Articles

A study method using early dynamic acquisition of [¹⁸F]fluorodopa positron emission tomography for the differential diagnosis between progression and radionecrosis of brain metastases after radiotherapy

It is difficult to distinguish between the brain metastasis progression (BMP) and brain radionecrosis (BRN) on the basis of ¹⁸F-3,4-dihydroxyphenylalanine positron emission tomography/computed-tomography (¹⁸F-FDO...

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Heparin does not improve myocardial glucose metabolism suppression in [18 F]FDG PET/CT in patients with low β-hydroxybutyrate level

Inadequate myocardial glucose metabolism suppression (GMS) can hamper interpretation of cardiac [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET/CT). Use of β-hydroxybutyrate (BHB) measurement befo...

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[¹⁸F]TFB PET/CT misses intense [¹²⁴I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer

Fluorine 18-labelled tetrafluoroborate ([¹⁸F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [¹⁸F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, elig...

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Biomarkers of bone metabolism in [²²³Ra] RaCl₂ therapy - association with extent of disease and prediction of overall survival

The alpha-emitting radionuclide therapy [²²³Ra]RaCl₂ (Radium-223) improves overall survival (OS) and time to symptomatic skeletal event (SSE) in patients with metastatic castration-resistant prostate cancer (mCRP...

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Physiological provocation compared to acetazolamide in the assessment of cerebral hemodynamics: a case report

Severe large vessel disease may lead to cerebral hemodynamic failure that critically impairs cerebral blood flow (CBF) regulation elevating the risk of ischemic events. Assessment of the condition is often bas...

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Diagnostic and evaluative efficiency of ⁶⁸Ga-FAPI-04 in skeletal muscle injury

Skeletal muscles are vital for daily function, yet assessing their injuries remain challenging. We aimed to elucidate the effectiveness of ⁶⁸Ga-FAPI-04 in evaluating skeletal muscle remodeling.

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Preclinical evaluation and first-in-human study of [¹⁸F]AlF-FAP-NUR for PET imaging cancer-associated fibroblasts

Fibroblast activation protein (FAP) has gained attention as a promising molecular target with potential utility for cancer diagnosis and therapy. [⁶⁸Ga]Ga-labeled FAP-targeting peptides have been successfully app...

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An in vivo tumour organoid model based on the chick embryonic chorioallantoic membrane mimics key characteristics of the patient tissue: a proof-of-concept study

Patient-derived tumour organoids (PDOs) are highly advanced in vitro models for disease modelling, yet they lack vascularisation. To overcome this shortcoming, organoids can be inoculated onto the chorioallant...

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Quantitation of mitral regurgitation using positron emission tomography

Cardiac positron emission tomography (PET) offers non-invasive assessment of perfusion and left ventricular (LV) function from a single dynamic scan. However, no prior assessment of mitral regurgitation severi...

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Prognostic evaluation in recurrent glioma through ¹¹C-Choline PET/CT imaging

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Brain perfusion SPECT in the presurgical evaluation of epilepsy: is additional ictal SPECT required in case of high-confidence lateralization of the seizure onset zone by interictal SPECT and vice versa?

Ictal brain perfusion SPECT provides higher sensitivity for the identification of the epileptic seizure onset zone (SOZ) than interictal SPECT. However, ictal SPECT is demanding due to the unpredictable waitin...

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Potential application of [¹⁸F]AlF-PSMA-11 PET/CT in radioiodine refractory thyroid carcinoma

Patients diagnosed with radioiodine refractory (RAI-R) thyroid carcinoma (TC) have a significantly worse prognosis than patients with radiosensitive TC. These refractory malignancies are often dedifferentiated...

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Role of [¹⁸F]FAPI-04 in staging and therapeutic management of intrahepatic cholangiocarcinoma: prospective comparison with [¹⁸F]FDG PET/CT

Fluorine-18 fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) has some limitations in diagnosis of Intrahepatic cholangiocarcinoma (ICC).

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Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated ¹⁸F-fluorination of boroxines, in vitro and initial in vivo evaluation

The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet been reported. This work repor...

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Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques

Neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (SN) pars compacta, and can be detected by magnetic resonance imaging (MRI). It is a promising imaging-base biomarker for neurolog...

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Evaluation of damage discrimination in dopaminergic neurons using dopamine transporter PET tracer [¹⁸F]FECNT-d₄

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder worldwide, diagnosed based on classic symptoms like motor dysfunction and cognitive impairments. With the development of various radioactive l...

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Validation of the C-X-C chemokine receptor 3 (CXCR3) as a target for PET imaging of T cell activation

CXCR3 is expressed on activated T cells and plays a crucial role in T-cell recruitment to the tumor microenvironment (TME) during cell-based and immune checkpoint inhibitor (ICI) immunotherapy. This study util...

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A radioligand for in vitro autoradiography of CSF1R in post-mortem CNS tissues

Reactive microglia and recruited peripheral macrophages contribute to the pathogenesis of Alzheimer’s dementia (AD). Monocytes, macrophages and microglia all express the marker colony-stimulating factor 1 rece...

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Imaging bone turnover assessment through volumetric density-adjusted standardized uptake value using quantitative bone SPECT/CT in osteoporosis

Serum bone turnover markers offer limited insight into metabolic activity at the individual vertebra level in osteoporosis. This study introduces a novel image-derived bone turnover marker for individual verte...

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Pilot study of humanized glypican-3-targeted zirconium-89 immuno-positron emission tomography for hepatocellular carcinoma

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Enhancing [¹⁷⁷Lu]Lu-DOTA-TATE therapeutic efficacy in vitro by combining it with metronomic chemotherapeutics

Peptide receptor radionuclide therapy (PRRT) uses [¹⁷⁷Lu]Lu-[DOTA⁰-Tyr³]octreotate ([¹⁷⁷Lu]Lu-DOTA-TATE) to treat patients with neuroendocrine tumours (NETs) overexpressing the somatostatin receptor 2A (SSTR2A). ...

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The impact of introducing deep learning based [¹⁸F]FDG PET denoising on EORTC and PERCIST therapeutic response assessments in digital PET/CT

[¹⁸F]FDG PET denoising by SubtlePET™ using deep learning artificial intelligence (AI) was previously found to induce slight modifications in lesion and reference organs’ quantification and in lesion detection. As...

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Clinical value of Tc-99m MDP SPECT/CT bone imaging for early diagnosis of Relapsing Polychondritis: a report of 5 cases

Relapsing Polychondritis(RP) is a rare rheumatic immune disease. As with most diseases, if intervention is delayed, the patient’s prognosis is worse. Currently, the diagnostic criteria used in clinical practic...

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Feasibility of safe outpatient treatment in pediatric patients following intraventricular radioimmunotherapy with ¹³¹I-omburtamab for leptomeningeal disease

Radiolabeled antibody ¹³¹I-omburtamab was administered intraventricularly in patients with leptomeningeal disease under an institutionally approved study (#NCT03275402). Radiation safety precautions were tailored...

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The pons as an optimal background reference region for spinal ¹⁸F-FET PET/MRI evaluation

This study aims to evaluate the effect of various background reference regions on spinal ¹⁸F-FET PET imaging, with a focus on distinguishing between spinal tumors and myelitis. To enhance diagnostic accuracy, we ...

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18 F-Choline-PET/CT for non-FDG-avid salivary gland cancer: a preliminary report

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Cardiac sympathetic activity and lethal arrhythmic events: insight into bell-shaped relationship between ¹²³I-meta-iodobenzylguanidine activity and event rates

¹²³I-meta-iodobenzylguanidine (mIBG) has been applied to patients with chronic heart failure (CHF). However, the relationship between ¹²³I-mIBG activity and lethal arrhythmic events (ArE) is not well defined. Thi...

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[⁶⁸Ga]Ga-FAPI versus 2-[¹⁸F]FDG PET/CT in patients with autoimmune thyroiditis: a case control study

Radiolabelled fibroblast activation protein inhibitors (FAPIs) are becoming increasingly important for imaging various tumour diseases. However, it is essential to be aware of potential pitfalls. Here, we inve...

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Age and gender effects on striatal dopamine transporter density and cerebral perfusion in individuals with non-degenerative parkinsonism: a dual-phase ¹⁸F-FP-CIT PET study

Dual-phase fluorine-18 labeled N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (¹⁸F-FP-CIT) positron emission tomography (PET) scans could be used to support disorders like Parkinson’s disease (PD)....

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The pivotal role of endoplasmic reticulum in FDG uptake in cancer cells

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Preclinical evaluation of [¹⁸F]SYN1 and [¹⁸F]SYN2, novel radiotracers for PET myocardial perfusion imaging

Positron emission tomography (PET) is now an established diagnostic method for myocardial perfusion imaging (MPI) in coronary artery disease, which is the main cause of death globally. The available tracers sh...

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Ultrasensitive detection of uveal melanoma using [¹⁸F]AlF-NOTA-PRGD2 PET imaging

Uveal melanoma (UM) is the most common primary intraocular tumor in adults, and early detection is critical to improve the clinical outcome of this disease. In this study, the diagnostic effectiveness of [¹⁸F]AlF...

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Clinical value of ⁶⁸Ga-pentixafor PET/CT in patients with primary aldosteronism and bilateral lesions: preliminary results of a single-centre study

Subtype diagnosis of primary aldosteronism (PA) is used to determine treatment, and the potential utility of ⁶⁸Ga-pentixafor PET/CT for investigation of PA has long been recognized. The study aimed to evaluate th...

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Respective contribution of baseline clinical data, tumour metabolism and tumour blood-flow in predicting pCR after neoadjuvant chemotherapy in HER2 and Triple Negative breast cancer

The aim of this study is to investigate the added value of combining tumour blood flow (BF) and metabolism parameters, including texture features, with clinical parameters to predict, at baseline, the patholog...

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Preclinical evaluation of [¹⁸F]FP-CIT, the radiotracer targeting dopamine transporter for diagnosing Parkinson’s disease: pharmacokinetic and efficacy analysis

N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of P.....

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A prospective clinical study of the influence of oral protein intake on [¹⁸F]FET-PET uptake and test–retest repeatability in glioma

O-(2-[¹⁸F]fluoroethyl)-l-tyrosine positron emission tomography ([¹⁸F]FET PET) scanning is used in routine clinical management and evaluation of gliomas with a recommended 4 h prior fasting. Knowledge of test–rete...

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Early diagnosis and staging of paraquat-induced pulmonary fibrosis using [¹⁸F]F-FAPI-42 PET/CT imaging

Paraquat (PQ) -induced pulmonary fibrosis poses a significant medical challenge due to limited treatment options and high mortality rates. Consequently, there is an urgent need for early diagnosis and accurate...

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Evaluation of [¹¹C]UCB-A positron emission tomography in human brains

In preclinical studies, the positron emission tomography (PET) imaging with [¹¹C]UCB-A provided promising results for imaging synaptic vesicle protein 2A (SV2A) as a proxy for synaptic density. This paper reports...

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Evaluation of gastrin-releasing peptide receptor, prostate-specific membrane antigen, and neurotensin receptor 1 as potential biomarkers for accurate prostate cancer stratified diagnosis

Studies on single-target PET imaging of gastrin-releasing peptide receptor (GRPR), prostate-specific membrane antigen (PSMA), or neurotensin receptor 1(NTR1) have been reported. However, the performance of the...

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Aurora Kinase A inhibition enhances DNA damage and tumor cell death with ¹³¹I-MIBG therapy in high-risk neuroblastoma

Neuroblastoma is the most common extra-cranial pediatric solid tumor. ¹³¹I-metaiodobenzylguanidine (MIBG) is a targeted radiopharmaceutical highly specific for neuroblastoma tumors, providing potent radiotherapy ...

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New improved radiometabolite analysis method for [¹⁸F]FTHA from human plasma: a test-retest study with postprandial and fasting state

Fatty acid uptake can be measured using PET and 14-(R,S)‐[¹⁸F]fluoro‐6‐thia‐heptadecanoic acid ([¹⁸F]FTHA). However, the relatively rapid rate of [¹⁸F]FTHA metabolism significantly affects kinetic modeling of tis...

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Distribution and predictors of F-18-FDG uptake values of non-malignant cervical lymph nodes in pediatric patients

F-18-flurodeoxyglucose (FDG) PET/CT is routinely used for staging, evaluation of response to treatment and follow-up of most pediatric malignancies. Cervical lymph nodes can be involved in some pediatric malig...

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Prognostic value of visual IMPeTUs criteria and metabolic tumor burden at baseline [¹⁸F]FDG PET/CT in patients with newly diagnosed multiple myeloma

2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) positron emission tomography combined with low-dose computed tomography (PET/CT) can be used at diagnosis to identify myeloma-defining events and also provides prognosti...

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Simultaneous assessment of blood flow and myelin content in the brain white matter with dynamic [11 C]PiB PET: a test-retest study in healthy controls

Exploring the relationship between oxygen supply and myelin damage would benefit from a simultaneous quantification of myelin and cerebral blood flow (CBF) in the brain’s white matter (WM). To validate an anal...

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Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study

Besides International Prognostic Index (IPI) score, baseline prognostic factors of post-transplant lymphoproliferative disorders (PTLD) are poorly identified due to the rarity of the disease. New indexes deriv...

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Radiation dosimetry of para-chloro-2-[¹⁸F]fluoroethyl-etomidate: a PET tracer for adrenocortical imaging

[¹¹C]metomidate, a methyl ester analogue of etomidate, is used for positron emission tomography of adrenocortical cancer, and has been tested in recent clinical trials for lateralization in primary aldosteronism ...

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Effect of radiation therapy on lymph node fluorescence in head and neck squamous cell carcinoma after intravenous injection of indocyanine green: a prospective evaluation

Indocyanine green (ICG)-guided surgery has proven effective in the identification of neoplastic tissues. The effect of radiation therapy (RT) on lymph node fluorescence after intravenous injection of ICG has n...

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In vivo assessment of safety, biodistribution, and radiation dosimetry of the [¹⁸F]Me4FDG PET-radiotracer in adults

Approaches targeting the sodium-glucose cotransporter (SGLT) could represent a promising future therapeutic strategy for numerous oncological and metabolic diseases. In this study, we evaluated the safety, bio...

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Distinguishing thymic cysts from low-risk thymomas via [¹⁸F]FDG PET/CT

Thymic cysts are a rare benign disease that needs to be distinguished from low-risk thymoma. [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is a non-invasive imaging tec...

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