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  1. Original research

    Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects

    18F-Tetrafluoroborate (18F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The ai...

    Huailei Jiang, Nicholas R. Schmit, Alex R. Koenen, Aditya Bansal, Mukesh K. Pandey, Robert B. Glynn, Bradley J. Kemp, Kera L. Delaney, Angela Dispenzieri, Jamie N. Bakkum-Gamez, Kah-Whye Peng, Stephen J. Russell, Tina M. Gunderson, Val J. Lowe and Timothy R. DeGrado

    EJNMMI Research 2017 7:90

    Published on: 27 October 2017

  2. Original research

    Oxygen-15 labeled CO2, O2, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

    Positron emission tomography (PET) studies using 15O-labeled CO2, O2, and CO have been used in humans to evaluate cerebral blood flow (CBF), the cerebral oxygen extraction fraction (OEF), and the cerebral metabol...

    Genki Horitsugi, Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Hiroki Kato, Sadahiro Naka, Mana Ishibashi, Keiko Matsunaga, Kayako Isohashi, Eku Shimosegawa and Jun Hatazawa

    EJNMMI Research 2017 7:91

    Published on: 27 October 2017

  3. Original research

    TSPO imaging using the novel PET ligand [18F]GE-180: quantification approaches in patients with multiple sclerosis

    PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [

    Lena Vomacka, Nathalie Lisa Albert, Simon Lindner, Marcus Unterrainer, Christoph Mahler, Matthias Brendel, Larissa Ermoschkin, Astrid Gosewisch, Anika Brunegraf, Christopher Buckley, Tania Kümpfel, Rainer Rupprecht, Sibylle Ziegler, Martin Kerschensteiner, Peter Bartenstein and Guido Böning

    EJNMMI Research 2017 7:89

    Published on: 26 October 2017

  4. Original research

    Simple, mild, one-step labelling of proteins with gallium-68 using a tris(hydroxypyridinone) bifunctional chelator: a 68Ga-THP-scFv targeting the prostate-specific membrane antigen

    Labelling proteins with gallium-68 using bifunctional chelators is often problematic because of unsuitably harsh labelling conditions such as low pH or high temperature and may entail post-labelling purificati...

    Saima Nawaz, Gregory E. D. Mullen, Kavitha Sunassee, Jayanta Bordoloi, Philip J. Blower and James R. Ballinger

    EJNMMI Research 2017 7:86

    Published on: 25 October 2017

  5. Original research

    Potential of asphericity as a novel diagnostic parameter in the evaluation of patients with 68Ga-PSMA-HBED-CC PET-positive prostate cancer lesions

    The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients ...

    Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Frank Hofheinz and Marcus R. Makowski

    EJNMMI Research 2017 7:85

    Published on: 23 October 2017

  6. Commentary

    Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

    Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands—(R)-PK1119...

    Masahiro Fujita, Masato Kobayashi, Masamichi Ikawa, Roger N. Gunn, Eugenii A. Rabiner, David R. Owen, Sami S. Zoghbi, Mohamad B. Haskali, Sanjay Telu, Victor W. Pike and Robert B. Innis

    EJNMMI Research 2017 7:84

    Published on: 16 October 2017

  7. Original research

    Initial evaluation of the Celesteion large-bore PET/CT scanner in accordance with the NEMA NU2-2012 standard and the Japanese guideline for oncology FDG PET/CT data acquisition protocol version 2.0

    The goal of this study was to evaluate the performance of the Celesteion positron emission tomography/computed tomography (PET/CT) scanner, which is characterized by a large-bore and time-of-flight (TOF) funct...

    Tomohiro Kaneta, Matsuyoshi Ogawa, Nobutoku Motomura, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida and Tomio Inoue

    EJNMMI Research 2017 7:83

    Published on: 11 October 2017

  8. Original research

    Automatic delineation of functional lung volumes with 68Ga-ventilation/perfusion PET/CT

    Functional volumes computed from 68Ga-ventilation/perfusion (V/Q) PET/CT, which we have shown to correlate with pulmonary function test parameters (PFTs), have potential diagnostic utility in a variety of clinica...

    Pierre-Yves Le Roux, Shankar Siva, Jason Callahan, Yannis Claudic, David Bourhis, Daniel P. Steinfort, Rodney J. Hicks and Michael S. Hofman

    EJNMMI Research 2017 7:82

    Published on: 10 October 2017

  9. Original research

    Ra-223 SPECT for semi-quantitative analysis in comparison with Tc-99m HMDP SPECT: phantom study and initial clinical experience

    Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to b...

    Yoshiki Owaki, Tadaki Nakahara, Takeo Kosaka, Junichi Fukada, Atsuhiro Kumabe, Akira Ichimura, Mikoto Murakami, Kiyotaka Nakajima, Masahiro Fukushi, Kazumasa Inoue, Mototsugu Oya and Masahiro Jinzaki

    EJNMMI Research 2017 7:81

    Published on: 3 October 2017

  10. Original research

    Correlation of 99mTc-sestamibi uptake in renal masses with mitochondrial content and multi-drug resistance pump expression

    99mTc-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has recently been explored for the characterization of indeterminate renal masses. As judged b...

    Steven P. Rowe, Michael A. Gorin, Lilja B. Solnes, Mark W. Ball, Ajuni Choudhary, Phillip M. Pierorazio, Jonathan I. Epstein, Mehrbod S. Javadi, Mohamad E. Allaf and Alex S. Baras

    EJNMMI Research 2017 7:80

    Published on: 2 October 2017

  11. Short communication

    Group-sequential analysis may allow for early trial termination: illustration by an intra-observer repeatability study

    Group-sequential testing is widely used in pivotal therapeutic, but rarely in diagnostic research, although it may save studies, time, and costs. The purpose of this paper was to demonstrate a group-sequential...

    Oke Gerke, Mie H. Vilstrup, Ulrich Halekoh, Malene Grubbe Hildebrandt and Poul Flemming Høilund-Carlsen

    EJNMMI Research 2017 7:79

    Published on: 26 September 2017

  12. Original research

    [18F]Fluoromisonidazole PET in rectal cancer

    There is an increasing interest in developing predictive biomarkers of tissue hypoxia using functional imaging for personalised radiotherapy in patients with rectal cancer that are considered for neoadjuvant c...

    Tanuj Puri, Tessa A. Greenhalgh, James M. Wilson, Jamie Franklin, Lia Mun Wang, Victoria Strauss, Chris Cunningham, Mike Partridge and Tim Maughan

    EJNMMI Research 2017 7:78

    Published on: 20 September 2017

  13. Original research

    Optimal MRI sequences for 68Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer

    PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings...

    Spencer T. Lake, Kirsten L. Greene, Antonio C. Westphalen, Spencer C. Behr, Ronald Zagoria, Eric J. Small, Peter R. Carroll and Thomas A. Hope

    EJNMMI Research 2017 7:77

    Published on: 19 September 2017

  14. Original research

    Gut microbiota and physiologic bowel 18F-FDG uptake

    We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology o...

    Ji Yeon Kang, Han-Na Kim, Yoosoo Chang, Yeojun Yun, Seungho Ryu, Hocheol Shin and Hyung-Lae Kim

    EJNMMI Research 2017 7:72

    Published on: 31 August 2017

  15. Original research

    Metabolic liver function in humans measured by 2-18F-fluoro-2-deoxy-D-galactose PET/CT–reproducibility and clinical potential

    PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We det...

    Kirstine P. Bak-Fredslund, Peter Lykke Eriksen, Ole L. Munk, Gerda E. Villadsen, Susanne Keiding and Michael Sørensen

    EJNMMI Research 2017 7:71

    Published on: 29 August 2017

  16. Original research

    Comparative evaluation of 18F-FLT and 18F-FDG for detecting cardiac and extra-cardiac thoracic involvement in patients with newly diagnosed sarcoidosis

    18F-FDG PET has been used in sarcoidosis for diagnosis and determination of the extent of the disease. However, assessing inflammatory lesions in cardiac sarcoidosis using 18F-FDG can ...

    Takashi Norikane, Yuka Yamamoto, Yukito Maeda, Takahisa Noma, Hiroaki Dobashi and Yoshihiro Nishiyama

    EJNMMI Research 2017 7:69

    Published on: 29 August 2017

    The original article was published in EJNMMI Research 2017 7:70

    The original article that this is related to.

  17. Original research

    Motor impairment and compensation in a hemiparkinsonian rat model: correlation between dopamine depletion severity, cerebral metabolism and gait patterns

    In Parkinson’s disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment...

    Elena Kordys, Nadine Apetz, Katharina Schneider, Eilidh Duncan, Beatriz Büschbell, Cathrin Rohleder, Michael Sué, Alexander Drzezga, Bernd Neumaier, Lars Timmermann and Heike Endepols

    EJNMMI Research 2017 7:68

    Published on: 23 August 2017

  18. Preliminary research

    Semi-quantitative metabolic values on FDG PET/CT including extracardiac sites of disease as a predictor of treatment course in patients with cardiac sarcoidosis

    Cardiac sarcoidosis is associated with major adverse cardiac events including cardiac arrest, for which anti-inflammatory treatment is indicated. Oral corticosteroid is the mainstay among treatment options; ho...

    Mitsutomi Ishiyama, Laurie A. Soine and Hubert J. Vesselle

    EJNMMI Research 2017 7:67

    Published on: 18 August 2017

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