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  1. Sigma2 (σ2) receptors are highly expressed in cancer cell lines and in tumours. Two novel selective 18F-phthalimido σ2 ligands, 18F-SIG343 and 18F-SIG353, were prepared and characterised for their potential tumou...

    Authors: Vu H Nguyen, Tien Pham, Chris Fookes, Paula Berghofer, Ivan Greguric, Andrew Arthur, Filomena Mattner, Gita Rahardjo, Emma Davis, Nicholas Howell, Marie-Claude Gregoire, Andrew Katsifis and Rachael Shepherd
    Citation: EJNMMI Research 2013 3:80
    Content type: Original research Published on:

  2. The aim of this randomised pilot study was to investigate the haemodynamic effects measured by oxygen-15 positron emission tomography (PET) of interventional treatment consisting of either endarterectomy or en...

    Authors: Suzanne Persoon, Bart NM van Berckel, Jochem P Bremmer, Ronald Boellaard, Ale Algra, Gert Jan de Borst, Adriaan A Lammertsma, L Jaap Kappelle and Catharina JM Klijn
    Citation: EJNMMI Research 2013 3:79
    Content type: Original research Published on:

  3. [11C]Befloxatone measures the density of the enzyme monoamine oxidase A (MAO-A) in the brain. MAO-A is responsible for the degradation of different neurotransmitters and is implicated in several neurologic and ps...

    Authors: Paolo Zanotti-Fregonara, Claire Leroy, Dimitri Roumenov, Christian Trichard, Jean-Luc Martinot and Michel Bottlaender
    Citation: EJNMMI Research 2013 3:78
    Content type: Original research Published on:

  4. The standard uptake value (SUV) approach in oncological positron emission tomography has known shortcomings, all of which affect the reliability of the SUV as a surrogate of the targeted quantity, the metaboli...

    Authors: Jörg van den Hoff, Liane Oehme, Georg Schramm, Jens Maus, Alexandr Lougovski, Jan Petr, Bettina Beuthien-Baumann and Frank Hofheinz
    Citation: EJNMMI Research 2013 3:77
    Content type: Original research Published on:

  5. Recently, we reported an information density theory and an analysis of three-parameter plus shorter scan than conventional method (3P+) for the amyloid-binding ligand [11C]Pittsburgh compound B (PIB) as an exampl...

    Authors: Koichi Sato, Kiyoshi Fukushi, Hitoshi Shinotoh, Hitoshi Shimada, Shigeki Hirano, Noriko Tanaka, Tetsuya Suhara, Toshiaki Irie and Hiroshi Ito
    Citation: EJNMMI Research 2013 3:76
    Content type: Original research Published on:

  6. Image-based diagnosis of tumours can be advanced and improved by targeted strategies addressing malignant molecular structures. A promising molecular target is the cholecystokinin-2-receptor (CCK2R) which can ...

    Authors: Susanne Kossatz, Rosalba Mansi, Martin Béhé, Peter Czerney and Ingrid Hilger
    Citation: EJNMMI Research 2013 3:75
    Content type: Original research Published on:

  7. The Langendorff perfused heart is a physiologically relevant and controllable model with potential for assessing the pharmacokinetics of new radiotracers under a range of pathophysiological conditions.. We ass...

    Authors: Erika Mariotti, Mattia Veronese, Joel T Dunn, Rodolfo A Medina, Philip J Blower, Richard Southworth and Thomas R Eykyn
    Citation: EJNMMI Research 2013 3:74
    Content type: Original research Published on:

  8. The radiopharmaceutical 131I-metaiodobenzylguanidine (131I-MIBG) is used for the targeted radiotherapy of noradrenaline transporter (NAT)-expressing neuroblastoma. Enhancement of 131I-MIBG's efficacy is achieved ...

    Authors: Colin Rae, Mathias Tesson, John W Babich, Marie Boyd and Robert J Mairs
    Citation: EJNMMI Research 2013 3:73
    Content type: Original research Published on:

  9. Stem cell therapy has a promising potential for the curing of various degenerative diseases, including congestive heart failure (CHF). In this study, we determined the efficacy of different delivery methods fo...

    Authors: Esmat Elhami, Bryson Dietz, Bo Xiang, Jixian Deng, Fei Wang, Chao Chi, Andrew L Goertzen, Shadreck Mzengeza, Darren Freed, Rakesh C Arora and Ganghong Tian
    Citation: EJNMMI Research 2013 3:72
    Content type: Original research Published on:

  10. This study is to evaluate the predictive value of FDG-PET (PET) in pediatric and adolescent patients suffering from non-Hodgkin lymphoma (pNHL) in comparison to information provided by conventional imaging met...

    Authors: Christian Furth, Ingo G Steffen, Anne S Erdrich, Patrick Hundsdoerfer, Juri Ruf, Günter Henze, Stefan Schönberger, Holger Amthauer and Hubertus Hautzel
    Citation: EJNMMI Research 2013 3:71
    Content type: Original research Published on:

  11. Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates th...

    Authors: Maxime J Parent, Marilyn Cyr, Antonio Aliaga, Alexey Kostikov, Esther Schirrmacher, Jean-Paul Soucy, Naguib Mechawar, Pedro Rosa-Neto and Marc-Andre Bedard
    Citation: EJNMMI Research 2013 3:70
    Content type: Original research Published on:

  12. [18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parame...

    Authors: Matthew D Walker, Katherine Dinelle, Rick Kornelsen, Anna Lee, Matthew J Farrer, A Jon Stoessl and Vesna Sossi
    Citation: EJNMMI Research 2013 3:69
    Content type: Original research Published on:

  13. The folate receptor (FR) is a well-established target for tumor imaging and therapy. To date, only a few 18 F-folate conjugates via 18 F-prosthetic group labeling for positron emission tomography (PET) imaging ha...

    Authors: Hanno Schieferstein, Thomas Betzel, Cindy R Fischer and Tobias L Ross
    Citation: EJNMMI Research 2013 3:68
    Content type: Original research Published on:

  14. Positron emission tomography (PET) with [2-18 F]-2-fluoro-2-deoxy-D-glucose ([18 F]FDG-PET) was acquired at multiple time-points a) to monitor the early response to RO5126766 (CH5126766) in xenograft models b) to...

    Authors: Tetyana Tegnebratt, Li Lu, Lucy Lee, Valerie Meresse, Jean Tessier, Nobuya Ishii, Naoki Harada, Pavel Pisa and Sharon Stone-Elander
    Citation: EJNMMI Research 2013 3:67
    Content type: Original research Published on:

  15. Until now, no kinetic model was described for the oncologic tracer [18F]fluoromethylcholine ([18F]FCho), so it was aimed to validate a proper model, which is easy to implement and allows tracer quantification in ...

    Authors: Dominique Slaets and Filip De Vos
    Citation: EJNMMI Research 2013 3:66
    Content type: Original research Published on:

  16. Adenosine may have beneficial effects on left ventricular function after myocardial infarction (MI), but the magnitude of this effect on remote and MI areas is controversial. We assessed the long-term effects ...

    Authors: Mélanie Bousquenaud, Fatiha Maskali, Sylvain Poussier, Jennifer Zangrando, Pierre-Yves Marie, Henri Boutley, Renaud Fay, Gilles Karcher, Daniel R Wagner and Yvan Devaux
    Citation: EJNMMI Research 2013 3:65
    Content type: Original research Published on:

  17. The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the progn...

    Authors: Reza Kaboteh, Peter Gjertsson, Håkan Leek, Milan Lomsky, Mattias Ohlsson, Karl Sjöstrand and Lars Edenbrandt
    Citation: EJNMMI Research 2013 3:64
    Content type: Original research Published on:

  18. The European Association of Nuclear Medicine procedure guidelines for whole-body fluorodeoxyglucose positron-emission tomography (FDG-PET) scanning prescribe a dose proportional to the patient’s body mass. How...

    Authors: Eleonore H de Groot, Nieky Post, Ronald Boellaard, Nils RL Wagenaar, Antoon TM Willemsen and Jorn A van Dalen
    Citation: EJNMMI Research 2013 3:63
    Content type: Original research Published on:

  19. The purpose of the present study was to quantify renal cell injury after ischemia and reperfusion in a pig model using 99mTc-lactadherin as a marker of apoptosis and 99mTc-sestamibi as a marker of mitochondrial d...

    Authors: Stine S Pedersen, Anna K Keller, Marie K Nielsen, Bente Jespersen, Lise Falborg, Jan T Rasmussen, Christian W Heegaard and Michael Rehling
    Citation: EJNMMI Research 2013 3:62
    Content type: Original research Published on:

  20. Kinetic modeling of brain glucose metabolism in small rodents from positron emission tomography (PET) data using 2-deoxy-2-[18 F]fluoro-d-glucose (FDG) has been highly inconsistent, due to different modeling para...

    Authors: Malte F Alf, Marianne I Martić-Kehl, Roger Schibli and Stefanie D Krämer
    Citation: EJNMMI Research 2013 3:61
    Content type: Original research Published on:

  21. Gastrointestinal (GI) disorders are commonly associated with chronic conditions such as diabetes, obesity, and hypertension. Direct consequences are obstipation or diarrhea as opposite aspects of the irritable...

    Authors: Parasuraman Padmanabhan, Johannes Grosse, Abu Bakar Md Ali Asad, George K Radda and Xavier Golay
    Citation: EJNMMI Research 2013 3:60
    Content type: Original research Published on:

  22. Preclinical and histological data show overexpression of the type 1 cannabinoid receptor (CB1R) in prostate carcinoma (PCa). In a prospective study, the feasibility of 18F-MK-9470 positron emission tomography (PE...

    Authors: Kimy M Emonds, Michel Koole, Cindy Casteels, Laura Van den Bergh, Guy M Bormans, Filip Claus, Liesbeth De Wever, Evelyne Lerut, Hendrik Van Poppel, Steven Joniau, Herlinde Dumez, Karin Haustermans, Luc Mortelmans, Karolien Goffin, Koen Van Laere, Christophe M Deroose…
    Citation: EJNMMI Research 2013 3:59
    Content type: Original research Published on:

  23. Stress myocardial perfusion scintigraphy (MPS) is widely regarded as a useful imaging modality for diagnosing patients with suspected ischemic heart disease. Current European guidelines recommend stress study ...

    Authors: Lars Edenbrandt, Mattias Ohlsson and Elin Trägårdh
    Citation: EJNMMI Research 2013 3:58
    Content type: Original research Published on:

  24. Coincidence imaging of low-abundance yttrium-90 (90Y) internal pair production by positron emission tomography with integrated computed tomography (PET/CT) achieves high-resolution imaging of post-radioembolizati...

    Authors: Yung-Hsiang Kao, Jeffrey D Steinberg, Young-Soon Tay, Gabriel KY Lim, Jianhua Yan, David W Townsend, Charley A Budgeon, Jan A Boucek, Roslyn J Francis, Timothy ST Cheo, Mark C Burgmans, Farah G Irani, Richard HG Lo, Kiang-Hiong Tay, Bien-Soo Tan, Pierce KH Chow…
    Citation: EJNMMI Research 2013 3:57
    Content type: Original research Published on:

  25. Yttrium-90 (90Y) positron emission tomography with integrated computed tomography (PET/CT) represents a technological leap from 90Y bremsstrahlung single-photon emission computed tomography with integrated comput...

    Authors: Yung-Hsiang Kao, Jeffrey D Steinberg, Young-Soon Tay, Gabriel KY Lim, Jianhua Yan, David W Townsend, Angela Takano, Mark C Burgmans, Farah G Irani, Terence KB Teo, Tow-Non Yeow, Apoorva Gogna, Richard HG Lo, Kiang-Hiong Tay, Bien-Soo Tan, Pierce KH Chow…
    Citation: EJNMMI Research 2013 3:56
    Content type: Original research Published on:

  26. Infectious diseases are the second leading cause of death worldwide. In order to better understand and treat them, an accurate evaluation using multi-modal imaging techniques for anatomical and functional char...

    Authors: Ulas Bagci, Brent Foster, Kirsten Miller-Jaster, Brian Luna, Bappaditya Dey, William R Bishai, Colleen B Jonsson, Sanjay Jain and Daniel J Mollura
    Citation: EJNMMI Research 2013 3:55
    Content type: Original research Published on:

  27. Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative r...

    Authors: Tomoteru Yamasaki, Katsushi Kumata, Joji Yui, Masayuki Fujinaga, Kenji Furutsuka, Akiko Hatori, Lin Xie, Masanao Ogawa, Nobuki Nengaki, Kazunori Kawamura and Ming-Rong Zhang
    Citation: EJNMMI Research 2013 3:54
    Content type: Original research Published on:

  28. Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed ...

    Authors: Shane B Claggett, Kevin M Quinn, Mark Lazari, Melissa D Moore and R Michael van Dam
    Citation: EJNMMI Research 2013 3:53
    Content type: Original research Published on:

  29. Automated radiosynthesizers are vital for routine production of positron-emission tomography tracers to minimize radiation exposure to operators and to ensure reproducible synthesis yields. The recent trend in...

    Authors: Mark Lazari, Kevin M Quinn, Shane B Claggett, Jeffrey Collins, Gaurav J Shah, Henry E Herman, Brandon Maraglia, Michael E Phelps, Melissa D Moore and R Michael van Dam
    Citation: EJNMMI Research 2013 3:52
    Content type: Original research Published on:

  30. Many biological factors of 2-[18 F]fluoro-2-deoxy-d-glucose (18 F-FDG) in blood can affect 18 F-FDG uptake in tumors. In this study, longitudinal 18 F-FDG positron emission tomography (PET) studies were performed...

    Authors: Wei Sha, Hu Ye, Keisuke S Iwamoto, Koon-Pong Wong, Moses Quinn Wilks, David Stout, William McBride and Sung-Cheng Huang
    Citation: EJNMMI Research 2013 3:51
    Content type: Original research Published on:

  31. The influence of the blood glucose level on the tracer uptake of normal tissues at [18F]-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) was retrospectively studied in examinations in clinical...

    Authors: Henry Lindholm, Fredrik Brolin, Cathrine Jonsson and Hans Jacobsson
    Citation: EJNMMI Research 2013 3:50
    Content type: Original research Published on:

  32. Care providers use complementary information from multiple imaging modalities to identify and characterize metastatic tumors in early stages and perform surveillance for cancer recurrence. These tasks require ...

    Authors: Ulas Bagci, Gabriela Kramer-Marek and Daniel J Mollura
    Citation: EJNMMI Research 2013 3:49
    Content type: Original research Published on:

  33. The cardiac PRKAG2 mutation in the γ2-subunit of adenosine monophosphate activated kinase (AMPK) is characterized by excessive glycogen deposition, hypertrophy, frequent arrhythmias, and progressive conduction...

    Authors: Stephanie L Thorn, Michael H Gollob, Mary-Ellen Harper, Rob S Beanlands, Robert A deKemp and Jean N DaSilva
    Citation: EJNMMI Research 2013 3:48
    Content type: Original research Published on:

  34. A recent study from our laboratory demonstrated that 11C-LY2428703, a new positron emission tomographic radioligand for metabotropic glutamate receptor 1 (mGluR1), has promising in vitro properties and excellent

    Authors: Paolo Zanotti-Fregonara, Vanessa N Barth, Sami S Zoghbi, Jeih-San Liow, Eric Nisenbaum, Edward Siuda, Robert L Gladding, Denise Rallis-Frutos, Cheryl Morse, Johannes Tauscher, Victor W Pike and Robert B Innis
    Citation: EJNMMI Research 2013 3:47
    Content type: Original research Published on:

  35. 6-Hydroxydopamine (6-OHDA) is widely used in pre-clinical animal studies to induce degeneration of midbrain dopamine neurons to create animal models of Parkinson's disease. The aim of our study was to evaluate...

    Authors: Susanne Bäck, Mari Raki, Raimo K Tuominen, Atso Raasmaja, Kim Bergström and Pekka T Männistö
    Citation: EJNMMI Research 2013 3:46
    Content type: Original research Published on:

  37. Although the treatment of Parkinson’s disease (PD) is very effective, in the course of the disease, 40% to 60% of patients develop dyskinesias. The pathophysiology of dyskinesias is still unclear. Results of p...

    Authors: Sven R Suwijn, Henk W Berendse, Constant VM Verschuur, Ania Winogrodzka, Rob MA de Bie and Jan Booij
    Citation: EJNMMI Research 2013 3:44
    Content type: Original research Published on:

  38. Florbetapir (AV-45) has been shown to be a reliable tool to assess amyloid load in patients with Alzheimer's disease (AD) at demential stages. Longitudinal studies also suggest that AV-45 has the ability to bi...

    Authors: Laure Saint-Aubert, Emmanuel J Barbeau, Patrice Péran, Federico Nemmi, Celine Vervueren, Helene Mirabel, Pierre Payoux, Anne Hitzel, Fabrice Bonneville, Raluca Gramada, Mathieu Tafani, Christian Vincent, Michele Puel, Sophie Dechaumont, Francois Chollet and Jeremie Pariente
    Citation: EJNMMI Research 2013 3:43
    Content type: Original research Published on:

  39. Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinic...

    Authors: Joseph A O’Donoghue, José G Guillem, Heiko Schöder, Nancy Y Lee, Chaitanya R Divgi, Jeannine A Ruby, John L Humm, Steven A Lee-Kong, Eva M Burnazi, Shangde Cai, Sean D Carlin, Tobias Leibold, Pat B Zanzonico and C Clifton Ling
    Citation: EJNMMI Research 2013 3:42
    Content type: Original research Published on:

  40. Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H2 15O (or C15O2) can quantify CBF and apply kinet...

    Authors: Nobuyuki Kudomi, Yukito Maeda, Yasuhiro Sasakawa, Toshihide Monden, Yuka Yamamoto, Nobuyuki Kawai, Hidehiro Iida and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2013 3:41
    Content type: Original research Published on:

  41. Since proteoglycans (PGs) appear as key partners in chondrosarcoma biology, PG-targeted imaging using the radiotracer 99mTc-N-(triethylammonium)-3-propyl-[15]ane-N5 (99mTc-NTP 15-5) developed by our group was pre...

    Authors: Elisabeth Miot-Noirault, Emmanuelle David, Aurélien Vidal, Caroline Peyrode, Sophie Besse, Marie-Mélanie Dauplat, Marie-Françoise Heymann, François Gouin, Jean-Michel Chezal, Dominique Heymann and Françoise Rédini
    Citation: EJNMMI Research 2013 3:40
    Content type: Short communication Published on:

  42. Mesolimbic and nigrostriatal dopaminergic pathways play important roles in both the rewarding and conditioning effects of drugs. The dopamine transporter (DAT) is of central importance in regulating dopaminerg...

    Authors: Gerda Thomsen, Gitte Moos Knudsen, Peter S Jensen, Morten Ziebell, Klaus K Holst, Susanne Asenbaum, Jan Booij, Jacques Darcourt, John C Dickson, Özlem L Kapucu, Flavio Nobili, Osama Sabri, Terez Sera, Klaus Tatsch, Livia Tossici-Bolt, Koen Van Laere…
    Citation: EJNMMI Research 2013 3:39
    Content type: Original research Published on:

  43. Expression of αvβ3 integrin is increased after myocardial infarction as part of the repair process. Increased expression of αvβ3 has been shown by molecular imaging with 18F-galacto-RGD in a rat model. The 68Ga-l...

    Authors: Iina Laitinen, Johannes Notni, Karolin Pohle, Martina Rudelius, Eliane Farrell, Stephan G Nekolla, Gjermund Henriksen, Stefanie Neubauer, Horst Kessler, Hans-Jürgen Wester and Markus Schwaiger
    Citation: EJNMMI Research 2013 3:38
    Content type: Original research Published on:

  45. Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to ...

    Authors: William J McBride, Robert M Sharkey and David M Goldenberg
    Citation: EJNMMI Research 2013 3:36
    Content type: Review Published on:

  46. [18F]UCB-H was developed as a novel radiotracer with a high affinity for synaptic vesicle protein 2A, the binding site for the antiepileptic levetiracetam. The objectives of this study were to evaluate the radiat...

    Authors: Florian Bretin, Geoffrey Warnock, Mohamed Ali Bahri, Joël Aerts, Nathalie Mestdagh, Tim Buchanan, Anne Valade, Frédéric Mievis, Fabrice Giacomelli, Christian Lemaire, André Luxen, Eric Salmon, Alain Seret and Alain Plenevaux
    Citation: EJNMMI Research 2013 3:35
    Content type: Original research Published on:

  47. Serotonergic neurons in the rodent hypothalamus are implicated in key neuroendocrine and metabolic functions, including circadian rhythmicity. However, the assessment of the serotonergic system in the human hy...

    Authors: Anke J Borgers, Anneke Alkemade, Elsmarieke M Van de Giessen, Madeleine L Drent, Jan Booij, Peter H Bisschop and Eric Fliers
    Citation: EJNMMI Research 2013 3:34
    Content type: Original research Published on:

  48. We propose a new approach to facilitate sentinel node biopsy examination by multimodality imaging in which radioactive and near-infrared (NIR) fluorescent nanoparticles depict deeply situated sentinel nodes an...

    Authors: Makoto Tsuchimochi, Kazuhide Hayama, Michio Toyama, Ichiro Sasagawa and Norio Tsubokawa
    Citation: EJNMMI Research 2013 3:33
    Content type: Original research Published on:

  49. Androgen deprivation (AD) is generally used as a first-line palliative treatment in prostate cancer (PCa) patients with rising prostate-specific antigen (PSA) after primary therapy. To acquire an accurate dete...

    Authors: Kimy M Emonds, Johannes V Swinnen, Evelyne Lerut, Michel Koole, Luc Mortelmans and Felix M Mottaghy
    Citation: EJNMMI Research 2013 3:31
    Content type: Original research Published on:

  50. Respiratory gating and gate optimization strategies present solutions for overcoming image degradation caused by respiratory motion in PET and traditionally utilize hardware systems and/or employ complex proce...

    Authors: Adam Leon Kesner, Galith Abourbeh, Eyal Mishani, Roland Chisin, Sagi Tshori and Nanette Freedman
    Citation: EJNMMI Research 2013 3:29
    Content type: Original research Published on:
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