Articles

Optimization of parathyroid ¹¹C-choline PET protocol for localization of parathyroid adenomas in patients with primary hyperparathyroidism

To evaluate the optimal tracer uptake time, the minimal amount of radioactivity and the inter-observer agreement for ¹¹C-choline positron emission tomography/computed tomography (PET/CT) in patients with primary ...

Authors: Milou E. Noltes, Schelto Kruijff, Walter Noordzij, Eef D. Telenga, David Vállez García, Malgorzata Trofimiuk-Müldner, Marta Opalińska, Alicja Hubalewska-Dydejczyk, Gert Luurtsema, Rudi A. J. O. Dierckx, Mostafa El Moumni, Ronald Boellaard and Adrienne H. Brouwers

Parathyroid imaging with ¹⁸F-fluorocholine PET/CT as a first-line imaging modality in primary hyperparathyroidism: a retrospective cohort study

¹⁸F-fluorocholine (FCH) PET/CT is a promising technique for visualizing hyperfunctioning parathyroid glands in hyperparathyroidism. It is still under debate whether to use this technique as a first-line imaging ....

Authors: Wouter A. M. Broos, Maurits Wondergem, Remco J. J. Knol and Friso M. van der Zant

Human biodistribution and radiation dosimetry of the 5-HT_2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions

Cimbi-36 can be ¹¹C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT_2A receptor in the brain. In its non-labeled form (25B-NBOMe), it is used as a recreationa...

Authors: Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen and Hanne D. Hansen

Sensitivity of ¹⁸F-fluorodihydrotestosterone PET-CT to count statistics and reconstruction protocol in metastatic castration-resistant prostate cancer

Whole body [¹⁸F]-fluorodihydrotestosterone positron emission tomography ([¹⁸F]FDHT PET) imaging directly targets the androgen receptor and is a promising prognostic and predictive biomarker in metastatic castrati...

Authors: Matthijs C. F. Cysouw, Gerbrand M. Kramer, Dennis Heijtel, Robert C. Schuit, Michael J. Morris, Alfons J. M. van den Eertwegh, Jens Voortman, Otto S. Hoekstra, Daniela E. Oprea-Lager and Ronald Boellaard

Zirconium-89-labelled rituximab PET-CT in orbital inflammatory disease

Orbital inflammatory diseases are a heterogenic group of conditions that often entail a difficult diagnostic process and many patients are treatment resistant. Inflammatory diseases can be visualized by Zircon...

Authors: Kamil G. Laban, Rachel Kalmann, Roos J. Leguit and Bart de Keizer

Preclinical investigations and first-in-human application of ¹⁵²Tb-PSMA-617 for PET/CT imaging of prostate cancer

For almost a decade, terbium radioisotopes have been explored for their potential theragnostic application in nuclear medicine: ¹⁵²Tb and ¹⁵⁵Tb are the radioisotopes identified for PET or SPECT imaging, while ¹⁴⁹

Authors: Cristina Müller, Aviral Singh, Christoph A. Umbricht, Harshad R. Kulkarni, Karl Johnston, Martina Benešová, Stefan Senftleben, Dirk Müller, Christiaan Vermeulen, Roger Schibli, Ulli Köster, Nicholas P. van der Meulen and Richard P. Baum

Radiomic detection of microscopic tumorous lesions in small animal liver SPECT imaging

Our aim was to present a new data analysis technique for the early detection of tumorous lesions using single-photon emission computed tomography (SPECT) imaging. Beyond standardized uptake value (SUV) and sta...

Authors: Dániel S. Veres, Domokos Máthé, Nikolett Hegedűs, Ildikó Horváth, Fanni J. Kiss, Gabriella Taba, Edit Tóth-Bodrogi, Tibor Kovács and Krisztián Szigeti

Biodistribution and radiation dosimetry of [¹⁸F]-JK-PSMA-7 as a novel prostate-specific membrane antigen-specific ligand for PET/CT imaging of prostate cancer

We investigated the whole-body distribution and the radiation dosimetry of [¹⁸F]-JK-PSMA-7, a novel ¹⁸F-labeled PSMA-ligand for PET/CT imaging of prostate cancer.

Authors: Melanie Hohberg, Carsten Kobe, Philipp Krapf, Philipp Täger, Jochen Hammes, Felix Dietlein, Boris D. Zlatopolskiy, Heike Endepols, Markus Wild, Stephan Neubauer, Axel Heidenreich, Bernd Neumaier, Alexander Drzezga and Markus Dietlein

The use of a proposed updated EARL harmonization of ¹⁸F-FDG PET-CT in patients with lymphoma yields significant differences in Deauville score compared with current EARL recommendations

The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of ¹⁸F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting t...

Authors: John Ly, David Minarik, Lars Edenbrandt, Per Wollmer and Elin Trägårdh

Impact of acquisition time and penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm on a Si-photomultiplier-based PET-CT system for ¹⁸F-FDG

Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstructi...

Authors: Elin Trägårdh, David Minarik, Helén Almquist, Ulrika Bitzén, Sabine Garpered, Erland Hvittfelt, Berit Olsson and Jenny Oddstig

Reliability of visual assessment by non-expert nuclear medicine physicians and appropriateness of indications of [¹²³I]FP-CIT SPECT imaging by neurologists in patients with early drug-naive Parkinson’s disease

To determine the reliability of visual assessment of [¹²³I]FP-CIT SPECT imaging by non-experts in dopamine transporter (DAT) SPECT imaging in patients with early drug-naive Parkinson’s disease (PD). Also, we expl...

Authors: Sven R. Suwijn, Constant V. M. Verschuur, Marleen A. Slim, Jan Booij and Rob M. A. de Bie

Analysis of differences between ^99mTc-MAA SPECT- and ⁹⁰Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy

The aim of this study was to compare predictive and post-treatment dosimetry and analyze the differences, investigating factors related to activity preparation and delivery, imaging modality used, and interven...

Authors: Marilyne Kafrouni, Carole Allimant, Marjolaine Fourcade, Sébastien Vauclin, Boris Guiu, Denis Mariano-Goulart and Fayçal Ben Bouallègue

Head-to-head comparison of image quality between brain ¹⁸F-FDG images recorded with a fully digital versus a last-generation analog PET camera

The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this differen...

Authors: Julien Salvadori, Laetitia Imbert, Mathieu Perrin, Gilles Karcher, Zohra Lamiral, Pierre-Yves Marie and Antoine Verger

Biodistribution and radiation dosimetry of the novel hypoxia PET probe [¹⁸F]DiFA and comparison with [¹⁸F]FMISO

To facilitate hypoxia imaging in a clinical setting, we developed 1-(2,2-dihydroxymethyl-3-[¹⁸F]-fluoropropyl)-2-nitroimidazole ([¹⁸F]DiFA) as a new tracer that targets tumor hypoxia with its lower lipophilicity ...

Authors: Shiro Watanabe, Tohru Shiga, Kenji Hirata, Keiichi Magota, Shozo Okamoto, Takuya Toyonaga, Kei Higashikawa, Hironobu Yasui, Jun Kobayashi, Ken-ichi Nishijima, Ken Iseki, Hiroki Matsumoto, Yuji Kuge and Nagara Tamaki

Diagnostic performance of regional cerebral blood flow images derived from dynamic PIB scans in Alzheimer’s disease

In clinical practice, visual assessment of glucose metabolism images is often used for the diagnosis of Alzheimer’s disease (AD) through 2-[¹⁸F]-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) s...

Authors: Débora E. Peretti, David Vállez García, Fransje E. Reesink, Janine Doorduin, Bauke M. de Jong, Peter P. De Deyn, Rudi A. J. O. Dierckx and Ronald Boellaard

Repeatability of tumor blood flow quantification with ⁸²Rubidium PET/CT in prostate cancer — a test-retest study

Non-invasive tumor blood flow (TBF) quantification is a candidate approach for risk stratification and monitoring of prostate cancer patients. Validation data have recently been published on prostate TBF measu...

Authors: Mads Ryø Jochumsen, Kirsten Bouchelouche, Katrine Bødkergaard Nielsen, Jørgen Frøkiær, Michael Borre, Jens Sörensen and Lars Poulsen Tolbod

Direct comparison of [¹¹C] choline and [¹⁸F] FET PET to detect glioma infiltration: a diagnostic accuracy study in eight patients

Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[¹⁸F]...

Authors: Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, Adriaan A. Lammertsma, Lothar A. Schwarte, Frederik Barkhof, Petra J. W. Pouwels, Jan J. Heimans, Jaap C. Reijneveld, Annemieke J. M. Rozemuller, William P. Vandertop, Pieter Wesseling, Ronald Boellaard and Philip C. de Witt Hamer

Radiation dosimetry of [¹⁸F]-PSS232—a PET radioligand for imaging mGlu5 receptors in humans

(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[¹⁸F]-fluoroethoxy)propyl) oxime ([¹⁸F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising re...

Authors: Bert-Ram Sah, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Geoffrey Warnock and Simon M. Ametamey

Noninvasive assessment and quantification of tumor vascularization using [18F]FDG-PET/CT and CE-CT in a tumor model with modifiable angiogenesis—an animal experimental prospective cohort study

This study investigated the noninvasive assessment of tumor vascularization with clinical F-18-fluorodeoxyglucose positron emission tomography/computed tomography and contrast-enhanced computed tomography ([18...

Authors: Martin Mirus, Sergey V. Tokalov, Andrij Abramyuk, Jessica Heinold, Vincent Prochnow, Klaus Zöphel, Jörg Kotzerke and Nasreddin Abolmaali

Quantification of pulmonary disease activity in sarcoidosis measured with ¹⁸F-FDG PET/CT: SUVmax versus total lung glycolysis

¹⁸F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, q....

Authors: Milou C. Schimmelpennink, Adriane D. M. Vorselaars, Marcel Veltkamp and Ruth G. M. Keijsers

Internal radiation dosimetry of a ¹⁵²Tb-labeled antibody in tumor-bearing mice

Biodistribution studies based on organ harvesting represent the gold standard pre-clinical technique for dose extrapolations. However, sequential imaging is becoming increasingly popular as it allows the extra...

Authors: Francesco Cicone, Silvano Gnesin, Thibaut Denoël, Thierry Stora, Nicholas P. van der Meulen, Cristina Müller, Christiaan Vermeulen, Martina Benešová, Ulli Köster, Karl Johnston, Ernesto Amato, Lucrezia Auditore, George Coukos, Michael Stabin, Niklaus Schaefer, David Viertl…

Comparison of the radiolabeled PSMA-inhibitor ¹¹¹In-PSMA-617 and the radiolabeled GRP-R antagonist ¹¹¹In-RM2 in primary prostate cancer samples

Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRP-R) are expressed in prostate cancer and can be targeted with radiolabeled inhibitors and antagonists. Their performances fo...

Authors: Romain Schollhammer, Henri De Clermont Gallerande, Mokrane Yacoub, Marie-Laure Quintyn Ranty, Nicole Barthe, Delphine Vimont, Elif Hindié, Philippe Fernandez and Clément Morgat

Elimination of tumor hypoxia by eribulin demonstrated by ¹⁸F-FMISO hypoxia imaging in human tumor xenograft models

Eribulin, an inhibitor of microtubule dynamics, shows antitumor potency against a variety of solid cancers through its antivascular activity and remodeling of tumor vasculature. ¹⁸F-Fluoromisonidazole (¹⁸F-FMISO)...

Authors: Songji Zhao, Wenwen Yu, Naoyuki Ukon, Chengbo Tan, Ken-ichi Nishijima, Yoichi Shimizu, Kei Higashikawa, Tohru Shiga, Hiroko Yamashita, Nagara Tamaki and Yuji Kuge

Correlation between ¹⁸F-1-amino-3-fluorocyclobutane-1-carboxylic acid (¹⁸F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer

To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of ¹⁸F-1-amino-3-fluorocyclobutane-1-carbo...

Authors: Irena Saarinen, Ivan Jambor, Mai Kim, Anna Kuisma, Jukka Kemppainen, Harri Merisaari, Olli Eskola, Anna-Riina Koskenniemi, Ileana Montoya Perez, Peter Boström, Pekka Taimen and Heikki Minn

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten ...

Authors: Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch and Matthias M. Herth

Instant kit preparation of ⁶⁸Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [⁶⁸Ga]Ga-DATA-TOC

The widespread use of ⁶⁸Ga for positron emission tomography (PET) relies on the development of radiopharmaceutical precursors that can be radiolabelled and dispensed in a simple, quick, and convenient manner. The...

Authors: Jean-Philippe Sinnes, Johannes Nagel, Bradley P. Waldron, Theodosia Maina, Berthold A. Nock, Ralf K. Bergmann, Martin Ullrich, Jens Pietzsch, Michael Bachmann, Richard P. Baum and Frank Rösch

PET imaging of hepatocellular carcinoma with anti-1-amino-3-[¹⁸F]fluorocyclobutanecarboxylic acid in comparison with l-[S-methyl-¹¹C]methionine

[¹¹C]methionine ([¹¹C]Met) was used for cancer imaging based on upregulated amino acid transport and protein synthesis in different tumor types. However, the short half-life of ¹¹C decay limited further clinical ...

Authors: Olga Sergeeva, Yifan Zhang, Jonathan D. Kenyon, Galen A. Miller-Atkins, Chunying Wu, Renuka Iyer, Sandra Sexton, Patrick Wojtylak, Amad Awadallah, Wei Xin, E. Ricky Chan, James K. O’Donnel and Zhenghong Lee

A phase 0 study of the pharmacokinetics, biodistribution, and dosimetry of ¹⁸⁸Re-liposome in patients with metastatic tumors

Liposomes are drug nano-carriers that are capable of targeting therapeutics to tumor sites because of enhanced permeability retention (EPR). In several preclinical studies with various tumor-bearing mice models,

Authors: Shyh-Jen Wang, Wen-Sheng Huang, Chi-Mu Chuang, Chih-Hsien Chang, Te-Wei Lee, Gann Ting, Ming-Huang Chen, Peter Mu-Hsin Chang, Ta-Chung Chao, Hao-Wei Teng, Yee Chao, Yuh-Min Chen, Tzu-Ping Lin, Ya-Jen Chang, Su-Jung Chen, Yuan-Ruei Huang…

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. To understand...

Authors: Kevin S. Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J. Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers, Andor W. J. M. Glaudemans, Veena Vincent, Jessica Renaux, Matt Szapacs, Mary Birchler, Matthew Cleveland…

Correction to: 3D skeletal uptake of ¹⁸F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer

Following publication of the original article [1], the authors flagged the that the Kaplan-Meier curve in Fig. 6 is a duplication of the Kaplan-Meier curve in Fig. 5, which is not correct.

Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh

Initial biological evaluations of ¹⁸F-KS1, a novel ascorbate derivative to image oxidative stress in cancer

Reactive oxygen species (ROS)-induced oxidative stress damages many cellular components such as fatty acids, DNA, and proteins. This damage is implicated in many disease pathologies including cancer and neurod...

Authors: Kiran Kumar Solingapuram Sai, Nagaraju Bashetti, Xiaofei Chen, Skylar Norman, Justin W. Hines, Omsai Meka, J. V. Shanmukha Kumar, Sriram Devanathan, Gagan Deep, Cristina M. Furdui and Akiva Mintz

Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide ⁴⁷Sc

In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued...

Authors: C. Shaun Loveless, Lauren L. Radford, Samuel J. Ferran, Stacy L. Queern, Matthew R. Shepherd and Suzanne E. Lapi

^99mTc-HYNIC-IL-2 scintigraphy to detect acute rejection in lung transplantation patients: a proof-of-concept study

Acute allograft rejection is one of the major complications after lung transplantation, and adequate and early recognition is important. Till now, the reference standard to detect acute rejection is the histop...

Authors: Eef D. Telenga, Wim van der Bij, Erik F. J. de Vries, Erik A. M. Verschuuren, Wim Timens, Gert Luurtsema, Riemer H. J. A. Slart, Alberto Signore and Andor W. J. M. Glaudemans

Optimising quantitative ⁹⁰Y PET imaging: an investigation into the effects of scan length and Bayesian penalised likelihood reconstruction

Positron emission tomography (PET) imaging of ⁹⁰Y following selective internal radiation therapy (SIRT) is possible, but image quality is poor, and therefore, accurate quantification and dosimetry are challenging...

Authors: Nathaniel P. Scott and Daniel R. McGowan

[¹⁸F]FMISO PET/CT as a preoperative prognostic factor in patients with pancreatic cancer

While [¹⁸F]fluoromisonidazole (FMISO), a representative PET tracer to detect hypoxia, is reported to be able to prospect the prognosis after treatment for various types of cancers, the relation is unclear for pan...

Authors: Tomohiko Yamane, Masayasu Aikawa, Masanori Yasuda, Kenji Fukushima, Akira Seto, Koujun Okamoto, Isamu Koyama and Ichiei Kuji

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation

Positron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protei...

Authors: S. K. Vainio, A. M. Dickens, J. Tuisku, O. Eskola, O. Solin, E. Löyttyniemi, D. C. Anthony, J. O. Rinne, L. Airas and M. Haaparanta-Solin

Diagnostic performance of the specific uptake size index for semi-quantitative analysis of I-123-FP-CIT SPECT: harmonized multi-center research setting versus typical clinical single-camera setting

The specific uptake size index (SUSI) of striatal FP-CIT uptake is independent of spatial resolution in the SPECT image, in contrast to the specific binding ratio (SBR). This suggests that the SUSI is particul...

Authors: Ralph Buchert, Catharina Lange, Timo S. Spehl, Ivayla Apostolova, Lars Frings, Cathrine Jonsson, Philipp T. Meyer and Sabine Hellwig

A comparative study of standardized quantitative and visual assessment for predicting tumor volume and outcome in newly diagnosed diffuse large B-cell lymphoma staged with 18F-FDG PET/CT

Semi-automated quantitative measurement of metabolic tumor volume (MTV) for prognosis in diffuse large B-Cell lymphoma (DLBCL) has gained considerable interest lately. However, simple tumor volume measures may...

Authors: Lars C. Gormsen, Mikkel H. Vendelbo, Mette Abildgaard Pedersen, Ate Haraldsen, Karin Hjorthaug, Trond Velde Bogsrud, Lars J. Petersen, Karen Juul Jensen, Rasmus Brøndum and Tarec C. El-Galaly

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines

Authors: Philip Elsinga, Angelika Bischof Delaloye, Arturo Chiti, Stefaan Vandenberghe, Francesco Giammarile and Ignasi Carrio

Intratumoral ¹⁸F-FLT infusion in metabolic targeted radiotherapy

The goal of targeted radiotherapy (TRT) is to administer radionuclides to tumor cells, while limiting radiation exposure to normal tissues. 3′-Deoxy-3′-[¹⁸F]-fluorothymidine (¹⁸F-FLT) is able to target tumor cell...

Authors: Thititip Tippayamontri, Brigitte Guérin, René Ouellet, Otman Sarrhini, Jacques Rousseau, Roger Lecomte, Benoit Paquette and Léon Sanche

Optimized dual-time-window protocols for quantitative [¹⁸F]flutemetamol and [¹⁸F]florbetaben PET studies

A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to stat...

Authors: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley and Adriaan A. Lammertsma

Determination of a pharmacokinetic model for [¹¹C]-acetate in brown adipose tissue

[¹¹C]-acetate positron emission tomography is used to assess oxidative metabolism in various tissues including the heart, tumor, and brown adipose tissue. For brown adipose tissue, a monoexponential decay model i...

Authors: Marie Anne Richard, Denis P. Blondin, Christophe Noll, Réjean Lebel, Martin Lepage and André C. Carpentier

Correction to: Comparison of three-parameter kinetic model analysis to standard Patlak’s analysis in ¹⁸F-FDG PET imaging of lung cancer patients

Following publication of the original article [1], the authors flagged that the author affiliations detailed in the article are incorrect for the authors M. L. Calcagni and A. Giordano.

Authors: E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan and L. Indovina

An untapped potential for imaging of peripheral osteomyelitis in paediatrics using [¹⁸F]FDG PET/CT —the inference from a juvenile porcine model

To examine parameters affecting the detection of osteomyelitis (OM) by [¹⁸F]FDG PET/CT and to reduce tracer activity in a pig model.

Authors: P. Afzelius, O. L. Nielsen, H. C. Schønheyder, A.K.O. Alstrup and S. B. Hansen

Transcriptional effects of ¹⁷⁷Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice

¹⁷⁷Lu-octreotate is used for therapy of somatostatin receptor expressing neuroendocrine tumors with promising results, although complete tumor remission is rarely seen. Previous studies on nude mice bearing the h...

Authors: Johan Spetz, Britta Langen, Nils-Petter Rudqvist, Toshima Z. Parris, Emman Shubbar, Johanna Dalmo, Bo Wängberg, Ola Nilsson, Khalil Helou and Eva Forssell-Aronsson

Bone SPECT-based segmented attenuation correction for quantitative analysis of bone metastasis (B-SAC): comparison with CT-based attenuation correction

Evidence has shown the clinical usefulness of measuring the metastatic tumor burden of bone for prognostic assessment especially in prostate cancer; quantitative evaluation by dedicated SPECT is difficult due ...

Authors: Tadaki Nakahara, Yoshiki Owaki, Tsubasa Shindou, Kiyotaka Nakajima and Masahiro Jinzaki

No significant difference found in PET/MRI CBF values reconstructed with CT-atlas-based and ZTE MR attenuation correction

Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been us...

Authors: Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino, Ken-Ichiro Kikuta, Tetsuya Mori, Akira Makino and Yasushi Kiyono

HYNIC and DOMA conjugated radiolabeled bombesin analogs as receptor-targeted probes for scintigraphic detection of breast tumor

Among the many peptide receptor systems, gastrin-releasing-peptide (GRP) receptors, the mammalian equivalent of bombesin (BN) receptors, are potential targets for diagnosis and therapy of breast tumors due to ...

Authors: Kakali De, Dibyanti Mukherjee, Samarendu Sinha and Shantanu Ganguly

Optimal respiratory-gated [¹⁸F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma

Metabolic parameters are increasingly being used to characterize tumors. Motion artifacts due to patient respiration introduce uncertainties in quantification of metabolic parameters during positron emission t...

Authors: Esther M. M. Smeets, Dominique S. Withaar, Willem Grootjans, John J. Hermans, Kees van Laarhoven, Lioe-Fee de Geus-Oei, Martin Gotthardt and Erik H. J. G. Aarntzen

Interobserver variability of image-derived arterial blood SUV in whole-body FDG PET

Today, the standardized uptake value (SUV) is essentially the only means for quantitative evaluation of static [¹⁸F-]fluorodeoxyglucose (FDG) positron emission tomography (PET) investigations. However, the SUV ap...

Authors: Frank Hofheinz, Jens Maus, Sebastian Zschaeck, Julian Rogasch, Georg Schramm, Liane Oehme, Ivayla Apostolova, Jörg Kotzerke and Jörg van den Hoff