Articles

The effect of dimethyl sulfoxide on the induction of DNA strand breaks in plasmid DNA and colony formation of PC Cl3 mammalian cells by alpha-, beta-, and Auger electron emitters ²²³Ra, ¹⁸⁸Re, and ^99mTc

DNA damage occurs as a consequence of both direct and indirect effects of ionizing radiation. The severity of DNA damage depends on the physical characteristics of the radiation quality, e.g., the linear energ...

Authors: Roswitha Runge, Liane Oehme, Jörg Kotzerke and Robert Freudenberg

Impact of attenuation correction on clinical [¹⁸F]FDG brain PET in combined PET/MRI

In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the av...

Authors: P. Werner, M. Rullmann, A. Bresch, S. Tiepolt, T. Jochimsen, D. Lobsien, M. L. Schroeter, O. Sabri and H. Barthel

¹⁸F-fluoride-PET for dynamic in vivo monitoring of bone formation in multiple myeloma

Bone disease in multiple myeloma is characterized by reduced bone formation. The gold standard of bone formation is the mineral apposition rate (MAR), an invasive technique reflecting bone formation at a singl...

Authors: J. C. Regelink, P. G. Raijmakers, N. Bravenboer, R. Milek, N. J. Hoetjes, A. M. de Kreuk, M. van Duin, M. J. Wondergem, P. Lips, P. Sonneveld, J. M. Zijlstra and S. Zweegman

Correlation of clinical outcomes with bremsstrahlung and Y-90 PET/CT imaging findings following Y-90 radiosynoviorthesis: a prospective study

It is unclear how to predict which patients will respond to Y-90 radiosynoviorthesis. The aim of this study is to correlate clinical outcomes following Y-90 radiosynoviorthesis with bremsstrahlung and Y-90 PET...

Authors: Thomas W. Barber, Martin H. Cherk, Anne Powell, Kenneth S. K. Yap, Baki Billah and Victor Kalff

Comparison of LDPI to SPECT perfusion imaging using ^99mTc-sestamibi and ^99mTc-pyrophosphate in a murine ischemic hind limb model of neovascularization

We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia.

Authors: Geert Hendrikx, Mark H. Vries, Matthias Bauwens, Marijke De Saint-Hubert, Allard Wagenaar, Joël Guillaume, Levinia Boonen, Mark J. Post and Felix M. Mottaghy

Evaluation of pulmonary perfusion by SPECT imaging using an endothelial cell tracer in supine humans and dogs

Pulmonary perfusion is not spatially homogeneously distributed, and its variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of the adrenomedullin receptor densely expressed ...

Authors: Xavier Levac, François Harel, Vincent Finnerty, Quang T. Nguyen, Myriam Letourneau, Sophie Marcil, Alain Fournier and Jocelyn Dupuis

Posttreatment FDG PET/CT in predicting survival of patients with ovarian carcinoma

The purposes of this study are to evaluate the prognostic value of posttreatment ¹⁸F-FDG PET/CT in predicting the survival of patients with ovarian carcinoma and to determine incremental value of combining posttr...

Authors: Linda C. Chu, Hua-Ling Tsai, Hao Wang, John Crandall, Mehrbod S. Javadi and Richard L. Wahl

Accelerated ^99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome

Accelerated clearance of ^99mtechnetium-sestamibi (MIBI) has been observed after reperfusion therapy in patients with acute coronary syndrome (ACS), but the mechanisms have not been fully investigated. MIBI retent...

Authors: Atsuro Masuda, Keiichiro Yoshinaga, Masanao Naya, Osamu Manabe, Satoshi Yamada, Hiroyuki Iwano, Tatsuya Okada, Chietsugu Katoh, Yasuchika Takeishi, Hiroyuki Tsutsui and Nagara Tamaki

Automated synthesis of [¹⁸F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models

Prostate-specific membrane antigen (PSMA) is frequently overexpressed and upregulated in prostate cancer. To date, various ¹⁸F- and ⁶⁸Ga-labeled urea-based radiotracers for PET imaging of PSMA have been developed...

Authors: Vincent Bouvet, Melinda Wuest, Hans-Soenke Jans, Nancy Janzen, Afaf R. Genady, John F. Valliant, Francois Benard and Frank Wuest

Calibration of PET/CT scanners for multicenter studies on differentiated thyroid cancer with ¹²⁴I

Studies on imaging of differentiated thyroid cancer (DTC) using ¹²⁴I often require a multicenter approach, as the prevalence of DTC is low. Calibration of participating scanners is required to obtain comparable q...

Authors: Jakob W. Kist, Manfred van der Vlies, Otto S. Hoekstra, Henri N. J. M. Greuter, Bart de Keizer, Marcel P. M. Stokkel, Wouter V. Vogel, Marc C. Huisman and Arthur van Lingen

Fluorescence imaging of in vivo miR-124a-induced neurogenesis of neuronal progenitor cells using neuron-specific reporters

Facilitation of the differentiation of the stem cells toward neuronal lineage is crucial for enhancing the differentiation efficacy of grafted stem cells for the possible treatment of neurodegenerative disorde...

Authors: Jaeho Jang, Song Lee, Hyun Jeong Oh, Yoori Choi, Jae Hyouk Choi, Do Won Hwang and Dong Soo Lee

PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model

Cyclooxygenase-2 (COX-2) is the inducible isoform of the cyclooxygenase enzyme family. COX-2 is involved in tumor development and progression, and frequent overexpression of COX-2 in a variety of human cancers...

Authors: Ole Tietz, Melinda Wuest, Alison Marshall, Darryl Glubrecht, Ingrit Hamann, Monica Wang, Cody Bergman, Jenilee D. Way and Frank Wuest

The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity

The overexpression of the chemokine receptor 4 (CXCR4) in different epithelial, mesenchymal, and hematopoietic cancers makes CXCR4 an attractive diagnostic and therapeutic target. However, targeting the CXCR4 ...

Authors: Andreas Poschenrieder, Margret Schottelius, Markus Schwaiger, Horst Kessler and Hans-Jürgen Wester

Preclinical in vivo application of ¹⁵²Tb-DOTANOC: a radiolanthanide for PET imaging

Terbium has attracted the attention of researchers and physicians due to the existence of four medically interesting radionuclides, potentially useful for SPECT and PET imaging, as well as for α- and β⁻-radionucl...

Authors: Cristina Müller, Christiaan Vermeulen, Karl Johnston, Ulli Köster, Raffaella Schmid, Andreas Türler and Nicholas P. van der Meulen

[¹⁸F]tetrafluoroborate as a PET tracer for the sodium/iodide symporter: the importance of specific activity

[¹⁸F]BF₄ ⁻, the first ¹⁸F-labelled PET imaging agent for the sodium/iodide symporter (NIS), was produced by isotopic exchange yielding a product with limited specific activity (SA, ca. ...

Authors: Alex Khoshnevisan, Maite Jauregui-Osoro, Karen Shaw, Julia Baguña Torres, Jennifer D. Young, Nisha K. Ramakrishnan, Alex Jackson, Gareth E. Smith, Antony D. Gee and Philip J. Blower

An exploratory study of volumetric analysis for assessing tumor response with ¹⁸F-FAZA PET/CT in patients with advanced non-small-cell lung cancer (NSCLC)

Hypoxia is associated with resistance to chemotherapy and radiotherapy and is randomly distributed within malignancies. Characterization of changes in intratumoral hypoxic regions is possible with specially de...

Authors: Gerald S. M. A. Kerner, Vikram R. Bollineni, Thijo J. N. Hiltermann, Nanna M. Sijtsema, Alexander Fischer, Alphons H. H. Bongaerts, Jan Pruim and Harry J. M. Groen

32nd International Austrian Winter Symposium

A1 68Ga-PSMA PET/CT in staging and restaging of Prostate Cancer Patients: comparative study with 18F-Choline PET/CT

Authors: W Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti, L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel…

[¹⁸F]FE@SNAP—a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?

The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a key role in energy homeostasis, obesity and other endocrine diseases. Hence, there is a majo...

Authors: Cécile Philippe, Daniela Haeusler, Thomas Scherer, Clemens Fürnsinn, Markus Zeilinger, Wolfgang Wadsak, Karem Shanab, Helmut Spreitzer, Marcus Hacker and Markus Mitterhauser

Dependence of treatment planning accuracy in peptide receptor radionuclide therapy on the sampling schedule

Peptide receptor radionuclide therapy (PRRT) plays an important role in the treatment of neuroendocrine tumors (NET). Pre-therapeutic dosimetry using the area under the measured time-activity curve (AUC) is im...

Authors: Christian Maaß, Jan Philipp Sachs, Deni Hardiansyah, Felix M. Mottaghy, Peter Kletting and Gerhard Glatting

α_Vβ₃ integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice

α_Vβ₃-integrin is expressed by activated endothelial cells and macrophages in atherosclerotic plaques and may represent a valuable marker of high-risk plaques. We evaluated ^99mTc-maraciclatide, an integrin-specifi...

Authors: David Vancraeynest, Véronique Roelants, Caroline Bouzin, François-Xavier Hanin, Stephan Walrand, Vanesa Bol, Anne Bol, Anne-Catherine Pouleur, Agnès Pasquet, Bernhard Gerber, Philippe Lesnik, Thierry Huby, François Jamar and Jean-Louis Vanoverschelde

Pharmacokinetic modeling of [¹⁸F]fluorodeoxyglucose (FDG) for premature infants, and newborns through 5-year-olds

Absorbed dose estimates for pediatric patients require pharmacokinetics that are, to the extent possible, age-specific. Such age-specific pharmacokinetic data are lacking for many of the diagnostic agents typi...

Authors: Kitiwat Khamwan, Donika Plyku, Shannon E. O’Reilly, Alison Goodkind, Xinhua Cao, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch and George Sgouros

Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2

Prostate cancer ranks as the second most lethal malignancy in the Western world. Previous targeting of prostate-specific antigen and human kallikrein-related peptidase 2, two related enzymes abundantly express...

Authors: O. Vilhelmsson Timmermand, E. Larsson, D. Ulmert, T. A. Tran and SE. Strand

Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers

The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery.

Authors: Ingrid J. G. Burvenich, Fook-Thean Lee, Graeme J. O’Keefe, Dahna Makris, Diana Cao, Sylvia Gong, Angela Rigopoulos, Laura C. Allan, Martin W. Brechbiel, Zhanqi Liu, Paul A. Ramsland and Andrew M. Scott

Angiotensin II increases gene expression after selective intra-arterial adenovirus delivery in a rabbit model assessed using in vivo SSTR2-based reporter imaging

Gene therapy has been hampered by low expression upon in vivo delivery. Using a somatostatin receptor type 2 (SSTR2)-based reporter, we assessed whether angiotensin II (AII) can improve gene expression by aden...

Authors: Sheela P. Singh, Murali K. Ravoori, Katherine A. Dixon, Lin Han, Sanjay Gupta, Rajesh Uthamanthil, Kenneth C. Wright and Vikas Kundra

A new method to quantify tau pathologies with ¹¹C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter

Quantitative in vivo imaging of tau pathologies potentially improves diagnostic accuracy of neurodegenerative tauopathies and would facilitate evaluation of disease-modifying drugs targeting tau lesions in the...

Authors: Yasuyuki Kimura, Hironobu Endo, Masanori Ichise, Hitoshi Shimada, Chie Seki, Yoko Ikoma, Hitoshi Shinotoh, Makiko Yamada, Makoto Higuchi, Ming-Rong Zhang and Tetsuya Suhara

Automated Bone Scan Index as a quantitative imaging biomarker in metastatic castration-resistant prostate cancer patients being treated with enzalutamide

Having performed analytical validation studies, we are now assessing the clinical utility of the upgraded automated Bone Scan Index (BSI) in metastatic castration-resistant prostate cancer (mCRPC). In the pres...

Authors: Aseem Anand, Michael J. Morris, Steven M. Larson, David Minarik, Andreas Josefsson, John T. Helgstrand, Peter S. Oturai, Lars Edenbrandt, Martin Andreas Røder and Anders Bjartell

ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes

Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioa...

Authors: Alex A. Dooraghi, Lewis Carroll, Jeffrey Collins, R. Michael van Dam and Arion F. Chatziioannou

For avid glucose tumors, the SUV peak is the most reliable parameter for [¹⁸F]FDG-PET/CT quantification, regardless of acquisition time

This study is an assessment of the impact of acquisition times on SUV with [¹⁸F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.

Authors: Avigaëlle Sher, Franck Lacoeuille, Pacôme Fosse, Laurent Vervueren, Aurélie Cahouet-Vannier, Djamel Dabli, Francis Bouchet and Olivier Couturier

Impact of MR-safe headphones on PET attenuation in combined PET/MRI scans

MR headphones are attenuation sources affecting PET quantification in hybrid PET/MRI. Despite potentially better patient communication, usage in PET/MRI scans is not approved by the vendor. This study aims to ...

Authors: Florian Büther, Alexis Vrachimis, Anne Becker and Lars Stegger

An investigation of the relation between tumor-to-liver ratio (TLR) and tumor-to-blood standard uptake ratio (SUR) in oncological FDG PET

The standardized uptake value (SUV) is the nearly exclusive means for quantitative evaluation of clinical [18F-]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) whole body investigations. Howeve...

Authors: Frank Hofheinz, Rebecca Bütof, Ivayla Apostolova, Klaus Zöphel, Ingo G. Steffen, Holger Amthauer, Jörg Kotzerke, Michael Baumann and Jörg van den Hoff

Discovery and characterization of a high-affinity and high-specificity peptide ligand LXY30 for in vivo targeting of α3 integrin-expressing human tumors

α3β1 integrin is overexpressed in several types of human cancer and is associated with poor prognosis, metastasis, and resistance to cancer treatment. We previously identified a cyclic peptide ligand LXY1 that...

Authors: Wenwu Xiao, Tianhong Li, Fernanda C. Bononi, Diana Lac, Ivy A. Kekessie, Yanlei Liu, Eduardo Sanchez, Anisha Mazloom, Ai-hong Ma, Jia Lin, Jimmy Tran, Kevin Yang, Kit S. Lam and Ruiwu Liu

Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors

Overexpression of the gastrin-releasing peptide receptor (GRP-R) has been documented in several human neoplasms such as breast, prostate, and ovarian cancer. There is growing interest in developing radiolabele...

Authors: Antonella Accardo, Filippo Galli, Rosalba Mansi, Luigi Del Pozzo, Michela Aurilio, Anna Morisco, Paola Ringhieri, Alberto Signore, Giancarlo Morelli and Luigi Aloj

Quantitative accuracy of ¹⁷⁷Lu SPECT reconstruction using different compensation methods: phantom and patient studies

In targeted radionuclide therapy (TRT), accurate quantification using SPECT/CT images is important for optimizing radiation dose delivered to both the tumour and healthy tissue. Quantitative SPECT images are r...

Authors: Eero Hippeläinen, Mikko Tenhunen, Hanna Mäenpää and Antti Sohlberg

Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [¹¹¹In-DOTA]MG11—first estimates for clinical translation

We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides. For the truncated ...

Authors: Aikaterini Kaloudi, Berthold A. Nock, Emmanouil Lymperis, Roelf Valkema, Eric P. Krenning, Marion de Jong and Theodosia Maina

Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization

Optical molecular imaging is an emerging novel technology with applications in the diagnosis of cancer and assistance in image-guided surgery. A high tumour-to-background (T/B) ratio is crucial for successful ...

Authors: Marta M. Kijanka, Aram S. A. van Brussel, Elsken van der Wall, Willem P. T. M. Mali, Paul J. van Diest, Paul M. P. van Bergen en Henegouwen and Sabrina Oliveira

Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of ¹⁶¹Tb-folate and ¹⁷⁷Lu-folate

The radiolanthanide ¹⁶¹Tb has, in recent years, attracted increasing interest due to its favorable characteristics for medical application. ¹⁶¹Tb exhibits similar properties to the widely-used therapeutic radionu...

Authors: Stephanie Haller, Giovanni Pellegrini, Christiaan Vermeulen, Nicholas P. van der Meulen, Ulli Köster, Peter Bernhardt, Roger Schibli and Cristina Müller

Radiolabeling polymeric micelles for in vivo evaluation: a novel, fast, and facile method

Single photon emission computed tomography (SPECT) is an indispensable tool in the determination of the in vivo fate of polymeric micelles. However, for this purpose, the micelles need to be radiolabeled, and ...

Authors: Adrianus C. Laan, Costanza Santini, Laurence Jennings, Marion de Jong, Monique R. Bernsen and Antonia G. Denkova

Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H₃ receptors

Histamine H₃ receptor (H₃R) is a potential therapeutic target of sleep- and cognition-related disorders. The purpose of the present study is to develop a novel positron emission tomography (PET) ligand for H₃Rs f...

Authors: Kazumi Koga, Jun Maeda, Masaki Tokunaga, Masayuki Hanyu, Kazunori Kawamura, Mari Ohmichi, Toshio Nakamura, Yuji Nagai, Chie Seki, Yasuyuki Kimura, Takafumi Minamimoto, Ming-Rong Zhang, Toshimitsu Fukumura, Tetsuya Suhara and Makoto Higuchi

Effects of erlotinib therapy on [¹¹C]erlotinib uptake in EGFR mutated, advanced NSCLC

In non-small cell lung cancer (NSCLC) patients off erlotinib therapy, positron emission tomography (PET) using [¹¹C]erlotinib distinguished epidermal growth factor receptor (EGFR) mutations from wild-type EGFR. H...

Authors: Idris Bahce, Maqsood Yaqub, Hanane Errami, Robert C. Schuit, Patrick Schober, Erik Thunnissen, Albert D. Windhorst, Adriaan A. Lammertsma, Egbert F. Smit and N. Harry Hendrikse

In vivo validation of gated myocardial SPECT imaging for quantification of small hearts: comparison with cardiac MRI

In patients with small hearts, the Quantitative Gated single-photon emission computed tomography (SPECT) (QGS) program frequently underestimates the left ventricular (LV) end-systolic volume (ESV) and overesti...

Authors: Chisato Kondo, Eri Watanabe, Mitsuru Momose, Kenji Fukushima, Koichiro Abe, Nobuhisa Hagiwara and Shuji Sakai

Erratum to: The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule

Authors: Janneke van Uhm

Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling

We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humaniz...

Authors: Edward K. Fung, Sarah M. Cheal, Shoaib B. Fareedy, Blesida Punzalan, Volkan Beylergil, Jawaria Amir, Sandhya Chalasani, Wolfgang A. Weber, Daniel E. Spratt, Darren R. Veach, Neil H. Bander, Steven M. Larson, Pat B. Zanzonico and Joseph R. Osborne

Influence of tumour size on the efficacy of targeted alpha therapy with ²¹³Bi-[DOTA⁰,Tyr³]-octreotate

Targeted alpha therapy has been postulated to have great potential for the treatment of small clusters of tumour cells as well as small metastases. ²¹³Bismuth, an α-emitter with a half-life of 46 min, has shown t...

Authors: Ho Sze Chan, Mark W. Konijnenberg, Erik de Blois, Stuart Koelewijn, Richard P. Baum, Alfred Morgenstern, Frank Bruchertseifer, Wouter A. Breeman and Marion de Jong

¹⁷⁷Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbid...

Authors: Ralf Bergmann, Marian Meckel, Vojtěch Kubíček, Jens Pietzsch, Jörg Steinbach, Petr Hermann and Frank Rösch

Targeted scVEGF/¹⁷⁷Lu radiopharmaceutical inhibits growth of metastases and can be effectively combined with chemotherapy

scVEGF/¹⁷⁷Lu is a novel radiopharmaceutical targeted by recombinant single-chain (sc) derivative of vascular endothelial growth factor (VEGF) that binds to and is internalized by vascular endothelial growth facto...

Authors: Mary Rusckowski, Yuzhen Wang, Francis G. Blankenberg, Zoia Levashova, Marina V. Backer and Joseph M. Backer

Imaging heterogeneity of peptide delivery and binding in solid tumors using SPECT imaging and MRI

As model system, a solid-tumor patient-derived xenograft (PDX) model characterized by high peptide receptor expression and histological tissue homogeneity was used to study radiopeptide targeting. In this soli...

Authors: J. C. Haeck, K. Bol, C. M. A. de Ridder, L. Brunel, J. A. Fehrentz, J. Martinez, W. M. van Weerden, M. R. Bernsen, M. de Jong and J. F. Veenland

Impact of fasting on ¹⁸F-fluorocholine gastrointestinal uptake and detection of lymph node metastases in patients with prostate cancer

¹⁸F-fluorocholine PET/CT is used to detect lymph node metastases in prostate cancer patients. Physiological ¹⁸F-fluorocholine in the gastrointestinal tract, especially in the intestine...

Authors: Maurits Wondergem, Friso M. van der Zant, Remco J. J. Knol, Jan Pruim and Igle J. de Jong

Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis

The inflammatory nature of atherosclerosis provides a broad range of potential molecular targets for atherosclerosis imaging. Growing interest is focused on targets related to plaque vulnerability such as the ...

Authors: Romana Meletta, Adrienne Müller Herde, Patrick Dennler, Eliane Fischer, Roger Schibli and Stefanie D. Krämer

The dog prostate cancer (DPC-1) model: a reliable tool for molecular imaging of prostate tumors and metastases

Clinical applicability of newly discovered reagents for molecular imaging is hampered by the lack of translational models. As the dog prostate cancer (DPC-1) model recapitulates in dogs the natural history of ...

Authors: Simone Chevalier, Serge Moffett, Eric Turcotte, Murillo Luz, Lyne Chauvette, Vilma Derbekyan, Eleonora Scarlata, Fatima Zouanat, Armen G. Aprikian and Maurice Anidjar

¹⁸F-FDG PET scanning of abdominal aortic aneurysms and correlation with molecular characteristics: a systematic review

The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 (¹⁸F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on mo...

Authors: U. T. Timur, J. A. van Herwaarden, D. Mihajlovic, P. De Jong, W. Mali and F. L. Moll