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  1. Florbetapir (AV-45) has been shown to be a reliable tool to assess amyloid load in patients with Alzheimer's disease (AD) at demential stages. Longitudinal studies also suggest that AV-45 has the ability to bi...

    Authors: Laure Saint-Aubert, Emmanuel J Barbeau, Patrice Péran, Federico Nemmi, Celine Vervueren, Helene Mirabel, Pierre Payoux, Anne Hitzel, Fabrice Bonneville, Raluca Gramada, Mathieu Tafani, Christian Vincent, Michele Puel, Sophie Dechaumont, Francois Chollet and Jeremie Pariente
    Citation: EJNMMI Research 2013 3:43
    Content type: Original research Published on:

  2. Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinic...

    Authors: Joseph A O’Donoghue, José G Guillem, Heiko Schöder, Nancy Y Lee, Chaitanya R Divgi, Jeannine A Ruby, John L Humm, Steven A Lee-Kong, Eva M Burnazi, Shangde Cai, Sean D Carlin, Tobias Leibold, Pat B Zanzonico and C Clifton Ling
    Citation: EJNMMI Research 2013 3:42
    Content type: Original research Published on:

  3. Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H2 15O (or C15O2) can quantify CBF and apply kinet...

    Authors: Nobuyuki Kudomi, Yukito Maeda, Yasuhiro Sasakawa, Toshihide Monden, Yuka Yamamoto, Nobuyuki Kawai, Hidehiro Iida and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2013 3:41
    Content type: Original research Published on:

  4. Since proteoglycans (PGs) appear as key partners in chondrosarcoma biology, PG-targeted imaging using the radiotracer 99mTc-N-(triethylammonium)-3-propyl-[15]ane-N5 (99mTc-NTP 15-5) developed by our group was pre...

    Authors: Elisabeth Miot-Noirault, Emmanuelle David, Aurélien Vidal, Caroline Peyrode, Sophie Besse, Marie-Mélanie Dauplat, Marie-Françoise Heymann, François Gouin, Jean-Michel Chezal, Dominique Heymann and Françoise Rédini
    Citation: EJNMMI Research 2013 3:40
    Content type: Short communication Published on:

  5. Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminerg...

    Authors: Gerda Thomsen, Gitte Moos Knudsen, Peter S Jensen, Morten Ziebell, Klaus K Holst, Susanne Asenbaum, Jan Booij, Jacques Darcourt, John C Dickson, Özlem L Kapucu, Flavio Nobili, Osama Sabri, Terez Sera, Klaus Tatsch, Livia Tossici-Bolt, Koen Van Laere…
    Citation: EJNMMI Research 2013 3:39
    Content type: Original research Published on:

  6. Expression of αvβ3 integrin is increased after myocardial infarction as part of the repair process. Increased expression of αvβ3 has been shown by molecular imaging with 18F-galacto-RGD in a rat model. The 68Ga-l...

    Authors: Iina Laitinen, Johannes Notni, Karolin Pohle, Martina Rudelius, Eliane Farrell, Stephan G Nekolla, Gjermund Henriksen, Stefanie Neubauer, Horst Kessler, Hans-Jürgen Wester and Markus Schwaiger
    Citation: EJNMMI Research 2013 3:38
    Content type: Original research Published on:

  8. Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to ...

    Authors: William J McBride, Robert M Sharkey and David M Goldenberg
    Citation: EJNMMI Research 2013 3:36
    Content type: Review Published on:

  9. [18F]UCB-H was developed as a novel radiotracer with a high affinity for synaptic vesicle protein 2A, the binding site for the antiepileptic levetiracetam. The objectives of this study were to evaluate the radiat...

    Authors: Florian Bretin, Geoffrey Warnock, Mohamed Ali Bahri, Joël Aerts, Nathalie Mestdagh, Tim Buchanan, Anne Valade, Frédéric Mievis, Fabrice Giacomelli, Christian Lemaire, André Luxen, Eric Salmon, Alain Seret and Alain Plenevaux
    Citation: EJNMMI Research 2013 3:35
    Content type: Original research Published on:

  10. Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hy...

    Authors: Anke J Borgers, Anneke Alkemade, Elsmarieke M Van de Giessen, Madeleine L Drent, Jan Booij, Peter H Bisschop and Eric Fliers
    Citation: EJNMMI Research 2013 3:34
    Content type: Original research Published on:

  11. We propose a new approach to facilitate sentinel node biopsy examination by multimodality imaging in which radioactive and near-infrared (NIR) fluorescent nanoparticles depict deeply situated sentinel nodes an...

    Authors: Makoto Tsuchimochi, Kazuhide Hayama, Michio Toyama, Ichiro Sasagawa and Norio Tsubokawa
    Citation: EJNMMI Research 2013 3:33
    Content type: Original research Published on:

  12. The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans.

    Authors: Miho Shidahara, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Shoichi Watanuki, Kotaro Hiraoka, Masayasu Miyake, Ren Iwata, Hajime Tamura, Hiroyuki Arai, Yukitsuka Kudo and Kazuhiko Yanai
    Citation: EJNMMI Research 2013 3:32
    Content type: Original research Published on:

  13. Androgen deprivation (AD) is generally used as a first-line palliative treatment in prostate cancer (PCa) patients with rising prostate-specific antigen (PSA) after primary therapy. To acquire an accurate dete...

    Authors: Kimy M Emonds, Johannes V Swinnen, Evelyne Lerut, Michel Koole, Luc Mortelmans and Felix M Mottaghy
    Citation: EJNMMI Research 2013 3:31
    Content type: Original research Published on:

  14. The activation of microglia, in general, and the upregulation of the translocator protein (18 kDa) (TSPO) system, in particular, are key features of neuroinflammation, of which the in vivo visualization and quant...

    Authors: Akihiro Takano, Fredrik Piehl, Jan Hillert, Andrea Varrone, Sangram Nag, Balázs Gulyás, Per Stenkrona, Victor L Villemagne, Christopher C Rowe, Richard Macdonell, Nabil Al Tawil, Thomas Kucinski, Torsten Zimmermann, Marcus Schultze-Mosgau, Andrea Thiele, Anja Hoffmann…
    Citation: EJNMMI Research 2013 3:30
    Content type: Original research Published on:

  15. Respiratory gating and gate optimization strategies present solutions for overcoming image degradation caused by respiratory motion in PET and traditionally utilize hardware systems and/or employ complex proce...

    Authors: Adam Leon Kesner, Galith Abourbeh, Eyal Mishani, Roland Chisin, Sagi Tshori and Nanette Freedman
    Citation: EJNMMI Research 2013 3:29
    Content type: Original research Published on:

  16. Reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (COPD), reflected as inhomogeneities in the single-photon emission computed tomography (SPECT) lung image, is correlated to...

    Authors: Pernilla Norberg, Hans Lennart Persson, Gudrun Alm Carlsson, Björn Bake, Magnus Kentson, Michael Sandborg and Agnetha Gustafsson
    Citation: EJNMMI Research 2013 3:28
    Content type: Original research Published on:

  17. [11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by ...

    Authors: Kayako Isohashi, Eku Shimosegawa, Hiroki Kato, Yasukazu Kanai, Sadahiro Naka, Koichi Fujino, Hiroshi Watabe and Jun Hatazawa
    Citation: EJNMMI Research 2013 3:27
    Content type: Original research Published on:

  18. A kinetic model analysis was recently proposed to estimate the 18F-fluorodeoxyglucose (18F-FDG) integrated activity in an arbitrary tissue that uses tracer uptake and release rate constants. The aim of the curren...

    Authors: Eric Laffon, Manuel Bardiès, Jacques Barbet and Roger Marthan
    Citation: EJNMMI Research 2013 3:26
    Content type: Original research Published on:

  19. Previous studies showed that radiolabeled murine monoclonal antibody (mAb) 14C5 and its Fab and F(ab')2 fragments, targeting αvβ5 integrin, have promising properties for diagnostic and therapeutic applications in...

    Authors: Caroline Dumolyn, Steve Schoonooghe, Lieselotte Moerman, Sara Neyt, Jurgen Haustraete and Filip De Vos
    Citation: EJNMMI Research 2013 3:25
    Content type: Original research Published on:

  20. Serotonin 5-HT4 receptor (5-HT4-R) agonists are potential therapeutic agents for enterokinetic and cognitive disorders and are marketed for treatment of constipation. The aim of this study was to develop an agoni...

    Authors: Hans JC Buiter, Albert D Windhorst, Marc C Huisman, Joris H De Maeyer, Jan AJ Schuurkes, Adriaan A Lammertsma and Josée E Leysen
    Citation: EJNMMI Research 2013 3:24
    Content type: Original research Published on:

  21. Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (2...

    Authors: Sophie E Eriksson, Tom Bäck, Erika Elgström, Holger Jensen, Rune Nilsson, Sture Lindegren and Jan Tennvall
    Citation: EJNMMI Research 2013 3:23
    Content type: Original research Published on:

  22. Functional brain changes induced by chemotherapy are still not well characterized. We used a novel approach with a multivariate technique to analyze brain resting state [18 F]FDG-PET in patients with lymphoma, to...

    Authors: Federico D'Agata, Tommaso Costa, Paola Caroppo, Bruno Baudino, Franco Cauda, Matteo Manfredi, Giuliano Geminiani, Paolo Mortara, Lorenzo Pinessi, Giancarlo Castellano and Gianni Bisi
    Citation: EJNMMI Research 2013 3:22
    Content type: Original research Published on:

  23. Breast cancer is one of the most prevalent forms of cancer in women. Breast-specific gamma imaging (BSGI) is a diagnostic imaging method that uses sestamibi-labelled 99Tc and a dedicated gamma camera to localize ...

    Authors: Dennis Dieckens, Jules Lavalaye, Leo Romijn and Jan Habraken
    Citation: EJNMMI Research 2013 3:21
    Content type: Original research Published on:

  24. Technetium-labeled agents, which are most often used for assessing myocardial perfusion in myocardial perfusion scintigraphy (MPS), are cleared by the liver and excreted by the biliary system. Spillover from e...

    Authors: Allan Johansen, Milan Lomsky, Oke Gerke, Lars Edenbrandt, Lena Johansson, Gunhild Hansen, Birgitte Jensen, Maria Sallerup Reid, Lise-Lott Johansson, Camilla Olofsson, David Minarik, Karin Nyström, Per Wollmer and Elin Trägårdh
    Citation: EJNMMI Research 2013 3:20
    Content type: Original research Published on:

  25. The M1 muscarinic acetylcholine receptor (M1ACh-R) is a G protein-coupled receptor that can occur in interconvertible coupled and uncoupled states. It is enriched in the basal ganglia, hippocampus, olfactory b...

    Authors: Hans JC Buiter, Albert D Windhorst, Marc C Huisman, Maqsood Yaqub, Dirk L Knol, Abraham Fisher, Adriaan A Lammertsma and Josée E Leysen
    Citation: EJNMMI Research 2013 3:19
    Content type: Original research Published on:

  26. An unknown location hampers removal of pancreatic tumours. We studied the effects of enzyme inhibitors on the uptake of 6-[18F]fluoro-l-3,4-dihydroxyphenylalanine ([18F]FDOPA) in the pancreas, aiming at improved ...

    Authors: Johanna Tuomela, Sarita Forsback, Laura Haavisto, Tero Vahlberg, Tove J Grönroos, Olof Solin and Merja Haaparanta-Solin
    Citation: EJNMMI Research 2013 3:18
    Content type: Original research Published on:

  27. In mice, 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET/CT) lymphography enables detailed imaging of the lymphatic system and quantification of lymph node function. If this...

    Authors: Mads Radmer Jensen, Lene Simonsen, Markus Lonsdale and Jens Bjørn Bülow
    Citation: EJNMMI Research 2013 3:17
    Content type: Short communication Published on:

  28. Assessment of dual time point (DTP) positron emission tomography was carried out with the aim of a quantitative determination of K m , the metabolic uptake rate of [18F]fluo...

    Authors: Jörg van den Hoff, Frank Hofheinz, Liane Oehme, Georg Schramm, Jens Langner, Bettina Beuthien-Baumann, Jörg Steinbach and Jörg Kotzerke
    Citation: EJNMMI Research 2013 3:16
    Content type: Original research Published on:

  29. Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of ap...

    Authors: Runa H Poulsen, Jan T Rasmussen, June Anita Ejlersen, Christian Flø, Lise Falborg, Christian W Heegaard and Michael Rehling
    Citation: EJNMMI Research 2013 3:15
    Content type: Original research Published on:

  30. Airway liquid hyper-absorption is a key pathophysiological link between the genetic mutations of cystic fibrosis (CF) and the development of lung disease. Here we consider whether the clearance of radiolabeled...

    Authors: Timothy E Corcoran, Kristina M Thomas, Stefanie Brown, Michael M Myerburg, Landon W Locke and Joseph M Pilewski
    Citation: EJNMMI Research 2013 3:14
    Content type: Original research Published on:

  31. Using positron emission tomography (PET), we compared two tracers, [11C]metomidate ([11C]MTO) and [11C]acetate ([11C]ACE), for the characterization of hepatic tumors.

    Authors: Anne Roivainen, Alexandru Naum, Heikki Nuutinen, Rauli Leino, Heimo Nurmi, Kjell Någren, Riitta Parkkola, Johanna Virtanen, Markku Kallajoki, Harry Kujari, Jari Ovaska, Peter Roberts and Marko Seppänen
    Citation: EJNMMI Research 2013 3:13
    Content type: Original research Published on:

  32. In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) fun...

    Authors: Åsa A Barrefelt, Torkel B Brismar, Gabriella Egri, Peter Aspelin, Annie Olsson, Letizia Oddo, Silvia Margheritelli, Kenneth Caidahl, Gaio Paradossi, Lars Dähne, Rimma Axelsson and Moustapha Hassan
    Citation: EJNMMI Research 2013 3:12
    Content type: Original research Published on:

  33. Despite the early theoretical prediction of the 0+-0+ transition of 90Zr, 90Y-PET underwent only recently a growing interest for the development of imaging radioembolization of liver tumors. The aim of this work ...

    Authors: Thomas Carlier, Thomas Eugène, Caroline Bodet-Milin, Etienne Garin, Catherine Ansquer, Caroline Rousseau, Ludovic Ferrer, Jacques Barbet, Frédéric Schoenahl and Françoise Kraeber-Bodéré
    Citation: EJNMMI Research 2013 3:11
    Content type: Original research Published on:

  34. 11C-PiB has been developed as a positron-emission tomography (PET) ligand for evaluating fibrillar β-amyloid (Aβ) in the human brain. The ligand is rapidly metabolized, with approximately 10% of intact tracer re...

    Authors: Anne Van Vlaslaer, Russell J Mortishire-Smith, Claire Mackie, Xavier Langlois and Mark E Schmidt
    Citation: EJNMMI Research 2013 3:10
    Content type: Short communication Published on:

  35. The objective of this study was to explore the prognostic value of the Bone Scan Index (BSI) obtained at the time of diagnosis in a group of high-risk prostate cancer patients receiving primary hormonal therapy.

    Authors: Reza Kaboteh, Jan-Erik Damber, Peter Gjertsson, Peter Höglund, Milan Lomsky, Mattias Ohlsson and Lars Edenbrandt
    Citation: EJNMMI Research 2013 3:9
    Content type: Original research Published on:

  36. This letter points out the correct definition of inflammation and infection that is important for differential diagnosis. The most common nuclear medicine techniques and interpretation criteria to differentiat...

    Authors: Alberto Signore
    Citation: EJNMMI Research 2013 3:8
    Content type: Letter to the Editor Published on:

  37. In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) c...

    Authors: Chao Wu, Hugo A Gratama van Andel, Peter Laverman, Otto C Boerman and Freek J Beekman
    Citation: EJNMMI Research 2013 3:7
    Content type: Original research Published on:

  38. The purpose of this work was to reveal the research interest value of positron emission tomography (PET) imaging in visualizing the induced tissue activity post high-energy photon radiation treatment. More spe...

    Authors: Sara Janek Strååt, Hans Jacobsson, Marilyn E Noz, Björn Andreassen, Ingemar Näslund and Cathrine Jonsson
    Citation: EJNMMI Research 2013 3:6
    Content type: Original research Published on:

  39. The use of iodinated contrast media in small-animal positron emission tomography (PET)/computed tomography (CT) could improve anatomic referencing and tumor delineation but may introduce inaccuracies in the at...

    Authors: Charline Lasnon, Elske Quak, Mélanie Briand, Zheng Gu, Marie-Hélène Louis and Nicolas Aide
    Citation: EJNMMI Research 2013 3:5
    Content type: Original research Published on:

  40. To date, few PET tracers for in vivo labeling of red blood cells (RBCs) are available. In this study, we report the radiosynthesis and in vitro and in vivo evaluation of 11C and 18F sulfonamide derivatives target...

    Authors: Olivier Gheysens, Vamsidhar Akurathi, Rufael Chekol, Tom Dresselaers, Sofie Celen, Michel Koole, Dieter Dauwe, Bernard J Cleynhens, Piet Claus, Stefan Janssens, Alfons M Verbruggen, Johan Nuyts, Uwe Himmelreich and Guy M Bormans
    Citation: EJNMMI Research 2013 3:4
    Content type: Original research Published on:

  41. The characterization of fast-decaying radiotracers that are labeled with carbon-11 (t 1/2 = 20.38 min), including critical measurement of specific radioactivity (activity per mole at a specific time) before relea...

    Authors: H Umesha Shetty, Cheryl L Morse, Yi Zhang and Victor W Pike
    Citation: EJNMMI Research 2013 3:3
    Content type: Original research Published on:

  42. Statistical parametric mapping (SPM) procedure is an objective tool to analyze 18F-fluoro-2-deoxy-d-glucose-positron-emission tomography (FDG-PET) images and a useful complement to visual analysis. However, SPM r...

    Authors: Frederique Archambaud, Viviane Bouilleret, Lucie Hertz-Pannier, Philippe Chaumet-Riffaud, Sebastian Rodrigo, Olivier Dulac, Francine Chassoux and Catherine Chiron
    Citation: EJNMMI Research 2013 3:2
    Content type: Original research Published on:

  44. There is a growing interest in developing non-invasive imaging techniques permitting infarct size (IS) measurements in mice. The aim of this study was to validate the high-resolution rodent Linoview single pho...

    Authors: Véronique Roelants, Marie Delgaudine, Stephan Walrand, Renaud Lhommel, Yves Beguin, François Jamar and Jean-Louis Vanoverschelde
    Citation: EJNMMI Research 2012 2:64
    Content type: Original research Published on:

  45. Positron emission tomography (PET) allows for the measurement of cerebral blood flow (CBF; based on [15O]H2O) and cerebral metabolic rate of glucose utilization (CMRglu; based on [18 F]-2-fluoro-2-deoxy-d-glucose...

    Authors: Marc C Huisman, Larissa W van Golen, Nikie J Hoetjes, Henri N Greuter, Patrick Schober, Richard G Ijzerman, Michaela Diamant and Adriaan A Lammertsma
    Citation: EJNMMI Research 2012 2:63
    Content type: Original research Published on:

  46. By providing estimates of tumor glucose metabolism, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can potentially characterize the response of breast tumors to treatment. To assess therapy respons...

    Authors: Xia Li, Richard G Abramson, Lori R Arlinghaus, Anuradha Bapsi Chakravarthy, Vandana Abramson, Ingrid Mayer, Jaime Farley, Dominique Delbeke and Thomas E Yankeelov
    Citation: EJNMMI Research 2012 2:62
    Content type: Preliminary research Published on:

  47. The estrogen receptor α (ERα) is known to play an important role in the modulation of tumor response to hormone therapy. In this work, the effect of different hormone therapies on tumors having different ERα e...

    Authors: Michel Paquette, Sébastien Tremblay, Francois Bénard and Roger Lecomte
    Citation: EJNMMI Research 2012 2:61
    Content type: Original research Published on:

  48. Recently, inflammatory cascades have been suggested as a target for epilepsy therapy. Positron emission tomography (PET) imaging offers the unique possibility to evaluate brain inflammation longitudinally in a...

    Authors: Stefanie Dedeurwaerdere, Paul D Callaghan, Tien Pham, Gita L Rahardjo, Halima Amhaoul, Paula Berghofer, Mitchell Quinlivan, Filomena Mattner, Christian Loc'h, Andrew Katsifis and Marie-Claude Grégoire
    Citation: EJNMMI Research 2012 2:60
    Content type: Original research Published on:

  49. This study evaluates the potential utility of a modular nanotransporter (MNT) for enhancing the nuclear delivery and cytotoxicity of the Auger electron emitter 125I in cancer cells that overexpress the epidermal ...

    Authors: Tatiana A Slastnikova, Eftychia Koumarianou, Andrey A Rosenkranz, Ganesan Vaidyanathan, Tatiana N Lupanova, Alexander S Sobolev and Michael R Zalutsky
    Citation: EJNMMI Research 2012 2:59
    Content type: Original research Published on:

  50. P-glycoprotein is a blood–brain barrier efflux transporter involved in the clearance of amyloid-beta from the brain and, as such, might be involved in the pathogenesis of Alzheimer's disease. P-glycoprotein is...

    Authors: Daniëlle ME van Assema, Mark Lubberink, Patrizia Rizzu, John C van Swieten, Robert C Schuit, Jonas Eriksson, Philip Scheltens, Matthias Koepp, Adriaan A Lammertsma and Bart NM van Berckel
    Citation: EJNMMI Research 2012 2:57
    Content type: Original research Published on:

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