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  1. We designed and synthesized a novel bisphosphonate radiopharmaceutical (68 Ga- or 177Lu-labeled DOTA-ibandronate [68 Ga/177Lu-DOTA-IBA]) for the targeted diagnosis and treatment of bone metastases. The biodistrib...

    Authors: Hongmei Li, Wenjie Pei, Xiqun Yang, Gengcuo Qu, Qingchu Hua, Lin Liu, Yudi Wang, Tingting Xu and Yue Chen
    Citation: EJNMMI Research 2024 14:30
    Content type: Original research Published on:

  2. Cancer stem cells play an important role in driving tumor growth and treatment resistance, which makes them a promising therapeutic target to prevent cancer recurrence. Emerging cance...

    Authors: Kevin Wyszatko, Nancy Janzen, Luis Rafael Silva, Luke Kwon, Teesha Komal, Manuela Ventura, Chitra Venugopal, Sheila K. Singh, John F. Valliant and Saman Sadeghi
    Citation: EJNMMI Research 2024 14:29
    Content type: Original research Published on:

  3. Neuropsychiatric sequelae of COVID-19 have been widely documented in patients with severe neurological symptoms during the chronic or subacute phase of the disease. However, it remains unclear whether subclini...

    Authors: Stephan P. M. Souza, Nicoli Colet, Mariana Fujiwara, Alins P. Fernandes, Natalia Tobar, Sergio S. J. Dertkigil, Maria Emilia S. Takahashi, Bárbara J. Amorim, Lucas S. Silva, Clarissa L. Yasuda, Fernando Cendes, Thiago F. de Souza, Juliano T. Rodrigues, Denise E. Zantut-Wittmann and Celso Dario Ramos
    Citation: EJNMMI Research 2024 14:28
    Content type: Original research Published on:

  4. Meta-analysis show the diagnostic performance of cardiac dedicated multi-pinhole cadmium-zinc-telluride myocardial perfusion imaging (MPI) with a sensibility around 0.9 and a specificity around 0.7. The aim of...

    Authors: Fabien Vauchot, Julien Dubois and Aurélie Bourdon
    Citation: EJNMMI Research 2024 14:27
    Content type: Original research Published on:

  5. Glioblastoma is an extremely aggressive malignant tumor with a very poor prognosis. Due to the increased proliferation rate of glioblastoma, there is the development of hypoxic regions, characterized by an inc...

    Authors: Catarina I. G. Pinto, André D. M. Branco, Sara Bucar, Alexandra Fonseca, Antero J. Abrunhosa, Cláudia L. da Silva, Joana F. Guerreiro and Filipa Mendes
    Citation: EJNMMI Research 2024 14:26
    Content type: Original research Published on:

  6. P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [11C]SMW139 is the most recently developed radiotracer to image P2X7 receptor. The a...

    Authors: Obada M. Alzghool, Richard Aarnio, Jatta S. Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J. Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O. Rinne and Merja Haaparanta-Solin
    Citation: EJNMMI Research 2024 14:25
    Content type: Original research Published on:

    The Correction to this article has been published in EJNMMI Research 2024 14:44

  7. Correct classification of estrogen receptor (ER) status is essential for prognosis and treatment planning in patients with breast cancer (BC). Therefore, it is recommended to sample tumor tissue from an access...

    Authors: Mette A. Pedersen, Ole L. Munk, André H. Dias, Johanne H. Steffensen, Anders L. Møller, Anna Lyhne Johnsson, Kim Vang Hansen, Dirk Bender, Steen Jakobsen, Morten Busk, Lars C. Gormsen, Trine Tramm, Signe Borgquist and Mikkel H. Vendelbo
    Citation: EJNMMI Research 2024 14:24
    Content type: Original research Published on:

  8. We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in t...

    Authors: Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester and Thomas Günther
    Citation: EJNMMI Research 2024 14:23
    Content type: Original research Published on:

  9. Cisplatin- based chemoradiotherapy is a crucial pillar in the treatment of HNSCC. The use of cisplatin comes with high toxicity rates as 35% of patients cannot sustain the planned dose while response is unpred...

    Authors: Reinout H. de Roest, Marijke Stigter van Walsum, Karlijn van der Schilden and Ruud H. Brakenhoff
    Citation: EJNMMI Research 2024 14:22
    Content type: Original research Published on:

  10. 18F-FDG positron emission tomography (PET) plays a crucial part in the evaluation for pediatric epileptic patients prior to therapy. Short-term scanning holds significant importance, especially for pediatrics ep....

    Authors: Min Li, Xiao Cui, Huixin Yue, Chao Ma, Kun Li, Leiying Chai, Min Ge, Hui Li, Yee Ling Ng, Yun Zhou, Jianguo Shi, Yanhua Duan and Zhaoping Cheng
    Citation: EJNMMI Research 2024 14:21
    Content type: Original research Published on:

  11. In the present study, we aimed to investigate the role of baseline (B), interim (I) and end-of-treatment (Eot) 18F-FDG PET/CT in assessing the prognosis of diffuse large B cell lymphoma (DLBCL), so as to identify...

    Authors: Wenyu Zhao, Xiaodong Wu, Shuo Huang, Hui Wang and Hongliang Fu
    Citation: EJNMMI Research 2024 14:20
    Content type: Original research Published on:

  12. Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, ther...

    Authors: Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier and Albert D. Windhorst
    Citation: EJNMMI Research 2024 14:19
    Content type: Original research Published on:

  13. Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irre...

    Authors: Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt and Marc C. Huisman
    Citation: EJNMMI Research 2024 14:18
    Content type: Original research Published on:

  14. Endometriosis is characterized by the ectopic occurrence of endometrial tissue. Though considered benign, endometriotic lesions possess tumor-like properties such as tissue invasion and remodeling of the extra...

    Authors: Belinda Trachsel, Stefan Imobersteg, Giulia Valpreda, Gad Singer, Regula Grabherr, Mark Ormos, Irene A. Burger, Rahel A. Kubik-Huch, Roger Schibli, Viola Vogel and Martin Béhé
    Citation: EJNMMI Research 2024 14:17
    Content type: Original research Published on:

  15. The prevalence of ischemia with non-obstructive coronary artery disease (INOCA) is substantial, but its risk stratification has been suboptimal. Resting SPECT myocardial perfusion imaging (MPI) could provide u...

    Authors: Yuting Zhao, Yingqi Hu, Yuanyuan Li, Yanhui Wang, Yuxin Xiao, Li Xu, Tailin Ren, Qiuyan Wu, Ruonan Wang, Zhifang Wu, Sijin Li and Ping Wu
    Citation: EJNMMI Research 2024 14:16
    Content type: Original research Published on:

  16. Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer-related deaths in men. Prostate-specific membrane antigen (PSMA) as a target has gained increasing attention. This resea...

    Authors: Yang Liu, Li Xia, Haiyang Li, Ping Cai, Sufan Tang, Yue Feng, Guangfu Liu, Yue Chen, Nan Liu, Wei Zhang and Zhijun Zhou
    Citation: EJNMMI Research 2024 14:15
    Content type: Original research Published on:

  17. Previous studies have demonstrated that delayed [68 Ga]Ga-PSMA PET/CT imaging improves lesion detection compared to early [68 Ga]Ga-PSMA PET/CT in patients with prostate cancer. However, the sole use of delayed [

    Authors: Xiaofeng Yu, Lian Xu, Gang Huang, Jianjun Liu, Ruohua Chen and Yumei Chen
    Citation: EJNMMI Research 2024 14:14
    Content type: Original research Published on:

  18. Peptide receptor radionuclide therapy is effective in treating neuroendocrine tumours, but treatment may be limited by kidney and bone marrow toxicity. In this work, the absorbed dose burden to the bone marrow...

    Authors: Märta Persson, Cecilia Hindorf, Oscar Ardenfors, Martin Larsson and Joachim N. Nilsson
    Citation: EJNMMI Research 2024 14:13
    Content type: Original research Published on:

  20. [15O]H2O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis and treatment of peripheral artery disease. We aimed to evaluate the reliability of dy...

    Authors: Nana Louise Christensen, Jens Sørensen, Kirsten Bouchelouche, Michael Alle Madsen, Christian Selmer Buhl and Lars Poulsen Tolbod
    Citation: EJNMMI Research 2024 14:11
    Content type: Original research Published on:

  21. The indirect method for generating parametric images in positron emission tomography (PET) involves the acquisition and reconstruction of dynamic images and temporal modelling of tissue activity given a measur...

    Authors: Rajat Vashistha, Hamed Moradi, Amanda Hammond, Kieran O’Brien, Axel Rominger, Hasan Sari, Kuangyu Shi, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:10
    Content type: Original research Published on:

  22. Developing biomarkers for early stage AD patients is crucial. Glucose metabolism measured by 18F-FDG PET is the most common biomarker for evaluating cellular energy metabolism to diagnose AD. Arterial spin labeli...

    Authors: Sheng Bi, Shaozhen Yan, Zhigeng Chen, Bixiao Cui, Yi Shan, Hongwei Yang, Zhigang Qi, Zhilian Zhao, Ying Han and Jie Lu
    Citation: EJNMMI Research 2024 14:9
    Content type: Original research Published on:

  23. The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury. Hence, we...

    Authors: Yong-il Kim, Seung Hak Lee, Jin Hwa Jung, Seog-Young Kim, Nare Ko, Sang Ju Lee, Seung Jun Oh, Jin-Sook Ryu, Dabin Ko, Won Kim and Kyunggon Kim
    Citation: EJNMMI Research 2024 14:8
    Content type: Original research Published on:

  24. Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targetin...

    Authors: Victoria J. M. Reid, Wesley K. X. McLoughlin, Kalyani Pandya, Holly Stott, Monika Iškauskienė, Algirdas Šačkus, Judit A. Marti, Dominic Kurian, Thomas M. Wishart, Christophe Lucatelli, Dan Peters, Gillian A. Gray, Andrew H. Baker, David E. Newby, Patrick W. F. Hadoke, Adriana A. S. Tavares…
    Citation: EJNMMI Research 2024 14:7
    Content type: Original research Published on:

  25. 68Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified a....

    Authors: Nathaniel J. Smith, Mark A. Green, Clinton D. Bahler, Mark Tann, Wendy Territo, Anne M. Smith and Gary D. Hutchins
    Citation: EJNMMI Research 2024 14:6
    Content type: Original research Published on:

  26. Immune checkpoint inhibitors (ICIs) have made significant progress in oncotherapy improving survival of patients. However, the benefits are limited to only a small subgroup of patients who could achieve durabl...

    Authors: Xiaoyu Fan, Hans W. Nijman, Marco de Bruyn and Philip H. Elsinga
    Citation: EJNMMI Research 2024 14:5
    Content type: Review Published on:

  27. The influence of anaesthetic depth and the potential influence of different anaesthetic beds and thus different handling procedures were investigated in 86 severe combined immunodeficient (SCID) mice using sem...

    Authors: Fabian Schmitz-Peiffer, Mathias Lukas, Ajay-Mohan Mohan, Jakob Albrecht, Jörg R. Aschenbach, Winfried Brenner and Nicola Beindorff
    Citation: EJNMMI Research 2024 14:4
    Content type: Original research Published on:

  29. The identification of biomarkers predicting the treatment response of rheumatoid arthritis (RA) is important. [68 Ga]Ga-FAPI-04 showed markedly increased uptake in the joints of patients with RA. The purpose of t...

    Authors: Qingqing Pan, Huaxia Yang, Ziyue Zhou, Min Li, Xu Jiang, Fang Li, Yaping Luo and Mengtao Li
    Citation: EJNMMI Research 2024 14:2
    Content type: Original research Published on:

  30. In parametric PET, kinetic parameters are extracted from dynamic PET images. It is not commonly used in clinical practice because of long scan times and the requirement for an arterial input function (AIF). To...

    Authors: Hamed Moradi, Rajat Vashistha, Kieran O’Brien, Amanda Hammond, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:1
    Content type: Original research Published on:

  31. The diagnostic accuracy of [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography imaging in accurately identifying thyroid lesions is limited, primarily due to the physiological uptake of normal head ...

    Authors: Yuhua Wang, Ye Liu, Huixia Geng and Wanchun Zhang
    Citation: EJNMMI Research 2023 13:109
    Content type: Review Published on:

  32. Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only avail...

    Authors: Peter Iversen, Stine Kramer, Andreas Ebbehoj, Esben Søndergaard, Kirstine Stochholm, Per Løgstrup Poulsen and Karin Hjorthaug
    Citation: EJNMMI Research 2023 13:108
    Content type: Original research Published on:

  33. Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1 diabetes, but widespread application is challenging due to shortages of donor...

    Authors: Pierre Cheung, Julia Thorngren, Bo Zhang, Svitlana Vasylovska, Francesco Lechi, Jonas Persson, Stefan Ståhl, John Löfblom, Olle Korsgren, Jonas Eriksson, Joey Lau and Olof Eriksson
    Citation: EJNMMI Research 2023 13:107
    Content type: Original research Published on:

  34. The apolipoprotein E-deficient (apoE−/−) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. ...

    Authors: Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx and Riemer H. J. A. Slart
    Citation: EJNMMI Research 2023 13:106
    Content type: Original research Published on:

  35. This study aimed to assess whether a combined model incorporating radiomic and depth features extracted from PET/CT can predict disease-free survival (DFS) in patients who failed to achieve pathologic complete...

    Authors: Xingxing Zheng, Yuhong Huang, Yingyi Lin, Teng Zhu, Jiachen Zou, Shuxia Wang and Kun Wang
    Citation: EJNMMI Research 2023 13:105
    Content type: Original research Published on:

  36. Until recently, quantitation of the net influx of 2-[18F]fluorodeoxyglucose (FDG) to brain (Ki) and the cerebrometabolic rate for glucose (CMRglc) required serial arterial blood sampling in conjunction with dynam...

    Authors: Paul Cumming, André H. Dias, Lars C. Gormsen, Allan K. Hansen, Ian Alberts, Axel Rominger, Ole L. Munk and Hasan Sari
    Citation: EJNMMI Research 2023 13:104
    Content type: Original research Published on:

  37. Metabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate the preclinical model of aortitis in BALB/c IL1rn−/− mice using [18F]fluorodeoxyglucose (...

    Authors: Samuel Deshayes, Caroline Baugé, Pierre-Antoine Dupont, Christophe Simard, Hanan Rida, Hubert de Boysson, Alain Manrique and Achille Aouba
    Citation: EJNMMI Research 2023 13:103
    Content type: Original research Published on:

  38. Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor microenvironment (TME) of BM and particularly hypoxia and redox state, known to play a ro...

    Authors: Jade Fantin, Jérôme Toutain, Elodie A. Pérès, Benoit Bernay, Sarina Maya Mehani, Charly Helaine, Mickael Bourgeois, Carole Brunaud, Laurent Chazalviel, Julien Pontin, Aurélien Corroyer-Dulmont, Samuel Valable, Michel Cherel and Myriam Bernaudin
    Citation: EJNMMI Research 2023 13:102
    Content type: Original research Published on:

  39. Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of this study was to evaluate the distribution of Lipiodol® ultra-fluid and microspheres a...

    Authors: Arnaud Dieudonné, Stéphanie Becker, Miguel Soares, Claire Hollenbeck, Marie-Christine De Goltstein, Pierre Vera and Robin Santus
    Citation: EJNMMI Research 2023 13:101
    Content type: Original research Published on:

  40. CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive ...

    Authors: Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman and Marco de Bruyn
    Citation: EJNMMI Research 2023 13:100
    Content type: Original research Published on:

  41. Targeting prostate-specific membrane antigen (PSMA) has been highly successful for imaging and treatment of prostate cancer. However, heterogeneity in immunohistochemistry indicates limitations in the effect o...

    Authors: Hui Wang, Marianne Remke, Thomas Horn, Kristina Schwamborn, Yiyao Chen, Katja Steiger, Wilko Weichert, Hans-Jürgen Wester, Margret Schottelius, Wolfgang A. Weber and Matthias Eiber
    Citation: EJNMMI Research 2023 13:99
    Content type: Original research Published on:

  42. Brain [18F]FDG PET is used clinically mainly in the presurgical evaluation for epilepsy surgery and in the differential diagnosis of neurodegenerative disorders. While scans are usually interpreted visually on an...

    Authors: Sameer Omer Jin, Inés Mérida, Ioannis Stavropoulos, Robert D. C. Elwes, Tanya Lam, Eric Guedj, Nadine Girard, Nicolas Costes and Alexander Hammers
    Citation: EJNMMI Research 2023 13:98
    Content type: Original research Published on:

  43. The need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research settings. Image-derived input function (IDIF) approaches have been proposed ...

    Authors: Tommaso Volpi, Lucia Maccioni, Maria Colpo, Giulia Debiasi, Amedeo Capotosti, Tommaso Ciceri, Richard E. Carson, Christine DeLorenzo, Andreas Hahn, Gitte Moos Knudsen, Adriaan A. Lammertsma, Julie C. Price, Vesna Sossi, Guobao Wang, Paolo Zanotti-Fregonara, Alessandra Bertoldo…
    Citation: EJNMMI Research 2023 13:97
    Content type: Review Published on:

  44. Splenic switch-off (SSO) is a marker of adequate adenosine-induced vasodilatation on cardiac magnetic resonance perfusion imaging. We evaluate the feasibility of quantitative assessment of SSO in myocardial po...

    Authors: Satu Irene Inkinen, Eero Hippeläinen and Valtteri Uusitalo
    Citation: EJNMMI Research 2023 13:96
    Content type: Original research Published on:

  45. PSMA expression is influenced by hormonal status. We evaluated changes in PSA and whole-body 68Ga-PSMA-11 PET/CT (WB-PSMA PET) after initiation of androgen receptor signaling inhibitors (ARSi).

    Authors: Ida Sonni, Andrei Gafita, Lena M. Unterrainer, Rejah M. Alano, Stephanie Lira, John Shen, Alexandra Drakaki, Tristan Grogan, Matthew B. Rettig, Johannes Czernin and Jeremie Calais
    Citation: EJNMMI Research 2023 13:95
    Content type: Short communication Published on:

  46. Owing to the advances in diagnosis and therapy, survival or remission rates for lymphoma have improved prominently. Apart from the lymphoma- and chemotherapy-related somatic symptom burden, increasing attentio...

    Authors: Junyi Liu, Ming Tang, Dongling Zhu, Ge Ruan, Sijuan Zou, Zhaoting Cheng, Xiaohua Zhu and Yuankai Zhu
    Citation: EJNMMI Research 2023 13:94
    Content type: Original research Published on:

  47. Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggeste...

    Authors: Hayel Tuncel, Denise Visser, Tessa Timmers, Emma E. Wolters, Rik Ossenkoppele, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard and Sandeep S. V. Golla
    Citation: EJNMMI Research 2023 13:93
    Content type: Original research Published on:

  48. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults. Standard treatment includes chemoimmunotherapy with R-CHOP or similar regimens. Despite treatment advancement...

    Authors: Fenglian Jing, Yunuan Liu, Xinming Zhao, Na Wang, Meng Dai, Xiaolin Chen, Zhaoqi Zhang, Jingmian Zhang, Jianfang Wang and Yingchen Wang
    Citation: EJNMMI Research 2023 13:92
    Content type: Original research Published on:

  49. The EANM Research Ltd. (EARL) guidelines give recommendations for harmonization of [18F]FDG PET-CT image acquisition and reconstruction, aiming to ensure reproducibility of quantitative data between PET scanners....

    Authors: Maurice C. Cox, Tijn Jurcka, Anne I. J. Arens, Maartje C. van Rijk, Johannes H. A. M. Kaanders and Sven van den Bosch
    Citation: EJNMMI Research 2023 13:91
    Content type: Original research Published on:

  50. After myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse cardiac remodeling. FDG PET is an imaging modality sensitive to inflammation as long a...

    Authors: Benjamin Wilk, Haris Smailovic, Rebecca Sullivan, Erik R. Sistermans, John Butler, Hannah Jago, Michael Kovacs, Gerald Wisenberg, Jonathan D. Thiessen and Frank S. Prato
    Citation: EJNMMI Research 2023 13:90
    Content type: Original research Published on:

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