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  1. Positron emission tomography (PET) allows for the measurement of cerebral blood flow (CBF; based on [15O]H2O) and cerebral metabolic rate of glucose utilization (CMRglu; based on [18 F]-2-fluoro-2-deoxy-d-glucose...

    Authors: Marc C Huisman, Larissa W van Golen, Nikie J Hoetjes, Henri N Greuter, Patrick Schober, Richard G Ijzerman, Michaela Diamant and Adriaan A Lammertsma
    Citation: EJNMMI Research 2012 2:63
  2. By providing estimates of tumor glucose metabolism, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can potentially characterize the response of breast tumors to treatment. To assess therapy respons...

    Authors: Xia Li, Richard G Abramson, Lori R Arlinghaus, Anuradha Bapsi Chakravarthy, Vandana Abramson, Ingrid Mayer, Jaime Farley, Dominique Delbeke and Thomas E Yankeelov
    Citation: EJNMMI Research 2012 2:62
  3. The estrogen receptor α (ERα) is known to play an important role in the modulation of tumor response to hormone therapy. In this work, the effect of different hormone therapies on tumors having different ERα e...

    Authors: Michel Paquette, Sébastien Tremblay, Francois Bénard and Roger Lecomte
    Citation: EJNMMI Research 2012 2:61
  4. Recently, inflammatory cascades have been suggested as a target for epilepsy therapy. Positron emission tomography (PET) imaging offers the unique possibility to evaluate brain inflammation longitudinally in a...

    Authors: Stefanie Dedeurwaerdere, Paul D Callaghan, Tien Pham, Gita L Rahardjo, Halima Amhaoul, Paula Berghofer, Mitchell Quinlivan, Filomena Mattner, Christian Loc'h, Andrew Katsifis and Marie-Claude Grégoire
    Citation: EJNMMI Research 2012 2:60
  5. This study evaluates the potential utility of a modular nanotransporter (MNT) for enhancing the nuclear delivery and cytotoxicity of the Auger electron emitter 125I in cancer cells that overexpress the epidermal ...

    Authors: Tatiana A Slastnikova, Eftychia Koumarianou, Andrey A Rosenkranz, Ganesan Vaidyanathan, Tatiana N Lupanova, Alexander S Sobolev and Michael R Zalutsky
    Citation: EJNMMI Research 2012 2:59
  6. This study investigated the influence of P-glycoprotein (P-gp) inhibitor tariquidar on the pharmacokinetics of P-gp substrate radiotracer (R)-[11C]verapamil in plasma and brain of rats and humans by means of posi...

    Authors: Julia Müllauer, Claudia Kuntner, Martin Bauer, Jens P Bankstahl, Markus Müller, Rob A Voskuyl, Oliver Langer and Stina Syvänen
    Citation: EJNMMI Research 2012 2:58
  7. P-glycoprotein is a blood–brain barrier efflux transporter involved in the clearance of amyloid-beta from the brain and, as such, might be involved in the pathogenesis of Alzheimer's disease. P-glycoprotein is...

    Authors: Daniëlle ME van Assema, Mark Lubberink, Patrizia Rizzu, John C van Swieten, Robert C Schuit, Jonas Eriksson, Philip Scheltens, Matthias Koepp, Adriaan A Lammertsma and Bart NM van Berckel
    Citation: EJNMMI Research 2012 2:57
  8. Positron emission tomography (PET) may be useful for defining the gross tumour volume for radiation treatment planning and for response monitoring of non-small cell lung cancer (NSCLC) patients. The purpose of...

    Authors: Patsuree Cheebsumon, Ronald Boellaard, Dirk de Ruysscher, Wouter van Elmpt, Angela van Baardwijk, Maqsood Yaqub, Otto S Hoekstra, Emile FI Comans, Adriaan A Lammertsma and Floris HP van Velden
    Citation: EJNMMI Research 2012 2:56
  9. Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively...

    Authors: Miia Pitkonen, Eero Hippeläinen, Mari Raki, Jaan-Olle Andressoo, Arto Urtti, Pekka T Männistö, Sauli Savolainen, Mart Saarma and Kim Bergström
    Citation: EJNMMI Research 2012 2:55
  10. Sigma receptors are highly expressed in human tumors and should be appropriate targets for developing tumor imaging agents. Previously, we synthesized a vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino]cycl...

    Authors: Kazuma Ogawa, Hiroya Kanbara, Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Tatsuto Kiwada and Akira Odani
    Citation: EJNMMI Research 2012 2:54
  11. Unspecific pain of the hand/wrist is a diagnostic challenge. Radiographs and planar bone scan are useful diagnostic tools in patients with unspecific wrist pain. Both modalities are deficient, either by not pr...

    Authors: Florian S Schleich, Maja Schürch, Martin W Huellner, Urs Hug, Urs von Wartburg, Klaus Strobel and Patrick Veit-Haibach
    Citation: EJNMMI Research 2012 2:53
  12. Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″- tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positi...

    Authors: Xiang Li, Samuel Samnick, Constantin Lapa, Ina Israel, Andreas K Buck, Michael C Kreissl and Wolfgang Bauer
    Citation: EJNMMI Research 2012 2:52
  13. Freehand single photon emission computed tomography (fSPECT) is a three-dimensional (3-D) tomographic imaging modality based on data acquisition with a handheld detector that is moved freely, in contrast to co...

    Authors: Kambiz Rahbar, Mario Colombo-Benkmann, Christina Haane, Christian Wenning, Alexis Vrachimis, Matthias Weckesser and Otmar Schober
    Citation: EJNMMI Research 2012 2:51
  14. We describe a new method for biodistribution studies with IRDye800CW fluorescent antibody probes. This method allows the quantification of the IRDye800CW fluorescent tracer in percentage of injected dose per g...

    Authors: Sabrina Oliveira, Ruth Cohen, Marijke Stigter-van Walsum, Guus AMS van Dongen, Sjoerd G Elias, Paul J van Diest, Willem Mali and Paul MP van Bergen en Henegouwen
    Citation: EJNMMI Research 2012 2:50
  15. Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used to treat neuroendocrine tumors with high somatostatin-receptor expression. 177Lu-octreotate is mainly excreted via the kidneys, but to some extent, accumulat...

    Authors: Maria Larsson, Peter Bernhardt, Johanna B Svensson, Bo Wängberg, Håkan Ahlman and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2012 2:49
  16. An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. Th...

    Authors: Barry C Gibney, Mi-Ae Park, Kenji Chamoto, Alexandra Ysasi, Moritz A Konerding, Akira Tsuda and Steven J Mentzer
    Citation: EJNMMI Research 2012 2:48
  17. Arterial spin labeling magnetic resonance imaging (ASL-MRI) has been recognised as a valuable method for non-invasive assessment of cerebral blood flow but validation studies regarding quantification accuracy ...

    Authors: Agnieszka Boś, Ralf Bergmann, Klaus Strobel, Frank Hofheinz, Jörg Steinbach and Jörg van den Hoff
    Citation: EJNMMI Research 2012 2:47
  18. We aimed to develop a mouse spontaneous liver metastasis model from an orthotopically implanted human colon cancer cell line stably expressing a human sodium/iodide symporter (NIS) reporter gene, which can be ...

    Authors: Masayuki Inubushi, Yong-Nan Jin, Chika Murai, Hironobu Hata, Yoshimasa Kitagawa and Tsuneo Saga
    Citation: EJNMMI Research 2012 2:46
  19. The implementation of imaging technologies has dramatically increased the efficiency of preclinical studies, enabling a powerful, non-invasive and clinically translatable way for monitoring disease progression...

    Authors: Jordi L Tremoleda, Angela Kerton and Willy Gsell
    Citation: EJNMMI Research 2012 2:44
  20. We performed an initial evaluation of non-invasive ECG-gated [18 F]FDG-positron emission tomography (FDG-PET) for serial measurements of left ventricular volumes and function in murine models of dilated (DCM) and...

    Authors: Stefan Brunner, Andrei Todica, Guido Böning, Stefan G Nekolla, Moritz Wildgruber, Sebastian Lehner, Martina Sauter, Christopher Übleis, Karin Klingel, Paul Cumming, Wolfgang Michael Franz and Marcus Hacker
    Citation: EJNMMI Research 2012 2:43
  21. Posterior lumbar interbody fusion (PLIF) is a method that allows decompression of the spinal canal and nerve roots by laminectomy combined with fusion by means of intervertebral cages filled with bone graft an...

    Authors: Boudewijn Brans, Rene Weijers, Serve Halders, Roel Wierts, Marloes Peters, Ilona Punt and Paul Willems
    Citation: EJNMMI Research 2012 2:42
  22. 18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infe...

    Authors: Petteri Lankinen, Kaisa Lehtimäki, Antti J Hakanen, Anne Roivainen and Hannu T Aro
    Citation: EJNMMI Research 2012 2:41
  23. Nanomedicine is emerging as a promising approach for diagnostic applications. Nanoparticles are structures in the nanometer size range, which can present different shapes, compositions, charges, surface modifi...

    Authors: AndréLuís Branco de Barros, Andrew Tsourkas, Babak Saboury, Valbert Nascimento Cardoso and Abass Alavi
    Citation: EJNMMI Research 2012 2:39
  24. This study compares the frequency and distribution of increased activity on 18 F-fluoride PET/CT with the presence of bone marrow edema on whole-body MR imaging in the spine and sacroiliac joints (SIJ) of pati...

    Authors: Dorothee R Fischer, Christian W A Pfirrmann, Veronika Zubler, Katrin D M Stumpe, Burkhardt Seifert, Klaus Strobel, Giorgio Tamborrini, Gustav K von Schulthess, Beat A Michel and Adrian Ciurea
    Citation: EJNMMI Research 2012 2:38
  25. Dysfunction of the glycine transporter 1 (GlyT1) has been suggested to be involved in psychiatric disorders such as schizophrenia. GlyT1 inhibitors have therefore been considered to have antipsychotic therapeu...

    Authors: Takeshi Fuchigami, Akihiro Takano, Balázs Gulyás, Zhisheng Jia, Sjoerd J Finnema, Jan D Andersson, Ryuji Nakao, Yasuhiro Magata, Mamoru Haratake, Morio Nakayama and Christer Halldin
    Citation: EJNMMI Research 2012 2:37
  26. At present, several positron emission tomography (PET) tracers are in use for imaging P-glycoprotein (P-gp) function in man. At baseline, substrate tracers such as R-[11C]verapamil display low brain concentration...

    Authors: Joost Verbeek, Jonas Eriksson, Stina Syvänen, Maaike Labots, Elizabeth C M de Lange, Rob A Voskuyl, Martinus P J Mooijer, Marissa Rongen, Adriaan A Lammertsma and Albert D Windhorst
    Citation: EJNMMI Research 2012 2:36
  27. We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor ...

    Authors: Simon-Peter Williams, Judith E Flores-Mercado, Andreas R Baudy, Ruediger E Port and Thomas Bengtsson
    Citation: EJNMMI Research 2012 2:35
  28. In breast cancer endocrine therapy, post-therapy Ki-67 assay of biopsy material predicts recurrence-free survival but is invasive and prone to sampling error. [18F]Fluorodeoxyglucose (FDG) positron emission tomog...

    Authors: Brenda F Kurland, Vijayakrishna K Gadi, Jennifer M Specht, Kimberly H Allison, Robert B Livingston, Eve T Rodler, Lanell M Peterson, Erin K Schubert, Xiaoyu Chai, David A Mankoff and Hannah M Linden
    Citation: EJNMMI Research 2012 2:34
  29. Attenuation correction of a single photon emission computed tomography (SPECT) image is possible using computed tomography (CT)-based attenuation maps with hybrid SPECT/CT. CT attenuation maps acquired during ...

    Authors: Kazuhiro Koshino, Kazuhito Fukushima, Masaji Fukumoto, Kazunari Sasaki, Tetsuaki Moriguchi, Yuki Hori, Tsutomu Zeniya, Yoshihiro Nishimura, Keisuke Kiso and Hidehiro Iida
    Citation: EJNMMI Research 2012 2:33
  30. Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer for creating DNA double-strand breaks and is thus proposed for radionuclide therapy when bound to tumor-seekin...

    Authors: Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2012 2:32
  31. We evaluated pharmacodynamic changes in tumour perfusion using positron emission tomography (PET) imaging with 15O-water to assess biological response to sunitinib, a multitargeted tyrosine kinase inhibitor.

    Authors: Andrew M Scott, Paul L Mitchell, Graeme O'Keefe, Timothy Saunder, Rodney J Hicks, Aurora Poon, Charles Baum, Nicoletta Brega, Timothy J McCarthy and Guy C Toner
    Citation: EJNMMI Research 2012 2:31
  32. Transcranial Doppler (TCD) CO2-reactivity and oxygen-15 positron emission tomography (PET) have both been used to measure the cerebral haemodynamic state in patients who may have a compromised blood flow. Our pur...

    Authors: Suzanne Persoon, L Jaap Kappelle, Bart N M van Berckel, Ronald Boellaard, Cyrille H Ferrier, Adriaan A Lammertsma and Catharina J M Klijn
    Citation: EJNMMI Research 2012 2:30
  33. Currently, 68Ga-labeled 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA)-peptides are the most widely used class of 68Ga radiotracers for PET, although DOTA is not optimal for 68Ga complexation. More recent...

    Authors: Johannes Notni, Karolin Pohle and Hans-Jürgen Wester
    Citation: EJNMMI Research 2012 2:28
  34. It is important that referring physicians and other treating clinicians properly understand the final reports from diagnostic tests. The aim of the study was to investigate whether referring physicians interpr...

    Authors: Elin Trägårdh, Peter Höglund, Mattias Ohlsson, Mattias Wieloch and Lars Edenbrandt
    Citation: EJNMMI Research 2012 2:27
  35. Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of ...

    Authors: Marianne Isabelle Martic-Kehl, Simon Mensah Ametamey, Malte Frederick Alf, Pius August Schubiger and Michael Honer
    Citation: EJNMMI Research 2012 2:26
  36. In this study, we report on the synthesis, radiolabeling, and biological evaluation of two new somatostatin-14 (SS14) analogs, modified with the universal chelator DOTA. We were interested to investigate if an...

    Authors: Aikaterini Tatsi, Theodosia Maina, Renzo Cescato, Beatrice Waser, Eric P Krenning, Marion de Jong, Paul Cordopatis, Jean Claude Reubi and Berthold A Nock
    Citation: EJNMMI Research 2012 2:25
  37. Radiolabelled bombesin (BN) conjugates are promising radiotracers for imaging and therapy of breast and prostate tumours, in which BN2/gastrin-releasing peptide receptors are overexpressed. We describe the influe...

    Authors: Simone Däpp, Cristina Müller, Elisa García Garayoa, Peter Bläuenstein, Veronique Maes, Luc Brans, Dirk A Tourwé and Roger Schibli
    Citation: EJNMMI Research 2012 2:24
  38. Alternative positron-emission tomography (PET) probes like labeled inhibitors of the prostate-specific membrane antigen (PSMA) are of emerging clinical impact as they show the ability to image small lesions of...

    Authors: Martin Schäfer, Ulrike Bauder-Wüst, Karin Leotta, Frederic Zoller, Walter Mier, Uwe Haberkorn, Michael Eisenhut and Matthias Eder
    Citation: EJNMMI Research 2012 2:23
  39. The BRAF inhibitor, vemurafenib, has recently been approved for the treatment of metastatic melanoma in patients harboring BRAFV600 mutations. Currently, dual BRAF and MEK inhibition are ongoing in clinical trial...

    Authors: Andreas R Baudy, Taner Dogan, Judith E Flores-Mercado, Klaus P Hoeflich, Fei Su, Nicholas van Bruggen and Simon-Peter Williams
    Citation: EJNMMI Research 2012 2:22
  40. The “back-translation” of clinically available protocols to measure myocardial perfusion to preclinical imaging in mouse models of human disease is attractive for basic biomedical research. With respect to sin...

    Authors: Alexis Vrachimis, Sven Hermann, Domokos Máthé, Otmar Schober and Michael Schäfers
    Citation: EJNMMI Research 2012 2:21
  41. Anemia is usually not taken into account in internal radiotherapy. We investigated whether the hemoglobin (Hb) level could have an impact on the tumor response, as observed in external beam radiotherapy (EBRT).

    Authors: Stephan Walrand, Renaud Lhommel, Pierre Goffette, Marc Van den Eynde, Stanislas Pauwels and FranÇois Jamar
    Citation: EJNMMI Research 2012 2:20
  42. Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors. The objective of...

    Authors: Xiao Tong, Anikitos Garofalakis, Albertine Dubois, Raphaël Boisgard, Frédéric Ducongé, Régine Trébossen and Bertrand Tavitian
    Citation: EJNMMI Research 2012 2:19
  43. As is well known, limited spatial resolution leads to partial volume effects (PVE) and consequently to limited signal recovery. Determination of the mean activity concentration of a target structure is thus co...

    Authors: Frank Hofheinz, Jens Langner, Jan Petr, Bettina Beuthien-Baumann, Liane Oehme, Jörg Steinbach, Jörg Kotzerke and Jörg van den Hoff
    Citation: EJNMMI Research 2012 2:16
  44. Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [

    Authors: Aurelija Jučaite, Zsolt Cselényi, Annie Arvidsson, Gabrielle Åhlberg, Per Julin, Katarina Varnäs, Per Stenkrona, Jan Andersson, Christer Halldin and Lars Farde
    Citation: EJNMMI Research 2012 2:15
  45. Tumor targeting is of high clinical and biological relevance, and major efforts have been made to develop molecular imaging technologies for visualization of the disease markers in tissue. Of particular intere...

    Authors: Andreas Buehler, Eva Herzog, Angelica Ale, Bradley D Smith, Vasilis Ntziachristos and Daniel Razansky
    Citation: EJNMMI Research 2012 2:14

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