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  1. In clinical diagnostic imaging, dopamine transporter (DAT) SPECT scans are commonly evaluated using automated semiquantitative analysis software. Age correction is routinely implemented, but usually no sex cor...

    Authors: Emma A. Honkanen, Tommi Noponen, Risto Hirvilammi, Kari Lindholm, Riitta Parkkola, Juho Joutsa, Andrea Varrone and Valtteri Kaasinen

    Citation: EJNMMI Research 2021 11:82

    Content type: Original research

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  2. The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia. We hypothesize that this is cause...

    Authors: Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen and Godelieve A. M. Tytgat

    Citation: EJNMMI Research 2021 11:81

    Content type: Original research

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  3. Although volumetric imaging by computed tomography (CT) is the gold standard for preoperative assessment of the future liver remnant, nuclear imaging studies have shown promising data. This systematic review s...

    Authors: Caroline Espersen, Lise Borgwardt, Peter Nørgaard Larsen, Trine Borup Andersen, Louise Stenholt and Lars J. Petersen

    Citation: EJNMMI Research 2021 11:80

    Content type: Review

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  4. Radiomics is a promising tool for identifying imaging-based biomarkers. Radiomics-based models are often trained on single-institution datasets; however, multi-centre imaging datasets are preferred for externa...

    Authors: Carol Oliveira, Florian Amstutz, Diem Vuong, Marta Bogowicz, Martin Hüllner, Robert Foerster, Lucas Basler, Christina Schröder, Eric I. Eboulet, Miklos Pless, Sandra Thierstein, Solange Peters, Sven Hillinger, Stephanie Tanadini-Lang and Matthias Guckenberger

    Citation: EJNMMI Research 2021 11:79

    Content type: Original research

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  5. Axillary staging before neoadjuvant systemic therapy in clinically node-positive breast cancer patients with tailored axillary treatment according to the Marking Axillary lymph nodes with radioactive iodine se...

    Authors: Ariane A. van Loevezijn, Marcel P. M. Stokkel, Maarten L. Donswijk, Erik D. van Werkhoven, Marieke E. M. van der Noordaa, Frederieke H. van Duijnhoven and Marie-Jeanne T. F. D. Vrancken Peeters

    Citation: EJNMMI Research 2021 11:78

    Content type: Original research

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  6. The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific p...

    Authors: Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter, Caroline Anna Peuker, Rudolf Werner, Valëza Ademaj-Kospiri, Alexander Gäble, Wolfgang Weber, Hans-Jürgen Wester, Andreas Buck, Peter Herhaus, Constantin Lapa and Ulrich Keller

    Citation: EJNMMI Research 2021 11:77

    Content type: Original research

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  7. The prostate-specific membrane antigen (PSMA) is a relevant target in prostate cancer, and immunohistochemistry studies showed associations with outcome. PSMA-ligand positron emission tomography (PET) is incre...

    Authors: Hui Wang, Thomas Amiel, Christoph Würnschimmel, Thomas Langbein, Katja Steiger, Isabel Rauscher, Thomas Horn, Tobias Maurer, Wolfgang Weber, Hans-Juergen Wester, Karina Knorr and Matthias Eiber

    Citation: EJNMMI Research 2021 11:76

    Content type: Original research

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  8. 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target...

    Authors: Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah and Yvonne W. S. Jauw

    Citation: EJNMMI Research 2021 11:74

    Content type: Short communication

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  9. Physiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at the organism level. Whole-body PBPK models contain an explicit repres...

    Authors: H. Siebinga, B. J. de Wit-van der Veen, J. H. Beijnen, M. P. M. Stokkel, T. P. C. Dorlo, A. D. R. Huitema and J. J. M. A. Hendrikx

    Citation: EJNMMI Research 2021 11:73

    Content type: Original research

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  10. Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are ref...

    Authors: Friederike Liesche-Starnecker, Georg Prokop, Igor Yakushev, Christine Preibisch, Claire Delbridge, Hanno S. Meyer, Kaywan Aftahy, Melanie Barz, Bernhard Meyer, Claus Zimmer, Jürgen Schlegel, Benedikt Wiestler and Jens Gempt

    Citation: EJNMMI Research 2021 11:72

    Content type: Original research

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  11. Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The a...

    Authors: Matthieu Dietz, Christel H. Kamani, Emmanuel Deshayes, Vincent Dunet, Periklis Mitsakis, George Coukos, Marie Nicod Lalonde, Niklaus Schaefer and John O. Prior

    Citation: EJNMMI Research 2021 11:71

    Content type: Original research

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  12. In this prospective exploratory study, we evaluated the feasibility of [18F]fluorodeoxyglucose ([18F]FDG) PET/MRI-based chemotherapy response prediction in pancreatic ductal adenocarcinoma at two weeks upon thera...

    Authors: Felix N. Harder, Friederike Jungmann, Georgios A. Kaissis, Fabian K. Lohöfer, Sebastian Ziegelmayer, Daniel Havel, Michael Quante, Maximillian Reichert, Roland M. Schmid, Ihsan Ekin Demir, Helmut Friess, Moritz Wildgruber, Jens Siveke, Alexander Muckenhuber, Katja Steiger, Wilko Weichert…

    Citation: EJNMMI Research 2021 11:70

    Content type: Original research

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  13. Bronchoscopy serves as direct visualisation of the airway. Virtual bronchoscopy provides similar visual information using a non-invasive imaging procedure(s). Early and accurate image-guided diagnosis requires...

    Authors: Gábor Opposits, Marianna Nagy, Zoltán Barta, Csaba Aranyi, Dániel Szabó, Attila Makai, Imre Varga, László Galuska, Lajos Trón, László Balkay and Miklós Emri

    Citation: EJNMMI Research 2021 11:69

    Content type: Original research

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  14. Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare entity occurring in less than 4% of all lung cancers. Due to its low differentiation and high glucose transporter 1 (GLUT1) expression, LCNEC d...

    Authors: Hubertus Hautzel, Yazan Alnajdawi, Wolfgang P. Fendler, Christoph Rischpler, Kaid Darwiche, Wilfried E. Eberhardt, Lale Umutlu, Dirk Theegarten, Martin Stuschke, Martin Schuler, Clemens Aigner, Ken Herrmann and Till Plönes

    Citation: EJNMMI Research 2021 11:68

    Content type: Original research

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  15. Tumor hypoxia and glycolysis have been recognized as determinant factors characterizing tumor aggressiveness in malignant gliomas. To clarify in vivo hypoxia and glucose metabolism in relation to isocitrate dehyd...

    Authors: Kenta Suzuki, Nobuyuki Kawai, Tomoya Ogawa, Keisuke Miyake, Aya Shinomiya, Yuka Yamamoto, Yoshihiro Nishiyama and Takashi Tamiya

    Citation: EJNMMI Research 2021 11:67

    Content type: Original research

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  16. PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radion...

    Authors: Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke and Frank I. Lin

    Citation: EJNMMI Research 2021 11:66

    Content type: Original research

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  17. The role of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in children is still expanding. Dedicated paediatric dosage regimens are needed to keep the radiati...

    Authors: Christina P. W. Cox, Daniëlle M. E. van Assema, Frederik A. Verburg, Tessa Brabander, Mark Konijnenberg and Marcel Segbers

    Citation: EJNMMI Research 2021 11:65

    Content type: Original research

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  18. The aim of this study was to explore the prognostic value of baseline metabolic parameters of 18F-FDG PET/CT imaging in patients with angioimmunoblastic T-cell lymphoma (AITL).

    Authors: Huanyu Gong, Tiannv Li, Jianyong Li, Lijun Tang and Chongyang Ding

    Citation: EJNMMI Research 2021 11:64

    Content type: Original research

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  19. Auger electron-emitting radionuclides have potential in targeted treatment of small tumors. Thallium-201 (201Tl), a gamma-emitting radionuclide used in myocardial perfusion scintigraphy, decays by electron captur...

    Authors: Katarzyna M. Osytek, Philip J. Blower, Ines M. Costa, Gareth E. Smith, Vincenzo Abbate and Samantha Y. A. Terry

    Citation: EJNMMI Research 2021 11:63

    Content type: Original research

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  20. In 2015, the revised International Pediatric Non-Hodgkin Lymphoma Staging System was published. It mentions [18F]-FDG-PET/MRI as the latest method to perform whole-body imaging. However, supporting data are pendi...

    Authors: L. Kurch, R. Kluge, O. Sabri, L. Fischer, S. Wendt, H. Graf Einsiedel, S. Starke, J.-S. Kühl, H. Christiansen, F. W. Hirsch, I. Sorge and C. Roth

    Citation: EJNMMI Research 2021 11:62

    Content type: Original research

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  21. Myelosuppression is a potential dose-limiting factor in radioligand therapy (RLT). This study aims to investigate occurrence, severity and reversibility of hematotoxic adverse events in patients undergoing RLT...

    Authors: Daniel Groener, Cam Tu Nguyen, Justus Baumgarten, Benjamin Bockisch, Karen Davis, Christian Happel, Nicolai Mader, Christina Nguyen Ngoc, Jennifer Wichert, Severine Banek, Philipp Mandel, Felix K. H. Chun, Nikolaos Tselis, Frank Grünwald and Amir Sabet

    Citation: EJNMMI Research 2021 11:61

    Content type: Original research

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  22. There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different 99mTc-dicarboxypropandiphosphate ([99mTc]Tc-DPD) SPECT/CT quantificati...

    Authors: Martin Braun, Michal Cachovan, Felix Kaul, Federico Caobelli, Markus Bäumer, A. Hans Vija, Geert Pagenstert, Damian Wild and Martin Kretzschmar

    Citation: EJNMMI Research 2021 11:60

    Content type: Original research

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  23. Epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) are beneficial in patients with lung cancer. We explored the clinical value of [99mTc]Tc-Galacto-RGD2 single-photon emission computed tomography ...

    Authors: Jingjing Fu, Yan Xie, Tong Fu, Fan Qiu, Fei Yu, Wei Qu, Xiaochen Yao, Aiping Zhang, Zhenhua Yang, Guoqiang Shao, Qingle Meng, Xiumin Shi, Yue Huang, Wei Gu and Feng Wang

    Citation: EJNMMI Research 2021 11:59

    Content type: Original research

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  24. DNA methylation inhibits gene expression by preventing transcription factors from binding to DNA. Functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (...

    Authors: Kyoungjune Pak, Ju Won Seok, Hyun-Yeol Nam, Seongho Seo, Myung Jun Lee, Keunyoung Kim and In Joo Kim

    Citation: EJNMMI Research 2021 11:58

    Content type: Original research

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  25. The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imagin...

    Authors: Marion Chomet, Maxime Schreurs, Ricardo Vos, Mariska Verlaan, Esther J. Kooijman, Alex J. Poot, Ronald Boellaard, Albert D. Windhorst, Guus AMS van Dongen, Danielle J. Vugts, Marc C. Huisman and Wissam Beaino

    Citation: EJNMMI Research 2021 11:57

    Content type: Original research

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  26. Considering the limited accessibility of amyloid position emission tomography (PET) in patients with dementia, we proposed a deep learning (DL)-based amyloid PET positivity classification model from PET images...

    Authors: Suhong Kim, Peter Lee, Kyeong Taek Oh, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Yu Kyeong Kim, Byoung Seok Ye, Mi Jin Yun, Dong Young Lee and Yong Jeong

    Citation: EJNMMI Research 2021 11:56

    Content type: Original research

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  27. Accurate sentinel lymph node (SLN) staging is essential for both prognosis and treatment in patients with breast cancer. However, the preoperative lymphoscintigraphy may fail to visualize the SLN in some patie...

    Authors: Youssef Chahid, Xinbo Qiu, Ewoudt M. W. van de Garde, Hein J. Verberne and Jan Booij

    Citation: EJNMMI Research 2021 11:54

    Content type: Original research

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  28. In this work, we address image segmentation in the scope of dosimetry using deep learning and make three main contributions: (a) to extend and optimize the architecture of an existing convolutional neural netw...

    Authors: Mahmood Nazari, Luis David Jiménez-Franco, Michael Schroeder, Andreas Kluge, Marcus Bronzel and Sharok Kimiaei

    Citation: EJNMMI Research 2021 11:53

    Content type: Original research

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  29. Diagnosis of Parkinson’s disease (PD) is informed by the presence of progressive motor and non-motor symptoms and by imaging dopamine transporter with [123I]ioflupane (DaTscan). Deep learning and ensemble methods...

    Authors: Kevin H. Leung, Steven P. Rowe, Martin G. Pomper and Yong Du

    Citation: EJNMMI Research 2021 11:52

    Content type: Original research

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  30. To confirm the prognostic value of previously published baseline interleukin 6 (IL6) and IL8 cutoff values in survival and liver dysfunction in patients with advanced HCC undergoing 90Y radioembolization.

    Authors: Osman Öcal, Juozas Kupčinskas, Egidijus Morkunas, Holger Amthauer, Kerstin Schütte, Peter Malfertheiner, Heinz Josef Klümpen, Christian Sengel, Julia Benckert, Ricarda Seidensticker, Bruno Sangro, Moritz Wildgruber, Maciej Pech, Peter Bartenstein, Jens Ricke and Max Seidensticker

    Citation: EJNMMI Research 2021 11:51

    Content type: Original research

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  31. Surgically induced nerve damage is a common but debilitating side effect in oncological surgery. With the aim to use fluorescence guidance to enable nerve-sparing interventions in future surgery, a fluorescent...

    Authors: Tessa Buckle, Albertus. W. Hensbergen, Danny M. van Willigen, Frank Bosse, Kevin Bauwens, Rob C. M. Pelger and Fijs W. B. van Leeuwen

    Citation: EJNMMI Research 2021 11:50

    Content type: Original research

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  32. [18F]MK-6240 is a PET tracer with sub-nanomolar affinity for neurofibrillary tangles. Therefore, tau quantification is possible with [18F]MK-6240 PET/CT scans, and it can be used for assessment of Alzheimer’s dis...

    Authors: Guilherme D. Kolinger, David Vállez García, Talakad G. Lohith, Eric D. Hostetler, Cyrille Sur, Arie Struyk, Ronald Boellaard and Michel Koole

    Citation: EJNMMI Research 2021 11:49

    Content type: Original research

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  33. There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surgery. New contrast agents are obtained by substituting the radioactive tag with, or adding a fluorescent cyanin...

    Authors: Marcus C. M. Stroet, Bianca M. Dijkstra, Sebastiaan E. Dulfer, Schelto Kruijff, Wilfred F. A. den Dunnen, Frank A. E. Kruyt, Rob J. M. Groen, Yann Seimbille, Kranthi M. Panth, Laura Mezzanotte, Clemens W. G. M. Lowik and Marion de Jong

    Citation: EJNMMI Research 2021 11:47

    Content type: Original research

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  34. Animal brain functions evaluated by in vivo imaging under anesthesia can be affected by anesthetic agents, resulting in incorrect assessment of physiological brain function. We therefore performed dynamic posi...

    Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata

    Citation: EJNMMI Research 2021 11:46

    Content type: Original research

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  35. Inflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image in...

    Authors: Romain Schollhammer, Sébastien Lepreux, Nicole Barthe, Delphine Vimont, Anne Rullier, Igor Sibon, Xavier Berard, Andrea Zhang, Yasuyuki Kimura, Masahiro Fujita, Robert B. Innis, Paolo Zanotti-Fregonara and Clément Morgat

    Citation: EJNMMI Research 2021 11:45

    Content type: Original research

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  36. High-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability for rapid data acquisition while preserving diagnostic image quality. However, determining a reliable and cl...

    Authors: Julia Pilz, Lukas Hehenwarter, Georg Zimmermann, Gundula Rendl, Gregor Schweighofer-Zwink, Mohsen Beheshti and Christian Pirich

    Citation: EJNMMI Research 2021 11:44

    Content type: Original research

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  37. 99mTc-tricarbonyl-nitrilotriacetic acid, [99mTc]Tc(CO)3(NTA), is a new 99mTc-renal radiopharmaceutical with a clearance equal to that of 131I-ortho-iodohippuran, [131I]I-OIH. Our purpose was to compare the perfor...

    Authors: Andrew T. Taylor, Malgorzata Lipowska and Raghuveer K. Halkar

    Citation: EJNMMI Research 2021 11:43

    Content type: Original research

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  38. To elucidate the biological association between tumor proliferation, tumor infiltration and neovascularization, we analyzed the association between volumetric information of 4′-[methyl-11C]thiothymidine (4DST) po...

    Authors: Takashi Norikane, Katsuya Mitamura, Yuka Yamamoto, Yukito Maeda, Kenichi Tanaka, Tetsuhiro Hatakeyama, Keisuke Miyake, Jun Toyohara and Yoshihiro Nishiyama

    Citation: EJNMMI Research 2021 11:42

    Content type: Original research

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  39. Detection of the site of recurrence using PSMA-PET/CT is important to guide treatment in patients with biochemical recurrence of prostate cancer (PCa). The aim of this study was to evaluate the positivity rate...

    Authors: Niloefar Ahmadi Bidakhvidi, Annouschka Laenen, Sander Jentjens, Christophe M. Deroose, Koen Van Laere, Liesbeth De Wever, Cindy Mai, Charlien Berghen, Gert De Meerleer, Karin Haustermans, Steven Joniau, Wouter Everaerts and Karolien Goffin

    Citation: EJNMMI Research 2021 11:41

    Content type: Original research

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  40. When Alzheimer’s disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in the case of a late onset. We aim at identifying [ ...

    Authors: Jing Li, Emanuele Antonecchia, Marco Camerlenghi, Agostino Chiaravalloti, Qian Chu, Alfonso Di Costanzo, Zhen Li, Lin Wan, Xiangsong Zhang, Nicola D’Ascenzo, Orazio Schillaci and Qingguo Xie

    Citation: EJNMMI Research 2021 11:40

    Content type: Original research

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  41. Glycolysis is increased by hypoxia, suggesting a possible correlation between the accumulation of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in malignant tumors and regional hypoxia defined by 1H-1-(3-[18F]fluoro-2-hy...

    Authors: Sadek A. Nehmeh, Mohamed B. Moussa, Nancy Lee, Pat Zanzonico, Mithat Gönen, John L. Humm and Heiko Schöder

    Citation: EJNMMI Research 2021 11:38

    Content type: Original research

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  42. Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [18F] fluorine arginine-glycine-aspartic (RGD-K5) positron emission tomography–computed tomography (PET) on ...

    Authors: David Tonnelet, M. D. Pierre Bohn, Stephanie Becker, Pierre Decazes, Vincent Camus, Sebastien Thureau, Hervé Tilly, Fabrice Jardin and Pierre Vera

    Citation: EJNMMI Research 2021 11:37

    Content type: Original research

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  43. Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used i...

    Authors: Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret and Nadja Van Camp

    Citation: EJNMMI Research 2021 11:36

    Content type: Original research

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  44. Previous studies found that the positron emission tomography (PET) radioligand [18F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to as...

    Authors: Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Mohammad B. Haskali, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis and Paolo Zanotti-Fregonara

    Citation: EJNMMI Research 2021 11:35

    Content type: Original research

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  45. The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius in the nasopharynx using prostate-specific membr...

    Authors: Yohji Matsusaka, Tomohiko Yamane, Kenji Fukushima, Akira Seto, Ichiro Matsunari and Ichiei Kuji

    Citation: EJNMMI Research 2021 11:34

    Content type: Original research

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  46. The aim of this prospective study was to evaluate a data-driven gating software’s performance, in terms of identifying the respiratory signal, comparing [68Ga]Ga-DOTATOC and [18F]FDG examinations. In addition, fo...

    Authors: Jonathan Sigfridsson, Elin Lindström, Victor Iyer, Maria Holstensson, Irina Velikyan, Anders Sundin and Mark Lubberink

    Citation: EJNMMI Research 2021 11:33

    Content type: Original research

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