Articles

Accuracy in dosimetry of diagnostic agents: impact of the number of source tissues used in whole organ S value-based calculations

Dosimetry for diagnostic agents is performed to assess the risk of radiation detriment (e.g., cancer) associated with the imaging agent and the risk is assessed by computing the effective dose coefficient, e. Sty...

Authors: Anders Josefsson, Klaikangwol Siritantikorn, Sagar Ranka, Jose Willegaignon de Amorim de Carvalho, Carlos Alberto Buchpiguel, Marcelo Tatit Sapienza, Wesley E. Bolch and George Sgouros

Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [¹⁸F]AmBF₃-TATE

[¹⁸F]AmBF₃-TATE is a somatostatin agonist that selectively binds to somatostatin receptor subtype 2 (SSTR2). For clinical translation, pharmacokinetics, radiation dosimetry, and acute toxicity of [¹⁸F]AmBF₃-TATE ...

Authors: Joseph Lau, Jinhe Pan, Etienne Rousseau, Carlos F. Uribe, Sudhakara Reddy Seelam, Brent W. Sutherland, David M. Perrin, Kuo-Shyan Lin and François Bénard

Quantitative γ-H2AX immunofluorescence method for DNA double-strand break analysis in testis and liver after intravenous administration of ¹¹¹InCl₃

It is well known that a severe cell injury after exposure to ionizing radiation is the induction of DNA double-strand breaks (DSBs). After exposure, an early response to DSBs is the phosphorylation of the hist...

Authors: Anna Stenvall, Erik Larsson, Bo Holmqvist, Sven-Erik Strand and Bo-Anders Jönsson

PET quantification of brain O-GlcNAcase with [¹⁸F]LSN3316612 in healthy human volunteers

Previous studies found that [¹⁸F]LSN3316612 was a promising positron emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and human volunteers. This study sought to further evaluate ...

Authors: Jae-Hoon Lee, Jeih-San Liow, Soumen Paul, Cheryl L. Morse, Mohammad B. Haskali, Lester Manly, Sergey Shcherbinin, J. Craig Ruble, Nancy Kant, Emily C. Collins, Hugh N. Nuthall, Paolo Zanotti-Fregonara, Sami S. Zoghbi, Victor W. Pike and Robert B. Innis

Quantification of [¹¹C]PBR28 data after systemic lipopolysaccharide challenge

Lipopolysaccharide (LPS) is a classic immune stimulus. LPS combined with positron emission tomography (PET) 18 kDa translocator protein (TSPO) brain imaging provides a robust human laboratory model to study ne...

Authors: Eric A. Woodcock, Martin Schain, Kelly P. Cosgrove and Ansel T. Hillmer

⁶⁸Ga-PSMA PET/CT in radioactive iodine-refractory differentiated thyroid cancer and first treatment results with ¹⁷⁷Lu-PSMA-617

Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients be...

Authors: Lisa H. de Vries, Lutske Lodewijk, Arthur J. A. T. Braat, Gerard C. Krijger, Gerlof D. Valk, Marnix G. E. H. Lam, Inne H. M. Borel Rinkes, Menno R. Vriens and Bart de Keizer

Results from extended lymphadenectomies with [¹¹¹In]PSMA-617 for intraoperative detection of PSMA-PET/CT-positive nodal metastatic prostate cancer

Identification of suspicious PSMA-PET/CT-positive lymph node (LN) metastases (LNM) from prostate cancer (PCa) during lymphadenectomy (LA) is challenging. We evaluated an ¹¹¹In-labelled PSMA ligand (DKFZ-617, refe...

Authors: Cordula A. Jilg, Kathrin Reichel, Christian Stoykow, H. Christian Rischke, Mark Bartholomä, Vanessa Drendel, Moritz von Büren, Wolfgang Schultze-Seemann, Philipp T. Meyer and Michael Mix

Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides

Targeting G protein-coupled receptors on the surface of cancer cells with peptide ligands is a promising concept for the selective tumor delivery of therapeutically active cargos, including radiometals for tar...

Authors: Adrien Chastel, Dennis J. Worm, Isabel D. Alves, Delphine Vimont, Melina Petrel, Samantha Fernandez, Philippe Garrigue, Philippe Fernandez, Elif Hindié, Annette G. Beck-Sickinger and Clément Morgat

Interobserver agreement of [⁶⁸Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer

Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aim...

Authors: Céline Derwael, Olivier Lavergne, Pierre Lovinfosse, Vlad Nechifor, Mallory Salvé, David Waltregny, Roland Hustinx and Nadia Withofs

Optimization of PET protocol and interrater reliability of ¹⁸F-PSMA-11 imaging of prostate cancer

Several scan parameters for PET imaging with ¹⁸F-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide admi...

Authors: Sarah Piron, Kathia De Man, Vanessa Schelfhout, Nick Van Laeken, Ken Kersemans, Eric Achten, Filip De Vos and Piet Ost

Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model

Cancer stem cells (CSCs) are involved in drug resistance, metastasis, and relapse of cancers, which can significantly affect tumor therapy. Hence, to develop specifically therapeutic target probe at CSCs for i...

Authors: Siao-Syun Guan, Cheng-Tien Wu, Tse-Zung Liao, Tsai-Yueh Luo, Kun-Liang Lin and Shing-Hwa Liu

Kinetic modeling of ⁶⁸Ga-PSMA-11 and validation of simplified methods for quantification in primary prostate cancer patients

The positron emission tomography (PET) ligand ⁶⁸Ga-Glu-urea-Lys(Ahx)-HBED-CC (⁶⁸Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although ⁶⁸Ga-PSMA-11 PET i...

Authors: Anna Ringheim, Guilherme de Carvalho Campos Neto, Udunna Anazodo, Lumeng Cui, Marcelo Livorsi da Cunha, Taise Vitor, Karine Minaif Martins, Ana Cláudia Camargo Miranda, Marycel Figols de Barboza, Leonardo Lima Fuscaldi, Gustavo Caserta Lemos, José Roberto Colombo Junior and Ronaldo Hueb Baroni

Paraneoplastic syndrome in undifferentiated embryonic sarcoma of the liver

The undifferentiated embryonic sarcoma of the liver (UESL) is a rare, aggressive tumor mainly affecting children. Since UESL has no specific clinical symptoms or imaging characteristics, many cases of UESL are...

Authors: Regine Mariette Perl, Almut Häring, Marius Stefan Horger, Christina Pfannenberg and Sergios Gatidis

Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors

Targeted alpha therapy (TAT) is a promising treatment for micrometastatic and minimal residual cancer. We evaluated systemic α-radioimmunotherapy (α-RIT) of metastatic castration-resistant prostate cancer (mCR...

Authors: Tom A. Bäck, Karin Jennbacken, Malin Hagberg Thulin, Sture Lindegren, Holger Jensen, Tove Olafsen, Paul J. Yazaki, Stig Palm, Per Albertsson, Jan-Erik Damber, Anna M. Wu and Karin Welén

Myocardial perfusion reserve of kidney transplant patients is well preserved

Chronic kidney disease (CKD) is associated with endothelial dysfunction and increased cardiovascular mortality. Endothelial dysfunction can be studied measuring myocardial perfusion reserve (MPR). MPR is the r...

Authors: Johanna Päivärinta, Kaj Metsärinne, Eliisa Löyttyniemi, Jarmo Teuho, Tuula Tolvanen, Juhani Knuuti and Niina Koivuviita

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and per...

Authors: Stephanus T. Malherbe, Ray Y. Chen, Patrick Dupont, Ilse Kant, Magdalena Kriel, André G. Loxton, Bronwyn Smith, Caroline G. G. Beltran, Susan van Zyl, Shirely McAnda, Charmaine Abrahams, Elizna Maasdorp, Alex Doruyter, Laura E. Via, Clifton E. Barry III, David Alland…

On the prevention of kidney uptake of radiolabeled DARPins

Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of ...

Authors: Mohamed Altai, Javad Garousi, Sara S. Rinne, Alexey Schulga, Sergey Deyev and Anzhelika Vorobyeva

Pre-test ⁶⁸Ga-PSMA-ligand PET/CT positivity in early biochemical recurrent prostate cancer after radical prostatectomy—validation of a prediction model

The aim of this study was the validation of a recently established comprehensive and compact prediction model for ⁶⁸Ga-PSMA-11-ligand positron-emission tomography (PET) positivity with an independent subsequent p...

Authors: Pia Kraft, Tobias Maurer, Andrei Gafita, Markus Krönke, Bernhard Haller, Wolfgang A. Weber, Matthias Eiber and Isabel Rauscher

Low-dose ¹⁸F-FDG TOF-PET/MR for accurate quantification of brown adipose tissue in healthy volunteers

Positron emission tomography (PET) is increasingly applied for in vivo brown adipose tissue (BAT) research in healthy volunteers. To limit the radiation exposure, the injected ¹⁸F-FDG tracer dose should be as low...

Authors: Edwin E. G. W. ter Voert, Hanna Svirydenka, Julian Müller, Anton S. Becker, Miroslav Balaz, Vissarion Efthymiou, Claudia Irene Maushart, Gani Gashi, Christian Wolfrum, Matthias J. Betz and Irene A. Burger

Biodistribution and imaging of an hsp90 ligand labelled with ¹¹¹In and ⁶⁷Ga for imaging of cell death

4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated at the γ-glutamyl residue with fluorophores and radio-isotopes is able to image dead and dying cells in vitro and in vivo by binding...

Authors: Ivan Ho Shon, Divesh Kumar, Chithradevi Sathiakumar, Paula Berghofer, Khang Van, Andrew Chicco and Philip J. Hogg

Prognostic value of ^99mTc-ECD brain perfusion SPECT in patients with atrial fibrillation and dementia

Patients with atrial fibrillation (AF) and dementia experience reduced quality of life and increased mortality. Technetium 99m ECD brain perfusion single-photon emission computed tomography (^99mTc-ECD brain perfu...

Authors: Hidenobu Hashimoto, Rine Nakanishi, Sunao Mizumura, Yukiko Hashimoto, Yuriko Okamura, Kyoko Yamanaka and Takanori Ikeda

[¹⁸F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer

Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still ne...

Authors: Elodie Jouberton, Sébastien Schmitt, Emmanuel Chautard, Aurélie Maisonial-Besset, Marie Roy, Nina Radosevic-Robin, Jean-Michel Chezal, Elisabeth Miot-Noirault, Yann Bouvet and Florent Cachin

Early response monitoring of neoadjuvant chemotherapy using [¹⁸F]FDG PET can predict the clinical outcome of extremity osteosarcoma

To propose a personalized therapeutic approach in osteosarcoma treatment, we assessed whether sequential [¹⁸F]FDG PET/CT (PET/CT) could predict the outcome of patients with osteosarcoma of the extremities after o...

Authors: Inki Lee, Byung Hyun Byun, Ilhan Lim, Byung Il Kim, Chang Woon Choi, Jae-Soo Koh, Won Seok Song, Wan Hyeong Cho, Chang-Bae Kong and Sang Moo Lim

The role of ¹⁸F-FCH PET/CT in patients with uremic hyperparathyroidism compared with ^99mTc-sestaMIBI SPECT/CT and ultrasonography

The aim of this study was to evaluate the diagnostic efficacy of ¹⁸F-fluorocholine (¹⁸F-FCH) PET/CT for uremic hyperparathyroidism (uHPT) compared to ^99mTc-sestaMIBI SPECT/CT and ultrasonography (US).

Authors: Yu Xue, Wenbo Li, Zhu Xia, Chengming Lei, Yiyi Cao, Zhengjie Wang and Hua Pang

Quantification of myocardial ^99mTc-labeled bisphosphonate uptake with cadmium zinc telluride camera in patients with transthyretin-related cardiac amyloidosis

We aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR).

Authors: Alain Manrique, David Dudoignon, Stéphanie Brun, Catherine N’Ganoa, Emmanuelle Cassol, Damien Legallois, Yoan Lavie-Badie, Denis Agostini and Olivier Lairez

Prediction of the aggressiveness of non-functional pancreatic neuroendocrine tumors based on the dual-tracer PET/CT

Predicting the aggressive behavior of non-functional pancreatic neuroendocrine tumors (NF-PNET) remains controversial. We wanted to explore, in a prospective setting, whether the diagnostic accuracy can be imp...

Authors: Susanna Majala, Hanna Seppänen, Jukka Kemppainen, Jari Sundström, Camilla Schalin-Jäntti, Risto Gullichsen, Jukka Schildt, Harri Mustonen, Tiina Vesterinen, Johanna Arola and Saila Kauhanen

What and how should we measure in paediatric oncology FDG-PET/CT? Comparison of commonly used SUV metrics for differentiation between paediatric tumours

In clinical routine, SUV_max and SUV_peak are most often used to determine the glucose metabolism in tumours by ¹⁸F-FDG PET/CT. Both metrics can be further normalised to SUVs in reference regions resulting in a SUV...

Authors: Janusch Blautzik, Leonie Grelich, Nicolai Schramm, Rebecca Henkel, Peter Bartenstein and Thomas Pfluger

⁶⁴Cu-ATSM/⁶⁴Cu-Cl₂ and their relationship to hypoxia in glioblastoma: a preclinical study

Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (⁶⁴Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may...

Authors: Elodie A. Pérès, Jérôme Toutain, Louis-Paul Paty, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Louisa Barré, Aurélien Vidal, Michel Cherel, Mickaël Bourgeois, Myriam Bernaudin and Samuel Valable

Quantifying disease activity in rheumatoid arthritis with the TSPO PET ligand ¹⁸F-GE-180 and comparison with ¹⁸F-FDG and DCE-MRI

While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...

Authors: Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer and Pilar Jimenez-Royo

¹⁸F-Fluorodeoxyglucose positron emission tomography may not visualize radiation pneumonitis

Radiation pneumonitis is a common and potentially fatal complication of radiotherapy (RT). Some patients with radiation pneumonitis show increases in uptake of fluorodeoxyglucose (FDG) on positron emission tom...

Authors: Meiying Guo, Liang Qi, Yun Zhang, Dongping Shang, Jinming Yu and Jinbo Yue

Changes in cerebral glucose metabolism caused by morphologic features of prodromal idiopathic normal pressure hydrocephalus

Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance in the preclinical stage of iNPH remains unknown. Herein, we evalua...

Authors: Koichi Miyazaki, Kohei Hanaoka, Hayato Kaida, Yasutaka Chiba and Kazunari Ishii

Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography

P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which effectively restrict the brain distribution of the majority of current...

Authors: Beatrix Wulkersdorfer, Martin Bauer, Rudolf Karch, Harald Stefanits, Cécile Philippe, Maria Weber, Thomas Czech, Marie-Claude Menet, Xavier Declèves, Johannes A. Hainfellner, Matthias Preusser, Marcus Hacker, Markus Zeitlinger, Markus Müller and Oliver Langer

Dual time point [¹⁸F]FLT-PET for differentiating proliferating tissues vs non-proliferating tissues

For differentiating tumor from inflammation and normal tissues, fluorodeoxyglucose ([¹⁸F]FDG) dual time point PET could be helpful. Albeit [¹⁸F]FLT is more specific for tumors than [¹⁸F]FDG; we explored the role ...

Authors: Pierre Lovinfosse, Caroline Rousseau, Jean-Yves Pierga, Francis Bouchet, Alexandre Cochet, Jean-Louis Alberini, Sylvie Girault, Pierre Vera, Pierre Olivier, Lionel Uwer, Florent Cachin, Benoit Scarwell, Jérome Lemonnier, Emmanuelle Fourme, Christel Mesleard, Anne-Laure Martin…

Carcinoembryonic antigen-targeted photodynamic therapy in colorectal cancer models

In colorectal cancer, survival of patients is drastically reduced when complete resection is hampered by involvement of critical structures. Targeted photodynamic therapy (tPDT) is a local and targeted therapy...

Authors: Fortuné M. K. Elekonawo, Desirée L. Bos, David M. Goldenberg, Otto C. Boerman and Mark Rijpkema

Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

Following publication of the original article [1], the authors have reported an error in the ‘Histopathology’ (under ‘Materials and methods’) section of the article that compromises the reproducibility of the ...

Authors: Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier and Melanie A. Kimm

SUV variability in EARL-accredited conventional and digital PET

A high SUV-reproducibility is crucial when different PET scanners are in use. We evaluated the SUV variability in whole-body FDG-PET scans of patients with suspected or proven cancer using an EARL-accredited c...

Authors: Daniëlle Koopman, Pieter L. Jager, Cornelis H. Slump, Siert Knollema and Jorn A. van Dalen

Low septal to lateral wall ¹⁸F-FDG ratio is highly associated with mechanical dyssynchrony in non-ischemic CRT candidates

In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and ...

Authors: Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Marta Cvijic, Georg Schramm, Johan Nuyts, Jens-Uwe Voigt and Olivier Gheysens

Combination of FDG-PET and FMISO-PET as a treatment strategy for patients undergoing early-stage NSCLC stereotactic radiotherapy

We investigated the prognostic predictive value of the combination of fluorodeoxyglucose (FDG)- and fluoromisonidazole (FMISO)-PET in patients with non-small cell lung carcinoma (NSCLC) treated with stereotact...

Authors: Shiro Watanabe, Tetsuya Inoue, Shozo Okamoto, Keiichi Magota, Ayumi Takayanagi, Jun Sakakibara-Konishi, Norio Katoh, Kenji Hirata, Osamu Manabe, Takuya Toyonaga, Yuji Kuge, Hiroki Shirato, Nagara Tamaki and Tohru Shiga

Evaluation of SUV normalized by lean body mass (SUL) in ⁶⁸Ga-PSMA11 PET/CT: a bi-centric analysis

The aim of this analysis was to investigate whether the standardized uptake value (SUV) normalized by lean body mass (SUL) is a more appropriate quantitative parameter compared to the commonly used SUV normali...

Authors: Andrei Gafita, Jeremie Calais, Charlott Franz, Isabel Rauscher, Hui Wang, Andrew Roberstson, Johannes Czernin, Wolfgang A. Weber and Matthias Eiber

Biodistribution and post-therapy dosimetric analysis of [¹⁷⁷Lu]Lu-DOTA^ZOL in patients with osteoblastic metastases: first results

Preclinical biodistribution and dosimetric analysis of [¹⁷⁷Lu]Lu-DOTA^ZOL suggest the bisphosphonate zoledronate as a promising new radiopharmaceutical for therapy of bone metastases. We evaluated biodistribution ...

Authors: Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian. C. Gaertner, Markus Essler and Ralph. A. Bundschuh

Short-term discontinuation of vagal nerve stimulation alters ¹⁸F-FDG blood pool activity: an exploratory interventional study in epilepsy patients

Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by ¹⁸F-FDG uptake.

Authors: Ellen Boswijk, Renee Franssen, Guy H. E. J. Vijgen, Roel Wierts, Jochem A. J. van der Pol, Alma M. A. Mingels, Erwin M. J. Cornips, Marian H. J. M. Majoie, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Joachim E. Wildberger and Jan Bucerius

Potential for imaging the high-affinity state of the 5-HT_1B receptor: a comparison of three PET radioligands with differing intrinsic activity

Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT_1B receptors. The 5-HT_1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity sta...

Authors: Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike and Christer Halldin

Role of F-18 FDG PET/CT in non-conjunctival origin ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphomas

Despite the widespread use of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the diagnosis and response assessment of patients with lymphoma, few studies have assessed...

Authors: Hye Lim Park, Joo Hyun O, Sonya Youngju Park, Seung-Eun Jung, Gyeongsin Park, Byung-Ock Choi, Sung Hoon Kim, Young-Woo Jeon, Seok-Goo Cho and Suk-Woo Yang

Multimodal image-guided surgery of HER2-positive breast cancer using [¹¹¹In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model

Combining modalities using dual-labeled antibodies may allow preoperative and intraoperative tumor localization and could be used in image-guided surgery to improve complete tumor resection. Trastuzumab is a m...

Authors: Marion M. Deken, Desirée L. Bos, Willemieke S. F. J. Tummers, Taryn L. March, Cornelis J. H. van de Velde, Mark Rijpkema and Alexander L. Vahrmeijer

Association of metabolic and genetic heterogeneity in head and neck squamous cell carcinoma with prognostic implications: integration of FDG PET and genomic analysis

The linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic heterogeneity features of the tumor are associ...

Authors: Jinyeong Choi, Jeong-An Gim, Chiwoo Oh, Seunggyun Ha, Howard Lee, Hongyoon Choi and Hyung-Jun Im

¹⁸F-florbetapir PET/MRI for quantitatively monitoring demyelination and remyelination in acute disseminated encephalomyelitis

Authors: Min Zhang, Jun Liu, Biao Li and Sheng Chen

Updating PET/CT performance standards and PET/CT interpretation criteria should go hand in hand

This letter aims at explaining that adjusting the performance of PET/CT systems to a new standard also requires updating of interpretation criteria. Simply changing one aspect of the imaging procedure, i.e., P...

Authors: Ronald Boellaard, Terez Sera, Andres Kaalep, Otto S. Hoekstra, Sally F. Barrington and Josée M. Zijlstra

Feasibility of radioguided occult lesion localization of clip-marked lymph nodes for tailored axillary treatment in breast cancer patients treated with neoadjuvant systemic therapy

Selective removal of initially tumor-positive axillary lymph nodes in breast cancer patients who underwent neoadjuvant systemic treatment (NST) improves the accuracy of nodal staging and provides the opportuni...

Authors: Daan Hellingman, Maarten L. Donswijk, Gonneke A. O. Winter-Warnars, Petra de Koekkoek-Doll, Marilyn Pinas, Yvonne Budde-van Namen, Johan Westerga, Marie-Jeanne T. F. D. Vrancken Peeters, Nikola Kimmings and Marcel P. M. Stokkel

PSMA expression level predicts differentiated thyroid cancer aggressiveness and patient outcome

Prostate-specific membrane antigen (PSMA) is overexpressed on the endothelial cells of tumor neo-vessels of several solid malignancies, including differentiated thyroid cancer (DTC). We aimed to test the poten...

Authors: Martina Sollini, Luca di Tommaso, Margarita Kirienko, Chiara Piombo, Marco Erreni, Andrea Gerardo Lania, Paola Anna Erba, Lidija Antunovic and Arturo Chiti

Voxel-based identification of local recurrence sub-regions from pre-treatment PET/CT for locally advanced head and neck cancers

Overall, 40% of patients with a locally advanced head and neck cancer (LAHNC) treated by chemoradiotherapy (CRT) present local recurrence within 2 years after the treatment. The aims of this study were to char...

Authors: J. Beaumont, O. Acosta, A. Devillers, X. Palard-Novello, E. Chajon, R. de Crevoisier and J. Castelli