Articles

PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

Inflammation is associated with major depressive disorder (MDD). Translocator protein 18 kDa (TSPO), a putative biomarker of neuroinflammation, is quantified using positron emission tomography (PET) and ¹¹C-PBR28...

Authors: Erica M. Richards, Paolo Zanotti-Fregonara, Masahiro Fujita, Laura Newman, Cristan Farmer, Elizabeth D. Ballard, Rodrigo Machado-Vieira, Peixiong Yuan, Mark J. Niciu, Chul Hyoung Lyoo, Ioline D. Henter, Giacomo Salvadore, Wayne C. Drevets, Hartmuth Kolb, Robert B. Innis and Carlos A. Zarate Jr

A semi-automatic technique to quantify complex tuberculous lung lesions on ¹⁸F-fluorodeoxyglucose positron emission tomography/computerised tomography images

There is a growing interest in the use of ¹⁸F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a rep...

Authors: Stephanus T. Malherbe, Patrick Dupont, Ilse Kant, Petri Ahlers, Magdalena Kriel, André G. Loxton, Ray Y. Chen, Laura E. Via, Friedrich Thienemann, Robert J. Wilkinson, Clifton E. Barry III, Stephanie Griffith-Richards, Annare Ellman, Katharina Ronacher, Jill Winter, Gerhard Walzl…

Uniform intratumoral distribution of radioactivity produced using two different radioagents, ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)₄ and ⁶⁴Cu-ATSM, improves therapeutic efficacy in a small animal tumor model

The present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined the efficacy of ...

Authors: Zhao-Hui Jin, Atsushi B. Tsuji, Mélissa Degardin, Aya Sugyo, Yukie Yoshii, Kotaro Nagatsu, Ming-Rong Zhang, Yasuhisa Fujibayashi, Pascal Dumy, Didier Boturyn and Tatsuya Higashi

¹⁸F-fluoromisonidazole predicts evofosfamide uptake in pancreatic tumor model

Quantitative imaging can facilitate patient stratification in clinical trials. The hypoxia-activated prodrug evofosfamide recently failed a phase III trial in pancreatic cancer. However, the study did not atte...

Authors: Milan Grkovski, Louise Fanchon, Naga Vara Kishore Pillarsetty, James Russell and John L. Humm

Spatial relationship of 2-deoxy-2-[¹⁸F]-fluoro-D-glucose positron emission tomography and magnetic resonance diffusion imaging metrics in cervical cancer

This study investigated the spatial relationship of 2-deoxy-2-[¹⁸F]-fluoro-D-glucose positron emission tomography ([¹⁸F]FDG-PET) standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) derive...

Authors: John M. Floberg, Kathryn J. Fowler, Dominique Fuser, Todd A. DeWees, Farrokh Dehdashti, Barry A. Siegel, Richard L. Wahl, Julie K. Schwarz and Perry W. Grigsby

PET imaging of ⁶⁸Ga-NODAGA-RGD, as compared with ¹⁸F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma

Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been perform...

Authors: Sibel Isal, Julien Pierson, Laetitia Imbert, Alexandra Clement, Charlotte Collet, Sophie Pinel, Nicolas Veran, Aurélie Reinhard, Sylvain Poussier, Guillaume Gauchotte, Steeven Frezier, Gilles Karcher, Pierre-Yves Marie and Fatiha Maskali

The value of ^99mTc-MAA SPECT/CT for lung shunt estimation in ⁹⁰Y radioembolization: a phantom and patient study

A major toxicity concern in radioembolization therapy of hepatic malignancies is radiation-induced pneumonitis and sclerosis due to hepatopulmonary shunting of ⁹⁰Y microspheres. Currently, ^99mTc macroaggregated a...

Authors: Jonathan D. Allred, Jeremy Niedbala, Justin K. Mikell, Dawn Owen, Kirk A. Frey and Yuni K. Dewaraja

Optimization of temporal sampling for ¹⁸F-choline uptake quantification in prostate cancer assessment

Suboptimal temporal sampling of time-activity curves (TAC) from dynamic ¹⁸F-fluoromethylcholine (FCH) PET images may introduce bias in quantification of FCH uptake in prostate cancer assessment. We sought to defi...

Authors: Xavier Palard-Novello, Anne-Lise Blin, Florence Le Jeune, Etienne Garin, Pierre-Yves Salaün, Anne Devillers, Giulio Gambarota, Solène Querellou, Patrick Bourguet and Hervé Saint-Jalmes

Histamine H₃ receptor density is negatively correlated with neural activity related to working memory in humans

The histamine H₃ receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H₃ receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cogni...

Authors: Takehito Ito, Yasuyuki Kimura, Chie Seki, Masanori Ichise, Keita Yokokawa, Kazunori Kawamura, Hidehiko Takahashi, Makoto Higuchi, Ming-Rong Zhang, Tetsuya Suhara and Makiko Yamada

Evaluation of D-isomers of 4-borono-2-¹⁸F-fluoro-phenylalanine and O-¹¹C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma

The potential of the D-isomerization of 4-borono-2-¹⁸F-fluoro-phenylalanine (¹⁸F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with...

Authors: Masakatsu Kanazawa, Shingo Nishiyama, Fumio Hashimoto, Takeharu Kakiuchi and Hideo Tsukada

Simplifying [¹⁸F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?

The NMDA receptor radiotracer [¹⁸F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.

Authors: Colm J. McGinnity, Daniela A. Riaño Barros, William Trigg, David J. Brooks, Rainer Hinz, John S. Duncan, Matthias J. Koepp and Alexander Hammers

The renal blood flow reserve in healthy humans and patients with atherosclerotic renovascular disease measured by positron emission tomography using [¹⁵O]H₂O

Microvascular function plays an important role in ARVD (atherosclerotic renovascular disease). RFR (renal flow reserve), the capacity of renal vasculature to dilate, is known to reflect renal microvascular fun...

Authors: Johanna Päivärinta, Niina Koivuviita, Vesa Oikonen, Hidehiro Iida, Kaisa Liukko, Ilkka Manner, Eliisa Löyttyniemi, Pirjo Nuutila and Kaj Metsärinne

Effect of starvation on brain glucose metabolism and ¹⁸F-2-fluoro-2-deoxyglucose uptake: an experimental in-vivo and ex-vivo study

The close connection between neuronal activity and glucose consumption accounts for the clinical value of 18F-fluoro-2-deoxyglucose (FDG) imaging in neurodegenerative disorders. Nevertheless, brain metabolic r...

Authors: Ambra Buschiazzo, Vanessa Cossu, Matteo Bauckneht, Annamaria Orengo, Patrizia Piccioli, Laura Emionite, Giovanna Bianchi, Federica Grillo, Anna Rocchi, Francesco Di Giulio, Francesco Fiz, Lizzia Raffaghello, Flavio Nobili, Silvia Bruno, Giacomo Caviglia, Silvia Ravera…

Detection of neuroinflammation before selective neuronal loss appearance after mild focal ischemia using [¹⁸F]DPA-714 imaging

Translocator protein (TSPO) imaging can be used to detect neuroinflammation (including microglial activation) after acute cerebral infarction. However, longitudinal changes of TSPO binding after mild ischemia ...

Authors: Natsumi Miyajima, Miwa Ito, Takemi Rokugawa, Hitoshi Iimori, Sotaro Momosaki, Shigeki Omachi, Eku Shimosegawa, Jun Hatazawa and Kohji Abe

Volume of interest delineation techniques for ¹⁸F-FDG PET-CT scans during neoadjuvant extremity soft tissue sarcoma treatment in adults: a feasibility study

This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (¹⁸F-FDG PET-CT) scans during neoadjuvant extre...

Authors: Marc G. Stevenson, Lukas B. Been, Harald J. Hoekstra, Albert J. H. Suurmeijer, Ronald Boellaard and Adrienne H. Brouwers

Impact of time-of-flight PET on quantification accuracy and lesion detection in simultaneous ¹⁸F-choline PET/MRI for prostate cancer

Accurate attenuation correction (AC) is an inherent problem of positron emission tomography magnetic resonance imaging (PET/MRI) systems. Simulation studies showed that time-of-flight (TOF) detectors can reduc...

Authors: Urs J. Muehlematter, Hannes W. Nagel, Anton Becker, Julian Mueller, Kerstin N. Vokinger, Felipe de Galiza Barbosa, Edwin E. G. T. ter Voert, Patrick Veit-Haibach and Irene A. Burger

Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by ¹⁸F-FPP-RGD₂ PET

Activated hepatic stellate cells (HSCs), which express integrin αvβ3, are a major fibrogenic factor in NASH pathophysiology. ¹⁸F-labeled cyclic arginine-glycine-aspartic acid penta-peptide (¹⁸F-FPP-RGD₂) has been...

Authors: Takemi Rokugawa, Haruyo Konishi, Miwa Ito, Hitoshi Iimori, Ryohei Nagai, Eku Shimosegawa, Jun Hatazawa and Kohji Abe

In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model

The protein cross-linking enzyme tissue transglutaminase (TG2; EC 2.3.2.13) is associated with the pathogenesis of various diseases, including cancer. Recently, the synthesis and initial evaluation of two high...

Authors: Berend van der Wildt, Micha M. M. Wilhelmus, Wissam Beaino, Esther J. M. Kooijman, Robert C. Schuit, John G. J. M. Bol, John J. P. Breve, Ralf Pasternack, Adriaan A. Lammertsma, Albert D. Windhorst and Benjamin Drukarch

Monitoring scanner calibration using the image-derived arterial blood SUV in whole-body FDG-PET

The current de facto standard for quantification of tumor metabolism in oncological whole-body PET is the standardized uptake value (SUV) approach. SUV determination requires accurate scanner calibration. Resi...

Authors: Jens Maus, Frank Hofheinz, Ivayla Apostolova, Michael C. Kreissl, Jörg Kotzerke and Jörg van den Hoff

Assessing the kidney function parameters glomerular filtration rate and effective renal plasma flow with dynamic FDG-PET/MRI in healthy subjects

A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG) concentration behavior in kidneys, measure...

Authors: Barbara K. Geist, Pascal Baltzer, Barbara Fueger, Martina Hamboeck, Thomas Nakuz, Laszlo Papp, Sazan Rasul, Lalith Kumar Shiyam Sundar, Marcus Hacker and Anton Staudenherz

Computer-aided diagnosis for (¹²³I)FP-CIT imaging: impact on clinical reporting

For (¹²³I)FP-CIT imaging, a number of algorithms have shown high performance in distinguishing normal patient images from those with disease, but none have yet been tested as part of reporting workflows. This stu...

Authors: Jonathan Christopher Taylor, Charles Romanowski, Eleanor Lorenz, Christine Lo, Oliver Bandmann and John Fenner

[¹⁸F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia

The potential application of bone marrow stromal cell (BMSC) therapy in stroke has been anticipated due to its immunomodulatory effects. Recently, positron emission tomography (PET) with [¹⁸F]DPA-714, a transloca...

Authors: Chengbo Tan, Songji Zhao, Kei Higashikawa, Zifeng Wang, Masahito Kawabori, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Naoyuki Ukon, Hironobu Yasui, Nagara Tamaki, Yuji Kuge, Hideo Shichinohe and Kiyohiro Houkin

On the optimal z-score threshold for SISCOM analysis to localize the ictal onset zone

In epilepsy patients, SISCOM or subtraction ictal single photon emission computed tomography co-registered to magnetic resonance imaging has become a routinely used, non-invasive technique to localize the icta...

Authors: Liesbeth De Coster, Koen Van Laere, Evy Cleeren, Kristof Baete, Patrick Dupont, Wim Van Paesschen and Karolien E. Goffin

Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor

The cholecystokinin receptor subtype 2 (CCK-2R) is an important target for diagnostic imaging and targeted radionuclide therapy (TRNT) due to its overexpression in certain cancers (e.g., medullary thyroid carc...

Authors: Piotr F. J. Lipiński, Piotr Garnuszek, Michał Maurin, Raphael Stoll, Nils Metzler-Nolte, Artur Wodyński, Jan Cz. Dobrowolski, Marta K. Dudek, Monika Orzełowska and Renata Mikołajczak

External radiation exposure, excretion, and effective half-life in ¹⁷⁷Lu-PSMA-targeted therapies

Prostate-specific membrane antigen (PSMA)-targeted therapy with ¹⁷⁷Lu-PSMA-617 is a therapeutic option for patients with metastatic castration-resistant prostate cancer (mCRPC). To optimize the therapy procedure,...

Authors: J. Kurth, B. J. Krause, S. M. Schwarzenböck, L. Stegger, M. Schäfers and K. Rahbar

Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis

Epilepsy surgery often causes changes in cognition and cerebral glucose metabolism. Our aim was to explore relationships between pre- and postoperative cerebral metabolism as measured with ¹⁸F-fluorodeoxyglucose ...

Authors: Canan Güvenç, Patrick Dupont, Jan Van den Stock, Laura Seynaeve, Kathleen Porke, Eva Dries, Karen Van Bouwel, Johannes van Loon, Tom Theys, Karolien E. Goffin and Wim Van Paesschen

Synthesis and preclinical evaluation of novel ¹⁸F-labeled Glu-urea-Glu-based PSMA inhibitors for prostate cancer imaging: a comparison with ¹⁸F-DCFPyl and ¹⁸F-PSMA-1007

Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific rad...

Authors: Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger and Hans-Jürgen Wester

Evaluation of prognostic models developed using standardised image features from different PET automated segmentation methods

Prognosis in oesophageal cancer (OC) is poor. The 5-year overall survival (OS) rate is approximately 15%. Personalised medicine is hoped to increase the 5- and 10-year OS rates. Quantitative analysis of PET is...

Authors: Craig Parkinson, Kieran Foley, Philip Whybra, Robert Hills, Ashley Roberts, Chris Marshall, John Staffurth and Emiliano Spezi

Assessment of glucose metabolism and cellular proliferation in multiple myeloma: a first report on combined ¹⁸F-FDG and ¹⁸F-FLT PET/CT imaging

Despite the significant upgrading in recent years of the role of ¹⁸F-FDG PET/CT in multiple myeloma (MM) diagnostics, there is a still unmet need for myeloma-specific radiotracers. 3′-Deoxy-3′-[¹⁸F]fluorothymidin...

Authors: C. Sachpekidis, H. Goldschmidt, K. Kopka, A. Kopp-Schneider and A. Dimitrakopoulou-Strauss

Hallmarks in prostate cancer imaging with Ga68-PSMA-11-PET/CT with reference to detection limits and quantitative properties

Gallium-68-labeled prostate-specific antigen positron emission tomography/computed tomography imaging (Ga68-PSMA-11-PET/CT) has emerged as a potential gold standard for prostate cancer (PCa) diagnosis. However...

Authors: Alejandro Sanchez-Crespo, Emma Jussing, Ann-Charlotte Björklund and Katja Pokrovskaja Tamm

Using in vivo fluorescence lifetime imaging to detect HER2-positive tumors

Assessment of the status of tumor biomarkers in individual patients would facilitate personalizing treatment strategy, and continuous monitoring of those biomarkers and their binding process to the therapeutic...

Authors: Yasaman Ardeshirpour, Dan L. Sackett, Jay R. Knutson and Amir H. Gandjbakhche

Treatment response assessment with (R)-[¹¹CPAQ PET in the MMTV-PyMT mouse model of breast cancer

The goal of the study was to assess the potential of the vascular endothelial growth factor receptor (VEGFR)-2-targeting carbon-11 labeled (R)-N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-3-piperidinyl)metho...

Authors: T. Tegnebratt, L. Lu, S. Eksborg, A. Chireh, P. Damberg, S. Nikkhou-Aski, T. Foukakis, H. Rundqvist, S. Holmin, R. V. Kuiper and E. Samen

Comparison of three-parameter kinetic model analysis to standard Patlak’s analysis in ¹⁸F-FDG PET imaging of lung cancer patients

Patlak’s graphical analysis can provide tracer net influx constant (Ki) with limitation of assuming irreversible tracer trapping, that is, release rate constant (k_b) set to zero. We compared linear Patlak’s analy...

Authors: E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan and L. Indovina

Accuracy of tumor segmentation from multi-parametric prostate MRI and ¹⁸F-choline PET/CT for focal prostate cancer therapy applications

The study aims to assess the accuracy of multi-parametric prostate MRI (mpMRI) and ¹⁸F-choline PET/CT in tumor segmentation for clinically significant prostate cancer. ¹⁸F-choline PET/CT and 3 T mpMRI were perfor...

Authors: Morand Piert, Prasad R. Shankar, Jeffrey Montgomery, Lakshmi Priya Kunju, Virginia Rogers, Javed Siddiqui, Thekkelnaycke Rajendiran, Jason Hearn, Arvin George, Xia Shao and Matthew S. Davenport

Validation of [¹⁸F]FLT as a perfusion-independent imaging biomarker of tumour response in EGFR-mutated NSCLC patients undergoing treatment with an EGFR tyrosine kinase inhibitor

3′-Deoxy-3′-[¹⁸F]fluorothymidine ([¹⁸F]FLT) was proposed as an imaging biomarker for the assessment of in vivo cellular proliferation with positron emission tomography (PET). The current study aimed to validate [

Authors: R. Iqbal, G. M. Kramer, V. Frings, E. F. Smit, O. S. Hoekstra and R. Boellaard

Noninvasive quantitation of rat cerebral blood flow using ^99mTc-HMPAO—assessment of input function with dynamic chest planar imaging

Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (^99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for sma...

Authors: Chie Suzuki, Mutsumi Kosugi and Yasuhiro Magata

I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma

I-124 codrituzumab (aka GC33), an antibody directed at Glypican 3, was evaluated in patients with hepatocellular carcinoma (HCC). Fourteen patients with HCC underwent baseline imaging with I-124 codrituzumab (...

Authors: Jorge A. Carrasquillo, Joseph A. O’Donoghue, Volkan Beylergil, Shutian Ruan, Neeta Pandit-Taskar, Steven M. Larson, Peter M. Smith-Jones, Serge K. Lyashchenko, Norihisa Ohishi, Toshihiko Ohtomo and Ghassan K. Abou-Alfa

Imaging Aβ and tau in early stage Alzheimer’s disease with [¹⁸F]AV45 and [¹⁸F]AV1451

AD is a progressive neurodegenerative disorder that is associated with the accumulation of two different insoluble protein aggregates, Aβ plaques and hyperphosphorylated tau. This study aimed to investigate th...

Authors: Azadeh Firouzian, Alex Whittington, Graham E. Searle, Ivan Koychev, Giovanna Zamboni, Simon Lovestone and Roger N. Gunn

Biokinetic and dosimetric aspects of ⁶⁴CuCl₂ in human prostate cancer: possible theranostic implications

The aim of the present study is to evaluate the kinetics and dosimetry of ⁶⁴CuCl₂ in human prostate cancer (PCa) lesions.

Authors: Sergio Righi, Martina Ugolini, Gianluca Bottoni, Matteo Puntoni, Massimiliano Iacozzi, Francesco Paparo, Manlio Cabria, Luca Ceriani, Monica Gambaro, Luca Giovanella and Arnoldo Piccardo

Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis

Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has...

Authors: Christian H. Pfob, Matthias Eiber, Peter Luppa, Florian Maurer, Tobias Maurer, Robert Tauber, Calogero D’Alessandria, Benedikt Feuerecker, Klemens Scheidhauer, Armin Ott, Uwe Heemann, Markus Schwaiger and Christoph Schmaderer

Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging

In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DO...

Authors: Elisabeth Eppard, Ana de la Fuente, Nicole Mohr, Mareli Allmeroth, Rudolf Zentel, Matthias Miederer, Stefanie Pektor and Frank Rösch

Feasibility of intraoperative detection of sentinel lymph nodes with 89-zirconium-labelled nanocolloidal albumin PET-CT and a handheld high-energy gamma probe

PET/CT lymphoscintigraphy using ⁸⁹Zr-nanocolloidal albumin has the potential to improve the preoperative identification of sentinel lymph nodes (SLNs), especially if located in the near proximity of the primary t...

Authors: Derrek A. Heuveling, K. Hakki Karagozoglu, Arthur Van Lingen, Otto S. Hoekstra, Guus A. M. S. Van Dongen and Remco De Bree

A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases

xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images wit...

Authors: Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis and Solène Querellou

Statistical evaluation of test-retest studies in PET brain imaging

Positron emission tomography (PET) is a molecular imaging technology that enables in vivo quantification of metabolic activity or receptor density, among other applications. Examples of applications of PET ima...

Authors: Richard Baumgartner, Aniket Joshi, Dai Feng, Francesca Zanderigo and R. Todd Ogden

Subcellular storage and release mode of the novel ¹⁸F-labeled sympathetic nerve PET tracer LMI1195

¹⁸F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (¹⁸F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural up...

Authors: Xinyu Chen, Rudolf A. Werner, Constantin Lapa, Naoko Nose, Mitsuru Hirano, Mehrbod S. Javadi, Simon Robinson and Takahiro Higuchi

Feasibility of ¹⁵O-water PET studies of auditory system activation during general anesthesia in children

¹⁵O-Water positron emission tomography (PET) enables functional imaging of the auditory system during stimulation via a promontory electrode or cochlear implant, which is not possible using functional magnetic r....

Authors: Martin Mamach, Florian Wilke, Martin Durisin, Frank A. Beger, Mareike Finke, Andreas Büchner, Barbara Schultz, Arthur Schultz, Lilli Geworski, Frank M. Bengel, Thomas Lenarz, Anke Lesinski-Schiedat and Georg Berding

Biokinetics, dosimetry, and radiation risk in infants after ^99mTc-MAG3 scans

Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochas...

Authors: J. Soares Machado, J. Tran-Gia, S. Schlögl, A. K. Buck and M. Lassmann

It is time to move forward into the era of Theranostics

Radionuclide therapy, which until 15 years ago included only a few approved therapies, is gaining importance in the treatment of various malignancies. The future of oncology will not be limited to surgery, che...

Authors: Hojjat Ahmadzadehfar and Markus Essler

Renal sympathetic nerve activity after catheter-based renal denervation

Catheter-based renal sympathetic denervation (RDN) has been considered a potential treatment for therapy resistant hypertension (RHT). However, in a randomized placebo-controlled trial, RDN did not lead to a s...

Authors: Linn C. Dobrowolski, Daan W. Eeftinck Schattenkerk, C. T. Paul Krediet, Peter M. Van Brussel, Liffert Vogt, Frederike J. Bemelman, Jim A. Reekers, Bert-Jan H. Van Den Born and Hein J. Verberne

Abstracts of the 33rd International Austrian Winter Symposium

Authors: K. Binzel, A. Adelaja, C. L. Wright, D. Scharre, J. Zhang, M. V. Knopp, E. J. Teoh, D. Bottomley, A. Scarsbrook, H. Payne, A. Afaq, J. Bomanji, N. van As, S. Chua, P. Hoskin, A. Chambers…