Endothelial dysfunction is associated with vascular risk factors such as dyslipidemia, hypertension, and diabetes, leading to coronary atherosclerosis. Sympathetic stress using cold-pressor testing (CPT) has b...
Authors: Etienne Croteau, Jennifer M Renaud, Christine Archer, Ran Klein, Jean N DaSilva, Terrence D Ruddy, Rob SB Beanlands and Robert A deKemp
Absolute quantitative single-photon emission computed tomography (SPECT) has several important applications including monitoring tumor response after treatment and dose estimation for targeted radionuclide the...
Authors: Nadège Anizan, Hao Wang, Xian C Zhou, Robert F Hobbs, Richard L Wahl and Eric C Frey
Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emis...
Authors: Antti Silvoniemi, Jonna Silén, Sarita Forsback, Eliisa Löyttyniemi, Aleksi R Schrey, Olof Solin, Reidar Grénman, Heikki Minn and Tove J Grönroos
Galectin-3 is a ß-galactoside-binding lectin expressed in most of tissues in normal conditions and overexpressed in myocardium from early stages of heart failure (HF). It is an established biomarker associated...
Authors: Teresa Arias, Artiom Petrov, Jiqiu Chen, Hans de Haas, Carlos Pérez-Medina, Gustav J Strijkers, Roger J Hajjar, Zahi A Fayad, Valentín Fuster and Jagat Narula
At fluorodeoxyglucose/positron emission tomography (FDG/PET) examinations, a generally increased uptake of the skeletal muscles is sometimes encountered. As the tracer distribution constitutes a ‘zero-sum-game...
Authors: Henry Lindholm, Fredrik Brolin, Cathrine Jonsson and Hans Jacobsson
Defining tumour volume for treatment response and radiotherapy planning is challenging and prone to inter- and intra-observer variability. Various automated tumour delineation methods have been proposed in the...
Authors: Azadeh Firouzian, Matthew D Kelly and Jérôme M Declerck
The ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB) provides valuable information for de-risking drug development of new molecules. Here, we...
Authors: Khanum Ridler, Vincent Cunningham, Mickael Huiban, Laurent Martarello, Sabina Pampols-Maso, Jan Passchier, Roger N Gunn, Graham Searle, Anissa Abi-Dargham, Mark Slifstein, Jeanette Watson, Marc Laruelle and Eugenii A Rabiner
We have explored the possibility that the serotonin 1B receptor radioligand [11C]AZ10419369 is a substrate for adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), Mrp4...
Authors: Miklós Tóth, Jenny Häggkvist, Andrea Varrone, Sjoerd J Finnema, Janine Doorduin, Masaki Tokunaga, Makoto Higuchi, Balázs Gulyás and Christer Halldin
The serotonin precursor 5-hydroxy-l-[β-11C]tryptophan ([11C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradat...
Authors: Jonas Eriksson, Ola Åberg, Ram Kumar Selvaraju, Gunnar Antoni, Lars Johansson and Olof Eriksson
Due to its high expression in prostate cancer, PSMA (prostate-specific membrane antigen) represents an ideal target for both diagnostic imaging and endoradiotherapeutic approaches. Based on a previously publis...
Authors: Martina Weineisen, Jakub Simecek, Margret Schottelius, Markus Schwaiger and Hans-Jürgen Wester
Three-dimensional (3D) hydrogel-based stem cell therapies contribute to enhanced therapeutic efficacy in treating diseases, and determining the optimal mechanical strength of the hydrogel in vivo is important for...
Authors: Do Won Hwang, Kyung Min Park, Hye-kyung Shim, Yeona Jin, Hyun Jeong Oh, So Won Oh, Song Lee, Hyewon Youn, Yoon Ki Joung, Hong J Lee, Seung U Kim, Ki Dong Park and Dong Soo Lee
Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker. Early diagnosis of EOC is plagued by its asymptom...
Authors: Sai Kiran Sharma, Melinda Wuest, Monica Wang, Darryl Glubrecht, Bonnie Andrais, Suzanne E Lapi and Frank Wuest
The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with 177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate), despite the successful use of kidney uptake bloc...
Authors: Johanna Dalmo, Emelie Westberg, Lars Barregard, Lisa Svedbom, Martin Johansson, Margareta Törnqvist and Eva Forssell-Aronsson
Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis,it has been shown to provide prognostic information...
Authors: Mariana Reza, Anders Bjartell, Mattias Ohlsson, Reza Kaboteh, Per Wollmer, Lars Edenbrandt and Elin Trägårdh
In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated ...
Authors: Matthias N van Oosterom, Rob Kreuger, Tessa Buckle, Wendy A Mahn, Anton Bunschoten, Lee Josephson, Fijs WB van Leeuwen and Freek J Beekman
Hepatic mitochondrial dysfunction has been implicated in pathological conditions leading to non-alcoholic steatohepatitis (NASH). Technetium-99 m-2-methoxyisobutyl-isonitrile (99mTc-MIBI), a lipophilic cationic m...
Radiation treatment with simultaneous integrated boost against suspected lymph node metastases may be a curative therapeutic option in patients with high-risk prostate cancer (>15% estimated risk of pelvic lym...
Authors: Sara Strandberg, Camilla Thellenberg Karlsson, Torbjörn Sundström, Mattias Ögren, Margareta Ögren, Jan Axelsson and Katrine Riklund
Dopamine D2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state...
Authors: Jan-Peter van Wieringen, Martin C Michel, Henk M Janssen, Anton G Janssen, Philip H Elsinga and Jan Booij
Today's standard treatment of advanced-stage ovarian cancer, including surgery followed by a paclitaxel-platinum-based chemotherapy, is limited in efficacy. Recently, we could show that radioimmunotherapy (RIT...
Authors: Dennis Lindenblatt, Eliane Fischer, Susan Cohrs, Roger Schibli and Jürgen Grünberg
The aims of this study were to determine the optimal tracer kinetic model for [11C]-meta- hydroxyephedrine ([11C]HED) and to evaluate the performance of several simplified methods.
Authors: Hendrik J Harms, Stefan de Haan, Paul Knaapen, Cornelis P Allaart, Mischa T Rijnierse, Robert C Schuit, Albert D Windhorst, Adriaan A Lammertsma, Marc C Huisman and Mark Lubberink
Development of tracers for imaging with positron emission tomography (PET) is often a time-consuming process associated with considerable attrition. In an effort to simplify this process, we herein propose a m...
Authors: Markus Fridén, Marie Wennerberg, Madeleine Antonsson, Maria Sandberg-Ställ, Lars Farde and Magnus Schou
Prostate cancer is a leading cause of death in the male population of the western world. Human kallikrein-related peptidase 2 (hK2) is abundantly expressed in malignant prostatic tissue, and its gene, KLK2, is re...
Authors: Oskar Vilhelmsson Timmermand, David Ulmert, Susan Evans-Axelsson, Kim Pettersson, Anders Bjartell, Hans Lilja, Sven-Erik Strand and Thuy A Tran
2-deoxy-2-[18F]fluoro-D-glucose-positron emission tomography (18F-FDG-PET) is applied in the clinic for infection assessment and is under consideration for investigating the inflammatory/immune response in lympho...
Authors: Svetlana Chefer, Richard C Reba, Christopher Z Leyson, Jurgen Seidel, Reed F Johnson, Joseph E Blaney, Peter B Jahrling and Julie Dyall
Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding ...
Authors: Jonas Högberg, Magnus Rizell, Ragnar Hultborn, Johanna Svensson, Olof Henrikson, Johan Mölne, Peter Gjertsson and Peter Bernhardt
Peptide receptor radionuclide therapy (PRRT) is an effective form of treatment for patients with metastatic neuroendocrine tumors (NETs). However, delivering sufficient radiation dose to the tumor to result in...
Authors: David L Bushnell, Mark T. Madsen, Thomas O'cdorisio, Yusuf Menda, Saima Muzahir, Randi Ryan and M. Sue O'dorisio
The multitargeting tyrosine kinase inhibitor (TKI) sunitinib is currently the first-line drug therapy for metastasizing renal cell carcinoma (RCC). TKIs have profound effects on tumor angiogenesis, leading to ...
Authors: David W Chapman, Hans-Sonke Jans, Ivy Ma, John R Mercer, Leonard I Wiebe, Melinda Wuest and Ronald B Moore
Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little a...
Authors: Rocío Pérez-Carro, Omar Cauli and Pilar López-Larrubia
Inhibition of mitogen-activated protein kinase (MEK, also known as MAPK2, MAPKK), a key molecule of the Ras/MAPK (mitogen-activated protein kinase) pathway, has shown promising effects on B-raf-mutated and some R...
Authors: Tetyana Tegnebratt, Elisabeth Ruge, Sabine Bader, Nobuya Ishii, Satoshi Aida, Yasushi Yoshimura, Chia-Huey Ooi, Li Lu, Nicholas Mitsios, Valerie Meresse, Jan Mulder, Michael Pawlak, Miro Venturi, Jean Tessier and Sharon Stone-Elander
Targeted radionuclide therapy with high-energy beta-emitters is generally considered suboptimal to cure small tumours (<300 mg). Tumour targeting of the CCK2 receptor-binding minigastrin analogue PP-F11 was de...
Authors: Mark W. Konijnenberg, Wout A. P. Breeman, Erik de Blois, Ho Sze Chan, Otto C. Boerman, Peter Laverman, Petra Kolenc-Peitl, Marleen Melis and Marion de Jong
Peptide receptor radionuclide therapy (PRRT) is routinely used for advanced or metastasized neuroendocrine tumours (NET). To prevent nephrotoxicity, positively charged amino acids (AA) are co-infused. The aim ...
Authors: Constantin Lapa, Rudolf A Werner, Christina Bluemel, Katharina Lückerath, Andreas Schirbel, Alexander Strate, Andreas K Buck and Ken Herrmann
Staphylococcus epidermidis (S. epidermidis) has emerged as one of the leading pathogens of biomaterial-related infections. Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible endothelial molecule con...
Authors: Helena Ahtinen, Julia Kulkova, Laura Lindholm, Erkki Eerola, Antti J Hakanen, Niko Moritz, Mirva Söderström, Tiina Saanijoki, Sirpa Jalkanen, Anne Roivainen and Hannu T Aro
[18F]fluciclatide, a peptide ligand with high affinity for αvβ3/αvβ5 integrins, is a proposed biomarker of tumor angiogenesis. The study rationale was to perform a preliminary evaluation of the relationship betwe...
Authors: Laura M Kenny, Giampaolo Tomasi, Federico Turkheimer, James Larkin, Martin Gore, Cathryn S Brock, Stephen Mangar and Eric O Aboagye
The α7 nicotinic acetylcholine receptor (nAChR) is an important molecular target in neuropsychiatry and oncology. Development of applicable highly specific radiotracers has been challenging due to comparably l...
Authors: Sven Rötering, Winnie Deuther-Conrad, Paul Cumming, Cornelius K Donat, Matthias Scheunemann, Steffen Fischer, Guoming Xiong, Jörg Steinbach, Dan Peters, Osama Sabri, Jan Bucerius and Peter Brust
The aim of this pilot study was to evaluate whether the uptake of 89Zr-bevacizumab in non-small cell lung cancer (NSCLC) tumors could be visualized and quantified. The correlation between tumor 89Zr-bevacizumab u...
Authors: Idris Bahce, Marc C Huisman, Eline E Verwer, Rogier Ooijevaar, Firdaouss Boutkourt, Danielle J Vugts, Guus AMS van Dongen, Ronald Boellaard and Egbert F Smit
Recent technical developments using solid-state technology have enabled rapid image acquisition with single photon emission computed tomography (SPECT) and have led to a renewed interest in technetium-99m-tebo...
Authors: David R Okada, Gerald Johnson and Robert D Okada
The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors f...
Authors: Yared Tekabe, Maria Kollaros, Adam Zerihoun, Geping Zhang, Marina V Backer, Joseph M Backer and Lynne L Johnson
The trapping mechanisms of the PET hypoxia imaging agent copper(II)-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu(ATSM)) remain unresolved, although its reduction prior to dissociation may be mediated by intrace...
Authors: Fiona Shaughnessy, Erika Mariotti, Karen P Shaw, Thomas R Eykyn, Philip J Blower, Richard Siow and Richard Southworth
Heterogeneous ventilation in lungs of individuals with allergies, cigarette smokers, asthmatics and chronic obstructive pulmonary disease (COPD) patients has been demonstrated using imaging modalities such as ...
Authors: Pernilla Norberg, Hans Lennart Persson, Birgitta Schmekel, Gudrun Alm Carlsson, Karl Wahlin, Michael Sandborg and Agnetha Gustafsson
The purpose of the study was to evaluate the applicability of 18F-labelled amyloid imaging positron emission tomography (PET) agent [18
...
Authors: Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne and Merja Haaparanta-Solin
With the increasing utilization of 68Ge-68Ga radionuclide generators, 68Ga labelled peptides like DOTATATE are receiving more attention in nuclear medicine. On the one hand, the long half-life of the parent nucli...
Authors: Ferdinand Sudbrock, Thomas Fischer, Beate Zimmermanns, Mehrab Guliyev, Markus Dietlein, Alexander Drzezga and Klaus Schomäcker
Abnormal behaviors of young patients after taking the anti-influenza agent oseltamivir (Tamiflu®, F. Hoffmann-La Roche, Ltd., Basel, Switzerland) have been suspected as neuropsychiatric adverse events (NPAEs)....
For yttrium-90 (90Y) radioembolization, the common practice of assuming a standard 1,000-g lung mass for predictive dosimetry is fundamentally incongruent with the modern philosophy of personalized medicine. We r...
Authors: Yung Hsiang Kao, Butch M Magsombol, Ying Toh, Kiang Hiong Tay, Pierce KH Chow, Anthony SW Goh and David CE Ng
To combine the sensitivity of bioluminescent imaging (BLI) with the 3D and quantitative properties of pinhole single-photon emission computed tomography (SPECT)/micro-computed tomography (CT) (phSPECT/micro-CT...
Authors: Lode RY Goethals, Tomas J Bos, Luc Baeyens, Frank De Geeter, Nick Devoogdt and Tony Lahoutte
Various diseases derive from pathologically altered β-cells. Their function can be increased, leading to hyperinsulinism, or decreased, resulting in diabetes. Non-invasive imaging of the β-cell-specific glucag...
Authors: Andreas Jodal, Brigitte Lankat-Buttgereit, Maarten Brom, Roger Schibli and Martin Béhé
Receptor for advanced glycated end product (RAGE) expression is a prominent feature of atherosclerosis. We have previously shown in apoE null mice uptake of a radiolabeled anti-RAGE antibody in atherosclerotic...
Authors: Lynne L Johnson, Yared Tekabe, Maria Kollaros, George Eng, Ketan Bhatia, Chong Li, Christian G Krueger, Dhanansayan Shanmuganayagam and Ann Marie Schmidt
Radioiodine is routinely used or proposed for diagnostic and therapeutic purposes: 123I, 125I and 131I for diagnostics and 125I and 131I for therapy. When radioiodine-labelled pharmaceuticals are administered to ...
Authors: Anders Josefsson and Eva Forssell-Aronsson
Cerebral stroke is a severe and frequent condition that requires rapid and reliable diagnosis. If administered shortly after the first symptoms manifest themselves, IV thrombolysis has been shown to increase t...
Authors: Maria-Joao Ribeiro, Johnny Vercouillie, Severine Debiais, Jean-Philippe Cottier, Isabelle Bonnaud, Vincent Camus, Samuel Banister, Michael Kassiou, Nicolas Arlicot and Denis Guilloteau
ROBO1 is a membrane protein that functions in axon guidance. ROBO1 contributes to tumour metastasis and angiogenesis and may have potential as a target protein of immunotherapy because ROBO1 is specifically ex...
The aim of this study was to investigate the reproducibility of intra- and inter-observer interpretation of [18F]choline positron emission tomography/computed tomography examinations in patients suffering from bi...
Authors: Clothilde Pegard, Céline Gallazzini-Crépin, Joris Giai, Julien Dubreuil, Cécile Caoduro, Marie-Dominique Desruet, Julie Roux, Alex Calizzano, Daniel Fagret, Chloé Lamesa, Hatem Boulahdour and Jean-Philippe Vuillez
Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [177Lu-DOTA0,T...
Authors: Sander M Bison, Stefan E Pool, Stuart J Koelewijn, Linda M van der Graaf, Harald C Groen, Marleen Melis and Marion de Jong
