Articles

Multimodal image-guided surgery of HER2-positive breast cancer using [¹¹¹In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model

Combining modalities using dual-labeled antibodies may allow preoperative and intraoperative tumor localization and could be used in image-guided surgery to improve complete tumor resection. Trastuzumab is a m...

Authors: Marion M. Deken, Desirée L. Bos, Willemieke S. F. J. Tummers, Taryn L. March, Cornelis J. H. van de Velde, Mark Rijpkema and Alexander L. Vahrmeijer

¹⁸F-florbetapir PET/MRI for quantitatively monitoring demyelination and remyelination in acute disseminated encephalomyelitis

Authors: Min Zhang, Jun Liu, Biao Li and Sheng Chen

Updating PET/CT performance standards and PET/CT interpretation criteria should go hand in hand

This letter aims at explaining that adjusting the performance of PET/CT systems to a new standard also requires updating of interpretation criteria. Simply changing one aspect of the imaging procedure, i.e., P...

Authors: Ronald Boellaard, Terez Sera, Andres Kaalep, Otto S. Hoekstra, Sally F. Barrington and Josée M. Zijlstra

Feasibility of radioguided occult lesion localization of clip-marked lymph nodes for tailored axillary treatment in breast cancer patients treated with neoadjuvant systemic therapy

Selective removal of initially tumor-positive axillary lymph nodes in breast cancer patients who underwent neoadjuvant systemic treatment (NST) improves the accuracy of nodal staging and provides the opportuni...

Authors: Daan Hellingman, Maarten L. Donswijk, Gonneke A. O. Winter-Warnars, Petra de Koekkoek-Doll, Marilyn Pinas, Yvonne Budde-van Namen, Johan Westerga, Marie-Jeanne T. F. D. Vrancken Peeters, Nikola Kimmings and Marcel P. M. Stokkel

PSMA expression level predicts differentiated thyroid cancer aggressiveness and patient outcome

Prostate-specific membrane antigen (PSMA) is overexpressed on the endothelial cells of tumor neo-vessels of several solid malignancies, including differentiated thyroid cancer (DTC). We aimed to test the poten...

Authors: Martina Sollini, Luca di Tommaso, Margarita Kirienko, Chiara Piombo, Marco Erreni, Andrea Gerardo Lania, Paola Anna Erba, Lidija Antunovic and Arturo Chiti

In vivo long-lasting alterations of central serotonin transporter activity and associated dopamine synthesis after acute repeated administration of methamphetamine

Methamphetamine (METH)-associated alterations in the striatal dopamine (DA) system or dopamine transport (DAT) have been identified in clinical and preclinical studies with positron emission tomography (PET) i...

Authors: Wen-Sheng Huang, Guann-Juh Chen, Tung-Han Tsai, Chen-Yi Cheng, Chyng-Yann Shiue, Kuo-Hsing Ma and Skye Hsin-Hsien Yeh

Voxel-based statistical analysis and quantification of amyloid PET in the Japanese Alzheimer’s disease neuroimaging initiative (J-ADNI) multi-center study

Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical st...

Authors: Go Akamatsu, Yasuhiko Ikari, Akihito Ohnishi, Keiichi Matsumoto, Hiroyuki Nishida, Yasuji Yamamoto and Michio Senda

Voxel-based identification of local recurrence sub-regions from pre-treatment PET/CT for locally advanced head and neck cancers

Overall, 40% of patients with a locally advanced head and neck cancer (LAHNC) treated by chemoradiotherapy (CRT) present local recurrence within 2 years after the treatment. The aims of this study were to char...

Authors: J. Beaumont, O. Acosta, A. Devillers, X. Palard-Novello, E. Chajon, R. de Crevoisier and J. Castelli

Texture analysis of pretreatment [¹⁸F]FDG PET/CT for the prognostic prediction of locally advanced salivary gland carcinoma treated with interstitial brachytherapy

The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([¹⁸F]FDG) uptake on pretreatment PET/com...

Authors: Wen-Jie Wu, Zhen-Yu Li, Shuang Dong, Shu-Ming Liu, Lei Zheng, Ming-Wei Huang and Jian-Guo Zhang

A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer

An efficient and cost-effective synthesis of the metal chelating agents that couple to tumor-targeting peptides is required to enhance the process of preclinical research toward the clinical translation of mol...

Authors: Subhani M. Okarvi and Ibrahim AlJammaz

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

Rheumatoid arthritis (RA) is one of the most common rheumatic diseases. Joint inflammation and pathological growth of joint cartilage cause swollen and painful joints, which severely diminishes the patients’ l...

Authors: Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier and Melanie A. Kimm

Comparison between silicon photomultiplier-based and conventional PET/CT in patients with suspected lung cancer—a pilot study

Lung cancer is one of the most common cancers in the world. Early detection and correct staging are fundamental for treatment and prognosis. Positron emission tomography with computed tomography (PET/CT) is re...

Authors: Johan Economou Lundeberg, Jenny Oddstig, Ulrika Bitzén and Elin Trägårdh

A pretargeted multimodal approach for image-guided resection in a xenograft model of colorectal cancer

Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcino...

Authors: Fortuné M. K. Elekonawo, Susanne Lütje, Gerben M. Franssen, Desirée L. Bos, David M. Goldenberg, Otto C. Boerman and Mark Rijpkema

Impact of the cerebrospinal fluid-mask algorithm on the diagnostic performance of ¹²³I-Ioflupane SPECT: an investigation of parkinsonian syndromes

A cerebrospinal fluid (CSF)-mask algorithm has been developed to reduce the adverse influence of CSF-low-counts on the diagnostic utility of the specific binding ratio (SBR) index calculated with Southampton m...

Authors: Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yohji Matsusaka, Yasuhiro Minami, Daisuke Ito, Hajime Tabuchi, Yoshitake Yamada and Masahiro Jinzaki

[⁶⁸Ga]Ga-PSMA-11 PET/CT for monitoring response to treatment in metastatic prostate cancer: is there any added value over standard follow-up?

The aim of the current study was to assess whether and to what extent monitoring response to treatment using prostate-specific membrane antigen (PSMA)-based positron-emitting tomography/computerized tomography...

Authors: Jonathan Kuten, David Sarid, Ofer Yossepowitch, Nicola J. Mabjeesh and Einat Even-Sapir

Quantitative and clinical impact of MRI-based attenuation correction methods in [¹⁸F]FDG evaluation of dementia

Positron emission tomography/magnetic resonance imaging (PET/MRI) is a promising diagnostic imaging tool for the diagnosis of dementia, as PET can add complementary information to the routine imaging examinati...

Authors: Silje Kjærnes Øen, Thomas Morten Keil, Erik Magnus Berntsen, Joel Fredrik Aanerud, Thomas Schwarzlmüller, Claes Nøhr Ladefoged, Anna Maria Karlberg and Live Eikenes

Enhanced pulmonary uptake on ¹⁸F-FES-PET/CT scans after irradiation of the thoracic area: related to fibrosis?

The use of 16α-[¹⁸F]fluoro-17β-estradiol (FES) positron emission tomography (PET) in clinical dilemmas and for therapy decision-making in lesions expressing estrogen receptors is growing. However, on a considerab...

Authors: C. M. Venema, E. F. J. de Vries, S. J. van der Veen, M. D. Dorrius, M. van Kruchten, C. P. Schröder, G. A. P. Hospers and A. W. J. M. Glaudemans

Voxel-based correlation of ¹⁸F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults

Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) v...

Authors: Yoko Shigemoto, Daichi Sone, Miho Ota, Norihide Maikusa, Masayo Ogawa, Kyoji Okita, Harumasa Takano, Koichi Kato, Yukio Kimura, Emiko Morimoto, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato and Hiroshi Matsuda

Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis

Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce.

Authors: Guillaume Rucher, Lucie Cameliere, Jihene Fendri, Antoine Anfray, Ahmed Abbas, Saïd Kamel, Quentin Dupas, Nicolas Delcroix, Ludovic Berger and Alain Manrique

Comprehensive analysis of the influence of G-CSF on the biodistribution of ¹⁸F-FDG in lymphoma patients: insights for PET/CT scheduling

(1) To perform a comprehensive analysis of the time elapsed between the last G-CSF injection and the PET/CT examination on the biodistribution of ¹⁸F-FDG, with emphasis on liver, spleen, and bone marrow uptake, a...

Authors: Magno Oliveira, Charline Lasnon, Catherine Nganoa, Anne-Claire Gac, Gandhi Damaj and Nicolas Aide

Imaging-guided precision medicine in glioblastoma patients treated with immune checkpoint modulators: research trend and future directions in the field of imaging biomarkers and artificial intelligence

Immunotherapies that employ immune checkpoint modulators (ICMs) have emerged as an effective treatment for a variety of solid cancers, as well as a paradigm shift in the treatment of cancers. Despite this brea...

Authors: Mathieu Sinigaglia, Tarek Assi, Florent L. Besson, Samy Ammari, Myriam Edjlali, Whitney Feltus, Laura Rozenblum-Beddok, Binsheng Zhao, Lawrence H. Schwartz, Fatima-Zohra Mokrane and Laurent Dercle

Impact of non-uniform attenuation correction in a dynamic [¹⁸F]-FDOPA brain PET/MRI study

PET (positron emission tomography) biokinetic modelling relies on accurate quantitative data. One of the main corrections required in PET imaging to obtain high quantitative accuracy is tissue attenuation corr...

Authors: Jorge Cabello, Mihai Avram, Felix Brandl, Mona Mustafa, Martin Scherr, Claudia Leucht, Stefan Leucht, Christian Sorg and Sibylle I. Ziegler

3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT

The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed f...

Authors: Astrid Gosewisch, Harun Ilhan, Sebastian Tattenberg, Andrea Mairani, Katia Parodi, Julia Brosch, Lena Kaiser, Franz Josef Gildehaus, Andrei Todica, Sibylle Ziegler, Peter Bartenstein and Guido Böning

Validation of [¹²⁵I]CPCR4.3 as an investigative tool for the sensitive and specific detection of hCXCR4 and mCXCR4 expression in vitro and in vivo

The development and clinical translation of [⁶⁸Ga] Pentixafor has substantially promoted the relevance of non-invasive PET imaging of CXCR4 expression in a broad spectrum of diseases, including cancer and inflamm...

Authors: Margret Schottelius, Marina Ludescher, Frauke Richter, Tobias G. Kapp, Horst Kessler and Hans-Jürgen Wester

Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [¹⁸F]HX4 PET imaging study in colorectal cancer xenografts

In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [¹⁸F]flortanidazole ([¹⁸F]HX4) small-animal positron emission tomography (μPET). We also assessed ...

Authors: Sven De Bruycker, Christel Vangestel, Steven Staelens, Leonie wyffels, Jan Detrez, Marlies Verschuuren, Winnok H. De Vos, Patrick Pauwels, Tim Van den Wyngaert and Sigrid Stroobants

Optimization of parathyroid ¹¹C-choline PET protocol for localization of parathyroid adenomas in patients with primary hyperparathyroidism

To evaluate the optimal tracer uptake time, the minimal amount of radioactivity and the inter-observer agreement for ¹¹C-choline positron emission tomography/computed tomography (PET/CT) in patients with primary ...

Authors: Milou E. Noltes, Schelto Kruijff, Walter Noordzij, Eef D. Telenga, David Vállez García, Malgorzata Trofimiuk-Müldner, Marta Opalińska, Alicja Hubalewska-Dydejczyk, Gert Luurtsema, Rudi A. J. O. Dierckx, Mostafa El Moumni, Ronald Boellaard and Adrienne H. Brouwers

Parathyroid imaging with ¹⁸F-fluorocholine PET/CT as a first-line imaging modality in primary hyperparathyroidism: a retrospective cohort study

¹⁸F-fluorocholine (FCH) PET/CT is a promising technique for visualizing hyperfunctioning parathyroid glands in hyperparathyroidism. It is still under debate whether to use this technique as a first-line imaging ....

Authors: Wouter A. M. Broos, Maurits Wondergem, Remco J. J. Knol and Friso M. van der Zant

Human biodistribution and radiation dosimetry of the 5-HT_2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions

Cimbi-36 can be ¹¹C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT_2A receptor in the brain. In its non-labeled form (25B-NBOMe), it is used as a recreationa...

Authors: Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen and Hanne D. Hansen

Sensitivity of ¹⁸F-fluorodihydrotestosterone PET-CT to count statistics and reconstruction protocol in metastatic castration-resistant prostate cancer

Whole body [¹⁸F]-fluorodihydrotestosterone positron emission tomography ([¹⁸F]FDHT PET) imaging directly targets the androgen receptor and is a promising prognostic and predictive biomarker in metastatic castrati...

Authors: Matthijs C. F. Cysouw, Gerbrand M. Kramer, Dennis Heijtel, Robert C. Schuit, Michael J. Morris, Alfons J. M. van den Eertwegh, Jens Voortman, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard

Zirconium-89-labelled rituximab PET-CT in orbital inflammatory disease

Orbital inflammatory diseases are a heterogenic group of conditions that often entail a difficult diagnostic process and many patients are treatment resistant. Inflammatory diseases can be visualized by Zircon...

Authors: Kamil G. Laban, Rachel Kalmann, Roos J. Leguit and Bart de Keizer

Preclinical investigations and first-in-human application of ¹⁵²Tb-PSMA-617 for PET/CT imaging of prostate cancer

For almost a decade, terbium radioisotopes have been explored for their potential theragnostic application in nuclear medicine: ¹⁵²Tb and ¹⁵⁵Tb are the radioisotopes identified for PET or SPECT imaging, while ¹⁴⁹

Authors: Cristina Müller, Aviral Singh, Christoph A. Umbricht, Harshad R. Kulkarni, Karl Johnston, Martina Benešová, Stefan Senftleben, Dirk Müller, Christiaan Vermeulen, Roger Schibli, Ulli Köster, Nicholas P. van der Meulen and Richard P. Baum

Radiomic detection of microscopic tumorous lesions in small animal liver SPECT imaging

Our aim was to present a new data analysis technique for the early detection of tumorous lesions using single-photon emission computed tomography (SPECT) imaging. Beyond standardized uptake value (SUV) and sta...

Authors: Dániel S. Veres, Domokos Máthé, Nikolett Hegedűs, Ildikó Horváth, Fanni J. Kiss, Gabriella Taba, Edit Tóth-Bodrogi, Tibor Kovács and Krisztián Szigeti

Biodistribution and radiation dosimetry of [¹⁸F]-JK-PSMA-7 as a novel prostate-specific membrane antigen-specific ligand for PET/CT imaging of prostate cancer

We investigated the whole-body distribution and the radiation dosimetry of [¹⁸F]-JK-PSMA-7, a novel ¹⁸F-labeled PSMA-ligand for PET/CT imaging of prostate cancer.

Authors: Melanie Hohberg, Carsten Kobe, Philipp Krapf, Philipp Täger, Jochen Hammes, Felix Dietlein, Boris D. Zlatopolskiy, Heike Endepols, Markus Wild, Stephan Neubauer, Axel Heidenreich, Bernd Neumaier, Alexander Drzezga and Markus Dietlein

The use of a proposed updated EARL harmonization of ¹⁸F-FDG PET-CT in patients with lymphoma yields significant differences in Deauville score compared with current EARL recommendations

The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of ¹⁸F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting t...

Authors: John Ly, David Minarik, Lars Edenbrandt, Per Wollmer and Elin Trägårdh

Impact of acquisition time and penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm on a Si-photomultiplier-based PET-CT system for ¹⁸F-FDG

Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstructi...

Authors: Elin Trägårdh, David Minarik, Helén Almquist, Ulrika Bitzén, Sabine Garpered, Erland Hvittfelt, Berit Olsson and Jenny Oddstig

Reliability of visual assessment by non-expert nuclear medicine physicians and appropriateness of indications of [¹²³I]FP-CIT SPECT imaging by neurologists in patients with early drug-naive Parkinson’s disease

To determine the reliability of visual assessment of [¹²³I]FP-CIT SPECT imaging by non-experts in dopamine transporter (DAT) SPECT imaging in patients with early drug-naive Parkinson’s disease (PD). Also, we expl...

Authors: Sven R. Suwijn, Constant V. M. Verschuur, Marleen A. Slim, Jan Booij and Rob M. A. de Bie

Analysis of differences between ^99mTc-MAA SPECT- and ⁹⁰Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy

The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interven...

Authors: Marilyne Kafrouni, Carole Allimant, Marjolaine Fourcade, Sébastien Vauclin, Boris Guiu, Denis Mariano-Goulart and Fayçal Ben Bouallègue

Head-to-head comparison of image quality between brain ¹⁸F-FDG images recorded with a fully digital versus a last-generation analog PET camera

The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this differen...

Authors: Julien Salvadori, Laetitia Imbert, Mathieu Perrin, Gilles Karcher, Zohra Lamiral, Pierre-Yves Marie and Antoine Verger

Biodistribution and radiation dosimetry of the novel hypoxia PET probe [¹⁸F]DiFA and comparison with [¹⁸F]FMISO

To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[¹⁸F]-fluoropropyl)-2-nitroimidazole ([¹⁸F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity ...

Authors: Shiro Watanabe, Tohru Shiga, Kenji Hirata, Keiichi Magota, Shozo Okamoto, Takuya Toyonaga, Kei Higashikawa, Hironobu Yasui, Jun Kobayashi, Ken-ichi Nishijima, Ken Iseki, Hiroki Matsumoto, Yuji Kuge and Nagara Tamaki

Diagnostic performance of regional cerebral blood flow images derived from dynamic PIB scans in Alzheimer’s disease

In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer’s disease (AD) through 2-[¹⁸F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) s...

Authors: Débora E. Peretti, David Vállez García, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard

Repeatability of tumor blood flow quantification with ⁸²Rubidium PET/CT in prostate cancer — a test-retest study

Non-invasive tumor blood flow (TBF) quantification is a candidate approach for risk stratification and monitoring of prostate cancer patients. Validation data have recently been published on prostate TBF measu...

Authors: Mads Ryø Jochumsen, Kirsten Bouchelouche, Katrine Bødkergaard Nielsen, Jørgen Frøkiær, Michael Borre, Jens Sörensen and Lars Poulsen Tolbod

Direct comparison of [¹¹C] choline and [¹⁸F] FET PET to detect glioma infiltration: a diagnostic accuracy study in eight patients

Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[¹⁸F]...

Authors: Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Lothar A. Schwarte, Frederik Barkhof, Petra J. W. Pouwels, Jan J. Heimans, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, William P. Vandertop, Pieter Wesseling, Ronald Boellaard and Philip C. de Witt Hamer

Radiation dosimetry of [¹⁸F]-PSS232—a PET radioligand for imaging mGlu5 receptors in humans

(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[¹⁸F]-fluoroethoxy)propyl) oxime ([¹⁸F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising re...

Authors: Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock and Simon M. Ametamey

Noninvasive assessment and quantification of tumor vascularization using [18F]FDG-PET/CT and CE-CT in a tumor model with modifiable angiogenesis—an animal experimental prospective cohort study

This study investigated the noninvasive assessment of tumor vascularization with clinical F-18-fluorodeoxyglucose positron emission tomography/computed tomography and contrast-enhanced computed tomography ([18...

Authors: Martin Mirus, Sergey V. Tokalov, Andrij Abramyuk, Jessica Heinold, Vincent Prochnow, Klaus Zöphel, Jörg Kotzerke and Nasreddin Abolmaali

Quantification of pulmonary disease activity in sarcoidosis measured with ¹⁸F-FDG PET/CT: SUVmax versus total lung glycolysis

¹⁸F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, q....

Authors: Milou C. Schimmelpennink, Adriane D. M. Vorselaars, Marcel Veltkamp and Ruth G. M. Keijsers

Internal radiation dosimetry of a ¹⁵²Tb-labeled antibody in tumor-bearing mice

Biodistribution studies based on organ harvesting represent the gold standard pre-clinical technique for dose extrapolations. However, sequential imaging is becoming increasingly popular as it allows the extra...

Authors: Francesco Cicone, Silvano Gnesin, Thibaut Denoël, Thierry Stora, Nicholas P. van der Meulen, Cristina Müller, Christiaan Vermeulen, Martina Benešová, Ulli Köster, Karl Johnston, Ernesto Amato, Lucrezia Auditore, George Coukos, Michael Stabin, Niklaus Schaefer, David Viertl…

Comparison of the radiolabeled PSMA-inhibitor ¹¹¹In-PSMA-617 and the radiolabeled GRP-R antagonist ¹¹¹In-RM2 in primary prostate cancer samples

Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRP-R) are expressed in prostate cancer and can be targeted with radiolabeled inhibitors and antagonists. Their performances fo...

Authors: Romain Schollhammer, Henri De Clermont Gallerande, Mokrane Yacoub, Marie-Laure Quintyn Ranty, Nicole Barthe, Delphine Vimont, Elif Hindié, Philippe Fernandez and Clément Morgat

Elimination of tumor hypoxia by eribulin demonstrated by ¹⁸F-FMISO hypoxia imaging in human tumor xenograft models

Eribulin, an inhibitor of microtubule dynamics, shows antitumor potency against a variety of solid cancers through its antivascular activity and remodeling of tumor vasculature. ¹⁸F-Fluoromisonidazole (¹⁸F-FMISO)...

Authors: Songji Zhao, Wenwen Yu, Naoyuki Ukon, Chengbo Tan, Ken-ichi Nishijima, Yoichi Shimizu, Kei Higashikawa, Tohru Shiga, Hiroko Yamashita, Nagara Tamaki and Yuji Kuge

Correlation between ¹⁸F-1-amino-3-fluorocyclobutane-1-carboxylic acid (¹⁸F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer

To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of ¹⁸F-1-amino-3-fluorocyclobutane-1-carbo...

Authors: Irena Saarinen, Ivan Jambor, Mai Kim, Anna Kuisma, Jukka Kemppainen, Harri Merisaari, Olli Eskola, Anna-Riina Koskenniemi, Ileana Montoya Perez, Peter Boström, Pekka Taimen and Heikki Minn

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten ...

Authors: Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch and Matthias M. Herth