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  1. This study aimed to retrospectively evaluate the feasibility of total-body 18F-FDG PET/CT ultrafast acquisition combined with a deep learning (DL) image filter in the diagnosis of colorectal cancers (CRCs).

    Authors: Entao Liu, Zejian Lyu, Yuelong Yang, Yang Lv, Yumo Zhao, Xiaochun Zhang, Taotao Sun, Lei Jiang and Zaiyi Liu
    Citation: EJNMMI Research 2023 13:66
  2. Over the last years, several strategies have been reported to improve the metabolic stability of minigastrin analogs. However, currently applied compounds still reveal limited in vitro and in vivo stability. W...

    Authors: Nadine Holzleitner, Thomas Günther, Amira Daoud-Gadieh, Constantin Lapa and Hans-Jürgen Wester
    Citation: EJNMMI Research 2023 13:65
  3. Non-regional lymph node (NRLN) metastases has shown increasing importance in the prognosis evaluation and clinical management of primary metastatic hormone-sensitive prostate cancer (mHSPC). Hence, this study ...

    Authors: Zhangdong Jiang, Junjie Fan, Chaosheng Gan, Xiaoxin Dong, Guoqiang Gao, Zhuonan Wang, Dalin He, Lei Li, XiaoYi Duan and Kaijie Wu
    Citation: EJNMMI Research 2023 13:64
  4. Selective internal radiation therapy with 90Y radioembolization aims to selectively irradiate liver tumours by administering radioactive microspheres under the theragnostic assumption that the pre-therapy injecti...

    Authors: Mercedes Riveira-Martin, Azadeh Akhavanallaf, Zahra Mansouri, Nicola Bianchetto Wolf, Yazdan Salimi, Alexis Ricoeur, Ismini Mainta, Valentina Garibotto, Antonio López Medina and Habib Zaidi
    Citation: EJNMMI Research 2023 13:63
  5. Penile cancer is characterized by an early lymphatic dissemination. In intermediate and high-risk primary tumors without palpable inguinal lymph nodes, there is a 6–30% risk of micro-metastatic disease. Invasi...

    Authors: Juanito Gebruers, Laura Elst, Marcella Baldewijns, Liesbeth De Wever, Koen Van Laere, Maarten Albersen and Karolien Goffin
    Citation: EJNMMI Research 2023 13:62
  6. Butylscopolamine (or hyoscine butylbromide, trade name Buscopan®) is occasionally administered as a premedication to reduce non-specific FDG uptake in the gastrointestinal tract based on its antiperistaltic effec...

    Authors: Falk Gühne, Ferdinand Ndum, Philipp Seifert, Thomas Winkens, Robert Drescher and Martin Freesmeyer
    Citation: EJNMMI Research 2023 13:61
  7. Folate intake might reduce [68Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this co...

    Authors: Hinke Siebinga, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema and Berlinda J. de Wit-van der Veen
    Citation: EJNMMI Research 2023 13:60
  8. The development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under development necessitating both biokinetic and dosimetry extrapo...

    Authors: Silvano Gnesin, Nicolas Chouin, Michel Cherel, Steven Mark Dunn, Niklaus Schaefer, Alain Faivre-Chauvet, John O. Prior and Judith Anna Delage
    Citation: EJNMMI Research 2023 13:59
  9. Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC). No imaging method can successfully detect all (micro)metastases. This may result in (lymph node) recurrence a...

    Authors: Judit A. Adam, Edwin Poel, Berthe L. F. van Eck-Smit, Constantijne H. Mom, Lukas J. A. Stalpers, Jaap Stoker and Shandra Bipat
    Citation: EJNMMI Research 2023 13:58
  10. Dosimetry promises many advantages for radiopharmaceutical therapies but repeat post-therapy imaging for dosimetry can burden both patients and clinics. Recent applications of reduced time point imaging for ti...

    Authors: Avery B. Peterson, David M. Mirando and Yuni K. Dewaraja
    Citation: EJNMMI Research 2023 13:57
  11. The gastrin-releasing peptide receptor (GRPr) is a molecular target for the visualization of prostate cancer. Bombesin (BN) analogs are short peptides with a high affinity for GRPr. RM2 is a bombesin-based ant...

    Authors: Yinwen Wang, Hongmei Yuan, Sufan Tang, Yang Liu, Ping Cai, Nan Liu, Yue Chen and Zhijun Zhou
    Citation: EJNMMI Research 2023 13:56
  12. The lack of noninvasive methods for assessment of dysregulated inflammation as a major driver of fibrosis (i.e., inflammation-fibrosis axis) has been a major challenge to precision management of fibrotic lung ...

    Authors: Qin Zhu, Clayton E. Barnes, Philip Z. Mannes, Joseph D. Latoche, Kathryn E. Day, Jessie R. Nedrow, Enrico M. Novelli, Carolyn J. Anderson and Sina Tavakoli
    Citation: EJNMMI Research 2023 13:55
  13. The value of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) is still unknown. We aimed to test the potential complementary role of PSMA expression and 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FD...

    Authors: Martina Sollini, Margarita Kirienko, Luca di Tommaso, Cristiano Pini, Fabrizia Gelardi, Salvatore Ariano, Andrea Gerardo Lania, Gherardo Mazziotti, Giuseppe Mercante and Arturo Chiti
    Citation: EJNMMI Research 2023 13:54
  14. Fluorine-18-labeled SSAs have the potential to become the next-generation tracer in SSTR-imaging in neuroendocrine tumor (NET) patients given their logistical advantages over the current gold standard gallium-...

    Authors: Lennert Boeckxstaens, Elin Pauwels, Vincent Vandecaveye, Wies Deckers, Frederik Cleeren, Jeroen Dekervel, Timon Vandamme, Kim Serdons, Michel Koole, Guy Bormans, Annouschka Laenen, Paul M. Clement, Karen Geboes, Eric Van Cutsem, Kristiaan Nackaerts, Sigrid Stroobants…
    Citation: EJNMMI Research 2023 13:53
  15. Stage I lung adenocarcinoma is a heterogeneous group. Previous studies have shown the prognostic evaluation value of PET/CT in this cohort; however, few studies focused on stage I invasive adenocarcinoma manif...

    Authors: Xuan Zheng, Jie Lin, Jiageng Xie, Jia Jiang, Junping Lan, Xiaowei Ji, Kun Tang, Xiangwu Zheng and Jinjin Liu
    Citation: EJNMMI Research 2023 13:52
  16. Immune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to treat non-small cell lung cancer (NSCLC). PD-L1 is a validated prognost...

    Authors: Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh and Gary J. R. Cook
    Citation: EJNMMI Research 2023 13:51
  17. 68 Ga-PSMA PET is the leading prostate cancer imaging technique, but the image quality remains noisy and could be further improved using an artificial intelligence-based denoising algorithm. To address this issu....

    Authors: Charles Margail, Charles Merlin, Tommy Billoux, Maxence Wallaert, Hosameldin Otman, Nicolas Sas, Ioana Molnar, Florent Guillemin, Louis Boyer, Laurent Guy, Marion Tempier, Sophie Levesque, Alban Revy, Florent Cachin and Marion Chanchou
    Citation: EJNMMI Research 2023 13:50
  18. The determination of pathological grading has a guiding significance for the treatment of pancreatic ductal adenocarcinoma (PDAC) patients. However, there is a lack of an accurate and safe method to obtain pat...

    Authors: Gong Zhang, Chengkai Bao, Yanzhe Liu, Zizheng Wang, Lei Du, Yue Zhang, Fei Wang, Baixuan Xu, S. Kevin Zhou and Rong Liu
    Citation: EJNMMI Research 2023 13:49
  19. Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease pathogenesis. In clinical practice, trained readers will visually categorise positron emission tomography (PET) s...

    Authors: Hugh G. Pemberton, Christopher Buckley, Mark Battle, Ariane Bollack, Vrajesh Patel, Petya Tomova, David Cooke, Will Balhorn, Katherine Hegedorn, Johan Lilja, Christine Brand and Gill Farrar
    Citation: EJNMMI Research 2023 13:48
  20. Alzheimer’s disease-related pattern (ADRP) is a metabolic brain biomarker of Alzheimer’s disease (AD). While ADRP is being introduced into research, the effect of the size of the identification cohort and the ...

    Authors: Eva Štokelj, Petra Tomše, Tadej Tomanič, Vijay Dhawan, David Eidelberg, Maja Trošt and Urban Simončič
    Citation: EJNMMI Research 2023 13:47
  21. The dopamine transporter (DaT) PET ligand [18F]FE-PE2I is used to aid the diagnosis of Parkinson’s disease. After encountering four patients with a history of daily sertraline use, who all showed atypical finding...

    Authors: Thomas E. H. Justesen, Per Borghammer, Joel Aanerud, Peter Hovind and Lisbeth Marner
    Citation: EJNMMI Research 2023 13:46
  22. The accumulation of 177Lu-DOTATATE might be influenced by the amount of administered peptide in relation to the tumor somatostatin receptor expression. The effect of the administered peptide mass on the resulting...

    Authors: Ulrika Jahn, Ulrike Garske-Román, Mattias Sandström, Mark Lubberink and Anders Sundin
    Citation: EJNMMI Research 2023 13:45
  23. Myocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis. Measurement of myocardial PD-L1 expression may have potential use as a mechani...

    Authors: Muhummad Sohaib Nazir, Daniel Johnathan Hughes, Gitasha Chand, Kathryn Adamson, Jessica Johnson, Damion Bailey, Victoria Gibson, Hong Hoi Ting, Alexander R. Lyon and Gary J. R. Cook
    Citation: EJNMMI Research 2023 13:44
  24. Expanding therapeutic possibilities have improved disease-related prospects for breast cancer patients. Pathological analysis on a tumor biopsy is the current reference standard biomarker used to select for tr...

    Authors: Renske Altena, Antonios Tzortzakakis, Siri Af Burén, Thuy A. Tran, Fredrik Y. Frejd, Jonas Bergh and Rimma Axelsson
    Citation: EJNMMI Research 2023 13:43
  25. By clearing GABA from the synaptic cleft, GABA transporters (GATs) play an essential role in inhibitory neurotransmission. Consequently, in vivo visualization of GATs can be a valuable diagnostic tool and biom...

    Authors: Niels Knippenberg, Matthias Bauwens, Olaf Schijns, Govert Hoogland, Alexandru Florea, Kim Rijkers, Thomas J. Cleij, Kasper Eersels, Bart van Grinsven and Hanne Diliën
    Citation: EJNMMI Research 2023 13:42
  26. CXCR4-targeted radioligand therapy (RLT) with [177Lu]Lu/[90Y]Y-PentixaTher has recently evolved as a promising therapeutic option for patients with advanced hematological cancers. Given their advanced disease sta...

    Authors: Sebastian Martin, David Viertl, Anna Janz, Stefan Habringer, Ulrich Keller and Margret Schottelius
    Citation: EJNMMI Research 2023 13:40
  27. Accumulating studies have demonstrated that elevated TIGIT expression in tumor microenvironment correlates with better therapeutic response to TIGIT-based immunotherapy in pre-clinical studies. Therefore, a no...

    Authors: Dinghu Weng, Rong Guo, Ziyang Zhu, Yu Gao, Rui An and Xiuman Zhou
    Citation: EJNMMI Research 2023 13:38
  28. To show the equivalence between the specific binding ratios (SBR) of visually normal 123I-FP-CIT SPECT scans from patients to those from healthy volunteers (Hv) or patients without dopaminergic degeneration to al...

    Authors: Anthime Flaus, Remi Philippe, Stephane Thobois, Marc Janier and Christian Scheiber
    Citation: EJNMMI Research 2023 13:37
  29. (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a promising PET probe for imaging the tumor-specific L-type amino acid transporter (LAT) 1. Our previous study revealed tha...

    Authors: Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi and Yasuyoshi Watanabe
    Citation: EJNMMI Research 2023 13:36
  30. Early intrahepatic recurrence is common after surgical resection of hepatocellular carcinoma (HCC) and leads to increased morbidity and mortality. Insensitive and nonspecific diagnostic imaging contributes to ...

    Authors: Kevin P. Labadie, Adrienne L. Lehnert, Aimee L. Kenoyer, Donald K. Hamlin, Andrew D. Ludwig, Alan F. Utria, Sara K. Daniel, Tara N. Mihailovic, Alexander Prossnitz, Johnnie J. Orozco, Yawen Li, D. Scott Wilbur, Robert S. Miyaoka and James O. Park
    Citation: EJNMMI Research 2023 13:35
  31. Prostate-Specific Membrane Antigen (PSMA) PET/CT and multiparametric MRI (mpMRI) are well-established modalities for identifying intra-prostatic lesions (IPLs) in localised prostate cancer. This study aimed to...

    Authors: Tsz Him Chan, Annette Haworth, Alan Wang, Mahyar Osanlouy, Scott Williams, Catherine Mitchell, Michael S. Hofman, Rodney J. Hicks, Declan G. Murphy and Hayley M. Reynolds
    Citation: EJNMMI Research 2023 13:34
  32. The IQ-SPECT system is equipped with multifocal collimators and uses ordered-subset conjugate gradient minimization (OSCGM) as its reconstruction algorithm, achieving a shorter acquisition time than convention...

    Authors: Hua Wei, Jiaojiao Wu, Ke Han, Guang Hu, Hongliang Wang, Xiaoshan Guo, Haiyan Liu, Zhifang Wu and Sijin Li
    Citation: EJNMMI Research 2023 13:33
  33. The angiotensin converting enzyme-2 (ACE2)—entry receptor of SARS-CoV-2—and its homologue, the angiotensin-converting enzyme (ACE), play a pivotal role in maintaining cardiovascular homeostasis. Potential chan...

    Authors: Darja Beyer, Christian Vaccarin, Xavier Deupi, Ana Katrina Mapanao, Susan Cohrs, Fan Sozzi-Guo, Pascal V. Grundler, Nicholas P. van der Meulen, Jinling Wang, Matthias Tanriver, Jeffrey W. Bode, Roger Schibli and Cristina Müller
    Citation: EJNMMI Research 2023 13:32
  34. Routine prostate-specific membrane antigen (PSMA) positron emission tomography (PET) performed for primary staging or restaging of prostate cancer patients is usually done as a single static image acquisition ...

    Authors: André H. Dias, Mads R. Jochumsen, Helle D. Zacho, Ole L. Munk and Lars C. Gormsen
    Citation: EJNMMI Research 2023 13:31
  35. Correlations between dopamine transporter (DAT) availability and Parkinson’s disease (PD) motor symptoms vary depending on the imaging modality, choice of regions of interest and clinical measures. We aimed to...

    Authors: Vera S. Kerstens, Patrik Fazio, Mathias Sundgren, Christer Halldin, Per Svenningsson and Andrea Varrone
    Citation: EJNMMI Research 2023 13:29
  36. We recently reported 11C-NR2B-SMe ([S-methyl-11C](R,S)-7-thiomethoxy-3-(4-(4-methyl-phenyl)butyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol) and its enantiomers as candidate radioligands for imaging the GluN2B su...

    Authors: Lisheng Cai, Jeih-San Liow, Cheryl L. Morse, Sanjay Telu, Riley Davies, Lester S. Manly, Sami S. Zoghbi, Frederick T. Chin, Robert B. Innis and Victor W. Pike
    Citation: EJNMMI Research 2023 13:28
  37. The high incidence of epidermal growth factor receptor (EGFR) mutations is usually found in female patients with lung adenocarcinoma who have never-smoked. However, reports concerning male patients are scarce....

    Authors: Maoqing Jiang, Ping Chen, Xiuyu Guo, Xiaohui Zhang, Qiaoling Gao, Jingfeng Zhang, Guofang Zhao and Jianjun Zheng
    Citation: EJNMMI Research 2023 13:27
  38. This study aims to construct radiomics models based on [18F]FDG PET/CT using multiple machine learning methods to predict the EGFR mutation status of lung adenocarcinoma and evaluate whether incorporating clinica...

    Authors: Jianxiong Gao, Rong Niu, Yunmei Shi, Xiaoliang Shao, Zhenxing Jiang, Xinyu Ge, Yuetao Wang and Xiaonan Shao
    Citation: EJNMMI Research 2023 13:26
  39. Osteoradionecrosis (ORN) of the jaw requires a differential diagnosis to exclude cancer recurrence. Here, we sought to develop a scoring system comprising 18F-FDG PET/CT parameters for distinguishing between the ...

    Authors: Nai-Ming Cheng, Chien-Yu Lin, Chun-Ta Liao, Din-Li Tsan, Shu-Hang Ng and Tzu-Chen Yen
    Citation: EJNMMI Research 2023 13:25
  40. The aims of this study were to establish a normal database (NDB) for semiquantification of dopamine transporter (DAT) single-photon emission computed tomography (SPECT) with [123I]FP-CIT on a cadmium zinc telluri...

    Authors: Felix Thiele, Franziska Schau, Julian M. M. Rogasch, Christoph Wetz, Stephanie Bluemel, Winfried Brenner, Holger Amthauer, Catharina Lange and Imke Schatka
    Citation: EJNMMI Research 2023 13:24
  41. Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhi...

    Authors: Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard and Albert D. Windhorst
    Citation: EJNMMI Research 2023 13:23
  42. IgG4-related disease (IgG4-RD) is a heterogeneous autoimmune disorder characterised by inflammatory lesions. Diagnostic imaging, such as 2-[18F]FDG PET/CT, is critical in evaluation of the disease, especially for...

    Authors: Mingwei Chen, Charlene Yu Lin Tang, Warren Weng Seng Fong and Winnie Wing-Chuen Lam
    Citation: EJNMMI Research 2023 13:22
  43. In the development of new 18F-labelled tracers, it is important to assess the amount of released [18F]fluoride taken up in the bones of experimental animals because all 18F-labelled PET-tracers are prone, to less...

    Authors: Nina Savisto, Tove J. Grönroos, Vesa Oikonen, Johan Rajander, Eliisa Löyttyniemi, Jörgen Bergman, Sarita Forsback, Olof Solin and Merja Haaparanta-Solin
    Citation: EJNMMI Research 2023 13:21
  44. PET/MRI hybrid imaging in pulmonary arterial hypertension (PAH) provides important prognostic information identifying patients who might benefit from early therapy escalation, as right ventricle (RV) metabolic...

    Authors: Remigiusz Kazimierczyk, Piotr Szumowski, Stephan G. Nekolla, Lukasz A. Malek, Piotr Blaszczak, Marcin Hladunski, Bozena Sobkowicz, Janusz Mysliwiec and Karol A. Kaminski
    Citation: EJNMMI Research 2023 13:20
  45. Authors: Lisbeth Marner, Kirsten Korsholm, Lasse Anderberg, Markus N. Lonsdale, Mads Radmer Jensen, Eva Brødsgaard, Charlotte L. Denholt, Nic Gillings, Ian Law and Lars Friberg
    Citation: EJNMMI Research 2023 13:19

    The original article was published in EJNMMI Research 2022 12:56

  46. To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants.

    Authors: Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Raffaele Cacciaglia, Gemma Salvadó, Mahnaz Shekari, Lyduine E. Collij, Christopher Buckley, Bart N. M. van Berckel, Andrés Perissinotti, Aida Niñerola-Baizán, Marta Milà-Alomà, Natàlia Vilor-Tejedor, Grégory Operto, Carles Falcon, Oriol Grau-Rivera, Eider M. Arenaza-Urquijo…
    Citation: EJNMMI Research 2023 13:18
  47. 44Sc/47Sc is an attractive theranostic pair for targeted in vivo positron emission tomographic (PET) imaging and beta-particle treatment of cancer. The 44Ti/44Sc generator allows daily onsite production of this d...

    Authors: Nadia Benabdallah, Hanwen Zhang, Ryan Unnerstall, Amanda Fears, Lucy Summer, Michael Fassbender, Buck E. Rodgers, Diane Abou, Valery Radchenko and Daniel L. J. Thorek
    Citation: EJNMMI Research 2023 13:17

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