Somatostatin receptor targeting radiopeptides are successfully being used to image, stage, and monitor patients with neuroendocrine tumours. They are exclusively agonists that internalise upon binding to the r...
Authors: Keelara Abiraj, Samer Ursillo, Maria Luisa Tamma, Svetlana N. Rylova, Beatrice Waser, Edwin C. Constable, Melpomeni Fani, Guillaume P. Nicolas, Jean Claude Reubi and Helmut R. Maecke
To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumor uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using...
Authors: Daniel R. McGowan, Michael Skwarski, Bartlomiej W. Papiez, Ruth E. Macpherson, Fergus V. Gleeson, Julia A. Schnabel, Geoff S. Higgins and John D. Fenwick
This study identified the optimal tracer kinetic model for quantification of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) positron emission tomography (PET) studies in seven patients with diffuse glioma (...
Authors: Thomas Koopman, Niels Verburg, Robert C. Schuit, Petra J. W. Pouwels, Pieter Wesseling, Albert D. Windhorst, Otto S. Hoekstra, Philip C. de Witt Hamer, Adriaan A. Lammertsma, Ronald Boellaard and Maqsood Yaqub
We measured whole body distribution of 11C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline2 binding site. The purpose of this phase I study was to evaluate the biodistribution and ...
Authors: Ashwin V. Venkataraman, Nicholas Keat, James F. Myers, Samuel Turton, Inge Mick, Roger N. Gunn, Eugenii A. Rabiner, Jan Passchier, Christine A. Parker, Robin J. Tyacke and David J. Nutt
In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full conv...
Authors: Edwin E. G. W. ter Voert, Urs J. Muehlematter, Gaspar Delso, Daniele A. Pizzuto, Julian Müller, Hannes W. Nagel and Irene A. Burger
Efforts to develop suitable positron emission tomography (PET) tracers for the ion channel site of human N-methyl-d-aspartate (NMDA) receptors have had limited success. [18F]PK-209 is a GMOM derivative that binds...
Authors: Jasper van der Aart, Sandeep S. V. Golla, Marieke van der Pluijm, Lothar A. Schwarte, Robert C. Schuit, Pieter J. Klein, Athanasios Metaxas, Albert D. Windhorst, Ronald Boellaard, Adriaan A. Lammertsma and Bart N. M. van Berckel
Unfortunately, after publication of this article [1], it was noticed that the name of Urs J. Muehlematter was incorrectly displayed as Urs J. Mühlematter. The corrected author list can be seen above and the or...
Authors: Urs J. Muehlematter, Hannes W. Nagel, Anton Becker, Julian Mueller, Kerstin N. Vokinger, Felipe de Galiza Barbosa, Edwin E. G. T. ter Voert, Patrick Veit-Haibach and Irene A. Burger
The ability to accurately and non-invasively distinguish high-grade glioma from low-grade glioma remains a challenge despite advances in molecular and magnetic resonance imaging. We investigated the ability of...
Authors: Ephraim E. Parent, Marc Benayoun, Ijeoma Ibeanu, Jeffrey J. Olson, Constantinos G. Hadjipanayis, Daniel J. Brat, Vikram Adhikarla, Jonathon Nye, David M. Schuster and Mark M. Goodman
Florbetaben, a 18F-labeled stilbene derivative (Neuraceq®, formerly known as BAY-949172), is a diagnostic radiopharmaceutical developed to visualize β-amyloid plaques in the brain. Here, we report a pilot study e...
Authors: Lucia Baratto, Sonya Youngju Park, Negin Hatami, Praveen Gulaka, Shreyas Vasanawala, Thomas Koshy Yohannan, Robert Herfkens, Ronald Witteles and Andrei Iagaru
Localizing and removing the infected sequestrum in long-standing trauma-related chronic osteomyelitis remains a clinical challenge. PET/CT with 18F-fluorodeoxyglucose (FDG-PET) has a high sensitivity for chron...
Authors: Albert Christersson, Sune Larsson and Jens Sörensen
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga...
Authors: Silvia Taralli, Martina Sollini, Michele Milella, Germano Perotti, Angelina Filice, Massimo Menga, Annibale Versari and Vittoria Rufini
Graphical methods of radiotracer kinetic modeling in PET are ideal for parametric imaging and data quality assurance but can suffer from noise bias. This study compared the Logan and Multilinear Analysis-1 (MA...
Authors: Tong Wang, Kai Yi Wu, Robert C. Miner, Jennifer M. Renaud, Rob S. B. Beanlands and Robert A. deKemp
The 18F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, 18F-THK-5351 can also moni...
Nonalcoholic fatty liver disease is a common disorder that progresses from simple fatty liver (steatosis) to nonalcoholic steatohepatitis (NASH). It is thought that mitochondrial dysfunction plays a critical r...
The aim of this work was to confirm that post-selective internal radiation therapy (SIRT) 90Y-PET/CT-based dosimetry correlates with lesion metabolic response and to determine its correlation with overall surviva...
Authors: Hugo Levillain, Ivan Duran Derijckere, Gwennaëlle Marin, Thomas Guiot, Michaël Vouche, Nick Reynaert, Alain Hendlisz, Bruno Vanderlinden and Patrick Flamen
Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, o...
Authors: Patrick L. Donabedian, Susanne Kossatz, John A. Engelbach, Stephen A. Jannetti, Brandon Carney, Robert J. Young, Wolfgang A. Weber, Joel R. Garbow and Thomas Reiner
Kinetic analysis of dynamic PET data requires an accurate knowledge of available PET tracer concentration within blood plasma over time, known as the arterial input function (AIF). The gold standard method use...
Authors: Hasan Sari, Kjell Erlandsson, Lisbeth Marner, Ian Law, Henrik B.W. Larsson, Kris Thielemans, Sébastien Ourselin, Simon Arridge, David Atkinson and Brian F. Hutton
Inflammation is associated with major depressive disorder (MDD). Translocator protein 18 kDa (TSPO), a putative biomarker of neuroinflammation, is quantified using positron emission tomography (PET) and 11C-PBR28...
Authors: Erica M. Richards, Paolo Zanotti-Fregonara, Masahiro Fujita, Laura Newman, Cristan Farmer, Elizabeth D. Ballard, Rodrigo Machado-Vieira, Peixiong Yuan, Mark J. Niciu, Chul Hyoung Lyoo, Ioline D. Henter, Giacomo Salvadore, Wayne C. Drevets, Hartmuth Kolb, Robert B. Innis and Carlos A. Zarate Jr
External cooling of the salivary glands is advised to prevent xerostomia in lutetium-177-PSMA treatment for advanced prostate cancer. Since evidence addressing this subject is sparse, this study aims to determ...
Authors: Ludwike W. M. van Kalmthout, Marnix G. E. H. Lam, Bart de Keizer, Gerard C. Krijger, Tessa F. T. Ververs, Rememrt de Roos and Arthur J. A. T. Braat
There is a growing interest in the use of 18F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a rep...
Authors: Stephanus T. Malherbe, Patrick Dupont, Ilse Kant, Petri Ahlers, Magdalena Kriel, André G. Loxton, Ray Y. Chen, Laura E. Via, Friedrich Thienemann, Robert J. Wilkinson, Clifton E. Barry III, Stephanie Griffith-Richards, Annare Ellman, Katharina Ronacher, Jill Winter, Gerhard Walzl…
The present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined the efficacy of ...
Authors: Zhao-Hui Jin, Atsushi B. Tsuji, Mélissa Degardin, Aya Sugyo, Yukie Yoshii, Kotaro Nagatsu, Ming-Rong Zhang, Yasuhisa Fujibayashi, Pascal Dumy, Didier Boturyn and Tatsuya Higashi
Quantitative imaging can facilitate patient stratification in clinical trials. The hypoxia-activated prodrug evofosfamide recently failed a phase III trial in pancreatic cancer. However, the study did not atte...
Authors: Milan Grkovski, Louise Fanchon, Naga Vara Kishore Pillarsetty, James Russell and John L. Humm
This study investigated the spatial relationship of 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography ([18F]FDG-PET) standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) derive...
Authors: John M. Floberg, Kathryn J. Fowler, Dominique Fuser, Todd A. DeWees, Farrokh Dehdashti, Barry A. Siegel, Richard L. Wahl, Julie K. Schwarz and Perry W. Grigsby
Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been perform...
Authors: Sibel Isal, Julien Pierson, Laetitia Imbert, Alexandra Clement, Charlotte Collet, Sophie Pinel, Nicolas Veran, Aurélie Reinhard, Sylvain Poussier, Guillaume Gauchotte, Steeven Frezier, Gilles Karcher, Pierre-Yves Marie and Fatiha Maskali
A major toxicity concern in radioembolization therapy of hepatic malignancies is radiation-induced pneumonitis and sclerosis due to hepatopulmonary shunting of 90Y microspheres. Currently, 99mTc macroaggregated a...
Authors: Jonathan D. Allred, Jeremy Niedbala, Justin K. Mikell, Dawn Owen, Kirk A. Frey and Yuni K. Dewaraja
Suboptimal temporal sampling of time-activity curves (TAC) from dynamic 18F-fluoromethylcholine (FCH) PET images may introduce bias in quantification of FCH uptake in prostate cancer assessment. We sought to defi...
Authors: Xavier Palard-Novello, Anne-Lise Blin, Florence Le Jeune, Etienne Garin, Pierre-Yves Salaün, Anne Devillers, Giulio Gambarota, Solène Querellou, Patrick Bourguet and Hervé Saint-Jalmes
The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cogni...
The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with...
The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.
Authors: Colm J. McGinnity, Daniela A. Riaño Barros, William Trigg, David J. Brooks, Rainer Hinz, John S. Duncan, Matthias J. Koepp and Alexander Hammers
Microvascular function plays an important role in ARVD (atherosclerotic renovascular disease). RFR (renal flow reserve), the capacity of renal vasculature to dilate, is known to reflect renal microvascular fun...
Authors: Johanna Päivärinta, Niina Koivuviita, Vesa Oikonen, Hidehiro Iida, Kaisa Liukko, Ilkka Manner, Eliisa Löyttyniemi, Pirjo Nuutila and Kaj Metsärinne
The close connection between neuronal activity and glucose consumption accounts for the clinical value of 18F-fluoro-2-deoxyglucose (FDG) imaging in neurodegenerative disorders. Nevertheless, brain metabolic r...
Authors: Ambra Buschiazzo, Vanessa Cossu, Matteo Bauckneht, Annamaria Orengo, Patrizia Piccioli, Laura Emionite, Giovanna Bianchi, Federica Grillo, Anna Rocchi, Francesco Di Giulio, Francesco Fiz, Lizzia Raffaghello, Flavio Nobili, Silvia Bruno, Giacomo Caviglia, Silvia Ravera…
Translocator protein (TSPO) imaging can be used to detect neuroinflammation (including microglial activation) after acute cerebral infarction. However, longitudinal changes of TSPO binding after mild ischemia ...
Authors: Natsumi Miyajima, Miwa Ito, Takemi Rokugawa, Hitoshi Iimori, Sotaro Momosaki, Shigeki Omachi, Eku Shimosegawa, Jun Hatazawa and Kohji Abe
This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET-CT) scans during neoadjuvant extre...
Authors: Marc G. Stevenson, Lukas B. Been, Harald J. Hoekstra, Albert J. H. Suurmeijer, Ronald Boellaard and Adrienne H. Brouwers
Accurate attenuation correction (AC) is an inherent problem of positron emission tomography magnetic resonance imaging (PET/MRI) systems. Simulation studies showed that time-of-flight (TOF) detectors can reduc...
Authors: Urs J. Muehlematter, Hannes W. Nagel, Anton Becker, Julian Mueller, Kerstin N. Vokinger, Felipe de Galiza Barbosa, Edwin E. G. T. ter Voert, Patrick Veit-Haibach and Irene A. Burger
Activated hepatic stellate cells (HSCs), which express integrin αvβ3, are a major fibrogenic factor in NASH pathophysiology. 18F-labeled cyclic arginine-glycine-aspartic acid penta-peptide (18F-FPP-RGD2) has been...
Authors: Takemi Rokugawa, Haruyo Konishi, Miwa Ito, Hitoshi Iimori, Ryohei Nagai, Eku Shimosegawa, Jun Hatazawa and Kohji Abe
The protein cross-linking enzyme tissue transglutaminase (TG2; EC 2.3.2.13) is associated with the pathogenesis of various diseases, including cancer. Recently, the synthesis and initial evaluation of two high...
Authors: Berend van der Wildt, Micha M. M. Wilhelmus, Wissam Beaino, Esther J. M. Kooijman, Robert C. Schuit, John G. J. M. Bol, John J. P. Breve, Ralf Pasternack, Adriaan A. Lammertsma, Albert D. Windhorst and Benjamin Drukarch
The current de facto standard for quantification of tumor metabolism in oncological whole-body PET is the standardized uptake value (SUV) approach. SUV determination requires accurate scanner calibration. Resi...
Authors: Jens Maus, Frank Hofheinz, Ivayla Apostolova, Michael C. Kreissl, Jörg Kotzerke and Jörg van den Hoff
A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[18F]fluoro-d-glucose (FDG) concentration behavior in kidneys, measure...
Authors: Barbara K. Geist, Pascal Baltzer, Barbara Fueger, Martina Hamboeck, Thomas Nakuz, Laszlo Papp, Sazan Rasul, Lalith Kumar Shiyam Sundar, Marcus Hacker and Anton Staudenherz
For (123I)FP-CIT imaging, a number of algorithms have shown high performance in distinguishing normal patient images from those with disease, but none have yet been tested as part of reporting workflows. This stu...
Authors: Jonathan Christopher Taylor, Charles Romanowski, Eleanor Lorenz, Christine Lo, Oliver Bandmann and John Fenner
The potential application of bone marrow stromal cell (BMSC) therapy in stroke has been anticipated due to its immunomodulatory effects. Recently, positron emission tomography (PET) with [18F]DPA-714, a transloca...
Authors: Chengbo Tan, Songji Zhao, Kei Higashikawa, Zifeng Wang, Masahito Kawabori, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Naoyuki Ukon, Hironobu Yasui, Nagara Tamaki, Yuji Kuge, Hideo Shichinohe and Kiyohiro Houkin
In epilepsy patients, SISCOM or subtraction ictal single photon emission computed tomography co-registered to magnetic resonance imaging has become a routinely used, non-invasive technique to localize the icta...
Authors: Liesbeth De Coster, Koen Van Laere, Evy Cleeren, Kristof Baete, Patrick Dupont, Wim Van Paesschen and Karolien E. Goffin
The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carc...
Authors: Piotr F. J. Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz. Dobrowolski, Marta K. Dudek, Monika Orzełowska and Renata Mikołajczak
Prostate-specific membrane antigen (PSMA)-targeted therapy with 177Lu-PSMA-617 is a therapeutic option for patients with metastatic castration-resistant prostate cancer (mCRPC). To optimize the therapy procedure,...
Authors: J. Kurth, B. J. Krause, S. M. Schwarzenböck, L. Stegger, M. Schäfers and K. Rahbar
Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with 18F-fluorodeoxyglucose ...
Authors: Canan Güvenç, Patrick Dupont, Jan Van den Stock, Laura Seynaeve, Kathleen Porke, Eva Dries, Karen Van Bouwel, Johannes van Loon, Tom Theys, Karolien E. Goffin and Wim Van Paesschen
Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific rad...
Authors: Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger and Hans-Jürgen Wester
Prognosis in oesophageal cancer (OC) is poor. The 5-year overall survival (OS) rate is approximately 15%. Personalised medicine is hoped to increase the 5- and 10-year OS rates. Quantitative analysis of PET is...
Authors: Craig Parkinson, Kieran Foley, Philip Whybra, Robert Hills, Ashley Roberts, Chris Marshall, John Staffurth and Emiliano Spezi
Despite the significant upgrading in recent years of the role of 18F-FDG PET/CT in multiple myeloma (MM) diagnostics, there is a still unmet need for myeloma-specific radiotracers. 3′-Deoxy-3′-[18F]fluorothymidin...
Authors: C. Sachpekidis, H. Goldschmidt, K. Kopka, A. Kopp-Schneider and A. Dimitrakopoulou-Strauss
Gallium-68-labeled prostate-specific antigen positron emission tomography/computed tomography imaging (Ga68-PSMA-11-PET/CT) has emerged as a potential gold standard for prostate cancer (PCa) diagnosis. However...
Authors: Alejandro Sanchez-Crespo, Emma Jussing, Ann-Charlotte Björklund and Katja Pokrovskaja Tamm
Assessment of the status of tumor biomarkers in individual patients would facilitate personalizing treatment strategy, and continuous monitoring of those biomarkers and their binding process to the therapeutic...
Authors: Yasaman Ardeshirpour, Dan L. Sackett, Jay R. Knutson and Amir H. Gandjbakhche
The goal of the study was to assess the potential of the vascular endothelial growth factor receptor (VEGFR)-2-targeting carbon-11 labeled (R)-N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)metho...
Authors: T. Tegnebratt, L. Lu, S. Eksborg, A. Chireh, P. Damberg, S. Nikkhou-Aski, T. Foukakis, H. Rundqvist, S. Holmin, R. V. Kuiper and E. Samen
