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  1. 68 Ga-PSMA PET is the leading prostate cancer imaging technique, but the image quality remains noisy and could be further improved using an artificial intelligence-based denoising algorithm. To address this issu....

    Authors: Charles Margail, Charles Merlin, Tommy Billoux, Maxence Wallaert, Hosameldin Otman, Nicolas Sas, Ioana Molnar, Florent Guillemin, Louis Boyer, Laurent Guy, Marion Tempier, Sophie Levesque, Alban Revy, Florent Cachin and Marion Chanchou
    Citation: EJNMMI Research 2023 13:50
    Content type: Original research Published on:

  2. The determination of pathological grading has a guiding significance for the treatment of pancreatic ductal adenocarcinoma (PDAC) patients. However, there is a lack of an accurate and safe method to obtain pat...

    Authors: Gong Zhang, Chengkai Bao, Yanzhe Liu, Zizheng Wang, Lei Du, Yue Zhang, Fei Wang, Baixuan Xu, S. Kevin Zhou and Rong Liu
    Citation: EJNMMI Research 2023 13:49
    Content type: Original research Published on:

  3. Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease pathogenesis. In clinical practice, trained readers will visually categorise positron emission tomography (PET) s...

    Authors: Hugh G. Pemberton, Christopher Buckley, Mark Battle, Ariane Bollack, Vrajesh Patel, Petya Tomova, David Cooke, Will Balhorn, Katherine Hegedorn, Johan Lilja, Christine Brand and Gill Farrar
    Citation: EJNMMI Research 2023 13:48
    Content type: Original research Published on:

  4. Alzheimer’s disease-related pattern (ADRP) is a metabolic brain biomarker of Alzheimer’s disease (AD). While ADRP is being introduced into research, the effect of the size of the identification cohort and the ...

    Authors: Eva Štokelj, Petra Tomše, Tadej Tomanič, Vijay Dhawan, David Eidelberg, Maja Trošt and Urban Simončič
    Citation: EJNMMI Research 2023 13:47
    Content type: Original research Published on:

  5. The dopamine transporter (DaT) PET ligand [18F]FE-PE2I is used to aid the diagnosis of Parkinson’s disease. After encountering four patients with a history of daily sertraline use, who all showed atypical finding...

    Authors: Thomas E. H. Justesen, Per Borghammer, Joel Aanerud, Peter Hovind and Lisbeth Marner
    Citation: EJNMMI Research 2023 13:46
    Content type: Short communication Published on:

  6. The accumulation of 177Lu-DOTATATE might be influenced by the amount of administered peptide in relation to the tumor somatostatin receptor expression. The effect of the administered peptide mass on the resulting...

    Authors: Ulrika Jahn, Ulrike Garske-Román, Mattias Sandström, Mark Lubberink and Anders Sundin
    Citation: EJNMMI Research 2023 13:45
    Content type: Original research Published on:

  7. Myocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis. Measurement of myocardial PD-L1 expression may have potential use as a mechani...

    Authors: Muhummad Sohaib Nazir, Daniel Johnathan Hughes, Gitasha Chand, Kathryn Adamson, Jessica Johnson, Damion Bailey, Victoria Gibson, Hong Hoi Ting, Alexander R. Lyon and Gary J. R. Cook
    Citation: EJNMMI Research 2023 13:44
    Content type: Original research Published on:

  8. Expanding therapeutic possibilities have improved disease-related prospects for breast cancer patients. Pathological analysis on a tumor biopsy is the current reference standard biomarker used to select for tr...

    Authors: Renske Altena, Antonios Tzortzakakis, Siri Af Burén, Thuy A. Tran, Fredrik Y. Frejd, Jonas Bergh and Rimma Axelsson
    Citation: EJNMMI Research 2023 13:43
    Content type: Review Published on:

  9. By clearing GABA from the synaptic cleft, GABA transporters (GATs) play an essential role in inhibitory neurotransmission. Consequently, in vivo visualization of GATs can be a valuable diagnostic tool and biom...

    Authors: Niels Knippenberg, Matthias Bauwens, Olaf Schijns, Govert Hoogland, Alexandru Florea, Kim Rijkers, Thomas J. Cleij, Kasper Eersels, Bart van Grinsven and Hanne Diliën
    Citation: EJNMMI Research 2023 13:42
    Content type: Review Published on:

  11. CXCR4-targeted radioligand therapy (RLT) with [177Lu]Lu/[90Y]Y-PentixaTher has recently evolved as a promising therapeutic option for patients with advanced hematological cancers. Given their advanced disease sta...

    Authors: Sebastian Martin, David Viertl, Anna Janz, Stefan Habringer, Ulrich Keller and Margret Schottelius
    Citation: EJNMMI Research 2023 13:40
    Content type: Short communication Published on:

  13. Accumulating studies have demonstrated that elevated TIGIT expression in tumor microenvironment correlates with better therapeutic response to TIGIT-based immunotherapy in pre-clinical studies. Therefore, a no...

    Authors: Dinghu Weng, Rong Guo, Ziyang Zhu, Yu Gao, Rui An and Xiuman Zhou
    Citation: EJNMMI Research 2023 13:38
    Content type: Original research Published on:

  14. To show the equivalence between the specific binding ratios (SBR) of visually normal 123I-FP-CIT SPECT scans from patients to those from healthy volunteers (Hv) or patients without dopaminergic degeneration to al...

    Authors: Anthime Flaus, Remi Philippe, Stephane Thobois, Marc Janier and Christian Scheiber
    Citation: EJNMMI Research 2023 13:37
    Content type: Original research Published on:

  15. (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a promising PET probe for imaging the tumor-specific L-type amino acid transporter (LAT) 1. Our previous study revealed tha...

    Authors: Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi and Yasuyoshi Watanabe
    Citation: EJNMMI Research 2023 13:36
    Content type: Original research Published on:

  16. Early intrahepatic recurrence is common after surgical resection of hepatocellular carcinoma (HCC) and leads to increased morbidity and mortality. Insensitive and nonspecific diagnostic imaging contributes to ...

    Authors: Kevin P. Labadie, Adrienne L. Lehnert, Aimee L. Kenoyer, Donald K. Hamlin, Andrew D. Ludwig, Alan F. Utria, Sara K. Daniel, Tara N. Mihailovic, Alexander Prossnitz, Johnnie J. Orozco, Yawen Li, D. Scott Wilbur, Robert S. Miyaoka and James O. Park
    Citation: EJNMMI Research 2023 13:35
    Content type: Original research Published on:

  17. Prostate-Specific Membrane Antigen (PSMA) PET/CT and multiparametric MRI (mpMRI) are well-established modalities for identifying intra-prostatic lesions (IPLs) in localised prostate cancer. This study aimed to...

    Authors: Tsz Him Chan, Annette Haworth, Alan Wang, Mahyar Osanlouy, Scott Williams, Catherine Mitchell, Michael S. Hofman, Rodney J. Hicks, Declan G. Murphy and Hayley M. Reynolds
    Citation: EJNMMI Research 2023 13:34
    Content type: Original research Published on:

  18. The IQ-SPECT system is equipped with multifocal collimators and uses ordered-subset conjugate gradient minimization (OSCGM) as its reconstruction algorithm, achieving a shorter acquisition time than convention...

    Authors: Hua Wei, Jiaojiao Wu, Ke Han, Guang Hu, Hongliang Wang, Xiaoshan Guo, Haiyan Liu, Zhifang Wu and Sijin Li
    Citation: EJNMMI Research 2023 13:33
    Content type: Original research Published on:

  19. The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential chan...

    Authors: Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli and Cristina Müller
    Citation: EJNMMI Research 2023 13:32
    Content type: Original research Published on:

  20. Routine prostate-specific membrane antigen (PSMA) positron emission tomography (PET) performed for primary staging or restaging of prostate cancer patients is usually done as a single static image acquisition ...

    Authors: André H. Dias, Mads R. Jochumsen, Helle D. Zacho, Ole L. Munk and Lars C. Gormsen
    Citation: EJNMMI Research 2023 13:31
    Content type: Original research Published on:

  22. Correlations between dopamine transporter (DAT) availability and Parkinson’s disease (PD) motor symptoms vary depending on the imaging modality, choice of regions of interest and clinical measures. We aimed to...

    Authors: Vera S. Kerstens, Patrik Fazio, Mathias Sundgren, Christer Halldin, Per Svenningsson and Andrea Varrone
    Citation: EJNMMI Research 2023 13:29
    Content type: Original research Published on:

  23. We recently reported 11C-NR2B-SMe ([S-methyl-11C](R,S)-7-thiomethoxy-3-(4-(4-methyl-phenyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol) and its enantiomers as candidate radioligands for imaging the GluN2B su...

    Authors: Lisheng Cai, Jeih-San Liow, Cheryl L. Morse, Sanjay Telu, Riley Davies, Lester S. Manly, Sami S. Zoghbi, Frederick T. Chin, Robert B. Innis and Victor W. Pike
    Citation: EJNMMI Research 2023 13:28
    Content type: Original research Published on:

  24. The high incidence of epidermal growth factor receptor (EGFR) mutations is usually found in female patients with lung adenocarcinoma who have never-smoked. However, reports concerning male patients are scarce....

    Authors: Maoqing Jiang, Ping Chen, Xiuyu Guo, Xiaohui Zhang, Qiaoling Gao, Jingfeng Zhang, Guofang Zhao and Jianjun Zheng
    Citation: EJNMMI Research 2023 13:27
    Content type: Original research Published on:

  25. This study aims to construct radiomics models based on [18F]FDG PET/CT using multiple machine learning methods to predict the EGFR mutation status of lung adenocarcinoma and evaluate whether incorporating clinica...

    Authors: Jianxiong Gao, Rong Niu, Yunmei Shi, Xiaoliang Shao, Zhenxing Jiang, Xinyu Ge, Yuetao Wang and Xiaonan Shao
    Citation: EJNMMI Research 2023 13:26
    Content type: Original research Published on:

  26. Osteoradionecrosis (ORN) of the jaw requires a differential diagnosis to exclude cancer recurrence. Here, we sought to develop a scoring system comprising 18F-FDG PET/CT parameters for distinguishing between the ...

    Authors: Nai-Ming Cheng, Chien-Yu Lin, Chun-Ta Liao, Din-Li Tsan, Shu-Hang Ng and Tzu-Chen Yen
    Citation: EJNMMI Research 2023 13:25
    Content type: Original research Published on:

  27. The aims of this study were to establish a normal database (NDB) for semiquantification of dopamine transporter (DAT) single-photon emission computed tomography (SPECT) with [123I]FP-CIT on a cadmium zinc telluri...

    Authors: Felix Thiele, Franziska Schau, Julian M. M. Rogasch, Christoph Wetz, Stephanie Bluemel, Winfried Brenner, Holger Amthauer, Catharina Lange and Imke Schatka
    Citation: EJNMMI Research 2023 13:24
    Content type: Original research Published on:

  28. Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhi...

    Authors: Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard and Albert D. Windhorst
    Citation: EJNMMI Research 2023 13:23
    Content type: Original research Published on:

  29. IgG4-related disease (IgG4-RD) is a heterogeneous autoimmune disorder characterised by inflammatory lesions. Diagnostic imaging, such as 2-[18F]FDG PET/CT, is critical in evaluation of the disease, especially for...

    Authors: Mingwei Chen, Charlene Yu Lin Tang, Warren Weng Seng Fong and Winnie Wing-Chuen Lam
    Citation: EJNMMI Research 2023 13:22
    Content type: Original research Published on:

  30. In the development of new 18F-labelled tracers, it is important to assess the amount of released [18F]fluoride taken up in the bones of experimental animals because all 18F-labelled PET-tracers are prone, to less...

    Authors: Nina Savisto, Tove J. Grönroos, Vesa Oikonen, Johan Rajander, Eliisa Löyttyniemi, Jörgen Bergman, Sarita Forsback, Olof Solin and Merja Haaparanta-Solin
    Citation: EJNMMI Research 2023 13:21
    Content type: Original research Published on:

  31. PET/MRI hybrid imaging in pulmonary arterial hypertension (PAH) provides important prognostic information identifying patients who might benefit from early therapy escalation, as right ventricle (RV) metabolic...

    Authors: Remigiusz Kazimierczyk, Piotr Szumowski, Stephan G. Nekolla, Lukasz A. Malek, Piotr Blaszczak, Marcin Hladunski, Bozena Sobkowicz, Janusz Mysliwiec and Karol A. Kaminski
    Citation: EJNMMI Research 2023 13:20
    Content type: Original research Published on:

  32. Authors: Lisbeth Marner, Kirsten Korsholm, Lasse Anderberg, Markus N. Lonsdale, Mads Radmer Jensen, Eva Brødsgaard, Charlotte L. Denholt, Nic Gillings, Ian Law and Lars Friberg
    Citation: EJNMMI Research 2023 13:19
    Content type: Correction Published on:

    The original article was published in EJNMMI Research 2022 12:56

  33. To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants.

    Authors: Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Raffaele Cacciaglia, Gemma Salvadó, Mahnaz Shekari, Lyduine E. Collij, Christopher Buckley, Bart N. M. van Berckel, Andrés Perissinotti, Aida Niñerola-Baizán, Marta Milà-Alomà, Natàlia Vilor-Tejedor, Grégory Operto, Carles Falcon, Oriol Grau-Rivera, Eider M. Arenaza-Urquijo…
    Citation: EJNMMI Research 2023 13:18
    Content type: Original research Published on:

  34. 44Sc/47Sc is an attractive theranostic pair for targeted in vivo positron emission tomographic (PET) imaging and beta-particle treatment of cancer. The 44Ti/44Sc generator allows daily onsite production of this d...

    Authors: Nadia Benabdallah, Hanwen Zhang, Ryan Unnerstall, Amanda Fears, Lucy Summer, Michael Fassbender, Buck E. Rodgers, Diane Abou, Valery Radchenko and Daniel L. J. Thorek
    Citation: EJNMMI Research 2023 13:17
    Content type: Original research Published on:

  36. We aimed to evaluate the correlation between 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake and disease activity assessed by serum inflammatory biomarker levels in patients with spondyloarthritis (SpA).

    Authors: Yuri Manabe, Takashi Norikane, Yuka Yamamoto, Mitsumasa Murao, Hiromi Shimada, Risa Wakiya, Shusaku Nakashima, Hiroaki Dobashi and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2023 13:15
    Content type: Original research Published on:

  37. By comparing the prognostic performance of 18F-FDG PET/CT-based radiomics combining dose features [Includes Dosiomics feature and the dose volume histogram (DVH) features] with that of conventional radiomics in h...

    Authors: Bingzhen Wang, Jinghua Liu, Xiaolei Zhang, Zhongxiao Wang, Zhendong Cao, Lijun Lu, Wenbing Lv, Aihui Wang, Shuyan Li, Xiaotian Wu and Xianling Dong
    Citation: EJNMMI Research 2023 13:14
    Content type: Original research Published on:

  38. To decipher the relevance of visual and semi-quantitative 6-fluoro-(18F)-L-DOPA (18F-DOPA) interpretation methods for the diagnostic of idiopathic Parkinson disease (IPD) in hybrid positron emission tomography (P...

    Authors: Alex Iep, Mohammad B. Chawki, Lucas Goldfarb, Loc Nguyen, Vincent Brulon, Claude Comtat, Vincent Lebon and Florent L. Besson
    Citation: EJNMMI Research 2023 13:13
    Content type: Original research Published on:

  39. Authors: Ramya Ambur Sankaranarayanan, Alexandru Florea, Susanne Allekotte, Andreas T. J. Vogg, Jochen Maurer, Laura Schäfer, Carsten Bolm, Steven Terhorst, Arno Classen, Matthias Bauwens, Agnieszka Morgenroth and Felix M. Mottaghy
    Citation: EJNMMI Research 2023 13:12
    Content type: Correction Published on:

    The original article was published in EJNMMI Research 2022 12:60

  40. For positron emission tomography (PET) ligands, such as [11C]ABP688, to be able to provide more evidence about the glutamatergic hypothesis in schizophrenia (SZ), quantification bias during dynamic PET studies an...

    Authors: Cláudia Régio Brambilla, Jürgen Scheins, Lutz Tellmann, Ahlam Issa, Hans Herzog, N. Jon Shah, Irene Neuner and Christoph W. Lerche
    Citation: EJNMMI Research 2023 13:11
    Content type: Original research Published on:

  41. To evaluate the utility of 68Ga-DOTATATE and 18F-FDG PET/MR for prediction of grade and stage of pancreatic neuroendocrine tumors (PNETs), and to examine the correlation between parameters obtained from FDG PET a...

    Authors: Jing Gao, Si Xu, Huijun Ju, Yu Pan and Yifan Zhang
    Citation: EJNMMI Research 2023 13:10
    Content type: Original research Published on:

  42. 82-Rubidium-Positron emission tomography myocardial perfusion imaging (Rb-PET-MPI) offers higher diagnostic performance for the detection of myocardial ischemia compared to Tc-SPECT-MPI. The aim of this econom...

    Authors: Maroua Mimouni, Julie Bulsei, Meryl Darlington, Candice Estellat, François Rouzet, Fabien Hyafil and Isabelle Durand-Zaleski
    Citation: EJNMMI Research 2023 13:9
    Content type: Original research Published on:

  43. Little is known about parameters that have a relevant impact on (dis)similarities in biodistribution between various 68Ga-labeled somatostatin analogues. Additionally, the effect of tumor burden on organ uptake r...

    Authors: Hinke Siebinga, Berlinda J. de Wit-van der Veen, Jos H. Beijnen, Thomas P. C. Dorlo, Alwin D. R. Huitema and Jeroen J. M. A. Hendrikx
    Citation: EJNMMI Research 2023 13:8
    Content type: Original research Published on:

  45. Dosimetry in [177Lu]Lu-PSMA therapy is a valuable tool to assess treatment efficacy and toxicity. This study aims to develop a clinically implementable protocol to determine the absorbed dose in organs and tumor ...

    Authors: Steffie M. B. Peters, Maaike C. T. Mink, Bastiaan M. Privé, Maarten de Bakker, Frank de Lange, Constantijn H. J. Muselaers, Niven Mehra, J. Alfred Witjes, Martin Gotthardt, James Nagarajah and Mark W. Konijnenberg
    Citation: EJNMMI Research 2023 13:6
    Content type: Original research Published on:

  46. To quantify the relationship between [18F]FDG uptake of the primary tumour measured by PET-imaging with immunohistochemical (IHC) expression of ER, PR, HER2, Ki-67, and clinical subtypes based on these markers...

    Authors: Cornelis M. de Mooij, Roxanne A. W. Ploumen, Patty J. Nelemans, Felix M. Mottaghy, Marjolein L. Smidt and Thiemo J. A. van Nijnatten
    Citation: EJNMMI Research 2023 13:5
    Content type: Review Published on:

  47. In recent years, immune checkpoint inhibitor (ICI) therapy has greatly changed the treatment prospects of patients with non-small cell lung cancer (NSCLC). Among the available ICI therapy strategies, programme...

    Authors: Xiaoqian Zhao, Yan Zhao, Jingmian Zhang, Zhaoqi Zhang, Lihua Liu and Xinming Zhao
    Citation: EJNMMI Research 2023 13:4
    Content type: Original research Published on:

  48. Positron emission tomography (PET)/computed tomography (CT) imaging with fluorine-18 (18F)-sodium fluoride (NaF) provides assessment of active vascular microcalcification, but its utility for evaluating diabetes ...

    Authors: Ting-Heng Chou, Eleanor T. Rimmerman, Surina Patel, Molly K. Wynveen, Susan N. Eisert, Kumudha Narayana Musini, Sarah A. Janse, Adam J. Bobbey, Timur P. Sarac, Said A. Atway, Michael R. Go and Mitchel R. Stacy
    Citation: EJNMMI Research 2023 13:3
    Content type: Original research Published on:

  49. Radioguided surgery (RGS) has recently emerged as a valuable new tool in the management of recurrent prostate cancer (PCa). After preoperative injection of a 99mTc-labeled prostate-specific membrane antigen (PSMA...

    Authors: Jan-Philip Kunert, Max Müller, Thomas Günther, León Stopper, Nicole Urtz-Urban, Roswitha Beck and Hans-Jürgen Wester
    Citation: EJNMMI Research 2023 13:2
    Content type: Original research Published on:

  50. The purpose of this study was to assess the feasibility of using a minimally invasive simultaneous estimation method (SIME) to quantify the binding of the 18-kDa translocator protein tracer [18F]FEPPA. Arterial s...

    Authors: Praveen Dassanayake, Udunna C. Anazodo, Linshan Liu, Lucas Narciso, Maryssa Iacobelli, Justin Hicks, Pablo Rusjan, Elizabeth Finger and Keith St Lawrence
    Citation: EJNMMI Research 2023 13:1
    Content type: Original Research Published on:

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