The number of routine care patient examinations with 68Ga radiopharmaceuticals is still relatively limited, probably caused by the presumed need for large investments in hot cells, automated synthesis modules, la...
Authors: Roeland Vis, Jules Lavalaye and Ewoudt MW van de Garde
Positron emission tomography (PET) with 18F-3′-deoxy-3′-fluorothymidine ([18F]FLT) can be used to assess tumour proliferation. A kinetic-filtering (KF) classification algorithm has been suggested for segmentation...
Authors: Lieke L Hoyng, Virginie Frings, Otto S Hoekstra, Laura M Kenny, Eric O Aboagye and Ronald Boellaard
High-grade gliomas (HGGs) express somatostatin receptors (SSTR), rendering them candidates for peptide receptor radionuclide therapy (PRRT). Our purpose was to evaluate the potential of 68Ga-DOTA-1-Nal3-octreotid...
Authors: Aida Kiviniemi, Maria Gardberg, Janek Frantzén, Marko Pesola, Ville Vuorinen, Riitta Parkkola, Tuula Tolvanen, Sami Suilamo, Jarkko Johansson, Pauliina Luoto, Jukka Kemppainen, Anne Roivainen and Heikki Minn
Features of the tumor microenvironment influence the efficacy of cancer nanotherapeutics. The ability to directly radiolabel nanotherapeutics offers a valuable translational tool to obtain biodistribution and ...
Authors: Daniel F Gaddy, Helen Lee, Jinzi Zheng, David A Jaffray, Thomas J Wickham and Bart S Hendriks
[18F]Fludarabine is a novel positron emission tomography (PET) radiotracer for imaging lymphoma. The purpose of this preclinical study was to evaluate the robustness of [18F]fludarabine during rituximab therapy. ...
Authors: Narinée Hovhannisyan, Stéphane Guillouet, Fabien Fillesoye, Martine Dhilly, Delphine Patin, Françoise Galateau, Michel Leporrier and Louisa Barré
Recently, an intra-patient comparison demonstrated that the somatostatin (sst) ligand [68Ga]HA-DOTATATE ([68Ga]DOTA-3-iodo-Tyr3-octreotate) provides PET images comparable to or superior to those obtained with [68
Authors: Margret Schottelius, Jakub Šimeček, Frauke Hoffmann, Marina Willibald, Markus Schwaiger and Hans-Jürgen Wester
Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) a...
Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different 18F-radiopharmaceuticals for clinical characterization of Alzheimer’s disease (AD)...
Authors: Behrooz H Yousefi, Boris von Reutern, Daniela Scherübl, André Manook, Markus Schwaiger, Timo Grimmer, Gjermund Henriksen, Stefan Förster, Alexander Drzezga and Hans-Jürgen Wester
With the recent growth of interest in cell-based therapies and radiolabeled cell products, there is a need to develop more robust cell labeling and imaging methods for in vivo tracking of living cells. This study...
Authors: Aditya Bansal, Mukesh K Pandey, Yunus E Demirhan, Jonathan J Nesbitt, Ruben J Crespo-Diaz, Andre Terzic, Atta Behfar and Timothy R DeGrado
In vivo imaging using genetic reporters is a central supporting tool in the development of cell and gene therapies affording us the ability to selectively track the therapeutic indefinitely. Pr...
Authors: Adam Badar, Louise Kiru, Tammy L Kalber, Amit Jathoul, Karin Straathof, Erik Årstad, Mark F Lythgoe and Martin Pule
The frequent expression of neurotensin receptors (NT-R) in primaries of pancreatic ductal carcinomas has triggered the development of radioactive neurotensin analogs for possible in vivo targeting of these tumors...
Authors: Meike Körner, Beatrice Waser, Oliver Strobel, Markus Büchler and Jean Claude Reubi
The amount of inhomogeneities in a 99mTc Technegas single-photon emission computed tomography (SPECT) lung image, caused by reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (C...
Authors: Pernilla Norberg, Anna Olsson, Gudrun Alm Carlsson, Michael Sandborg and Agnetha Gustafsson
Deformable image registration allows volume of interest (VOI)- and voxel-based analysis of longitudinal changes in fluorodeoxyglucose (FDG) tumor uptake in patients with non-small cell lung cancer (NSCLC). Thi...
Authors: Gerald SMA Kerner, Alexander Fischer, Michel JB Koole, Jan Pruim and Harry JM Groen
Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical s...
Authors: Paul Slobbe, Albert D Windhorst, Marijke Stigter-van Walsum, Egbert F Smit, Heiko G Niessen, Flavio Solca, Gerd Stehle, Guus A M S van Dongen and Alex J Poot
Management of infection is a major clinical problem. Staphylococcus aureus is a Gram-positive bacterium which colonises approximately one third of the adult human population. Staphylococcal infections can be life...
Authors: Bethany Mills, Ramla O Awais, Jeni Luckett, Dave Turton, Paul Williams, Alan C Perkins and Philip J Hill
In specialized movement disorder centers, Parkinson’s disease (PD) is wrongly diagnosed in 6 to 25% of cases. To improve the accuracy of the clinical diagnosis, it is necessary to have a reliable and practical...
Authors: Sven R Suwijn, Caroline JM van Boheemen, Rob J de Haan, Gerrit Tissingh, Jan Booij and Rob MA de Bie
Technetium-99m methoxyisobutylisonitrile (Tc MIBI) is a substrate with the same uptake kinetics as doxorubicin. Multidrug resistance (MDR) is a mechanism that impedes chemotherapy of non-small cell lung cancer...
The purpose of this study was to quantitatively evaluate the tumor accumulation and heterogeneity of 111In-ibritumomab tiuxetan (Zevalin®) and tumor accumulation of 18F-fluoro-deoxyglucose (FDG) and compare them ...
Recent research has demonstrated the potential of 18-kDa translocator protein (TSPO) to serve as a target for nuclear imaging of gliomas. The aim of this study was to evaluate SPECT imaging of GL26 mouse gliom...
Authors: Stergios Tsartsalis, Noé Dumas, Benjamin B Tournier, Tien Pham, Marcelle Moulin-Sallanon, Marie-Claude Grégoire, Yves Charnay and Philippe Millet
The purpose of this study was to determine whether brain metastases from HER2-positive breast cancer could be detected noninvasively using positron emission tomography (PET) with 64Cu-1,4,7,10-tetraazacyclododeca...
3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) has been used to evaluate tumor malignancy and cell proliferation in human brain gliomas. However, 18F-FLT has several limitations in clinical use. Recently, 11C-labeled...
Authors: Yasunori Toyota, Keisuke Miyake, Nobuyuki Kawai, Tetsuhiro Hatakeyama, Yuka Yamamoto, Jun Toyohara, Yoshihiro Nishiyama and Takashi Tamiya
Systematic evaluations of the diagnostic accuracy of positron emission tomography (PET) imaging have been widely conducted in many countries. Although Japan’s total number of PET units is the second highest in...
Authors: Shuhei Nomura, Akinori Hisashige, Daisuke Yoneoka, Mikiko Kanda, Karin Miyamoto, Miwako Segawa, Erika Ota and Kenji Shibuya
Botulinum neurotoxin A (BoNT-A) is a highly neurotoxic drug and frequently used in patients. Knowledge on the optimal way of administration of BoNT-A and its subsequent distribution is still rather limited. An...
Authors: Janneke IM van Uhm, Gerard WM Visser, Marcel J van der Schans, Albert A Geldof, Eric JH Meuleman and Jakko A Nieuwenhuijzen
Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine k...
Authors: Galith Abourbeh, Batel Itamar, Olga Salnikov, Sergey Beltsov and Eyal Mishani
CD8-positive cells might play a crucial role in the therapeutic response to radiation, which has however not been investigated in radioimmunotherapy (RIT). The aim of this study was to evaluate whether cytotox...
Authors: Erika Elgström, Sophie E Eriksson, Tomas G Ohlsson, Rune Nilsson and Jan Tennvall
CD13 is selectively upregulated in angiogenic active endothelium and can serve as a target for molecular imaging tracers to non-invasively visualise angiogenesis in vivo. Non-invasive determination of CD13 expres...
Authors: Geert Hendrikx, Marijke De Saint-Hubert, Ingrid Dijkgraaf, Matthias Bauwens, Kim Douma, Roel Wierts, Ivo Pooters, Nynke MS Van den Akker, Tilman M Hackeng, Mark J Post and Felix M Mottaghy
In cancer radiotherapy, knowledge of normal tissue responses and toxicity risks is essential in order to deliver the highest possible absorbed dose to the tumor while maintaining normal tissue exposure at non-...
Authors: Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou and Eva Forssell-Aronsson
The goal of the present study was to evaluate the reproducibility of cerebral adenosine A2A receptor (A2AR) quantification using 11C-TMSX and PET in a test-retest study.
Authors: Mika Naganawa, Masahiro Mishina, Muneyuki Sakata, Keiichi Oda, Mikio Hiura, Kenji Ishii and Kiichi Ishiwata
[18 F]AFM is a potent and promising PET imaging agent for the serotonin transporter. We carried out an acute toxicity study in rats and radiation dosimetry in monkeys before the translation of the tracer to human...
Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the ...
Authors: Constantin Lapa, Rudolf A Werner, Christina Bluemel, Katharina Lueckerath, Dirk O Muegge, Alexander Strate, Heribert Haenscheid, Andreas Schirbel, Martin S Allen-Auerbach, Ralph A Bundschuh, Andreas K Buck and Ken Herrmann
Boron neutron capture therapy (BNCT) is a molecular radiation treatment based on the 10B (n, α) 7Li nuclear reaction in cancer cells, in which delivery of 10B by 4-borono-phenylalanine conjugated with fructose (B...
Hepatobiliary scintigraphy using 99mTc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic ext...
Authors: Anastasios Kaxiras, Shinji Yamamoto, Gunnar Söderdahl, Annika Wernerson, Rimma Axelsson and Bo-Göran Ericzon
Endothelial dysfunction is associated with vascular risk factors such as dyslipidemia, hypertension, and diabetes, leading to coronary atherosclerosis. Sympathetic stress using cold-pressor testing (CPT) has b...
Authors: Etienne Croteau, Jennifer M Renaud, Christine Archer, Ran Klein, Jean N DaSilva, Terrence D Ruddy, Rob SB Beanlands and Robert A deKemp
Absolute quantitative single-photon emission computed tomography (SPECT) has several important applications including monitoring tumor response after treatment and dose estimation for targeted radionuclide the...
Authors: Nadège Anizan, Hao Wang, Xian C Zhou, Robert F Hobbs, Richard L Wahl and Eric C Frey
Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emis...
Authors: Antti Silvoniemi, Jonna Silén, Sarita Forsback, Eliisa Löyttyniemi, Aleksi R Schrey, Olof Solin, Reidar Grénman, Heikki Minn and Tove J Grönroos
Galectin-3 is a ß-galactoside-binding lectin expressed in most of tissues in normal conditions and overexpressed in myocardium from early stages of heart failure (HF). It is an established biomarker associated...
Authors: Teresa Arias, Artiom Petrov, Jiqiu Chen, Hans de Haas, Carlos Pérez-Medina, Gustav J Strijkers, Roger J Hajjar, Zahi A Fayad, Valentín Fuster and Jagat Narula
At fluorodeoxyglucose/positron emission tomography (FDG/PET) examinations, a generally increased uptake of the skeletal muscles is sometimes encountered. As the tracer distribution constitutes a ‘zero-sum-game...
Authors: Henry Lindholm, Fredrik Brolin, Cathrine Jonsson and Hans Jacobsson
Defining tumour volume for treatment response and radiotherapy planning is challenging and prone to inter- and intra-observer variability. Various automated tumour delineation methods have been proposed in the...
Authors: Azadeh Firouzian, Matthew D Kelly and Jérôme M Declerck
The ability to quantify the capacity of a central nervous system (CNS) drug to cross the human blood-brain barrier (BBB) provides valuable information for de-risking drug development of new molecules. Here, we...
Authors: Khanum Ridler, Vincent Cunningham, Mickael Huiban, Laurent Martarello, Sabina Pampols-Maso, Jan Passchier, Roger N Gunn, Graham Searle, Anissa Abi-Dargham, Mark Slifstein, Jeanette Watson, Marc Laruelle and Eugenii A Rabiner
We have explored the possibility that the serotonin 1B receptor radioligand [11C]AZ10419369 is a substrate for adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), Mrp4...
Authors: Miklós Tóth, Jenny Häggkvist, Andrea Varrone, Sjoerd J Finnema, Janine Doorduin, Masaki Tokunaga, Makoto Higuchi, Balázs Gulyás and Christer Halldin
The serotonin precursor 5-hydroxy-l-[β-11C]tryptophan ([11C]HTP) is in clinical use for localization of neuroendocrine tumors and has been suggested as a proxy marker for pancreatic islet cells. However, degradat...
Authors: Jonas Eriksson, Ola Åberg, Ram Kumar Selvaraju, Gunnar Antoni, Lars Johansson and Olof Eriksson
Due to its high expression in prostate cancer, PSMA (prostate-specific membrane antigen) represents an ideal target for both diagnostic imaging and endoradiotherapeutic approaches. Based on a previously publis...
Authors: Martina Weineisen, Jakub Simecek, Margret Schottelius, Markus Schwaiger and Hans-Jürgen Wester
Three-dimensional (3D) hydrogel-based stem cell therapies contribute to enhanced therapeutic efficacy in treating diseases, and determining the optimal mechanical strength of the hydrogel in vivo is important for...
Authors: Do Won Hwang, Kyung Min Park, Hye-kyung Shim, Yeona Jin, Hyun Jeong Oh, So Won Oh, Song Lee, Hyewon Youn, Yoon Ki Joung, Hong J Lee, Seung U Kim, Ki Dong Park and Dong Soo Lee
Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker. Early diagnosis of EOC is plagued by its asymptom...
Authors: Sai Kiran Sharma, Melinda Wuest, Monica Wang, Darryl Glubrecht, Bonnie Andrais, Suzanne E Lapi and Frank Wuest
The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with 177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate), despite the successful use of kidney uptake bloc...
Authors: Johanna Dalmo, Emelie Westberg, Lars Barregard, Lisa Svedbom, Martin Johansson, Margareta Törnqvist and Eva Forssell-Aronsson
Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis,it has been shown to provide prognostic information...
Authors: Mariana Reza, Anders Bjartell, Mattias Ohlsson, Reza Kaboteh, Per Wollmer, Lars Edenbrandt and Elin Trägårdh
In vivo bioluminescence, fluorescence, and single-photon emission computed tomography (SPECT) imaging provide complementary information about biological processes. However, to date these signatures are evaluated ...
Authors: Matthias N van Oosterom, Rob Kreuger, Tessa Buckle, Wendy A Mahn, Anton Bunschoten, Lee Josephson, Fijs WB van Leeuwen and Freek J Beekman
Hepatic mitochondrial dysfunction has been implicated in pathological conditions leading to non-alcoholic steatohepatitis (NASH). Technetium-99 m-2-methoxyisobutyl-isonitrile (99mTc-MIBI), a lipophilic cationic m...
Radiation treatment with simultaneous integrated boost against suspected lymph node metastases may be a curative therapeutic option in patients with high-risk prostate cancer (>15% estimated risk of pelvic lym...
Authors: Sara Strandberg, Camilla Thellenberg Karlsson, Torbjörn Sundström, Mattias Ögren, Margareta Ögren, Jan Axelsson and Katrine Riklund
Dopamine D2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state...
Authors: Jan-Peter van Wieringen, Martin C Michel, Henk M Janssen, Anton G Janssen, Philip H Elsinga and Jan Booij
