonathan M. Brotchie and Ralf Schirrmacher
    Citation: EJNMMI Research 2022 12:46
  5. Differentiated thyroid carcinoma (DTC) originates from abnormal follicular cells and accounts for approximately 90–95% of thyroid malignancies. The diagnosis of radioiodine refractory DTC (RR-DTC) is based on ...

    Authors: Ye Liu, Yuhua Wang and Wanchun Zhang
    Citation: EJNMMI Research 2022 12:45
  6. [18F]FDG PET-based metabolic tumor volume (MTV) is a promising prognostic marker for lymphoma patients. The aim of this study is to assess the sensitivity of several MTV segmentation methods to variations in imag...

    Authors: Maria C. Ferrández, Jakoba J. Eertink, Sandeep S. V. Golla, Sanne E. Wiegers, Gerben J. C. Zwezerijnen, Simone Pieplenbosch, Josée M. Zijlstra and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:44
  7. Oxidative stress is implicated in the pathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s disease (AD). However, tracking oxidative stress in the brain has proven difficult and impe...

    Authors: Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J. McManus and Robert H. Mach
    Citation: EJNMMI Research 2022 12:43
  8. High urinary activity in urinary bladder and ureters may hamper interpretation of prostate cancer and regional nodal metastases in prostate-specific membrane antigen (PSMA) PET/CT. The goal of this study was t...

    Authors: Maarten L. Donswijk, Maurits Wondergem, Linda de Wit - van der Veen, Natascha M. Bruin, Pim J. van Leeuwen, Henk G. van der Poel, Marcel P. M. Stokkel and Wouter V. Vogel
    Citation: EJNMMI Research 2022 12:42
  9. Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis as evidenced by persistent negative regulation (phosphorylatio...

    Authors: Naresh Damuka, Miranda E. Orr, Avinash H. Bansode, Ivan Krizan, Mack Miller, Jillian Lee, Shannon L. Macauley, Christopher T. Whitlow, Akiva Mintz, Suzanne Craft and Kiran Kumar Solingapuram Sai
    Citation: EJNMMI Research 2022 12:41
  10. Tumor equivalent uniform dose (EUD) is proposed as a predictor of patient outcome after liver radioembolization (RE) of hepatocellular carcinoma (HCC) and can be evaluated with 90Y-TOF-PET. The aim is to evaluate...

    Authors: Philippe d’Abadie, Stephan Walrand, Michel Hesse, Ivan Borbath, Renaud Lhommel and François Jamar
    Citation: EJNMMI Research 2022 12:40
  11. We hypothesised that the radiomics signature, which includes texture information of dopamine transporter single-photon emission computed tomography (DAT-SPECT) images for Parkinson’s disease (PD), may assist s...

    Authors: Takuro Shiiba, Kazuki Takano, Akihiro Takaki and Shugo Suwazono
    Citation: EJNMMI Research 2022 12:39
  12. High levels of 18F-fluorodeoxyglucose (18F-FDG) tumor uptake are associated with worse prognosis in patients with non-small cell lung cancer (NSCLC). Meanwhile, high levels of immune cell infiltration in primary ...

    Authors: Jinyeong Choi, Azmal Sarker, Hongyoon Choi, Dong Soo Lee and Hyung-Jun Im
    Citation: EJNMMI Research 2022 12:38
  13. 2-Deoxy-2-[18F]fluoroglucose (FDG) PET is an important tool for the identification of Alzheimer’s disease (AD) patients through the characteristic neurodegeneration pattern that these patients present. Regional c...

    Authors: Débora E. Peretti, David Vállez García, Remco J. Renken, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard
    Citation: EJNMMI Research 2022 12:37
  14. Minimally invasive radioguided sentinel lymph node (SLN) procedures, increasingly performed with robot-assisted laparoscopy, can benefit from using a drop-in γ-probe instead of the conventional rigid laparosco...

    Authors: Ilse G. T. Baeten, Jacob P. Hoogendam, Arthur J. A. T. Braat, Ronald P. Zweemer and Cornelis G. Gerestein
    Citation: EJNMMI Research 2022 12:36
  15. Adnectin is a protein family derived from the 10th type III domain of human fibronectin (10Fn3) with high-affinity targeting capabilities. Positron emission tomography (PET) probes derived from anti-programmed de...

    Authors: Huimin Zhou, Guangfa Bao, Ziqiang Wang, Buchuan Zhang, Dan Li, Lixing Chen, Xiaoyun Deng, Bo Yu, Jun Zhao and Xiaohua Zhu
    Citation: EJNMMI Research 2022 12:35
  16. FDG-PET/CT has a high negative predictive value to detect residual nodal disease in patients with locally advanced squamous cell head and neck cancer after completing concurrent chemoradiotherapy (CCRT). Howev...

    Authors: Frederik Soffers, Nils Helsen, Tim Van den Wyngaert, Laurens Carp, Otto S. Hoekstra, Laurence Goethals, Michel Martens, Kristof Deben, Karoline Spaepen, Remco De Bree, Frank De Geeter, G. J. C. Zwezerijnen, Carl Van Laer, Alex Maes, Olivier Lenssen and Sigrid Stroobants
    Citation: EJNMMI Research 2022 12:34
  17. Aortic microcalcification activity is a recently described method of measuring aortic sodium [18F]fluoride uptake in the thoracic aorta on positron emission tomography. In this study, we aimed to compare and to m...

    Authors: Samuel Debono, Jennifer Nash, Alexander J. Fletcher, Maaz B. J. Syed, Scott I. Semple, Edwin J. R. van Beek, Alison Fletcher, Sebastien Cadet, Michelle C. Williams, Damini Dey, Piotr J. Slomka, Rachael O. Forsythe, Marc R. Dweck and David E. Newby
    Citation: EJNMMI Research 2022 12:33
  18. Hand automatisms (HA) are common clinical manifestations in mesial temporal lobe epilepsy. However, the location of the symptomatogenic zone (EZ) in HA as well as the networks involved, are still unclear. To h...

    Authors: Jiajie Mo, Yao Wang, Jianguo Zhang, Lixin Cai, Qingzhu Liu, Wenhan Hu, Lin Sang, Chao Zhang, Xiu Wang, Xiaoqiu Shao and Kai Zhang
    Citation: EJNMMI Research 2022 12:32
  19. Segmentation of neuroendocrine neoplasms (NENs) in [64Cu]Cu-DOTATATE positron emission tomography makes it possible to extract quantitative measures useable for prognostication of patients. However, manual tumor ...

    Authors: Esben Andreas Carlsen, Kristian Lindholm, Amalie Hindsholm, Mathias Gæde, Claes Nøhr Ladefoged, Mathias Loft, Camilla Bardram Johnbeck, Seppo Wang Langer, Peter Oturai, Ulrich Knigge, Andreas Kjaer and Flemming Littrup Andersen
    Citation: EJNMMI Research 2022 12:30
  20. Despite its widespread use, the semi-quantitative standardized uptake value ratio (SUVR) may be biased compared with the distribution volume ratio (DVR). This bias may be partially explained by changes in cere...

    Authors: Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Bart N. M. van Berckel, Lyduine E. Collij, Katherine R. Gray, Richard Manber, Robin Wolz, Valentina Garibotto, Catriona Wimberley, Craig Ritchie, Frederik Barkhof, Juan Domingo Gispert, David Vállez García, Isadora Lopes Alves and Adriaan A. Lammertsma
    Citation: EJNMMI Research 2022 12:29
  21. Although most guidelines suggest performing a positron emission tomography/computed tomography (PET/CT) with somatostatin receptor (SSTR) ligands for staging of pulmonary carcinoid tumours (PC), only a limited...

    Authors: Anne-Leen Deleu, Annouschka Laenen, Herbert Decaluwé, Birgit Weynand, Christophe Dooms, Walter De Wever, Sander Jentjens, Karolien Goffin, Johan Vansteenkiste, Koen Van Laere, Paul De Leyn, Kristiaan Nackaerts and Christophe M. Deroose
    Citation: EJNMMI Research 2022 12:28
  22. Transthyretin amyloidosis (ATTR) is a progressive disease which can be diagnosed non-invasively using bone avid [99mTc]-labeled radiotracers. Thus, ATTR is also an occasional incidental finding on bone scintigrap...

    Authors: Hanna-Leena Halme, Toni Ihalainen, Olli Suomalainen, Antti Loimaala, Sorjo Mätzke, Valtteri Uusitalo, Outi Sipilä and Eero Hippeläinen
    Citation: EJNMMI Research 2022 12:27
  23. Pituitary adenomas (PA) affect ~ 1:1200 of the population and can cause a wide range of symptoms due to hormone over-secretion, loss of normal pituitary gland function and/or compression of visual pathways, re...

    Authors: Daniel Gillett, Russell Senanayake, James MacFarlane, Merel van der Meulen, Olympia Koulouri, Andrew S. Powlson, Rosy Crawford, Bethany Gillett, Nick Bird, Sarah Heard, Angelos Kolias, Richard Mannion, Luigi Aloj, Iosif A. Mendichovszky, Heok Cheow, Waiel A. Bashari…
    Citation: EJNMMI Research 2022 12:26
  24. Cloning of the sodium iodide symporter (NIS) in 1996 has provided an opportunity to use NIS as a powerful theranostic transgene. Novel gene therapy strategies rely on image-guided selective NIS gene transfer in n...

    Authors: Carolin Kitzberger, Rebekka Spellerberg, Volker Morath, Nathalie Schwenk, Kathrin A. Schmohl, Christina Schug, Sarah Urnauer, Mariella Tutter, Matthias Eiber, Franz Schilling, Wolfgang A. Weber, Sibylle Ziegler, Peter Bartenstein, Ernst Wagner, Peter J. Nelson and Christine Spitzweg
    Citation: EJNMMI Research 2022 12:25
  25. Hyperpolarization enhances the sensitivity of nuclear magnetic resonance experiments by between four and five orders of magnitude. Several hyperpolarized sensor molecules have been introduced that enable high ...

    Authors: Wai-Yan Ryana Fok, Martin Grashei, Jason G. Skinner, Bjoern H. Menze and Franz Schilling
    Citation: EJNMMI Research 2022 12:24
  26. To investigate the value of 18F-FDG PET/CT molecular radiomics combined with a clinical model in predicting thoracic lymph node metastasis (LNM) in invasive lung adenocarcinoma (≤ 3 cm).

    Authors: Cheng Chang, Maomei Ruan, Bei Lei, Hong Yu, Wenlu Zhao, Yaqiong Ge, Shaofeng Duan, Wenjing Teng, Qianfu Wu, Xiaohua Qian, Lihua Wang, Hui Yan, Ciyi Liu, Liu Liu, Jian Feng and Wenhui Xie
    Citation: EJNMMI Research 2022 12:23
  27. To investigate the relationship between 18F-fluoroboronotyrosine (FBY) positron emission tomography (PET)- and magnetic resonance imaging (MRI)-defined tumor volumes in contrast-enhanced diffuse gliomas and circu...

    Authors: Ziren Kong, Zhu Li, Junyi Chen, Wenbin Ma, Yu Wang, Zhi Yang and Zhibo Liu
    Citation: EJNMMI Research 2022 12:22
  28. Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between...

    Authors: Francesco Cicone, David Viertl, Thibaut Denoël, Michael G. Stabin, John O. Prior and Silvano Gnesin
    Citation: EJNMMI Research 2022 12:21
  29. The recent phase III VISION-trial confirms the treatment efficacy of radioligand therapy with [177Lu]PSMA-617 (PSMA-RLT) in metastatic castration-resistant prostate cancer (mCRPC). In PSMA-RLT, the relatively low...

    Authors: Felix Kind, Kerstin Michalski, Elham Yousefzadeh-Nowshahr, Philipp T. Meyer, Michael Mix and Juri Ruf
    Citation: EJNMMI Research 2022 12:20
  30. In the characterization of severe lung diseases, early detection of specific inflammatory cells could help to monitor patients’ response to therapy and increase chances of survival. Macrophages contribute to r...

    Authors: Emmi Puuvuori, Francesco Liggieri, Irina Velikyan, Elena Chiodaroli, Jonathan Sigfridsson, Hampus Romelin, Sofie Ingvast, Olle Korsgren, Gry Hulsart-Billström, Gaetano Perchiazzi and Olof Eriksson
    Citation: EJNMMI Research 2022 12:19
  31. Pulmonary artery sarcoma (PAS) is a rare and fatal malignancy. Due to the lack of specific clinical and radiological features, PAS is always misdiagnosed as pulmonary thromboembolism (PTE). This study aimed to...

    Authors: Jingyun Ren, Huiting Li, Qing Zhang, Entao Liu, Baozhen Zeng, Yan Huang, Lan Wang and Lei Jiang
    Citation: EJNMMI Research 2022 12:18
  32. The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson’s disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the periph...

    Authors: Jacob Horsager, Niels Okkels, Nathalie Van Den Berge, Jan Jacobsen, Anna Schact, Ole Lajord Munk, Kim Vang, Dirk Bender, David J. Brooks and Per Borghammer
    Citation: EJNMMI Research 2022 12:17
  33. This study examines the clinical feasibility and impact of implementing a fully automated whole-body PET protocol with data-driven respiratory gating in patients with a broad range of oncological and non-oncol...

    Authors: André H. Dias, Paul Schleyer, Mikkel H. Vendelbo, Karin Hjorthaug, Lars C. Gormsen and Ole L. Munk
    Citation: EJNMMI Research 2022 12:16
  34. Dynamic whole-body (D-WB) FDG PET/CT is a recently developed technique that allows direct reconstruction of multiparametric images of metabolic rate of FDG uptake (MRFDG) and “free” FDG (DVFDG). Multiparametric i...

    Authors: André H. Dias, Allan K. Hansen, Ole L. Munk and Lars C. Gormsen
    Citation: EJNMMI Research 2022 12:15
  35. With the rise of prostate-specific membrane antigen (PSMA) radioguided surgery, which is performed using a microdosing regime, demand for visual target confirmation via fluorescence guidance is growing. While ...

    Authors: Paolo Dell’Oglio, Danny M. van Willigen, Matthias N. van Oosterom, Kevin Bauwens, Fabian Hensbergen, Mick M. Welling, Huijbert van der Stadt, Elise Bekers, Martin Pool, Pim van Leeuwen, Tobias Maurer, Fijs W. B. van Leeuwen and Tessa Buckle
    Citation: EJNMMI Research 2022 12:14
  36. Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]...

    Authors: Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca…
    Citation: EJNMMI Research 2022 12:13
  37. To assess the diagnostic value of an additional late-phase PET/CT scan after urination as part of 68 Ga-PSMA-11 PET/CT for the restaging of patients with biochemically recurrent prostate cancer (BCR).

    Authors: Janna Morawitz, Julian Kirchner, Johannes Hertelendy, Christina Loberg, Lars Schimmöller, Mardjan Dabir, Lena Häberle, Eduards Mamlins, Christina Antke, Christian Arsov, Gerald Antoch and Lino M. Sawicki
    Citation: EJNMMI Research 2022 12:12
  38. Q.Clear is a Bayesian penalised likelihood (BPL) reconstruction algorithm available on General Electric (GE) Positron Emission Tomography (PET)-Computed Tomography (CT) and PET-Magnetic Resonance (MR) scanners...

    Authors: Daniela Ribeiro, William Hallett, Oliver Howes, Robert McCutcheon, Matthew M. Nour and Adriana A. S. Tavares
    Citation: EJNMMI Research 2022 12:11
  39. To assess 68Ga-PSMA PET/CT for detection of low- and intermediate-risk prostate cancer (PCa), high-risk PCa in comparison with mpMRI, respectively, and to determine which of low- and intermediate-risk PCa are mor...

    Authors: Chuanchi Zhou, Yongxiang Tang, Zhihe Deng, Jinhui Yang, Ming Zhou, Long Wang and Shuo Hu
    Citation: EJNMMI Research 2022 12:10
  40. Post-therapy [90Y] PET/CT-based dosimetry is currently recommended to validate treatment planning as [99mTc] MAA SPECT/CT is often a poor predictor of subsequent actual [90Y] absorbed dose. Treatment planning sof...

    Authors: Emile B. Veenstra, Simeon J. S. Ruiter, Robbert J. de Haas, Reinoud P. H. Bokkers, Koert P. de Jong and Walter Noordzij
    Citation: EJNMMI Research 2022 12:9
  41. Radiohybrid prostate-specific membrane antigen (rhPSMA) ligands such as 18F-rhPSMA-7 are a new class of theranostic agents in clinical development for prostate cancer. We compared preclinical dosimetry and human ...

    Authors: Karina Knorr, So Won Oh, Markus Krönke, Alexander Wurzer, Calogero D’Alessandria, Michael Herz, Wolfgang Weber, Hans-Jürgen Wester, Matthias Eiber, Nahid Yusufi and Stephan Nekolla
    Citation: EJNMMI Research 2022 12:8
  42. In patients with neuroendocrine tumor liver metastases, additional tumor reduction can be achieved by sequential treatment with [166Ho]-radioembolization after peptide receptor radionuclide therapy (PRRT). The ai...

    Authors: Sander C. Ebbers, Tessa Brabander, Margot E. T. Tesselaar, Johannes Hofland, Manon N. G. J. A. Braat, Frank J. Wessels, Maarten W. Barentsz, Marnix G. E. H. Lam and Arthur J. A. T. Braat
    Citation: EJNMMI Research 2022 12:7
  43. Dimethyl fumarate (DMF) is an oral immunomodulatory drug used in the treatment of autoimmune diseases. Here, we sought to study whether the effect of DMF can be detected using positron emission tomography (PET...

    Authors: S. K. Vainio, A. M. Dickens, M. Matilainen, F. R. López-Picón, R. Aarnio, O. Eskola, O. Solin, D. C. Anthony, J. O. Rinne, L. Airas and M. Haaparanta-Solin
    Citation: EJNMMI Research 2022 12:6
  44. In the last decades, our understanding of the role of the immune system in cancer has significantly improved and led to the discovery of new immunotherapeutic targets and tools, which boosted the advances in c...

    Authors: Dario Gosmann, Lisa Russelli, Wolfgang A. Weber, Markus Schwaiger, Angela M. Krackhardt and Calogero D’Alessandria
    Citation: EJNMMI Research 2022 12:5
  45. Multiple myeloma (MM) cells synthesize large amounts of paraproteins, making radiolabeled amino acids promising candidates for PET imaging of MM patients.

    Authors: Volker Morath, Michael Heider, Markus Mittelhäuser, Hannes Rolbieski, Jacob Stroh, Jérémie Calais, Matthias Eiber, Florian Bassermann and Wolfgang A. Weber
    Citation: EJNMMI Research 2022 12:4
  46. [11C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [11C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evalu...

    Authors: Hayel Tuncel, Ronald Boellaard, Emma M. Coomans, Marijke den Hollander-Meeuwsen, Erik F. J. de Vries, Andor W. J. M. Glaudemans, Paula Kopschina Feltes, David Vállez García, Sander C. J. Verfaillie, Emma E. Wolters, Steven P. Sweeney, J. Michael Ryan, Magnus Ivarsson, Berkley A. Lynch, Patrick Schober, Philip Scheltens…
    Citation: EJNMMI Research 2022 12:3
  47. Near-infrared (NIR) fluorescence imaging has been emerging as a promising strategy to overcome the high number of early esophageal adenocarcinomas missed by white light endoscopy and random biopsy collection. ...

    Authors: Sabrina Marcazzan, Marcos J. Braz Carvalho, Matthias Konrad, Julia Strangmann, Anna Tenditnaya, Theresa Baumeister, Roland M. Schmid, Hans-Jürgen Wester, Vasilis Ntziachristos, Dimitris Gorpas, Timothy C. Wang, Margret Schottelius and Michael Quante
    Citation: EJNMMI Research 2022 12:2