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  1. Convolutional neural networks (CNNs), applied to baseline [18F]-FDG PET/CT maximum intensity projections (MIPs), show potential for treatment outcome prediction in diffuse large B-cell lymphoma (DLBCL). The aim o...

    Authors: Maria C. Ferrández, Sandeep S. V. Golla, Jakoba J. Eertink, Bart M. de Vries, Sanne E. Wiegers, Gerben J. C. Zwezerijnen, Simone Pieplenbosch, Louise Schilder, Martijn W. Heymans, Josée M. Zijlstra and Ronald Boellaard
    Citation: EJNMMI Research 2023 13:88
    Content type: Original research Published on:

  2. Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower....

    Authors: Robert M. Bober, Richard V. Milani, Sergey M. Kachur and Daniel P. Morin
    Citation: EJNMMI Research 2023 13:87
    Content type: Original research Published on:

  3. Kinetic modelling of dynamic PET typically requires knowledge of the arterial radiotracer concentration (arterial input function, AIF). Its accurate determination is very difficult in mice. AIF measurements in...

    Authors: Juela Cufe, Florian Gierse, Klaus P. Schäfers, Sven Hermann, Michael A. Schäfers, Philipp Backhaus and Florian Büther
    Citation: EJNMMI Research 2023 13:86
    Content type: Original research Published on:

  4. Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-inflammatory activation. We aimed to investigate the hematopoietic-inflammatory activat...

    Authors: Yao Lu, Jingjing Meng, Mingkai Yun, Marcus Hacker, Xiang Li and Xiaoli Zhang
    Citation: EJNMMI Research 2023 13:85
    Content type: Original research Published on:

  6. In 2022, the American Food and Drug Administration and the European Medicines Agency approved [177Lu]Lu-PSMA-617 (PLUVICTO™, Novartis AG, Basel, Switzerland) for radionuclide therapy with prostate-specific membra...

    Authors: Jan Heilinger, Jasmin Weindler, Katrin Sabine Roth, Philipp Krapf, Klaus Schomäcker, Markus Dietlein, Alexander Drzezga and Carsten Kobe
    Citation: EJNMMI Research 2023 13:83
    Content type: Original research Published on:

  7. The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection are...

    Authors: Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato and Yasuyuki Kimura
    Citation: EJNMMI Research 2023 13:82
    Content type: Original research Published on:

  8. Radiolabeled-antibodies usually display non-specific liver accumulation that may impair image analysis and antibody biodistribution. Here, we investigated whether Fc silencing influenced antibody biodistributi...

    Authors: Tristan Mangeat, Matthieu Gracia, Alexandre Pichard, Sophie Poty, Pierre Martineau, Bruno Robert and Emmanuel Deshayes
    Citation: EJNMMI Research 2023 13:81
    Content type: Preliminary research Published on:

  9. The low throughout of small animal positron emission tomography (PET) images acquisitions represents a substantial limitation. The aims of this study were (i) to design a low-cost support for simultaneous dyna...

    Authors: Caroline Bouillot, Sébastien Daligault, Radu Bolbos, Nicolas Costes and Luc Zimmer
    Citation: EJNMMI Research 2023 13:80
    Content type: Original research Published on:

  10. Accurate analysis of quantitative PET data plays a crucial role in studying small, specific brain structures. The integration of PET and MRI through an integrated PET/MR system presents an opportunity to lever...

    Authors: Yi Shan, Shao-zhen Yan, Zhe Wang, Bi-xiao Cui, Hong-wei Yang, Jian-min Yuan, Ya-yan Yin, Feng Shi and Jie Lu
    Citation: EJNMMI Research 2023 13:79
    Content type: Original research Published on:

  11. Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments target...

    Authors: Wolfgang Roll, Michael Müther, Guido Böning, Astrid Delker, Nils Warneke, Franz-Josef Gildehaus, Michael Schäfers, Walter Stummer, Reinhard Zeidler, Hans-Jürgen Reulen and Lars Stegger
    Citation: EJNMMI Research 2023 13:78
    Content type: Original research Published on:

  12. Early detection of recurrent or progressive HCC remains the strongest prognostic factor for survival. Dual tracer PET/CT imaging with [11C]CH and [18F]FDG can further increase detection rates as both tracers enta...

    Authors: Emile B. Veenstra, Simeon J. S. Ruiter, Robbert J. de Haas, Koert P. de Jong, Paola A. Erba, Rudi A. J. O. Dierckx and Walter Noordzij
    Citation: EJNMMI Research 2023 13:77
    Content type: Original research Published on:

  14. Several software tools have been developed for gated PET imaging that use distinct algorithms to analyze tracer uptake, myocardial perfusion, and left ventricle volumes and function. Studies suggest that diffe...

    Authors: Mathias J. Zacherl, Agus Simenhandra, Magdalena Lindner, Peter Bartenstein, Andrei Todica, Guido Boening and Maximilian Fischer
    Citation: EJNMMI Research 2023 13:75
    Content type: Original research Published on:

  15. Atypical parkinsonism (AP) often presents with Parkinson’s symptoms but has a much worse long-term prognosis. The diagnosis is presently based on clinical criteria, but a cerebral positron emission tomography ...

    Authors: Naba Jawad Houssein, Alexander Cuculiza Henriksen, Anne-Mette Hejl and Lisbeth Marner
    Citation: EJNMMI Research 2023 13:74
    Content type: Original research Published on:

  16. In vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize cell therapies and related new developments in the field. Our...

    Authors: Ida Friberger, Joachim N. Nilsson, Li Lu, Jonathan Siikanen, Oscar Ardenfors, Stefan Milton, Erik Samén, Jeroen A. C. M. Goos, Mattias Carlsten, Staffan Holmin and Thuy A. Tran
    Citation: EJNMMI Research 2023 13:73
    Content type: Original research Published on:

  17. Chylothorax is a condition that can be challenging to diagnose due to its nonspecific clinical presentation. Several biochemical parameters of chylous pleural effusion have been identified as important indicat...

    Authors: Li Zhang, Xiaoyue Zhang, Zhe Wen, Guansheng Tong, Kun Hao, Yongkang Qiu and Lei Kang
    Citation: EJNMMI Research 2023 13:72
    Content type: Original research Published on:

  18. Behavioural symptoms and frontotemporal hypometabolism overlap between behavioural variant of frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), hampering diagnostic distinction. Voxel-wi...

    Authors: Marie-Paule E. van Engelen, Sander C. J. Verfaillie, Annemieke Dols, Mardien L. Oudega, Ronald Boellaard, Sandeep S. V. Golla, Marijke den Hollander, Rik Ossenkoppele, Philip Scheltens, Bart N. M. van Berckel, Yolande A. L. Pijnenburg and Everard G. B. Vijverberg
    Citation: EJNMMI Research 2023 13:71
    Content type: Original research Published on:

  19. To investigate the use of dynamic radiomics features derived from dual-time-point (DTP-feature) [18F]FDG PET metabolic uptake rate Ki parametric maps to develop a predictive model for response to chemotherapy in ...

    Authors: Rezvan Samimi, Isaac Shiri, Yashar Ahmadyar, Jörg van den Hoff, Alireza Kamali-Asl, Alireza Rezaee, Fereshteh Yousefirizi, Parham Geramifar and Arman Rahmim
    Citation: EJNMMI Research 2023 13:70
    Content type: Original research Published on:

  20. Lenvatinib is widely used to treat unresectable and advanced thyroid carcinomas. We aimed to determine whether 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) performed 1 we...

    Authors: Satoshi Takeuchi, Kenji Hirata, Keiichi Magota, Shiro Watanabe, Rika Moku, Akihiko Shiiya, Jun Taguchi, Shin Ariga, Tomohiro Goda, Yoshihito Ohhara, Takurou Noguchi, Yasushi Shimizu, Ichiro Kinoshita, Rio Honma, Yasushi Tsuji, Akihiro Homma…
    Citation: EJNMMI Research 2023 13:69
    Content type: Original research Published on:

  21. For safe and effective holmium-166 (166Ho) liver radioembolization, dosimetry is crucial and requires accurate healthy liver definition. The current clinical standard relies on manual segmentation and registratio...

    Authors: Martina Stella, Rob van Rooij, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Arthur J. A. T. Braat
    Citation: EJNMMI Research 2023 13:68
    Content type: Original research Published on:

  22. CXCR3 is a chemokine receptor and is expressed in innate and adaptive immune cells. It promotes the recruitment of T-lymphocytes and other immune cells to the inflammatory site in response to the binding of co...

    Authors: Santosh R. Alluri, Yusuke Higashi, Ashley Berendzen, Laurel A. Grisanti, Lisa D. Watkinson, Kamlendra Singh, Timothy J. Hoffman, Terry Carmack, Elizabeth A. Devanny, Miles Tanner and Kun-Eek Kil
    Citation: EJNMMI Research 2023 13:67
    Content type: Original research Published on:

  23. This study aimed to retrospectively evaluate the feasibility of total-body 18F-FDG PET/CT ultrafast acquisition combined with a deep learning (DL) image filter in the diagnosis of colorectal cancers (CRCs).

    Authors: Entao Liu, Zejian Lyu, Yuelong Yang, Yang Lv, Yumo Zhao, Xiaochun Zhang, Taotao Sun, Lei Jiang and Zaiyi Liu
    Citation: EJNMMI Research 2023 13:66
    Content type: Original research Published on:

  24. Over the last years, several strategies have been reported to improve the metabolic stability of minigastrin analogs. However, currently applied compounds still reveal limited in vitro and in vivo stability. W...

    Authors: Nadine Holzleitner, Thomas Günther, Amira Daoud-Gadieh, Constantin Lapa and Hans-Jürgen Wester
    Citation: EJNMMI Research 2023 13:65
    Content type: Original research Published on:

  25. Non-regional lymph node (NRLN) metastases has shown increasing importance in the prognosis evaluation and clinical management of primary metastatic hormone-sensitive prostate cancer (mHSPC). Hence, this study ...

    Authors: Zhangdong Jiang, Junjie Fan, Chaosheng Gan, Xiaoxin Dong, Guoqiang Gao, Zhuonan Wang, Dalin He, Lei Li, XiaoYi Duan and Kaijie Wu
    Citation: EJNMMI Research 2023 13:64
    Content type: Original research Published on:

  26. Selective internal radiation therapy with 90Y radioembolization aims to selectively irradiate liver tumours by administering radioactive microspheres under the theragnostic assumption that the pre-therapy injecti...

    Authors: Mercedes Riveira-Martin, Azadeh Akhavanallaf, Zahra Mansouri, Nicola Bianchetto Wolf, Yazdan Salimi, Alexis Ricoeur, Ismini Mainta, Valentina Garibotto, Antonio López Medina and Habib Zaidi
    Citation: EJNMMI Research 2023 13:63
    Content type: Original research Published on:

  27. Penile cancer is characterized by an early lymphatic dissemination. In intermediate and high-risk primary tumors without palpable inguinal lymph nodes, there is a 6–30% risk of micro-metastatic disease. Invasi...

    Authors: Juanito Gebruers, Laura Elst, Marcella Baldewijns, Liesbeth De Wever, Koen Van Laere, Maarten Albersen and Karolien Goffin
    Citation: EJNMMI Research 2023 13:62
    Content type: Original research Published on:

  28. Butylscopolamine (or hyoscine butylbromide, trade name Buscopan®) is occasionally administered as a premedication to reduce non-specific FDG uptake in the gastrointestinal tract based on its antiperistaltic effec...

    Authors: Falk Gühne, Ferdinand Ndum, Philipp Seifert, Thomas Winkens, Robert Drescher and Martin Freesmeyer
    Citation: EJNMMI Research 2023 13:61
    Content type: Original research Published on:

  29. Folate intake might reduce [68Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this co...

    Authors: Hinke Siebinga, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema and Berlinda J. de Wit-van der Veen
    Citation: EJNMMI Research 2023 13:60
    Content type: Original research Published on:

  30. The development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under development necessitating both biokinetic and dosimetry extrapo...

    Authors: Silvano Gnesin, Nicolas Chouin, Michel Cherel, Steven Mark Dunn, Niklaus Schaefer, Alain Faivre-Chauvet, John O. Prior and Judith Anna Delage
    Citation: EJNMMI Research 2023 13:59
    Content type: Original research Published on:

  31. Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC). No imaging method can successfully detect all (micro)metastases. This may result in (lymph node) recurrence a...

    Authors: Judit A. Adam, Edwin Poel, Berthe L. F. van Eck-Smit, Constantijne H. Mom, Lukas J. A. Stalpers, Jaap Stoker and Shandra Bipat
    Citation: EJNMMI Research 2023 13:58
    Content type: Original research Published on:

  32. Dosimetry promises many advantages for radiopharmaceutical therapies but repeat post-therapy imaging for dosimetry can burden both patients and clinics. Recent applications of reduced time point imaging for ti...

    Authors: Avery B. Peterson, David M. Mirando and Yuni K. Dewaraja
    Citation: EJNMMI Research 2023 13:57
    Content type: Original research Published on:

  33. The gastrin-releasing peptide receptor (GRPr) is a molecular target for the visualization of prostate cancer. Bombesin (BN) analogs are short peptides with a high affinity for GRPr. RM2 is a bombesin-based ant...

    Authors: Yinwen Wang, Hongmei Yuan, Sufan Tang, Yang Liu, Ping Cai, Nan Liu, Yue Chen and Zhijun Zhou
    Citation: EJNMMI Research 2023 13:56
    Content type: Original research Published on:

  34. The lack of noninvasive methods for assessment of dysregulated inflammation as a major driver of fibrosis (i.e., inflammation-fibrosis axis) has been a major challenge to precision management of fibrotic lung ...

    Authors: Qin Zhu, Clayton E. Barnes, Philip Z. Mannes, Joseph D. Latoche, Kathryn E. Day, Jessie R. Nedrow, Enrico M. Novelli, Carolyn J. Anderson and Sina Tavakoli
    Citation: EJNMMI Research 2023 13:55
    Content type: Original research Published on:

  35. The value of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) is still unknown. We aimed to test the potential complementary role of PSMA expression and 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FD...

    Authors: Martina Sollini, Margarita Kirienko, Luca di Tommaso, Cristiano Pini, Fabrizia Gelardi, Salvatore Ariano, Andrea Gerardo Lania, Gherardo Mazziotti, Giuseppe Mercante and Arturo Chiti
    Citation: EJNMMI Research 2023 13:54
    Content type: Short communication Published on:

  36. Fluorine-18-labeled SSAs have the potential to become the next-generation tracer in SSTR-imaging in neuroendocrine tumor (NET) patients given their logistical advantages over the current gold standard gallium-...

    Authors: Lennert Boeckxstaens, Elin Pauwels, Vincent Vandecaveye, Wies Deckers, Frederik Cleeren, Jeroen Dekervel, Timon Vandamme, Kim Serdons, Michel Koole, Guy Bormans, Annouschka Laenen, Paul M. Clement, Karen Geboes, Eric Van Cutsem, Kristiaan Nackaerts, Sigrid Stroobants…
    Citation: EJNMMI Research 2023 13:53
    Content type: Original research Published on:

  37. Stage I lung adenocarcinoma is a heterogeneous group. Previous studies have shown the prognostic evaluation value of PET/CT in this cohort; however, few studies focused on stage I invasive adenocarcinoma manif...

    Authors: Xuan Zheng, Jie Lin, Jiageng Xie, Jia Jiang, Junping Lan, Xiaowei Ji, Kun Tang, Xiangwu Zheng and Jinjin Liu
    Citation: EJNMMI Research 2023 13:52
    Content type: Original research Published on:

  38. Immune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to treat non-small cell lung cancer (NSCLC). PD-L1 is a validated prognost...

    Authors: Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh and Gary J. R. Cook
    Citation: EJNMMI Research 2023 13:51
    Content type: Original research Published on:

  39. 68 Ga-PSMA PET is the leading prostate cancer imaging technique, but the image quality remains noisy and could be further improved using an artificial intelligence-based denoising algorithm. To address this issu....

    Authors: Charles Margail, Charles Merlin, Tommy Billoux, Maxence Wallaert, Hosameldin Otman, Nicolas Sas, Ioana Molnar, Florent Guillemin, Louis Boyer, Laurent Guy, Marion Tempier, Sophie Levesque, Alban Revy, Florent Cachin and Marion Chanchou
    Citation: EJNMMI Research 2023 13:50
    Content type: Original research Published on:

  40. The determination of pathological grading has a guiding significance for the treatment of pancreatic ductal adenocarcinoma (PDAC) patients. However, there is a lack of an accurate and safe method to obtain pat...

    Authors: Gong Zhang, Chengkai Bao, Yanzhe Liu, Zizheng Wang, Lei Du, Yue Zhang, Fei Wang, Baixuan Xu, S. Kevin Zhou and Rong Liu
    Citation: EJNMMI Research 2023 13:49
    Content type: Original research Published on:

  41. Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease pathogenesis. In clinical practice, trained readers will visually categorise positron emission tomography (PET) s...

    Authors: Hugh G. Pemberton, Christopher Buckley, Mark Battle, Ariane Bollack, Vrajesh Patel, Petya Tomova, David Cooke, Will Balhorn, Katherine Hegedorn, Johan Lilja, Christine Brand and Gill Farrar
    Citation: EJNMMI Research 2023 13:48
    Content type: Original research Published on:

  42. Alzheimer’s disease-related pattern (ADRP) is a metabolic brain biomarker of Alzheimer’s disease (AD). While ADRP is being introduced into research, the effect of the size of the identification cohort and the ...

    Authors: Eva Štokelj, Petra Tomše, Tadej Tomanič, Vijay Dhawan, David Eidelberg, Maja Trošt and Urban Simončič
    Citation: EJNMMI Research 2023 13:47
    Content type: Original research Published on:

  43. The dopamine transporter (DaT) PET ligand [18F]FE-PE2I is used to aid the diagnosis of Parkinson’s disease. After encountering four patients with a history of daily sertraline use, who all showed atypical finding...

    Authors: Thomas E. H. Justesen, Per Borghammer, Joel Aanerud, Peter Hovind and Lisbeth Marner
    Citation: EJNMMI Research 2023 13:46
    Content type: Short communication Published on:

  44. The accumulation of 177Lu-DOTATATE might be influenced by the amount of administered peptide in relation to the tumor somatostatin receptor expression. The effect of the administered peptide mass on the resulting...

    Authors: Ulrika Jahn, Ulrike Garske-Román, Mattias Sandström, Mark Lubberink and Anders Sundin
    Citation: EJNMMI Research 2023 13:45
    Content type: Original research Published on:

  45. Myocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis. Measurement of myocardial PD-L1 expression may have potential use as a mechani...

    Authors: Muhummad Sohaib Nazir, Daniel Johnathan Hughes, Gitasha Chand, Kathryn Adamson, Jessica Johnson, Damion Bailey, Victoria Gibson, Hong Hoi Ting, Alexander R. Lyon and Gary J. R. Cook
    Citation: EJNMMI Research 2023 13:44
    Content type: Original research Published on:

  46. Expanding therapeutic possibilities have improved disease-related prospects for breast cancer patients. Pathological analysis on a tumor biopsy is the current reference standard biomarker used to select for tr...

    Authors: Renske Altena, Antonios Tzortzakakis, Siri Af Burén, Thuy A. Tran, Fredrik Y. Frejd, Jonas Bergh and Rimma Axelsson
    Citation: EJNMMI Research 2023 13:43
    Content type: Review Published on:

  47. By clearing GABA from the synaptic cleft, GABA transporters (GATs) play an essential role in inhibitory neurotransmission. Consequently, in vivo visualization of GATs can be a valuable diagnostic tool and biom...

    Authors: Niels Knippenberg, Matthias Bauwens, Olaf Schijns, Govert Hoogland, Alexandru Florea, Kim Rijkers, Thomas J. Cleij, Kasper Eersels, Bart van Grinsven and Hanne Diliën
    Citation: EJNMMI Research 2023 13:42
    Content type: Review Published on:

  49. CXCR4-targeted radioligand therapy (RLT) with [177Lu]Lu/[90Y]Y-PentixaTher has recently evolved as a promising therapeutic option for patients with advanced hematological cancers. Given their advanced disease sta...

    Authors: Sebastian Martin, David Viertl, Anna Janz, Stefan Habringer, Ulrich Keller and Margret Schottelius
    Citation: EJNMMI Research 2023 13:40
    Content type: Short communication Published on:
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  • ISSN: 2191-219X (electronic)