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Original research

A human PET study of [¹¹C]HMS011, a potential radioligand for AMPA receptors

α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We ...

Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma…

EJNMMI Research 2017 7:63

Published on: 16 August 2017
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Original research

O-(2-[¹⁸F]fluoroethyl)-l-tyrosine PET in gliomas: influence of data processing in different centres

PET using O-(2-[¹⁸F]fluoroethyl)-l-tyrosine (¹⁸F-FET) is an established method for brain tumour diagnostics, but data processing varies in different centres. This study analyses the influence of methodological di...

Christian P. Filss, Nathalie L. Albert, Guido Böning, Elena Rota Kops, Bogdana Suchorska, Gabriele Stoffels, Norbert Galldiks, Nadim J. Shah, Felix M. Mottaghy, Peter Bartenstein, Jörg C. Tonn and Karl-Josef Langen

EJNMMI Research 2017 7:64

Published on: 16 August 2017
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Original research

Selective targeting of melanoma using N-(2-diethylaminoethyl) 4-[¹⁸F]fluoroethoxy benzamide (4-[¹⁸F]FEBZA): a novel PET imaging probe

The purpose of this study was to develop a positron emission tomography (PET) imaging probe that is easy to synthesize and selectively targets melanoma in vivo. Herein, we report the synthesis and preclinical ...

Pradeep K. Garg, Rachid Nazih, Yanjun Wu, Vladimir P. Grinevich and Sudha Garg

EJNMMI Research 2017 7:61

Published on: 8 August 2017
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Original research

The effects of segmentation algorithms on the measurement of ¹⁸F-FDG PET texture parameters in non-small cell lung cancer

Measures of tumour heterogeneity derived from 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) scans are increasingly reported as potential biomarkers of non-small cell l...

Usman Bashir, Gurdip Azad, Muhammad Musib Siddique, Saana Dhillon, Nikheel Patel, Paul Bassett, David Landau, Vicky Goh and Gary Cook

EJNMMI Research 2017 7:60

Published on: 26 July 2017
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Preliminary research

Microglial depletion and activation: A [¹¹C]PBR28 PET study in nonhuman primates

The 18-kDa translocator protein (TSPO) is an important target for assessing neuroimmune function in brain with positron-emission tomography (PET) imaging. The goal of this work was to assess two [¹¹C]PBR28 imagin...

Ansel T. Hillmer, Daniel Holden, Krista Fowles, Nabeel Nabulsi, Brian L. West, Richard E. Carson and Kelly P. Cosgrove

EJNMMI Research 2017 7:59

Published on: 24 July 2017
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Short communication

Assessment of simplified ratio-based approaches for quantification of PET [¹¹C]PBR28 data

Kinetic modelling with metabolite-corrected arterial plasma is considered the gold standard for quantification of [¹¹C]PBR28 binding to the translocator protein (TSPO), since there is no brain region devoid of TS...

Granville J. Matheson, Pontus Plavén-Sigray, Anton Forsberg, Andrea Varrone, Lars Farde and Simon Cervenka

EJNMMI Research 2017 7:58

Published on: 21 July 2017
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Original research

Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted deli...

Jessie R. Nedrow, Anders Josefsson, Sunju Park, Tom Bäck, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern and George Sgouros

EJNMMI Research 2017 7:57

Published on: 18 July 2017
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Original research

FLT-PET for early response evaluation of colorectal cancer patients with liver metastases: a prospective study

Fluoro-L-thymidine (FLT) is a positron emission tomography/computed tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main objective of this prospective explorative study...

Marie Benzon Mogensen, Annika Loft, Marianne Aznar, Thomas Axelsen, Ben Vainer, Kell Osterlind and Andreas Kjaer

EJNMMI Research 2017 7:56

Published on: 10 July 2017
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Erratum

Erratum to: Quantitative 18F-fluorocholine positron emission tomography for prostate cancer: correlation between kinetic parameters and Gleason scoring

Joshua D. Schaefferkoetter, Ziting Wang, Mary C. Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W. Townsend, Thomas Thamboo and Edmund Chiong

EJNMMI Research 2017 7:55

Published on: 21 June 2017

The original article was published in EJNMMI Research 2017 7:25
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Preliminary Research

Use of a digital phantom developed by QIBA for harmonizing SUVs obtained from the state-of-the-art SPECT/CT systems: a multicenter study

Although quantitative analysis using standardized uptake value (SUV) becomes realistic in clinical single-photon emission computed tomography/computed tomography (SPECT/CT) imaging, reconstruction parameter se...

Tadaki Nakahara, Hiromitsu Daisaki, Yasushi Yamamoto, Takashi Iimori, Kazuyuki Miyagawa, Tomoya Okamoto, Yoshiki Owaki, Nobuhiro Yada, Koichi Sawada, Ryotaro Tokorodani and Masahiro Jinzaki

EJNMMI Research 2017 7:53

Published on: 20 June 2017
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Original research

Test-retest reproducibility of [¹¹C]-l-deprenyl-D₂ binding to MAO-B in the human brain

[¹¹C]-l-deprenyl-D₂ is a positron emission tomography (PET) radioligand for measurement of the monoamine oxidase B (MAO-B) activity in vivo brain. The estimation of the test-retest reproducibility is important fo...

Ryosuke Arakawa, Per Stenkrona, Akihiro Takano, Sangram Nag, Rafael S. Maior and Christer Halldin

EJNMMI Research 2017 7:54

Published on: 20 June 2017
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Original research

PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease

The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). ¹⁵O-water positron emission tomogra...

Osamu Manabe, Masanao Naya, Tadao Aikawa, Masahiko Obara, Keiichi Magota, Markus Kroenke, Noriko Oyama-Manabe, Kenji Hirata, Daiki Shinyama, Chietsugu Katoh and Nagara Tamaki

EJNMMI Research 2017 7:52

Published on: 5 June 2017
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Short communication

Response assessment with the CXCR4-directed positron emission tomography tracer [⁶⁸Ga]Pentixafor in a patient with extranodal marginal zone lymphoma of the orbital cavities

CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is over...

Peter Herhaus, Stefan Habringer, Tibor Vag, Katja Steiger, Julia Slotta-Huspenina, Carlos Gerngroß, Benedikt Wiestler, Hans-Jürgen Wester, Markus Schwaiger and Ulrich Keller

EJNMMI Research 2017 7:51

Published on: 2 June 2017
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Original research

Clinical value of fluorine-18α-methyltyrosine PET in patients with gliomas: comparison with fluorine-18 fluorodeoxyglucose PET

We investigated the relationship between metabolic activity and histological features of gliomas using fluorine-18α-methyltyrosine (¹⁸F-FAMT) positron emission tomography (PET) compared with fluorine-18 fluorodeo...

Keishi Horiguchi, Masahiko Tosaka, Tetsuya Higuchi, Yukiko Arisaka, Kenichi Sugawara, Junko Hirato, Hideaki Yokoo, Yoshito Tsushima and Yuhei Yoshimoto

EJNMMI Research 2017 7:50

Published on: 31 May 2017
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Original research

Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using ¹¹¹In-bevacizumab

The ability to image vascular endothelial growth factor (VEGF) could enable prospective, non-invasive monitoring of patients receiving anti-angiogenic therapy. This study investigates the specificity and pharm...

Neel Patel, Sarah Able, Danny Allen, Emmanouil Fokas, Bart Cornelissen, Fergus V. Gleeson, Adrian L. Harris and Katherine A. Vallis

EJNMMI Research 2017 7:49

Published on: 30 May 2017
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Original research

Towards standardization of ¹⁸F-FET PET imaging: do we need a consistent method of background activity assessment?

PET with O-(2-¹⁸F-fluoroethyl)-L-tyrosine (¹⁸F-FET) has reached increasing clinical significance for patients with brain neoplasms. For quantification of standard PET-derived parameters such as the tumor-to-backg...

Marcus Unterrainer, Franziska Vettermann, Matthias Brendel, Adrien Holzgreve, Michael Lifschitz, Matthias Zähringer, Bogdana Suchorska, Vera Wenter, Ben M. Illigens, Peter Bartenstein and Nathalie L. Albert

EJNMMI Research 2017 7:48

Published on: 30 May 2017
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Original research

Quantitative analysis of dynamic ¹⁸F-FDG PET/CT for measurement of lung inflammation

An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fl...

Christopher Coello, Marie Fisk, Divya Mohan, Frederick J. Wilson, Andrew P. Brown, Michael I. Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S. Murphy, Joseph Cheriyan and Roger N. Gunn

EJNMMI Research 2017 7:47

Published on: 25 May 2017
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Original Research

Clinical and imaging-based prognostic factors in radioembolisation of liver metastases from colorectal cancer: a retrospective exploratory analysis

The aim of this study was to investigate the relationship between absorbed dose and response of colorectal cancer liver metastases treated with [⁹⁰Y]-resin microspheres and to explore possible clinical and imagin...

Kathy P. Willowson, Aimee R. Hayes, David L. H. Chan, Michael Tapner, Elizabeth J. Bernard, Richard Maher, Nick Pavlakis, Stephen J. Clarke and Dale L. Bailey

EJNMMI Research 2017 7:46

Published on: 23 May 2017
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Original research

Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected ¹¹C-methionine uptake

Tumor to normal tissue ratio (T/N ratio) on ¹¹C-methionine (¹¹C-MET) positron emission tomography/computed tomography (PET/CT) is affected by variable factors. We investigated whether T/N ratio cutoff values corr...

Tae-Young Jung, In-Young Kim, Sa-Hoe Lim, Ki Seong Park, Dong-Yeon Kim, Shin Jung, Kyung-Sub Moon, Woo-Youl Jang, Sae-Ryung Kang, Sang-Geon Cho, Jung-Joon Min, Hee-Seung Bom and Seong Young Kwon

EJNMMI Research 2017 7:45

Published on: 23 May 2017
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Letter to Editor

Cryogenic transmission electron microscopy: the technique of choice for the characterization of polymeric nanocarriers

This letter is meant to make scientists aware of the proper application of transmission electron microscopy (TEM) for the assessment of polymeric self-assemblies. Cryogenic (cryo)-TEM should be the method of c...

Adrianus C. Laan and Antonia G. Denkova

EJNMMI Research 2017 7:44

Published on: 22 May 2017
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Original research

First in-human radiation dosimetry of ⁶⁸Ga-NODAGA-RGDyK

Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of ⁶⁸Ga-NODAGA-RG...

Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F. Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl and John O. Prior

EJNMMI Research 2017 7:43

Published on: 18 May 2017
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Original research

Repeatability of quantitative parameters of 18F-fluoride PET/CT and biochemical tumour and specific bone remodelling markers in prostate cancer bone metastases

18F-fluoride PET/CT exhibits high sensitivity to delineate and measure the extent of bone metastatic disease in patients with prostate cancer. 18F-fluoride PET/CT could potentially replace traditional bone sci...

Cecilia Wassberg, Mark Lubberink, Jens Sörensen and Silvia Johansson

EJNMMI Research 2017 7:42

Published on: 15 May 2017
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Review

Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review

Mesenchymal–epithelial transition factor also named c-MET is a receptor tyrosine kinase for the hepatocyte growth factor that plays a pivotal role in tumorigenesis. c-MET-targeted therapies have been tested in...

Zhaoguo Han, Yongyi Wu, Kai Wang, Yadi Xiao, Zhen Cheng, Xilin Sun and Baozhong Shen

EJNMMI Research 2017 7:41

Published on: 8 May 2017
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Original research

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using ¹¹¹In-tilmanocept

Atherosclerotic plaque phenotypes are classified based on the extent of macrophage infiltration into the lesions, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The ma...

Zohreh Varasteh, Fabien Hyafil, Nadège Anizan, Devy Diallo, Rachida Aid-Launais, Sarajo Mohanta, Yuanfang Li, Miriam Braeuer, Katja Steiger, Jonathan Vigne, Zhengtao Qin, Stephan G. Nekolla, Jean-Etienne Fabre, Yvonne Döring, Dominique Le Guludec, Andreas Habenicht…

EJNMMI Research 2017 7:40

Published on: 3 May 2017
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Original research

Carotid atherosclerotic plaques standardised uptake values: software challenges and reproducibility

Positron emission tomography–computed tomography (PET-CT) carotid standardised uptake values (SUV) of ¹⁸F-fluorodeoxyglucose (¹⁸FDG) have been proposed as an inflammatory biomarker for determining cerebrovascular...

Nicola Giannotti, Martin J. O’Connell, Shane J. Foley, Peter J. Kelly and Jonathan P. McNulty

EJNMMI Research 2017 7:39

Published on: 28 April 2017
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ISSN: 2191-219X