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  1. In the present study, we aimed to investigate the role of baseline (B), interim (I) and end-of-treatment (Eot) 18F-FDG PET/CT in assessing the prognosis of diffuse large B cell lymphoma (DLBCL), so as to identify...

    Authors: Wenyu Zhao, Xiaodong Wu, Shuo Huang, Hui Wang and Hongliang Fu
    Citation: EJNMMI Research 2024 14:20
  2. Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, ther...

    Authors: Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier and Albert D. Windhorst
    Citation: EJNMMI Research 2024 14:19
  3. Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irre...

    Authors: Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt and Marc C. Huisman
    Citation: EJNMMI Research 2024 14:18
  4. Endometriosis is characterized by the ectopic occurrence of endometrial tissue. Though considered benign, endometriotic lesions possess tumor-like properties such as tissue invasion and remodeling of the extra...

    Authors: Belinda Trachsel, Stefan Imobersteg, Giulia Valpreda, Gad Singer, Regula Grabherr, Mark Ormos, Irene A. Burger, Rahel A. Kubik-Huch, Roger Schibli, Viola Vogel and Martin Béhé
    Citation: EJNMMI Research 2024 14:17
  5. The prevalence of ischemia with non-obstructive coronary artery disease (INOCA) is substantial, but its risk stratification has been suboptimal. Resting SPECT myocardial perfusion imaging (MPI) could provide u...

    Authors: Yuting Zhao, Yingqi Hu, Yuanyuan Li, Yanhui Wang, Yuxin Xiao, Li Xu, Tailin Ren, Qiuyan Wu, Ruonan Wang, Zhifang Wu, Sijin Li and Ping Wu
    Citation: EJNMMI Research 2024 14:16
  6. Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer-related deaths in men. Prostate-specific membrane antigen (PSMA) as a target has gained increasing attention. This resea...

    Authors: Yang Liu, Li Xia, Haiyang Li, Ping Cai, Sufan Tang, Yue Feng, Guangfu Liu, Yue Chen, Nan Liu, Wei Zhang and Zhijun Zhou
    Citation: EJNMMI Research 2024 14:15
  7. Previous studies have demonstrated that delayed [68 Ga]Ga-PSMA PET/CT imaging improves lesion detection compared to early [68 Ga]Ga-PSMA PET/CT in patients with prostate cancer. However, the sole use of delayed [

    Authors: Xiaofeng Yu, Lian Xu, Gang Huang, Jianjun Liu, Ruohua Chen and Yumei Chen
    Citation: EJNMMI Research 2024 14:14
  8. Peptide receptor radionuclide therapy is effective in treating neuroendocrine tumours, but treatment may be limited by kidney and bone marrow toxicity. In this work, the absorbed dose burden to the bone marrow...

    Authors: Märta Persson, Cecilia Hindorf, Oscar Ardenfors, Martin Larsson and Joachim N. Nilsson
    Citation: EJNMMI Research 2024 14:13
  9. [15O]H2O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis and treatment of peripheral artery disease. We aimed to evaluate the reliability of dy...

    Authors: Nana Louise Christensen, Jens Sørensen, Kirsten Bouchelouche, Michael Alle Madsen, Christian Selmer Buhl and Lars Poulsen Tolbod
    Citation: EJNMMI Research 2024 14:11
  10. The indirect method for generating parametric images in positron emission tomography (PET) involves the acquisition and reconstruction of dynamic images and temporal modelling of tissue activity given a measur...

    Authors: Rajat Vashistha, Hamed Moradi, Amanda Hammond, Kieran O’Brien, Axel Rominger, Hasan Sari, Kuangyu Shi, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:10
  11. Developing biomarkers for early stage AD patients is crucial. Glucose metabolism measured by 18F-FDG PET is the most common biomarker for evaluating cellular energy metabolism to diagnose AD. Arterial spin labeli...

    Authors: Sheng Bi, Shaozhen Yan, Zhigeng Chen, Bixiao Cui, Yi Shan, Hongwei Yang, Zhigang Qi, Zhilian Zhao, Ying Han and Jie Lu
    Citation: EJNMMI Research 2024 14:9
  12. The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury. Hence, we...

    Authors: Yong-il Kim, Seung Hak Lee, Jin Hwa Jung, Seog-Young Kim, Nare Ko, Sang Ju Lee, Seung Jun Oh, Jin-Sook Ryu, Dabin Ko, Won Kim and Kyunggon Kim
    Citation: EJNMMI Research 2024 14:8
  13. Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targetin...

    Authors: Victoria J. M. Reid, Wesley K. X. McLoughlin, Kalyani Pandya, Holly Stott, Monika Iškauskienė, Algirdas Šačkus, Judit A. Marti, Dominic Kurian, Thomas M. Wishart, Christophe Lucatelli, Dan Peters, Gillian A. Gray, Andrew H. Baker, David E. Newby, Patrick W. F. Hadoke, Adriana A. S. Tavares…
    Citation: EJNMMI Research 2024 14:7
  14. 68Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified a....

    Authors: Nathaniel J. Smith, Mark A. Green, Clinton D. Bahler, Mark Tann, Wendy Territo, Anne M. Smith and Gary D. Hutchins
    Citation: EJNMMI Research 2024 14:6
  15. Immune checkpoint inhibitors (ICIs) have made significant progress in oncotherapy improving survival of patients. However, the benefits are limited to only a small subgroup of patients who could achieve durabl...

    Authors: Xiaoyu Fan, Hans W. Nijman, Marco de Bruyn and Philip H. Elsinga
    Citation: EJNMMI Research 2024 14:5
  16. The influence of anaesthetic depth and the potential influence of different anaesthetic beds and thus different handling procedures were investigated in 86 severe combined immunodeficient (SCID) mice using sem...

    Authors: Fabian Schmitz-Peiffer, Mathias Lukas, Ajay-Mohan Mohan, Jakob Albrecht, Jörg R. Aschenbach, Winfried Brenner and Nicola Beindorff
    Citation: EJNMMI Research 2024 14:4
  17. The identification of biomarkers predicting the treatment response of rheumatoid arthritis (RA) is important. [68 Ga]Ga-FAPI-04 showed markedly increased uptake in the joints of patients with RA. The purpose of t...

    Authors: Qingqing Pan, Huaxia Yang, Ziyue Zhou, Min Li, Xu Jiang, Fang Li, Yaping Luo and Mengtao Li
    Citation: EJNMMI Research 2024 14:2
  18. In parametric PET, kinetic parameters are extracted from dynamic PET images. It is not commonly used in clinical practice because of long scan times and the requirement for an arterial input function (AIF). To...

    Authors: Hamed Moradi, Rajat Vashistha, Kieran O’Brien, Amanda Hammond, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:1
  19. The diagnostic accuracy of [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography imaging in accurately identifying thyroid lesions is limited, primarily due to the physiological uptake of normal head ...

    Authors: Yuhua Wang, Ye Liu, Huixia Geng and Wanchun Zhang
    Citation: EJNMMI Research 2023 13:109
  20. Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only avail...

    Authors: Peter Iversen, Stine Kramer, Andreas Ebbehoj, Esben Søndergaard, Kirstine Stochholm, Per Løgstrup Poulsen and Karin Hjorthaug
    Citation: EJNMMI Research 2023 13:108
  21. Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1 diabetes, but widespread application is challenging due to shortages of donor...

    Authors: Pierre Cheung, Julia Thorngren, Bo Zhang, Svitlana Vasylovska, Francesco Lechi, Jonas Persson, Stefan Ståhl, John Löfblom, Olle Korsgren, Jonas Eriksson, Joey Lau and Olof Eriksson
    Citation: EJNMMI Research 2023 13:107
  22. The apolipoprotein E-deficient (apoE−/−) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. ...

    Authors: Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx and Riemer H. J. A. Slart
    Citation: EJNMMI Research 2023 13:106
  23. This study aimed to assess whether a combined model incorporating radiomic and depth features extracted from PET/CT can predict disease-free survival (DFS) in patients who failed to achieve pathologic complete...

    Authors: Xingxing Zheng, Yuhong Huang, Yingyi Lin, Teng Zhu, Jiachen Zou, Shuxia Wang and Kun Wang
    Citation: EJNMMI Research 2023 13:105
  24. Until recently, quantitation of the net influx of 2-[18F]fluorodeoxyglucose (FDG) to brain (Ki) and the cerebrometabolic rate for glucose (CMRglc) required serial arterial blood sampling in conjunction with dynam...

    Authors: Paul Cumming, André H. Dias, Lars C. Gormsen, Allan K. Hansen, Ian Alberts, Axel Rominger, Ole L. Munk and Hasan Sari
    Citation: EJNMMI Research 2023 13:104
  25. Metabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate the preclinical model of aortitis in BALB/c IL1rn−/− mice using [18F]fluorodeoxyglucose (...

    Authors: Samuel Deshayes, Caroline Baugé, Pierre-Antoine Dupont, Christophe Simard, Hanan Rida, Hubert de Boysson, Alain Manrique and Achille Aouba
    Citation: EJNMMI Research 2023 13:103
  26. Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor microenvironment (TME) of BM and particularly hypoxia and redox state, known to play a ro...

    Authors: Jade Fantin, Jérôme Toutain, Elodie A. Pérès, Benoit Bernay, Sarina Maya Mehani, Charly Helaine, Mickael Bourgeois, Carole Brunaud, Laurent Chazalviel, Julien Pontin, Aurélien Corroyer-Dulmont, Samuel Valable, Michel Cherel and Myriam Bernaudin
    Citation: EJNMMI Research 2023 13:102
  27. Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of this study was to evaluate the distribution of Lipiodol® ultra-fluid and microspheres a...

    Authors: Arnaud Dieudonné, Stéphanie Becker, Miguel Soares, Claire Hollenbeck, Marie-Christine De Goltstein, Pierre Vera and Robin Santus
    Citation: EJNMMI Research 2023 13:101
  28. CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive ...

    Authors: Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman and Marco de Bruyn
    Citation: EJNMMI Research 2023 13:100
  29. Targeting prostate-specific membrane antigen (PSMA) has been highly successful for imaging and treatment of prostate cancer. However, heterogeneity in immunohistochemistry indicates limitations in the effect o...

    Authors: Hui Wang, Marianne Remke, Thomas Horn, Kristina Schwamborn, Yiyao Chen, Katja Steiger, Wilko Weichert, Hans-Jürgen Wester, Margret Schottelius, Wolfgang A. Weber and Matthias Eiber
    Citation: EJNMMI Research 2023 13:99
  30. Brain [18F]FDG PET is used clinically mainly in the presurgical evaluation for epilepsy surgery and in the differential diagnosis of neurodegenerative disorders. While scans are usually interpreted visually on an...

    Authors: Sameer Omer Jin, Inés Mérida, Ioannis Stavropoulos, Robert D. C. Elwes, Tanya Lam, Eric Guedj, Nadine Girard, Nicolas Costes and Alexander Hammers
    Citation: EJNMMI Research 2023 13:98
  31. The need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research settings. Image-derived input function (IDIF) approaches have been proposed ...

    Authors: Tommaso Volpi, Lucia Maccioni, Maria Colpo, Giulia Debiasi, Amedeo Capotosti, Tommaso Ciceri, Richard E. Carson, Christine DeLorenzo, Andreas Hahn, Gitte Moos Knudsen, Adriaan A. Lammertsma, Julie C. Price, Vesna Sossi, Guobao Wang, Paolo Zanotti-Fregonara, Alessandra Bertoldo…
    Citation: EJNMMI Research 2023 13:97
  32. Splenic switch-off (SSO) is a marker of adequate adenosine-induced vasodilatation on cardiac magnetic resonance perfusion imaging. We evaluate the feasibility of quantitative assessment of SSO in myocardial po...

    Authors: Satu Irene Inkinen, Eero Hippeläinen and Valtteri Uusitalo
    Citation: EJNMMI Research 2023 13:96
  33. PSMA expression is influenced by hormonal status. We evaluated changes in PSA and whole-body 68Ga-PSMA-11 PET/CT (WB-PSMA PET) after initiation of androgen receptor signaling inhibitors (ARSi).

    Authors: Ida Sonni, Andrei Gafita, Lena M. Unterrainer, Rejah M. Alano, Stephanie Lira, John Shen, Alexandra Drakaki, Tristan Grogan, Matthew B. Rettig, Johannes Czernin and Jeremie Calais
    Citation: EJNMMI Research 2023 13:95
  34. Owing to the advances in diagnosis and therapy, survival or remission rates for lymphoma have improved prominently. Apart from the lymphoma- and chemotherapy-related somatic symptom burden, increasing attentio...

    Authors: Junyi Liu, Ming Tang, Dongling Zhu, Ge Ruan, Sijuan Zou, Zhaoting Cheng, Xiaohua Zhu and Yuankai Zhu
    Citation: EJNMMI Research 2023 13:94
  35. Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggeste...

    Authors: Hayel Tuncel, Denise Visser, Tessa Timmers, Emma E. Wolters, Rik Ossenkoppele, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard and Sandeep S. V. Golla
    Citation: EJNMMI Research 2023 13:93
  36. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults. Standard treatment includes chemoimmunotherapy with R-CHOP or similar regimens. Despite treatment advancement...

    Authors: Fenglian Jing, Yunuan Liu, Xinming Zhao, Na Wang, Meng Dai, Xiaolin Chen, Zhaoqi Zhang, Jingmian Zhang, Jianfang Wang and Yingchen Wang
    Citation: EJNMMI Research 2023 13:92
  37. The EANM Research Ltd. (EARL) guidelines give recommendations for harmonization of [18F]FDG PET-CT image acquisition and reconstruction, aiming to ensure reproducibility of quantitative data between PET scanners....

    Authors: Maurice C. Cox, Tijn Jurcka, Anne I. J. Arens, Maartje C. van Rijk, Johannes H. A. M. Kaanders and Sven van den Bosch
    Citation: EJNMMI Research 2023 13:91
  38. After myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse cardiac remodeling. FDG PET is an imaging modality sensitive to inflammation as long a...

    Authors: Benjamin Wilk, Haris Smailovic, Rebecca Sullivan, Erik R. Sistermans, John Butler, Hannah Jago, Michael Kovacs, Gerald Wisenberg, Jonathan D. Thiessen and Frank S. Prato
    Citation: EJNMMI Research 2023 13:90
  39. Vertebral compression fractures (VCFs) are common clinical problems that arise from various reasons. The differential diagnosis of benign and malignant VCFs is challenging. This study was designed to develop a...

    Authors: Xun Wang, Dandan Zhou, Yu Kong, Nan Cheng, Ming Gao, Guqing Zhang, Junli Ma, Yueqin Chen and Shuang Ge
    Citation: EJNMMI Research 2023 13:89
  40. Convolutional neural networks (CNNs), applied to baseline [18F]-FDG PET/CT maximum intensity projections (MIPs), show potential for treatment outcome prediction in diffuse large B-cell lymphoma (DLBCL). The aim o...

    Authors: Maria C. Ferrández, Sandeep S. V. Golla, Jakoba J. Eertink, Bart M. de Vries, Sanne E. Wiegers, Gerben J. C. Zwezerijnen, Simone Pieplenbosch, Louise Schilder, Martijn W. Heymans, Josée M. Zijlstra and Ronald Boellaard
    Citation: EJNMMI Research 2023 13:88
  41. Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower....

    Authors: Robert M. Bober, Richard V. Milani, Sergey M. Kachur and Daniel P. Morin
    Citation: EJNMMI Research 2023 13:87
  42. Kinetic modelling of dynamic PET typically requires knowledge of the arterial radiotracer concentration (arterial input function, AIF). Its accurate determination is very difficult in mice. AIF measurements in...

    Authors: Juela Cufe, Florian Gierse, Klaus P. Schäfers, Sven Hermann, Michael A. Schäfers, Philipp Backhaus and Florian Büther
    Citation: EJNMMI Research 2023 13:86
  43. Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-inflammatory activation. We aimed to investigate the hematopoietic-inflammatory activat...

    Authors: Yao Lu, Jingjing Meng, Mingkai Yun, Marcus Hacker, Xiang Li and Xiaoli Zhang
    Citation: EJNMMI Research 2023 13:85
  44. In 2022, the American Food and Drug Administration and the European Medicines Agency approved [177Lu]Lu-PSMA-617 (PLUVICTO™, Novartis AG, Basel, Switzerland) for radionuclide therapy with prostate-specific membra...

    Authors: Jan Heilinger, Jasmin Weindler, Katrin Sabine Roth, Philipp Krapf, Klaus Schomäcker, Markus Dietlein, Alexander Drzezga and Carsten Kobe
    Citation: EJNMMI Research 2023 13:83
  45. The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection are...

    Authors: Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato and Yasuyuki Kimura
    Citation: EJNMMI Research 2023 13:82
  46. Radiolabeled-antibodies usually display non-specific liver accumulation that may impair image analysis and antibody biodistribution. Here, we investigated whether Fc silencing influenced antibody biodistributi...

    Authors: Tristan Mangeat, Matthieu Gracia, Alexandre Pichard, Sophie Poty, Pierre Martineau, Bruno Robert and Emmanuel Deshayes
    Citation: EJNMMI Research 2023 13:81
  47. The low throughout of small animal positron emission tomography (PET) images acquisitions represents a substantial limitation. The aims of this study were (i) to design a low-cost support for simultaneous dyna...

    Authors: Caroline Bouillot, Sébastien Daligault, Radu Bolbos, Nicolas Costes and Luc Zimmer
    Citation: EJNMMI Research 2023 13:80