Articles

Comparison of three-parameter kinetic model analysis to standard Patlak’s analysis in ¹⁸F-FDG PET imaging of lung cancer patients

Patlak’s graphical analysis can provide tracer net influx constant (Ki) with limitation of assuming irreversible tracer trapping, that is, release rate constant (k_b) set to zero. We compared linear Patlak’s analy...

Authors: E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan and L. Indovina

Accuracy of tumor segmentation from multi-parametric prostate MRI and ¹⁸F-choline PET/CT for focal prostate cancer therapy applications

The study aims to assess the accuracy of multi-parametric prostate MRI (mpMRI) and ¹⁸F-choline PET/CT in tumor segmentation for clinically significant prostate cancer. ¹⁸F-choline PET/CT and 3 T mpMRI were perfor...

Authors: Morand Piert, Prasad R. Shankar, Jeffrey Montgomery, Lakshmi Priya Kunju, Virginia Rogers, Javed Siddiqui, Thekkelnaycke Rajendiran, Jason Hearn, Arvin George, Xia Shao and Matthew S. Davenport

Validation of [¹⁸F]FLT as a perfusion-independent imaging biomarker of tumour response in EGFR-mutated NSCLC patients undergoing treatment with an EGFR tyrosine kinase inhibitor

3′-Deoxy-3′-[¹⁸F]fluorothymidine ([¹⁸F]FLT) was proposed as an imaging biomarker for the assessment of in vivo cellular proliferation with positron emission tomography (PET). The current study aimed to validate [

Authors: R. Iqbal, G. M. Kramer, V. Frings, E. F. Smit, O. S. Hoekstra and R. Boellaard

Noninvasive quantitation of rat cerebral blood flow using ^99mTc-HMPAO—assessment of input function with dynamic chest planar imaging

Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (^99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for sma...

Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata

I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma

I-124 codrituzumab (aka GC33), an antibody directed at Glypican 3, was evaluated in patients with hepatocellular carcinoma (HCC). Fourteen patients with HCC underwent baseline imaging with I-124 codrituzumab (...

Authors: Jorge A. Carrasquillo, Joseph A. O’Donoghue, Volkan Beylergil, Shutian Ruan, Neeta Pandit-Taskar, Steven M. Larson, Peter M. Smith-Jones, Serge K. Lyashchenko, Norihisa Ohishi, Toshihiko Ohtomo and Ghassan K. Abou-Alfa

Imaging Aβ and tau in early stage Alzheimer’s disease with [¹⁸F]AV45 and [¹⁸F]AV1451

AD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate th...

Authors: Azadeh Firouzian, Alex Whittington, Graham E. Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone and Roger N. Gunn

Biokinetic and dosimetric aspects of ⁶⁴CuCl₂ in human prostate cancer: possible theranostic implications

The aim of the present study is to evaluate the kinetics and dosimetry of ⁶⁴CuCl₂ in human prostate cancer (PCa) lesions.

Authors: Sergio Righi, Martina Ugolini, Gianluca Bottoni, Matteo Puntoni, Massimiliano Iacozzi, Francesco Paparo, Manlio Cabria, Luca Ceriani, Monica Gambaro, Luca Giovanella and Arnoldo Piccardo

Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis

Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has...

Authors: Christian H. Pfob, Matthias Eiber, Peter Luppa, Florian Maurer, Tobias Maurer, Robert Tauber, Calogero D’Alessandria, Benedikt Feuerecker, Klemens Scheidhauer, Armin Ott, Uwe Heemann, Markus Schwaiger and Christoph Schmaderer

Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging

In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DO...

Authors: Elisabeth Eppard, Ana de la Fuente, Nicole Mohr, Mareli Allmeroth, Rudolf Zentel, Matthias Miederer, Stefanie Pektor and Frank Rösch

Feasibility of intraoperative detection of sentinel lymph nodes with 89-zirconium-labelled nanocolloidal albumin PET-CT and a handheld high-energy gamma probe

PET/CT lymphoscintigraphy using ⁸⁹Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary t...

Authors: Derrek A. Heuveling, K. Hakki Karagozoglu, Arthur Van Lingen, Otto S. Hoekstra, Guus A. M. S. Van Dongen and Remco De Bree

A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases

xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images wit...

Authors: Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis and Solène Querellou

Statistical evaluation of test-retest studies in PET brain imaging

Positron emission tomography (PET) is a molecular imaging technology that enables in vivo quantification of metabolic activity or receptor density, among other applications. Examples of applications of PET ima...

Authors: Richard Baumgartner, Aniket Joshi, Dai Feng, Francesca Zanderigo and R. Todd Ogden

Subcellular storage and release mode of the novel ¹⁸F-labeled sympathetic nerve PET tracer LMI1195

¹⁸F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (¹⁸F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural up...

Authors: Xinyu Chen, Rudolf A. Werner, Constantin Lapa, Naoko Nose, Mitsuru Hirano, Mehrbod S. Javadi, Simon Robinson and Takahiro Higuchi

Feasibility of ¹⁵O-water PET studies of auditory system activation during general anesthesia in children

¹⁵O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic r....

Authors: Martin Mamach, Florian Wilke, Martin Durisin, Frank A. Beger, Mareike Finke, Andreas Büchner, Barbara Schultz, Arthur Schultz, Lilli Geworski, Frank M. Bengel, Thomas Lenarz, Anke Lesinski-Schiedat and Georg Berding

Biokinetics, dosimetry, and radiation risk in infants after ^99mTc-MAG3 scans

Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochas...

Authors: J. Soares Machado, J. Tran-Gia, S. Schlögl, A. K. Buck and M. Lassmann

It is time to move forward into the era of Theranostics

Radionuclide therapy, which until 15 years ago included only a few approved therapies, is gaining importance in the treatment of various malignancies. The future of oncology will not be limited to surgery, che...

Authors: Hojjat Ahmadzadehfar and Markus Essler

Renal sympathetic nerve activity after catheter-based renal denervation

Catheter-based renal sympathetic denervation (RDN) has been considered a potential treatment for therapy resistant hypertension (RHT). However, in a randomized placebo-controlled trial, RDN did not lead to a s...

Authors: Linn C. Dobrowolski, Daan W. Eeftinck Schattenkerk, C. T. Paul Krediet, Peter M. Van Brussel, Liffert Vogt, Frederike J. Bemelman, Jim A. Reekers, Bert-Jan H. Van Den Born and Hein J. Verberne

Abstracts of the 33rd International Austrian Winter Symposium

Authors: K. Binzel, A. Adelaja, C. L. Wright, D. Scharre, J. Zhang, M. V. Knopp, E. J. Teoh, D. Bottomley, A. Scarsbrook, H. Payne, A. Afaq, J. Bomanji, N. van As, S. Chua, P. Hoskin, A. Chambers…

Phantom and clinical evaluation of the effect of full Monte Carlo collimator modelling in post-SIRT yttrium-90 Bremsstrahlung SPECT imaging

Post-therapy SPECT/CT imaging of ⁹⁰Y microspheres delivered to hepatic malignancies is difficult, owing to the continuous, high-energy Bremsstrahlung spectrum emitted by ⁹⁰Y. This study aimed to evaluate the util...

Authors: Charlotte A. Porter, Kevin M. Bradley, Eero T. Hippeläinen, Matthew D. Walker and Daniel R. McGowan

Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody

Ideally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development....

Authors: Yvonne W. S. Jauw, Marc C. Huisman, Tapan K. Nayak, Danielle J. Vugts, Randolph Christen, Valerie Meresse Naegelen, Dominik Ruettinger, Florian Heil, Adriaan A. Lammertsma, Henk M. W. Verheul, Otto S. Hoekstra, Guus A. M. S. van Dongen and C. Willemien Menke-van der Houven van Oordt

A novel genomic signature predicting FDG uptake in diverse metastatic tumors

Building a universal genomic signature predicting the intensity of FDG uptake in diverse metastatic tumors may allow us to understand better the biological processes underlying this phenomenon and their requir...

Authors: Aurora Crespo-Jara, Maria Carmen Redal-Peña, Elena Maria Martinez-Navarro, Manuel Sureda, Francisco Jose Fernandez-Morejon, Francisco J. Garcia-Cases, Ramon Gonzalez Manzano and Antonio Brugarolas

Diagnostic implications of a small-voxel reconstruction for loco-regional lymph node characterization in breast cancer patients using FDG-PET/CT

We evaluated the diagnostic implications of a small-voxel reconstruction for lymph node characterization in breast cancer patients, using state-of-the-art FDG-PET/CT. We included 69 FDG-PET/CT scans from breas...

Authors: Daniëlle Koopman, Jorn A. van Dalen, Hester Arkies, Ad H. J. Oostdijk, Anne Brecht Francken, Jos Bart, Cornelis H. Slump, Siert Knollema and Pieter L. Jager

Prognostic value of simultaneous ¹⁸F-FDG PET/MRI using a combination of metabolo-volumetric parameters and apparent diffusion coefficient in treated head and neck cancer

The aim of this study was to determine the usefulness of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) parameters provided by simultaneous ¹⁸F-fluorodeoxyglucose (FDG) PET/MRI for t...

Authors: Yong-il Kim, Gi Jeong Cheon, Seo Young Kang, Jin Chul Paeng, Keon Wook Kang, Dong Soo Lee and June-Key Chung

Positron emission tomography-magnetic resonance imaging (PET-MRI) for response assessment after radiation therapy of cervical carcinoma: a pilot study

Advanced stage cervical cancer is primarily treated by radiotherapy. Local tumor control is a prerequisite for cure. Imaging after treatment is controversial. Positron emission tomography (PET) combined with c...

Authors: J. E. Mongula, F. C. H. Bakers, S. Vöö, L. Lutgens, T. van Gorp, R. F. P. M. Kruitwagen and B. F. M. Slangen

The effect of selective internal radiation therapy with yttrium-90 resin microspheres on lung carbon monoxide diffusion capacity

Selective internal radiation therapy (SIRT) with embolization of branches of the hepatic artery is a valuable therapeutic tool for patients with hepatic malignancies; however, it is also associated with lung i...

Authors: Tunc Ones, Emel Eryuksel, Feyyaz Baltacioglu, Berrin Ceyhan and Tanju Yusuf Erdil

Quantitative pulmonary blood flow measurement using ¹⁵O-H₂O PET with and without tissue fraction correction: a comparison study

Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpreta...

Authors: Keiko Matsunaga, Masahiro Yanagawa, Tomoyuki Otsuka, Haruhiko Hirata, Takashi Kijima, Atsushi Kumanogoh, Noriyuki Tomiyama, Eku Shimosegawa and Jun Hatazawa

Impact of tissue transport on PET hypoxia quantification in pancreatic tumours

The clinical impact of hypoxia in solid tumours is indisputable and yet questions about the sensitivity of hypoxia-PET imaging have impeded its uptake into routine clinical practice. Notably, the binding rate ...

Authors: Edward Taylor, Jennifer Gottwald, Ivan Yeung, Harald Keller, Michael Milosevic, Neesha C. Dhani, Iram Siddiqui, David W. Hedley and David A. Jaffray

Improved visualization of breast tissue on a dedicated breast PET system through ergonomic redesign of the imaging table

Breast lesions closer than 2 cm to the chest wall are difficult to position in the field of view of dedicated breast PET (db-PET) systems. This inability to detect such lesions is a significant limitation of t...

Authors: Michael K. O’Connor, Thuy D. Tran, Tiffinee N. Swanson, Lacey R. Ellingson, Katie N. Hunt and Dana H. Whaley

Correction to: The relationship between endogenous thymidine concentrations and [¹⁸F]FLT uptake in a range of preclinical tumour models

Unfortunately, the original version of Figs. 4, 5 and 6b in the article [1] contained errors in the n numbers as indicated on the columns. Please note that column heights and error bars in the original figures an...

Authors: Kathrin Heinzmann, Davina Jean Honess, David Yestin Lewis, Donna-Michelle Smith, Christopher Cawthorne, Heather Keen, Sandra Heskamp, Sonja Schelhaas, Timothy Howard Witney, Dmitry Soloviev, Kaye Janine Williams, Andreas Hans Jacobs, Eric Ofori Aboagye, John Richard Griffiths and Kevin Michael Brindle

Biodistribution and radiation dosimetry of [⁶⁴Cu]copper dichloride: first-in-human study in healthy volunteers

In recent years, Copper-64 (T_1/2 = 12.7 h) in the chemical form of copper dichloride ([⁶⁴Cu]CuCl₂) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper tran...

Authors: M.A. Avila-Rodriguez, C. Rios, J. Carrasco-Hernandez, J. C. Manrique-Arias, R. Martinez-Hernandez, F. O. García-Pérez, A. R. Jalilian, E. Martinez-Rodriguez, M. E. Romero-Piña and A. Diaz-Ruiz

Quantitative 3D scintigraphy shows increased muscular uptake of pyrophosphate in idiopathic inflammatory myopathy

Nuclear imaging is increasingly being used in the diagnostic work-up of idiopathic inflammatory myopathy (IIM). Increased muscular uptake of technetium-99m-pyrophosphate (^99mTc-PYP) has hitherto been assessed qua...

Authors: Karin Folmer Thøgersen, Jane Angel Simonsen, Svend Hvidsten, Oke Gerke, Søren Jacobsen, Poul Flemming Høilund-Carlsen, Karen Middelbo Buch-Olsen and Louise Pyndt Diederichsen

[¹⁸F]-BMS-747158-02PET imaging for evaluating hepatic mitochondrial complex 1dysfunction in a mouse model of non-alcoholic fatty liver disease

Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [¹⁸F]-BMS-747158-02 (¹⁸F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to...

Authors: Takemi Rokugawa, Sotaro Momosaki, Miwa Ito, Hitoshi Iimori, Yuki Kato and Kohji Abe

Pretargeting of internalizing trastuzumab and cetuximab with a ¹⁸F-tetrazine tracer in xenograft models

Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived r...

Authors: Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis and Mirkka Sarparanta

Phantom validation of quantitative Y-90 PET/CT-based dosimetry in liver radioembolization

PET/CT has recently been shown to be a viable alternative to traditional post-infusion imaging methods providing good quality images of ⁹⁰Y-laden microspheres after selective internal radiation therapy (SIRT). In...

Authors: Marco D’Arienzo, Maria Pimpinella, Marco Capogni, Vanessa De Coste, Luca Filippi, Emiliano Spezi, Nick Patterson, Francesca Mariotti, Paolo Ferrari, Paola Chiaramida, Michael Tapner, Alexander Fischer, Timo Paulus, Roberto Pani, Giuseppe Iaccarino, Marco D’Andrea…

Evaluation of the novel TSPO radiotracer [¹⁸F] VUIIS1008 in a preclinical model of cerebral ischemia in rats

In vivo positron-emission tomography (PET) imaging of transporter protein (TSPO) expression is an attractive and indispensable tool for the diagnosis and therapy evaluation of neuroinflammation after cerebral ...

Authors: Krishna R. Pulagam, Lorena Colás, Daniel Padro, Sandra Plaza-García, Vanessa Gómez-Vallejo, Makoto Higuchi, Jordi Llop and Abraham Martín

Diagnostic accuracy of coronary opacification derived from coronary computed tomography angiography to detect ischemia: first validation versus single-photon emission computed tomography

Estimation of functional relevance of a coronary stenosis by fractional flow reserve (FFR) from coronary computed tomography angiography (CCTA) has recently provided encouraging results. Due to its limited ava...

Authors: Dominik C. Benz, Fran Mikulicic, Christoph Gräni, Marvin Grossmann, Andreas A. Giannopoulos, Michael Messerli, Catherine Gebhard, Oliver Gaemperli, Ronny R. Buechel, Philipp A. Kaufmann and Aju P. Pazhenkottil

IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms

To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the bio...

Authors: Martin Andersson, Lennart Johansson, Keith Eckerman and Sören Mattsson

Oxygen-15 labeled CO₂, O₂, and CO PET in small animals: evaluation using a 3D-mode microPET scanner and impact of reconstruction algorithms

Positron emission tomography (PET) studies using ¹⁵O-labeled CO₂, O₂, and CO have been used in humans to evaluate cerebral blood flow (CBF), the cerebral oxygen extraction fraction (OEF), and the cerebral metabol...

Authors: Genki Horitsugi, Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Hiroki Kato, Sadahiro Naka, Mana Ishibashi, Keiko Matsunaga, Kayako Isohashi, Eku Shimosegawa and Jun Hatazawa

Safety, pharmacokinetics, metabolism and radiation dosimetry of ¹⁸F-tetrafluoroborate (¹⁸F-TFB) in healthy human subjects

¹⁸F-Tetrafluoroborate (¹⁸F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The ai...

Authors: Huailei Jiang, Nicholas R. Schmit, Alex R. Koenen, Aditya Bansal, Mukesh K. Pandey, Robert B. Glynn, Bradley J. Kemp, Kera L. Delaney, Angela Dispenzieri, Jamie N. Bakkum-Gamez, Kah-Whye Peng, Stephen J. Russell, Tina M. Gunderson, Val J. Lowe and Timothy R. DeGrado

TSPO imaging using the novel PET ligand [¹⁸F]GE-180: quantification approaches in patients with multiple sclerosis

PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [

Authors: Lena Vomacka, Nathalie Lisa Albert, Simon Lindner, Marcus Unterrainer, Christoph Mahler, Matthias Brendel, Larissa Ermoschkin, Astrid Gosewisch, Anika Brunegraf, Christopher Buckley, Tania Kümpfel, Rainer Rupprecht, Sibylle Ziegler, Martin Kerschensteiner, Peter Bartenstein and Guido Böning

Lower serotonin transporter binding in patients with cervical dystonia is associated with psychiatric symptoms

Cervical dystonia (CD) is often accompanied by depressive symptoms, anxiety, and jerks/tremor. The dopamine transporter (DAT) binding is related with both depressive symptoms and jerks/tremor in CD. Serotonerg...

Authors: E. Zoons, J. Booij, J. D. Speelman, Y. E. M. Dreissen, M. Smit and M. A. J. Tijssen

Simple, mild, one-step labelling of proteins with gallium-68 using a tris(hydroxypyridinone) bifunctional chelator: a ⁶⁸Ga-THP-scFv targeting the prostate-specific membrane antigen

Labelling proteins with gallium-68 using bifunctional chelators is often problematic because of unsuitably harsh labelling conditions such as low pH or high temperature and may entail post-labelling purificati...

Authors: Saima Nawaz, Gregory E. D. Mullen, Kavitha Sunassee, Jayanta Bordoloi, Philip J. Blower and James R. Ballinger

Potential of asphericity as a novel diagnostic parameter in the evaluation of patients with ⁶⁸Ga-PSMA-HBED-CC PET-positive prostate cancer lesions

The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients ...

Authors: Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Winfried Brenner, Gerd Diederichs, Bernd Hamm, Frank Hofheinz and Marcus R. Makowski

Comparison of four ¹¹C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. ¹¹C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four ¹¹C-labeled ligands—(R)-PK1119...

Authors: Masahiro Fujita, Masato Kobayashi, Masamichi Ikawa, Roger N. Gunn, Eugenii A. Rabiner, David R. Owen, Sami S. Zoghbi, Mohamad B. Haskali, Sanjay Telu, Victor W. Pike and Robert B. Innis

Initial evaluation of the Celesteion large-bore PET/CT scanner in accordance with the NEMA NU2-2012 standard and the Japanese guideline for oncology FDG PET/CT data acquisition protocol version 2.0

The goal of this study was to evaluate the performance of the Celesteion positron emission tomography/computed tomography (PET/CT) scanner, which is characterized by a large-bore and time-of-flight (TOF) funct...

Authors: Tomohiro Kaneta, Matsuyoshi Ogawa, Nobutoku Motomura, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida and Tomio Inoue

Automatic delineation of functional lung volumes with ⁶⁸Ga-ventilation/perfusion PET/CT

Functional volumes computed from ⁶⁸Ga-ventilation/perfusion (V/Q) PET/CT, which we have shown to correlate with pulmonary function test parameters (PFTs), have potential diagnostic utility in a variety of clinica...

Authors: Pierre-Yves Le Roux, Shankar Siva, Jason Callahan, Yannis Claudic, David Bourhis, Daniel P. Steinfort, Rodney J. Hicks and Michael S. Hofman

Ra-223 SPECT for semi-quantitative analysis in comparison with Tc-99m HMDP SPECT: phantom study and initial clinical experience

Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to b...

Authors: Yoshiki Owaki, Tadaki Nakahara, Takeo Kosaka, Junichi Fukada, Atsuhiro Kumabe, Akira Ichimura, Mikoto Murakami, Kiyotaka Nakajima, Masahiro Fukushi, Kazumasa Inoue, Mototsugu Oya and Masahiro Jinzaki

Correlation of ^99mTc-sestamibi uptake in renal masses with mitochondrial content and multi-drug resistance pump expression

^99mTc-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has recently been explored for the characterization of indeterminate renal masses. As judged b...

Authors: Steven P. Rowe, Michael A. Gorin, Lilja B. Solnes, Mark W. Ball, Ajuni Choudhary, Phillip M. Pierorazio, Jonathan I. Epstein, Mehrbod S. Javadi, Mohamad E. Allaf and Alex S. Baras

Group-sequential analysis may allow for early trial termination: illustration by an intra-observer repeatability study

Group-sequential testing is widely used in pivotal therapeutic, but rarely in diagnostic research, although it may save studies, time, and costs. The purpose of this paper was to demonstrate a group-sequential...

Authors: Oke Gerke, Mie H. Vilstrup, Ulrich Halekoh, Malene Grubbe Hildebrandt and Poul Flemming Høilund-Carlsen

[¹⁸F]Fluoromisonidazole PET in rectal cancer

There is an increasing interest in developing predictive biomarkers of tissue hypoxia using functional imaging for personalised radiotherapy in patients with rectal cancer that are considered for neoadjuvant c...

Authors: Tanuj Puri, Tessa A. Greenhalgh, James M. Wilson, Jamie Franklin, Lia Mun Wang, Victoria Strauss, Chris Cunningham, Mike Partridge and Tim Maughan