Articles

Sex correction improves the accuracy of clinical dopamine transporter imaging

In clinical diagnostic imaging, dopamine transporter (DAT) SPECT scans are commonly evaluated using automated semiquantitative analysis software. Age correction is routinely implemented, but usually no sex cor...

Authors: Emma A. Honkanen, Tommi Noponen, Risto Hirvilammi, Kari Lindholm, Riitta Parkkola, Juho Joutsa, Andrea Varrone and Valtteri Kaasinen

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes

The therapeutic use of [¹³¹I]meta-iodobenzylguanidine ([¹³¹I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is cause...

Authors: Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen and Godelieve A. M. Tytgat

Comparison of nuclear imaging techniques and volumetric imaging for the prediction of postoperative mortality and liver failure in patients undergoing localized liver-directed treatments: a systematic review

Although volumetric imaging by computed tomography (CT) is the gold standard for preoperative assessment of the future liver remnant, nuclear imaging studies have shown promising data. This systematic review s...

Authors: Caroline Espersen, Lise Borgwardt, Peter Nørgaard Larsen, Trine Borup Andersen, Louise Stenholt and Lars J. Petersen

Preselection of robust radiomic features does not improve outcome modelling in non-small cell lung cancer based on clinical routine FDG-PET imaging

Radiomics is a promising tool for identifying imaging-based biomarkers. Radiomics-based models are often trained on single-institution datasets; however, multi-centre imaging datasets are preferred for externa...

Authors: Carol Oliveira, Florian Amstutz, Diem Vuong, Marta Bogowicz, Martin Hüllner, Robert Foerster, Lucas Basler, Christina Schröder, Eric I. Eboulet, Miklos Pless, Sandra Thierstein, Solange Peters, Sven Hillinger, Stephanie Tanadini-Lang and Matthias Guckenberger

[¹⁸F]FDG-PET/CT in prone compared to supine position for optimal axillary staging and treatment in clinically node-positive breast cancer patients with neoadjuvant systemic therapy

Axillary staging before neoadjuvant systemic therapy in clinically node-positive breast cancer patients with tailored axillary treatment according to the Marking Axillary lymph nodes with radioactive iodine se...

Authors: Ariane A. van Loevezijn, Marcel P. M. Stokkel, Maarten L. Donswijk, Erik D. van Werkhoven, Marieke E. M. van der Noordaa, Frederieke H. van Duijnhoven and Marie-Jeanne T. F. D. Vrancken Peeters

Investigation of spleen CXCR4 expression by [⁶⁸Ga]Pentixafor PET in a cohort of 145 solid cancer patients

The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

Authors: Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter, Caroline Anna Peuker, Rudolf Werner, Valëza Ademaj-Kospiri, Alexander Gäble, Wolfgang Weber, Hans-Jürgen Wester, Andreas Buck, Peter Herhaus, Constantin Lapa and Ulrich Keller

PSMA-ligand uptake can serve as a novel biomarker in primary prostate cancer to predict outcome after radical prostatectomy

The prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer, and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is incre...

Authors: Hui Wang, Thomas Amiel, Christoph Würnschimmel, Thomas Langbein, Katja Steiger, Isabel Rauscher, Thomas Horn, Tobias Maurer, Wolfgang Weber, Hans-Juergen Wester, Karina Knorr and Matthias Eiber

An abbreviated therapy-dosimetric equation for the companion diagnostic/therapeutic [^64/67Cu]Cu-SARTATE

In a preclinical model of neuroblastoma, Dearling et al. recently demonstrated the potential interest for a theranostic approach of [⁶⁴/⁶⁷Cu]Cu-SARTATE for the detection and treatment of SSTR2-positive neuroblast...

Authors: Eric Laffon, Henri de Clermont and Roger Marthan

Potential and pitfalls of ⁸⁹Zr-immuno-PET to assess target status: ⁸⁹Zr-trastuzumab as an example

⁸⁹Zirconium-immuno-positron emission tomography (⁸⁹Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target...

Authors: Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah and Yvonne W. S. Jauw

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of ⁶⁸Ga-DOTATATE in patients without neuroendocrine tumors

Physiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at the organism level. Whole-body PBPK models contain an explicit repres...

Authors: H. Siebinga, B. J. de Wit-van der Veen, J. H. Beijnen, M. P. M. Stokkel, T. P. C. Dorlo, A. D. R. Huitema and J. J. M. A. Hendrikx

Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging

Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are ref...

Authors: Friederike Liesche-Starnecker, Georg Prokop, Igor Yakushev, Christine Preibisch, Claire Delbridge, Hanno S. Meyer, Kaywan Aftahy, Melanie Barz, Bernhard Meyer, Claus Zimmer, Jürgen Schlegel, Benedikt Wiestler and Jens Gempt

Imaging angiogenesis in atherosclerosis in large arteries with ⁶⁸Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease

Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The a...

Authors: Matthieu Dietz, Christel H. Kamani, Emmanuel Deshayes, Vincent Dunet, Periklis Mitsakis, George Coukos, Marie Nicod Lalonde, Niklaus Schaefer and John O. Prior

[¹⁸F]FDG PET/MRI enables early chemotherapy response prediction in pancreatic ductal adenocarcinoma

In this prospective exploratory study, we evaluated the feasibility of [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon thera...

Authors: Felix N. Harder, Friederike Jungmann, Georgios A. Kaissis, Fabian K. Lohöfer, Sebastian Ziegelmayer, Daniel Havel, Michael Quante, Maximillian Reichert, Roland M. Schmid, Ihsan Ekin Demir, Helmut Friess, Moritz Wildgruber, Jens Siveke, Alexander Muckenhuber, Katja Steiger, Wilko Weichert…

Automated procedure assessing the accuracy of HRCT–PET registration applied in functional virtual bronchoscopy

Bronchoscopy serves as direct visualisation of the airway. Virtual bronchoscopy provides similar visual information using a non-invasive imaging procedure(s). Early and accurate image-guided diagnosis requires...

Authors: Gábor Opposits, Marianna Nagy, Zoltán Barta, Csaba Aranyi, Dániel Szabó, Attila Makai, Imre Varga, László Galuska, Lajos Trón, László Balkay and Miklós Emri

N-staging in large cell neuroendocrine carcinoma of the lung: diagnostic value of [¹⁸F]FDG PET/CT compared to the histopathology reference standard

Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare entity occurring in less than 4% of all lung cancers. Due to its low differentiation and high glucose transporter 1 (GLUT1) expression, LCNEC d...

Authors: Hubertus Hautzel, Yazan Alnajdawi, Wolfgang P. Fendler, Christoph Rischpler, Kaid Darwiche, Wilfried E. Eberhardt, Lale Umutlu, Dirk Theegarten, Martin Stuschke, Martin Schuler, Clemens Aigner, Ken Herrmann and Till Plönes

Hypoxia and glucose metabolism assessed by FMISO and FDG PET for predicting IDH1 mutation and 1p/19q codeletion status in newly diagnosed malignant gliomas

Tumor hypoxia and glycolysis have been recognized as determinant factors characterizing tumor aggressiveness in malignant gliomas. To clarify in vivo hypoxia and glucose metabolism in relation to isocitrate dehyd...

Authors: Kenta Suzuki, Nobuyuki Kawai, Tomoya Ogawa, Keisuke Miyake, Aya Shinomiya, Yuka Yamamoto, Yoshihiro Nishiyama and Takashi Tamiya

Competitive blocking of salivary gland [¹⁸F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radion...

Authors: Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke and Frank I. Lin

A dedicated paediatric [¹⁸F]FDG PET/CT dosage regimen

The role of 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiati...

Authors: Christina P. W. Cox, Daniëlle M. E. van Assema, Frederik A. Verburg, Tessa Brabander, Mark Konijnenberg and Marcel Segbers

Prognostic value of baseline total metabolic tumour volume of ¹⁸F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma

The aim of this study was to explore the prognostic value of baseline metabolic parameters of ¹⁸F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).

Authors: Huanyu Gong, Tiannv Li, Jianyong Li, Lijun Tang and Chongyang Ding

In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201

Auger electron-emitting radionuclides have potential in targeted treatment of small tumors. Thallium-201 (²⁰¹Tl), a gamma-emitting radionuclide used in myocardial perfusion scintigraphy, decays by electron captur...

Authors: Katarzyna M. Osytek, Philip J. Blower, Ines M. Costa, Gareth E. Smith, Vincenzo Abbate and Samantha Y. A. Terry

Whole-body [¹⁸F]-FDG-PET/MRI for staging of pediatric non-Hodgkin lymphoma: first results from a single-center evaluation

In 2015, the revised International Pediatric Non-Hodgkin Lymphoma Staging System was published. It mentions [¹⁸F]-FDG-PET/MRI as the latest method to perform whole-body imaging. However, supporting data are pendi...

Authors: L. Kurch, R. Kluge, O. Sabri, L. Fischer, S. Wendt, H. Graf Einsiedel, S. Starke, J.-S. Kühl, H. Christiansen, F. W. Hirsch, I. Sorge and C. Roth

Hematologic safety of ¹⁷⁷Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer

Myelosuppression is a potential dose-limiting factor in radioligand therapy (RLT). This study aims to investigate occurrence, severity and reversibility of hematotoxic adverse events in patients undergoing RLT...

Authors: Daniel Groener, Cam Tu Nguyen, Justus Baumgarten, Benjamin Bockisch, Karen Davis, Christian Happel, Nicolai Mader, Christina Nguyen Ngoc, Jennifer Wichert, Severine Banek, Philipp Mandel, Felix K. H. Chun, Nikolaos Tselis, Frank Grünwald and Amir Sabet

Accuracy comparison of various quantitative [^99mTc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses

There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different ^99mTc-dicarboxypropandiphosphate ([^99mTc]Tc-DPD) SPECT/CT quantificati...

Authors: Martin Braun, Michal Cachovan, Felix Kaul, Federico Caobelli, Markus Bäumer, A. Hans Vija, Geert Pagenstert, Damian Wild and Martin Kretzschmar

[^99mTc]Tc-Galacto-RGD₂ integrin α_vβ₃-targeted imaging as a surrogate for molecular phenotyping in lung cancer: real-world data

Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of [^99mTc]Tc-Galacto-RGD₂ single-photon emission computed tomography ...

Authors: Jingjing Fu, Yan Xie, Tong Fu, Fan Qiu, Fei Yu, Wei Qu, Xiaochen Yao, Aiping Zhang, Zhenhua Yang, Guoqiang Shao, Qingle Meng, Xiumin Shi, Yue Huang, Wei Gu and Feng Wang

The association of DAT gene methylation with striatal DAT availability in healthy subjects

DNA methylation inhibits gene expression by preventing transcription factors from binding to DNA. Functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (...

Authors: Kyoungjune Pak, Ju Won Seok, Hyun-Yeol Nam, Seongho Seo, Myung Jun Lee, Keunyoung Kim and In Joo Kim

Performance of nanoScan PET/CT and PET/MR for quantitative imaging of ¹⁸F and ⁸⁹Zr as compared with ex vivo biodistribution in tumor-bearing mice

The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imagin...

Authors: Marion Chomet, Maxime Schreurs, Ricardo Vos, Mariska Verlaan, Esther J. Kooijman, Alex J. Poot, Ronald Boellaard, Albert D. Windhorst, Guus AMS van Dongen, Danielle J. Vugts, Marc C. Huisman and Wissam Beaino

Deep learning-based amyloid PET positivity classification model in the Alzheimer’s disease continuum by using 2-[¹⁸F]FDG PET

Considering the limited accessibility of amyloid position emission tomography (PET) in patients with dementia, we proposed a deep learning (DL)-based amyloid PET positivity classification model from PET images...

Authors: Suhong Kim, Peter Lee, Kyeong Taek Oh, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Yu Kyeong Kim, Byoung Seok Ye, Mi Jin Yun, Dong Young Lee and Yong Jeong

Evaluation of ¹⁸F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with ⁶⁸Ga-DOTATATE PET/CT

To evaluate the diagnostic efficacy of ¹⁸F-AlF-NOTA-octreotide (¹⁸F-OC) PET/CT compared with that of ⁶⁸Ga-DOTATATE PET/CT.

Authors: Jiale Hou, Tingting Long, Zhiyou He, Ming Zhou, Nengan Yang, Dengming Chen, Shan Zeng and Shuo Hu

Risk factors for nonvisualization of the sentinel lymph node on lymphoscintigraphy in breast cancer patients

Accurate sentinel lymph node (SLN) staging is essential for both prognosis and treatment in patients with breast cancer. However, the preoperative lymphoscintigraphy may fail to visualize the SLN in some patie...

Authors: Youssef Chahid, Xinbo Qiu, Ewoudt M. W. van de Garde, Hein J. Verberne and Jan Booij

Automated and robust organ segmentation for 3D-based internal dose calculation

In this work, we address image segmentation in the scope of dosimetry using deep learning and make three main contributions: (a) to extend and optimize the architecture of an existing convolutional neural netw...

Authors: Mahmood Nazari, Luis David Jiménez-Franco, Michael Schroeder, Andreas Kluge, Marcus Bronzel and Sharok Kimiaei

A three-stage, deep learning, ensemble approach for prognosis in patients with Parkinson’s disease

Diagnosis of Parkinson’s disease (PD) is informed by the presence of progressive motor and non-motor symptoms and by imaging dopamine transporter with [¹²³I]ioflupane (DaTscan). Deep learning and ensemble methods...

Authors: Kevin H. Leung, Steven P. Rowe, Martin G. Pomper and Yong Du

Prognostic value of baseline interleukin 6 levels in liver decompensation and survival in HCC patients undergoing radioembolization

To confirm the prognostic value of previously published baseline interleukin 6 (IL6) and IL8 cutoff values in survival and liver dysfunction in patients with advanced HCC undergoing ⁹⁰Y radioembolization.

Authors: Osman Öcal, Juozas Kupčinskas, Egidijus Morkunas, Holger Amthauer, Kerstin Schütte, Peter Malfertheiner, Heinz Josef Klümpen, Christian Sengel, Julia Benckert, Ricarda Seidensticker, Bruno Sangro, Moritz Wildgruber, Maciej Pech, Peter Bartenstein, Jens Ricke and Max Seidensticker

Intraoperative visualization of nerves using a myelin protein-zero specific fluorescent tracer

Surgically induced nerve damage is a common but debilitating side effect in oncological surgery. With the aim to use fluorescence guidance to enable nerve-sparing interventions in future surgery, a fluorescent...

Authors: Tessa Buckle, Albertus. W. Hensbergen, Danny M. van Willigen, Frank Bosse, Kevin Bauwens, Rob C. M. Pelger and Fijs W. B. van Leeuwen

A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [¹⁸F]MK-6240

[¹⁸F]MK-6240 is a PET tracer with sub-nanomolar affinity for neurofibrillary tangles. Therefore, tau quantification is possible with [¹⁸F]MK-6240 PET/CT scans, and it can be used for assessment of Alzheimer’s dis...

Authors: Guilherme D. Kolinger, David Vállez García, Talakad G. Lohith, Eric D. Hostetler, Cyrille Sur, Arie Struyk, Ronald Boellaard and Michel Koole

Post-reconstruction enhancement of [¹⁸F]FDG PET images with a convolutional neural network

The aim of the study was to develop and test an artificial intelligence (AI)-based method to improve the quality of [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET) images.

Authors: John Ly, David Minarik, Jonas Jögi, Per Wollmer and Elin Trägårdh

Necrosis binding of Ac-Lys⁰(IRDye800CW)-Tyr³-octreotate: a consequence from cyanine-labeling of small molecules

There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surgery. New contrast agents are obtained by substituting the radioactive tag with, or adding a fluorescent cyanin...

Authors: Marcus C. M. Stroet, Bianca M. Dijkstra, Sebastiaan E. Dulfer, Schelto Kruijff, Wilfred F. A. den Dunnen, Frank A. E. Kruyt, Rob J. M. Groen, Yann Seimbille, Kranthi M. Panth, Laura Mezzanotte, Clemens W. G. M. Lowik and Marion de Jong

Conscious rat PET imaging with soft immobilization for quantitation of brain functions: comprehensive assessment of anesthesia effects on cerebral blood flow and metabolism

Animal brain functions evaluated by in vivo imaging under anesthesia can be affected by anesthetic agents, resulting in incorrect assessment of physiological brain function. We therefore performed dynamic posi...

Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata

In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease

Inflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image in...

Authors: Romain Schollhammer, Sébastien Lepreux, Nicole Barthe, Delphine Vimont, Anne Rullier, Igor Sibon, Xavier Berard, Andrea Zhang, Yasuyuki Kimura, Masahiro Fujita, Robert B. Innis, Paolo Zanotti-Fregonara and Clément Morgat

Feasibility of equivalent performance of 3D TOF [¹⁸F]-FDG PET/CT with reduced acquisition time using clinical and semiquantitative parameters

High-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability for rapid data acquisition while preserving diagnostic image quality. However, determining a reliable and cl...

Authors: Julia Pilz, Lukas Hehenwarter, Georg Zimmermann, Gundula Rendl, Gregor Schweighofer-Zwink, Mohsen Beheshti and Christian Pirich

Head to head comparison of [^99mTc]Tc(CO)₃(NTA) and [^99mTc]Tc-MAG3 in patients with suspected obstruction

^99mTc-tricarbonyl-nitrilotriacetic acid, [^99mTc]Tc(CO)₃(NTA), is a new ^99mTc-renal radiopharmaceutical with a clearance equal to that of ¹³¹I-ortho-iodohippuran, [¹³¹I]I-OIH. Our purpose was to compare the perfor...

Authors: Andrew T. Taylor, Malgorzata Lipowska and Raghuveer K. Halkar

Correlation of 4′-[methyl-¹¹C]-thiothymidine PET with Gd-enhanced and FLAIR MRI in patients with newly diagnosed glioma

To elucidate the biological association between tumor proliferation, tumor infiltration and neovascularization, we analyzed the association between volumetric information of 4′-[methyl-¹¹C]thiothymidine (4DST) po...

Authors: Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kenichi Tanaka, Tetsuhiro Hatakeyama, Keisuke Miyake, Jun Toyohara and Yoshihiro Nishiyama

Parameters predicting [¹⁸F]PSMA-1007 scan positivity and type and number of detected lesions in patients with biochemical recurrence of prostate cancer

Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate...

Authors: Niloefar Ahmadi Bidakhvidi, Annouschka Laenen, Sander Jentjens, Christophe M. Deroose, Koen Van Laere, Liesbeth De Wever, Cindy Mai, Charlien Berghen, Gert De Meerleer, Karin Haustermans, Steven Joniau, Wouter Everaerts and Karolien Goffin

Correlation of [¹⁸F]florbetaben textural features and age of onset of Alzheimer’s disease: a principal components analysis approach

When Alzheimer’s disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in the case of a late onset. We aim at identifying [ ...

Authors: Jing Li, Emanuele Antonecchia, Marco Camerlenghi, Agostino Chiaravalloti, Qian Chu, Alfonso Di Costanzo, Zhen Li, Lin Wan, Xiangsong Zhang, Nicola D’Ascenzo, Orazio Schillaci and Qingguo Xie

10 years of EJNMMI Research: an overview

Authors: Angelika Bischof Delaloye

Comparison of FDG and FMISO uptakes and distributions in head and neck squamous cell cancer tumors

Glycolysis is increased by hypoxia, suggesting a possible correlation between the accumulation of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in malignant tumors and regional hypoxia defined by 1H-1-(3-[18F]fluoro-2-hy...

Authors: Sadek A. Nehmeh, Mohamed B. Moussa, Nancy Lee, Pat Zanzonico, Mithat Gönen, John L. Humm and Heiko Schöder

Angiogenesis imaging study using interim [¹⁸F] RGD-K5 PET/CT in patients with lymphoma undergoing chemotherapy: preliminary evidence

Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [¹⁸F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography–computed tomography (PET) on ...

Authors: David Tonnelet, M. D. Pierre Bohn, Stephanie Becker, Pierre Decazes, Vincent Camus, Sebastien Thureau, Hervé Tilly, Fabrice Jardin and Pierre Vera

The pharmacokinetics of [¹⁸F]UCB-H revisited in the healthy non-human primate brain

Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [¹⁸F]UCB-H was one of the first promising SV2A-ligands to be labelled and used i...

Authors: Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret and Nadja Van Camp

Region- and voxel-based quantification in human brain of [¹⁸F]LSN3316612, a radioligand for O-GlcNAcase

Previous studies found that the positron emission tomography (PET) radioligand [¹⁸F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to as...

Authors: Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Mohammad B. Haskali, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis and Paolo Zanotti-Fregonara

Can the function of the tubarial glands be evaluated using [^99mTc]pertechnetate SPECT/CT, [¹⁸F]FDG PET/CT, and [¹¹C]methionine PET/CT?

The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membr...

Authors: Yohji Matsusaka, Tomohiko Yamane, Kenji Fukushima, Akira Seto, Ichiro Matsunari and Ichiei Kuji

Prospective data-driven respiratory gating of [⁶⁸Ga]Ga-DOTATOC PET/CT

The aim of this prospective study was to evaluate a data-driven gating software’s performance, in terms of identifying the respiratory signal, comparing [⁶⁸Ga]Ga-DOTATOC and [¹⁸F]FDG examinations. In addition, fo...

Authors: Jonathan Sigfridsson, Elin Lindström, Victor Iyer, Maria Holstensson, Irina Velikyan, Anders Sundin and Mark Lubberink