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  1. As a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemore...

    Authors: Neil Gerard Quigley, Katja Steiger, Frauke Richter, Wilko Weichert, Sebastian Hoberück, Jörg Kotzerke and Johannes Notni
    Citation: EJNMMI Research 2020 10:133
  2. Prostate-specific membrane antigen (PSMA) agents, such as [68Ga]Ga-PSMA-11, have an unprecedented accuracy in staging prostate cancer (PCa) and detecting disease recurrence. PSMA PET/CT may also be used for respo...

    Authors: Judith olde Heuvel, Berlinda J. de Wit-van der Veen, Maarten L. Donswijk, Cornelis H. Slump and Marcel P. M. Stokkel
    Citation: EJNMMI Research 2020 10:132
  3. With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson’s disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. ...

    Authors: Jingjie Ge, Min Wang, Wei Lin, Ping Wu, Yihui Guan, Huiwei Zhang, Zhemin Huang, Likun Yang, Chuantao Zuo, Jiehui Jiang, Axel Rominger and Kuangyu Shi
    Citation: EJNMMI Research 2020 10:131
  4. [177Lu]Lu-DOTA-ZOL has shown promising results from the dosimetry and preclinical aspects, but data on its role in the clinical efficacy are limited. The objective of this study is to evaluate the efficacy and sa...

    Authors: Madhav Prasad Yadav, Sanjana Ballal, Marian Meckel, Frank Roesch and Chandrasekhar Bal
    Citation: EJNMMI Research 2020 10:130
  5. Prostate-specific membrane antigen (PSMA) is expressed in the microvasculature of thyroid cancer. This suggests the potential use of PSMA as a diagnostic agent in patients with aggressive forms of thyroid canc...

    Authors: Courtney Lawhn-Heath, Sue S. Yom, Chienying Liu, Javier E. Villanueva-Meyer, Maya Aslam, Raven Smith, Manpreet Narwal, Roxanna Juarez, Spencer C. Behr, Miguel Hernandez Pampaloni, Jason W. Chan, Christine M. Glastonbury, Thomas A. Hope and Robert R. Flavell
    Citation: EJNMMI Research 2020 10:128
  6. In vivo imaging of glucose analogue 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) via positron emission tomography (PET) is the current gold standard to visualize and assess brown adipose tissue (BAT) activity. Howe...

    Authors: Andreas Paulus, Natascha Drude, Wouter van Marken Lichtenbelt, Felix M. Mottaghy and Matthias Bauwens
    Citation: EJNMMI Research 2020 10:127
  7. Some neuropsychological diseases are associated with abnormal thiamine metabolism, including Korsakoff–Wernicke syndrome and Alzheimer’s disease. However, in vivo detection of the status of brain thiamine meta...

    Authors: Changpeng Wang, Siwei Zhang, Yuefei Zou, Hongzhao Ma, Donglang Jiang, Lei Sheng, Shaoming Sang, Lirong Jin, Yihui Guan, Yuan Gui, Zhihong Xu and Chunjiu Zhong
    Citation: EJNMMI Research 2020 10:126
  8. To analyze the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional ...

    Authors: Amalia Peix, Kenia Padrón, Lázaro O. Cabrera, Osmín Castañeda, Danet Milán, Jesús Castro, Roylan Falcón, Frank Martínez, Lydia Rodríguez, Jesús Sánchez, Erick Mena, Regla Carrillo, Yoel Fernández, Ricardo Escarano, Diana Páez and Maurizio Dondi
    Citation: EJNMMI Research 2020 10:125
  9. Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodent...

    Authors: Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Nakul R. Raval, Ida V. Andersen, Fraser G. Edgar, Nikolaj R. Speth, Simone L. Baerentzen, Hanne D. Hansen, Lene L. Donovan, Arafat Nasser, Siv T. Peitersen, Andreas Kjaer, Gitte M. Knudsen, Stina Syvänen, Mikael Palner…
    Citation: EJNMMI Research 2020 10:124
  10. The standard reference region (RR) for amyloid-beta (Aβ) PET studies is the cerebellar grey matter (GMCB), while alternative RRs have mostly been utilized without prior validation against the gold standard. Th...

    Authors: Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Rik Ossenkoppele, Nelleke Tolboom, Bart N. M. van Berckel, Adriaan A. Lammertsma and Maqsood Yaqub
    Citation: EJNMMI Research 2020 10:123
  11. This is a prospective, single-center trial in pediatric patients with sarcoma aiming to evaluate [18F]FDG PET/CT as a tool for early response assessment to neoadjuvant chemotherapy (neo-CTX).

    Authors: Giulia Polverari, Francesco Ceci, Roberto Passera, Jacquelyn Crane, Lin Du, Gang Li, Stefano Fanti, Nicholas Bernthal, Fritz C. Eilber, Martin Allen-Auerbach, Johannes Czernin, Jeremie Calais and Noah Federman
    Citation: EJNMMI Research 2020 10:122
  12. Brain SPECT perfusion and PET metabolism have been, most often interchangeably, proposed to study the underlying pathological process in major depressive disorder (MDD). The objective of this study was to spec...

    Authors: Maud Tastevin, Laurent Boyer, Theo Korchia, Guillaume Fond, Christophe Lançon, Raphaëlle Richieri and Eric Guedj
    Citation: EJNMMI Research 2020 10:121
  13. 18F-FDG PET/CT is a standard for many B cell malignancies, while blood DNA measurements are emerging tools. Our objective was to evaluate the correlations between baseline PET parameters and circulating DNA in d....

    Authors: Pierre Decazes, Vincent Camus, Elodie Bohers, Pierre-Julien Viailly, Hervé Tilly, Philippe Ruminy, Mathieu Viennot, Sébastien Hapdey, Isabelle Gardin, Stéphanie Becker, Pierre Vera and Fabrice Jardin
    Citation: EJNMMI Research 2020 10:120
  14. Strong line of evidence suggests that the increased risk to develop AD may at least be partly mediated by cholesterol metabolism. A key regulator of cholesterol transport is the Apolipoprotein E4 (ApoE4), whic...

    Authors: Angela Kuhla, Lou Meuth, Jan Stenzel, Tobias Lindner, Chris Lappe, Jens Kurth, Bernd J. Krause, Stefan Teipel, Änne Glass, Guenther Kundt and Brigitte Vollmar
    Citation: EJNMMI Research 2020 10:119
  15. Integrin αvβ3, which are expressed by activated hepatic stellate cells in non-alcoholic steatohepatitis (NASH), play an important role in the fibrosis. Recently, we reported that an RGD peptide positron emission ...

    Authors: Shuichi Hiroyama, Takemi Rokugawa, Miwa Ito, Hitoshi Iimori, Ippei Morita, Hiroki Maeda, Kae Fujisawa, Keiko Matsunaga, Eku Shimosegawa and Kohji Abe
    Citation: EJNMMI Research 2020 10:118
  16. Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiol...

    Authors: Yo-Han Joo, Yun-Kwan Kim, In-Gyu Choi, Hyeon-Jin Kim, Young-Don Son, Hang-Keun Kim, Paul Cumming and Jong-Hoon Kim
    Citation: EJNMMI Research 2020 10:116
  17. Increases in fasting plasma glucose (PG) levels lead to a decrease in 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) uptake in the normal brain, especially in the precuneus, resulting in an Alzheimer’s disease (AD)-l...

    Authors: Jun Toyohara, Norihiro Harada, Takeharu Kakiuchi, Hiroyuki Ohba, Masakatsu Kanazawa, Tetsuro Tago, Muneyuki Sakata and Kiichi Ishiwata
    Citation: EJNMMI Research 2020 10:115
  18. Clinical positron emission tomography (PET) imaging of the presynaptic norepinephrine transporter (NET) function provides valuable diagnostic information on sympathetic outflow and neuronal status. As data on ...

    Authors: Linjing Mu, Stefanie D. Krämer, Geoffrey I. Warnock, Ahmed Haider, Susan Bengs, Giovanni Cartolano, Dominic S. Bräm, Claudia Keller, Roger Schibli, Simon M. Ametamey, Philipp A. Kaufmann and Catherine Gebhard
    Citation: EJNMMI Research 2020 10:114
  19. Accurate and sensitive imaging biomarkers are required to study the progression of white matter (WM) inflammation in neurodegenerative diseases. Radioligands targeting the translocator protein (TSPO) are consi...

    Authors: Nassir U. Al-Khishman, Qi Qi, Austyn D. Roseborough, Alexander Levit, Brian L. Allman, Udunna C. Anazodo, Matthew S. Fox, Shawn N. Whitehead and Jonathan D. Thiessen
    Citation: EJNMMI Research 2020 10:113
  20. Stress exposure can significantly affect serotonergic signaling with a particular impact on 5-HT1A receptor expression. Positron emission tomography (PET) provides opportunities for molecular imaging of alteratio...

    Authors: Verena Buchecker, Ann-Marie Waldron, R. Maarten van Dijk, Ines Koska, Matthias Brendel, Barbara von Ungern-Sternberg, Simon Lindner, Franz Josef Gildehaus, Sibylle Ziegler, Peter Bartenstein and Heidrun Potschka
    Citation: EJNMMI Research 2020 10:112
  21. The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag tech...

    Authors: Frans V. Suurs, Si-Qi Qiu, Joshua J. Yim, Carolien P. Schröder, Hetty Timmer-Bosscha, Eric S. Bensen, John T. Santini Jr, Elisabeth G. E. de Vries, Matthew Bogyo and Gooitzen M. van Dam
    Citation: EJNMMI Research 2020 10:111
  22. The aim of this study was to explore the prognostic value of total metabolic tumor volume (TMTV) at baseline 18F-FDG PET/CT in patients diagnosed with peripheral T-cell lymphoma (PTCL).

    Authors: Chong Jiang, Yue Teng, Jieyu Chen, Zhen Wang, Zhengyang Zhou, Chongyang Ding and Jingyan Xu
    Citation: EJNMMI Research 2020 10:110
  23. Positron emission tomography (PET) offers the study of biochemical, physiological, and pharmacological functions at a cellular and molecular level. The performance of a ...

    Authors: Krishna Kanta Ghosh, Parasuraman Padmanabhan, Chang-Tong Yang, Sachin Mishra, Christer Halldin and Balázs Gulyás
    Citation: EJNMMI Research 2020 10:109
  24. Brain metastases from prostate cancer are rare and usually only occur in the context of widespread systemic disease. This is the first case report of a solitary brain oligometastasis, in a neurologically intac...

    Authors: M. I. Ross, N. Bird, I. A. Mendichovszky and Y. L. Rimmer
    Citation: EJNMMI Research 2020 10:108

    The Correction to this article has been published in EJNMMI Research 2020 10:129

  25. Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The ai...

    Authors: Caren van Roekel, Jennifer M. J. Jongen, Maarten L. J. Smits, Sjoerd G. Elias, Miriam Koopman, Onno Kranenburg, Inne H. M. Borel Rinkes and Marnix G. E. H. Lam
    Citation: EJNMMI Research 2020 10:107
  26. Albumin is commonly used as a carrier platform for drugs to extend their circulatory half-lives and influence their uptake into tissues that have altered permeability to the plasma protein. The albumin-binding...

    Authors: Emma Jussing, Li Lu, Jonas Grafström, Tetyana Tegnebratt, Fabian Arnberg, Helena Wållberg Rosik, Anders Wennborg, Staffan Holmin, Joachim Feldwisch and Sharon Stone-Elander
    Citation: EJNMMI Research 2020 10:106
  27. PET is a relatively noisy process compared to other imaging modalities, and sparsity of acquisition data leads to noise in the images. Recent work has focused on machine learning techniques to improve PET imag...

    Authors: Josh Schaefferkoetter, Jianhua Yan, Claudia Ortega, Andrew Sertic, Eli Lechtman, Yael Eshet, Ur Metser and Patrick Veit-Haibach
    Citation: EJNMMI Research 2020 10:105
  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexander S. Pasciak, Sasicha Manupipatpong, Ferdinand K. Hui, Larry Gainsburg, Rebecca Krimins, M. Christine Zink, Cory F. Brayton, Meaghan Morris, Jaime Sage, Danielle R. Donahue, Matthew R. Dreher, Dara L. Kraitchman and Clifford R. Weiss
    Citation: EJNMMI Research 2020 10:104

    The original article was published in EJNMMI Research 2020 10:96

  29. Radiomics is aimed at image-based tumor phenotyping, enabling application within clinical-decision-support-systems to improve diagnostic accuracy and allow for personalized treatment. The purpose was to identi...

    Authors: Roland M. Martens, Thomas Koopman, Daniel P. Noij, Elisabeth Pfaehler, Caroline Übelhör, Sughandi Sharma, Marije R. Vergeer, C. René Leemans, Otto S. Hoekstra, Maqsood Yaqub, Gerben J. Zwezerijnen, Martijn W. Heymans, Carel F. W. Peeters, Remco de Bree, Pim de Graaf, Jonas A. Castelijns…
    Citation: EJNMMI Research 2020 10:102
  30. Several nuclear imaging methods may predict postoperative liver function and outcome, but none has achieved recommendations in clinical guidelines. The purpose of this systematic review was to summarize the ex...

    Authors: Caroline Espersen, Lise Borgwardt, Peter Nørgaard Larsen, Trine Borup Andersen, Louise Stenholt and Lars Jelstrup Petersen
    Citation: EJNMMI Research 2020 10:101
  31. (4S)-4-(3-[18F]Fluoropropyl)-l-glutamic acid ([18F]FSPG) measures system xC transporter activity and shows promise for oncologic imaging. We present data on tumor uptake of this radiopharmaceutical in human subj...

    Authors: Sonya Y. Park, Camila Mosci, Meena Kumar, Mirwais Wardak, Norman Koglin, Santiago Bullich, Andre Mueller, Mathias Berndt, Andrew W. Stephens, Frederick T. Chin, Sanjiv S. Gambhir and Erik S. Mittra
    Citation: EJNMMI Research 2020 10:100
  32. Q.Clear is a new Bayesian penalized-likelihood PET reconstruction algorithm. It has been documented that Q.Clear increases the SUVmax values of different malignant lesions.

    Authors: Michał Wyrzykowski, Natalia Siminiak, Maciej Kaźmierczak, Marek Ruchała and Rafał Czepczyński
    Citation: EJNMMI Research 2020 10:99
  33. TEM-1 (tumor endothelial marker-1) is a single-pass transmembrane cell surface glycoprotein expressed at high levels by tumor vasculature and malignant cells. We aimed to perform a preclinical investigation of...

    Authors: J. A. Delage, A. Faivre-Chauvet, J. K. Fierle, S. Gnesin, N. Schaefer, G. Coukos, S. M. Dunn, D. Viertl and J. O. Prior
    Citation: EJNMMI Research 2020 10:98
  34. Only a subgroup of non-small cell lung cancer (NSCLC) patients benefit from treatment using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) such as afatinib. Tumour uptake of [18F]afatini...

    Authors: E. A. van de Stadt, M. Yaqub, A. A. Lammertsma, A. J. Poot, P. R. Schober, R. C. Schuit, E. F. Smit, I. Bahce and N. H. Hendrikse
    Citation: EJNMMI Research 2020 10:97
  35. To evaluate the safety, feasibility, and preliminary efficacy of yttrium-90 (90Y) radioembolization (RE) as a minimally invasive treatment in a canine model with presumed spontaneous brain cancers.

    Authors: Alexander S. Pasciak, Sasicha Manupipatpong, Ferdinand K. Hui, Larry Gainsburg, Rebecca Krimins, M. Christine Zink, Cory F. Brayton, Meaghan Morris, Jaime Sage, Danielle R. Donahue, Matthew R. Dreher, Dara L. Kraitchman and Clifford R. Weiss
    Citation: EJNMMI Research 2020 10:96

    The Correction to this article has been published in EJNMMI Research 2020 10:104

  36. Reliable quantification of dopamine transporter (DAT), a biomarker for Parkinson’s disease (PD), is essential for diagnostic purposes as well as for evaluation of potential disease-modifying treatment. Due to ...

    Authors: Vera S. Kerstens, Patrik Fazio, Mathias Sundgren, Granville J. Matheson, Erika Franzén, Christer Halldin, Simon Cervenka, Per Svenningsson and Andrea Varrone
    Citation: EJNMMI Research 2020 10:95
  37. Selective internal radiation therapy (SIRT) is a promising treatment for unresectable hepatic malignancies. Predictive dose calculation based on a simulation using 99mTc-labeled macro-aggregated albumin (99mTc-MA...

    Authors: Esmaeel Jafargholi Rangraz, Xikai Tang, Charlotte Van Laeken, Geert Maleux, Jeroen Dekervel, Eric Van Cutsem, Chris Verslype, Kristof Baete, Johan Nuyts and Christophe M. Deroose
    Citation: EJNMMI Research 2020 10:94
  38. The aim of this study was to examine whether the translocator protein 18-kDa (TSPO) PET ligand [18F]FEPPA has the sensitivity for detecting changes in CD68-positive microglial/macrophage activation in hemiparkins...

    Authors: Matthew Zammit, Yunlong Tao, Miles E. Olsen, Jeanette Metzger, Scott C. Vermilyea, Kathryn Bjornson, Maxim Slesarev, Walter F. Block, Kerri Fuchs, Sean Phillips, Viktorya Bondarenko, Su-Chun Zhang, Marina E. Emborg and Bradley T. Christian
    Citation: EJNMMI Research 2020 10:93
  39. Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. In parallel, a novel approach to achieve sensitive radioguidance usi...

    Authors: Francesco Collamati, Matthias N. van Oosterom, Micol De Simoni, Riccardo Faccini, Marta Fischetti, Carlo Mancini Terracciano, Riccardo Mirabelli, Roberto Moretti, Judith olde Heuvel, Elena Solfaroli Camillocci, Florian van Beurden, Henk G. van der Poel, Renato A. Valdes Olmos, Pim J. van Leeuwen, Fijs W. B. van Leeuwen and Silvio Morganti
    Citation: EJNMMI Research 2020 10:92
  40. The lack of visualization of the spinal cord hinders the evaluation of [18F]Fluoro-deoxy-glucose (FDG) uptake of the spinal cord in PET/CT. By exploiting the capability of MRI to precisely outline the spinal cord...

    Authors: Marco Aiello, Vincenzo Alfano, Elena Salvatore, Carlo Cavaliere, Marco Picardi, Roberta Della Pepa, Emanuele Nicolai, Andrea Soricelli, Alessandra Vella, Marco Salvatore and Mario Mascalchi
    Citation: EJNMMI Research 2020 10:91
  41. Somatostatin receptor (SST) targeting, specifically of the subtype 2 (SST2), with radiolabeled somatostatin analogs, is established for imaging and treatment of neuroendocrine tumors. Owing to the concomitant ...

    Authors: Rosalba Mansi, Karim Abid, Guillaume P. Nicolas, Luigi Del Pozzo, Eric Grouzmann and Melpomeni Fani
    Citation: EJNMMI Research 2020 10:90
  42. In order to study the CXCR4 expression with [68Ga]pentixafor PET in different types of non-Hodgkin lymphoma, we performed a retrospective study to describe the [68Ga]pentixafor PET/CT imaging in a spectrum of lym...

    Authors: Qingqing Pan, Yaping Luo, Yan Zhang, Long Chang, Ji Li, Xinxin Cao, Jian Li and Fang Li
    Citation: EJNMMI Research 2020 10:89
  43. To decipher the correlations between PET and DCE kinetic parameters in non-small-cell lung cancer (NSCLC), by using voxel-wise analysis of dynamic simultaneous [18F]FDG PET-MRI.

    Authors: Florent L. Besson, Brice Fernandez, Sylvain Faure, Olaf Mercier, Andrei Seferian, Xavier Mignard, Sacha Mussot, Cecile le Pechoux, Caroline Caramella, Angela Botticella, Antonin Levy, Florence Parent, Sophie Bulifon, David Montani, Delphine Mitilian, Elie Fadel…
    Citation: EJNMMI Research 2020 10:88
  44. The urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is involved such as inflammation, but also in diseases as arth...

    Authors: V. M. Baart, R. D. Houvast, L. F. de Geus-Oei, P. H. A. Quax, P. J. K. Kuppen, A. L. Vahrmeijer and C. F. M. Sier
    Citation: EJNMMI Research 2020 10:87
  45. Emphysema severity is frequently measured on CT via densitometry. Correlation with scintigraphic and spirometric functional measures of ventilation or perfusion varies widely, and no prior study has evaluated ...

    Authors: Asha Bonney, Carrie-Anne Wagner, Shankar Siva, Jason Callahan, Pierre-Yves Le Roux, Diane M. Pascoe, Louis Irving, Michael S. Hofman and Daniel P. Steinfort
    Citation: EJNMMI Research 2020 10:86
  46. Brown adipose tissue (BAT) is a thermogenic tissue which can generate heat in response to mild cold exposure. As it constitutes a promising target in the fight against obesity, we need reliable techniques to q...

    Authors: Jonas Gabriel William Fischer, Claudia Irene Maushart, Anton S. Becker, Julian Müller, Philipp Madoerin, Alin Chirindel, Damian Wild, Edwin E. G. W. ter Voert, Oliver Bieri, Irene Burger and Matthias Johannes Betz
    Citation: EJNMMI Research 2020 10:85
  47. [18F]MC225 is a selective substrate for P-glycoprotein (P-gp) that has good metabolic stability and shows higher baseline uptake compared with other P-gp substrates such as (R)-[11C]Verapamil. Prior to clinical t...

    Authors: Jun Toyohara, Muneyuki Sakata, Tetsuro Tago, Nicola A. Colabufo and Gert Luurtsema
    Citation: EJNMMI Research 2020 10:84