Open Access

Erratum to: Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

  • Anu Autio1,
  • Helena Virtanen1,
  • Tuula Tolvanen1,
  • Heidi Liljenbäck1, 2,
  • Vesa Oikonen1,
  • Tiina Saanijoki1,
  • Riikka Siitonen1,
  • Meeri Käkelä1,
  • Andrea Schüssele3,
  • Mika Teräs1 and
  • Anne Roivainen1, 2Email author
Contributed equally
EJNMMI Research20166:51

https://doi.org/10.1186/s13550-016-0205-8

Received: 1 June 2016

Accepted: 2 June 2016

Published: 13 June 2016

The original article was published in EJNMMI Research 2015 5:40

Erratum

After publishing of the paper [1], substantial errors in Tables 4, 5, 6 and 7 have been noticed. The correct Tables 4, 5, 6 and 7 are presented here. Authors regret any inconvenience.
Table 4

Human residence times and radiation dose estimates for 68Ga radioactivity extrapolated from the rat biodistribution data

Organ

Residence time (h)

Dose (mSv/MBq)

 

Female rat data

Male rat data

Female rat data

Male rat data

Adrenals

  

0.01140

0.00931

Blood

0.2080

0.5000

  

Bone

0.6645

0.3089

  

Bone marrow

0.0907

0.0479

  

Brain

0.0348

0.0326

0.01800

0.01340

Breasts

  

0.00587

0.00615

Gallbladder wall

  

0.00955

0.00810

Heart wall

0.0208

0.0187

0.17400

0 30300

Kidneys

0.0196

0.0100

0.03850

0.01970

Liver

0.2526

0.2653

0.09720

0.07660

Lower large intestine wall

  

0.00319

0.00152

Lungs

0.3174

0.2770

0.18600

0.13400

Muscle

0.1014

0.1084

0.00729

0.00510

Osteogenic cells

  

0.11600

0.04310

Ovaries

0.0004

 

0.01880

0.00169

Pancreas

0.0019

0.0023

0.01870

0.01870

Red marrow

  

0.02250

0.01380

Skin

  

0.000292

0.00202

Small intestine

  

0.00388

0.00222

Spleen

  

0.00554

0.00412

Stomach wall

  

0.0565

0.00477

Testes

 

0.000028

 

0.00077

Thymus

  

0.01000

0.00139

Thyroid

0.0087

0.0095

0.22100

0.19800

Upper large intestine wall

  

0.00399

0.00268

Urinary bladder wall

  

0.00232

0.00106

Uterus

0.0137

 

0.007920

0.00142

Whole body

  

0.01770

0.01150

Effective dose

  

0.0483

0.0338

Table 5

Additional dosimetry estimates based on a female rat distribution data

 

Absorbed dose per unit radioactivity administered (mSv/MBq)

Organ

15-year-old (50 kg)

10-year-old (30 kg)

5-year-old (17 kg)

1-year-old (10 kg)

Newborn (5 kg)

Adrenals

0.01120

0.01640

0.02380

0.04030

0.07820

Brain

0.01590

0.01760

0.02060

0.02920

0.06670

Breasts

0.00581

0.01100

0.01630

0.02690

0.05450

Gallbladder wall

0.00920

0.01270

0.02010

0.03900

0.07500

Heart wall

0.19400

0.30100

0.48300

0.87300

1.72000

Kidneys

0.04210

0.06000

0.08880

0.16000

0.41500

Liver

0.09740

0.14800

0.22000

0.42700

0.98900

Lower large intestine wall

0.00321

0.00504

0.00771

0.01330

0.02920

Lungs

0.22400

0.31900

0.49300

0.98400

2.71000

Muscle

0.00757

0.01310

0.03190

0.06220

0.09540

Osteogenic cells

0.11400

0.18400

0.31000

0.73500

2.35000

Ovaries

0.02030

0.05660

0.09880

0.22500

0.45900

Pancreas

0.002180

0.04060

0.05470

0.11200

0.34000

Red marrow

0.02560

0.04150

0.07770

0.17700

0.57100

Skin

0.00281

0.00435

0.00671

0.01220

0.02710

Small intestine

0.00386

0.00619

0.00986

0.01780

0.03760

Spleen

0.00562

0.00858

0.01300

0.02380

0.04920

Stomach wall

0.00559

0.00800

0.01330

0.02500

0.05020

Thymus

0.01020

0.01330

0.01900

0.02970

0.05700

Thyroid

0.29800

0.46000

1.02000

1.93000

2.63000

Upper large intestine wall

0.00389

0.00669

0.01040

0.01900

0.04250

Urinary bladder wall

0.00223

0.00377

0.00625

0.01100

0.02220

Uterus

0.08020

1.34000

2.03000

3.69000

1.47000

Total body

0.01780

0.02890

0.04680

0.09200

0.23400

Effective dose (mSv/MBq)

0.05740

0.12300

0.20900

0.41000

0.71700

Table 6

Additional dosimetry estimates based on a male rat distribution data

 

Absorbed dose per unit radioactivity administered (mSv/MBq)

Organ

15-year-old (50 kg)

10-year-old (30 kg)

5-year-old (17 kg)

1-year-old (10 kg)

Newborn (5 kg)

Adrenals

0.01120

0.01650

0.02350

0.03770

0.07490

Brain

0.01370

0.01480

0.01700

0.02410

0.05630

Breasts

0.00743

0.01420

0.02130

0.03500

0.07250

Gallbladder wall

0.00960

0.01370

0.02130

0.04090

0.08030

Heart wall

0.39300

0.61100

0.98300

1.78000

3.4900

Kidneys

0.02410

0.03450

0.05100

0.09110

0.23100

Liver

0.10300

0.15700

0.23300

0.45000

1.04000

Lower large intestine wall

0.00197

0.00308

0.00506

0.00907

0.02040

Lungs

0.20000

0.28500

0.43900

0.87200

2.38000

Muscle

0.00739

0.01290

0.03260

0.06360

0.09610

Pancreas

0.02570

0.04800

0.06460

0.13100

0.40300

Red marrow

0.01540

0.02430

0.04410

0.09800

0.31100

Osteogenic cells

0.05580

0.09010

0.15100

0.35600

1.13000

Skin

0.00244

0.00362

0.00572

0.01030

0.02320

Small intestine

0.00287

0.00483

0.00796

0.01460

0.03090

Spleen

0.0327

0.0503

0.0801

0.1460

0.3780

Stomach wall

0.000657

0.00988

0.01530

0.02870

0.05600

Testes

0.00178

0.00745

0.00935

0.01380

0.02390

Thymus

0.01580

0.01940

0.02760

0.04170

0.07940

Thyroid

0.32500

0.50200

1.12000

2.1100

2.88000

Upper large intestine wall

0.00327

0.00581

0.00935

0.01820

0.03850

Urinary bladder wall

0.00129

0.00224

0.00393

0.00699

0.01520

Total body

0.01470

0.02370

0.03830

0.07480

0.19000

Effective dose (mSv/MBq)

0.05060

0.07560

0.13400

0.26000

0.55500

Table 7

Human effective doses of 68Ga radiopharmaceuticals and 18F-FDG

Radiopharmaceutical

Effective dose (mSv/MBq)

Reference

68Ga-DOTANOC

0.025

Pettinato 2008 [10]

68Ga-DOTATOC

0.023

Hartmann 2009 [11]

68Ga-DOTATATE

0.021

Sandström 2013 [12]

68Ga-NOTA-2Rs15d

0.0218a

Xavier 2013 [13]

BAY86-7548

0.051

Roivainen 2013 [14]

18F-FDG

0.0190

ICRP Publication 1998 [15]

68Ga-eluate

0.0483b, 0.0338c

Present study

aExtrapolated from tumour xenograft mice; bObtained by using female rat data; cObtained by using male rat data

Notes

Declarations

Acknowledgements

The study was conducted within the Finnish Centre of Excellence in Cardiovascular and Metabolic Disease, supported by the Academy of Finland, University of Turku, Turku University Hospital and Åbo Akademi University. This study was sponsored by Eckert & Ziegler Radiopharma GmbH, Berlin, Germany (conducted as part of preclinical studies), and further supported by a grant from the Academy of Finland (#258814). Helena Virtanen is a Ph.D. student financially supported by the Drug Research Doctoral Program, University of Turku Graduate School, Finland, and the Finnish Cultural Foundation. Aake Honkaniemi and Jouni Tuisku are thanked for their help in PET imaging.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors’ Affiliations

(1)
Turku PET Centre, Turku University Hospital and University of Turku
(2)
Turku Center for Disease Modeling, University of Turku
(3)
Eckert & Ziegler Radiopharma GmbH

References

  1. Autio A, Virtanen H, Tolvanen T, Liljenbäck H, Oikonen V, Saanijoki T, et al. Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry. EJNMMI Res. 2015;5(1):117. doi:https://doi.org/10.1186/s13550-015-0117-z.

Copyright

© The Author(s). 2016