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  1. Original research

    Therapeutic efficacy of α-radioimmunotherapy with different activity levels of the 213Bi-labeled monoclonal antibody MX35 in an ovarian cancer model

    The aim of this study was to compare the therapeutic efficacy of two different activity levels of the 213Bi-labeled monoclonal antibody MX35 in an ovarian cancer model. Sixty female BALB/c (nu/nu) mice were inocu...

    Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Alfred Morgenstern, Frank Bruchertseifer, Per Albertsson and Sture Lindegren

    EJNMMI Research 2017 7:38

    Published on: 24 April 2017

  2. Original research

    Effective dose estimation for oncological and neurological PET/CT procedures

    The aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety of PET radiopharmaceutical compounds.

    Josep M. Martí-Climent, Elena Prieto, Verónica Morán, Lidia Sancho, Macarena Rodríguez-Fraile, Javier Arbizu, María J. García-Velloso and José A. Richter

    EJNMMI Research 2017 7:37

    Published on: 24 April 2017

  3. Original research

    Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising

    Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have...

    Sandeep S. V. Golla, Mark Lubberink, Bart N. M. van Berckel, Adriaan A. Lammertsma and Ronald Boellaard

    EJNMMI Research 2017 7:36

    Published on: 21 April 2017

  4. Original research

    The effect of post-injection 18F-FDG PET scanning time on texture analysis of peripheral nerve sheath tumours in neurofibromatosis-1

    Texture features are being increasingly evaluated in 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) as adjunctive imaging biomarkers in a number of different cancers. Whilst studies have report...

    Eitan Lovat, Musib Siddique, Vicky Goh, Rosalie E. Ferner, Gary J. R. Cook and Victoria S. Warbey

    EJNMMI Research 2017 7:35

    Published on: 20 April 2017

  5. Original research

    High-throughput high-volume nuclear imaging for preclinical in vivo compound screening§

    Preclinical single-photon emission computed tomography (SPECT)/CT imaging studies are hampered by low throughput, hence are found typically within small volume feasibility studies. Here, imaging and image anal...

    Sven Macholl, Ciara M. Finucane, Jacob Hesterman, Stephen J. Mather, Rachel Pauplis, Deirdre Scully, Jane K. Sosabowski and Erwan Jouannot

    EJNMMI Research 2017 7:33

    Published on: 7 April 2017

  6. Original research

    Tracking dendritic cell migration into lymph nodes by using a novel PET probe 18F-tetrafluoroborate for sodium/iodide symporter

    Recently, 18F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the ...

    Sang Bong Lee, Ho Won Lee, Hongje Lee, Yong Hyun Jeon, Sang-Woo Lee, Byeong-Cheol Ahn, Jaetae Lee and Shin Young Jeong

    EJNMMI Research 2017 7:32

    Published on: 4 April 2017

  7. Original research

    Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

    The P2X7 receptor has been shown to play a fundamental role in the initiation and sustenance of the inflammatory cascade. The development of a novel fluorine-18 PET tracer superior and with a longer half-life ...

    Enrico Raffaele Fantoni, Diego Dal Ben, Simonetta Falzoni, Francesco Di Virgilio, Simon Lovestone and Antony Gee

    EJNMMI Research 2017 7:31

    Published on: 4 April 2017

  8. Preliminary research

    Visual evaluation and differentiation of renal oncocytomas from renal cell carcinomas by means of 99mTc-sestamibi SPECT/CT

    Despite the progress in the quality of multiphasic CT and MRI scans, it is still difficult to fully characterize a solid kidney lesion. Approximately 10% of all solid renal tumours turn out to be oncocytomas. ...

    Antonios Tzortzakakis, Ove Gustafsson, Mattias Karlsson, Linnea Ekström-Ehn, Rammin Ghaffarpour and Rimma Axelsson

    EJNMMI Research 2017 7:29

    Published on: 29 March 2017

  9. Original research

    Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT

    Phase analysis of gated myocardial perfusion single-photon emission computed tomography (SPECT) for assessment of left ventricular (LV) dyssynchrony was investigated using the following dedicated software pack...

    Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Soichiro Kashiwaya, Hiroto Yoneyama, Takayuki Shibutani, Masahisa Onoguchi, Mitsumasa Hashimoto and Seigo Kinuya

    EJNMMI Research 2017 7:27

    Published on: 23 March 2017

  10. Original research

    I-123 iomazenil single photon emission computed tomography for detecting loss of neuronal integrity in patients with traumatic brain injury

    Traumatic brain injury (TBI) causes brain dysfunction in many patients. Using C-11 flumazenil (FMZ) positron emission tomography (PET), we have detected and reported the loss of neuronal integrity, leading to ...

    Kagari Abiko, Katsunori Ikoma, Tohru Shiga, Chietsugu Katoh, Kenji Hirata, Yuji Kuge, Kentaro Kobayashi and Nagara Tamaki

    EJNMMI Research 2017 7:28

    Published on: 23 March 2017

  11. Original research

    Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [11C]CB184, in healthy human volunteers

    N,N-di-n-propyl-2-[2-(4-[11C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([11C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), ...

    Muneyuki Sakata, Kenji Ishibashi, Masamichi Imai, Kei Wagatsuma, Kenji Ishii, Kentaro Hatano, Kiichi Ishiwata and Jun Toyohara

    EJNMMI Research 2017 7:26

    Published on: 23 March 2017

  12. Original research

    Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study

    Lack of treatment response in patients with late-life depression is common. The role of brain beta-amyloid (Aβ) deposition in treatment outcome in subjects with late-life depression remains unclear. The presen...

    Peng Li, Ing-Tsung Hsiao, Chia-Yih Liu, Chia-Hsiang Chen, She-Yao Huang, Tzu-Chen Yen, Kuan-Yi Wu and Kun-Ju Lin

    EJNMMI Research 2017 7:24

    Published on: 21 March 2017

  13. Original research

    Quantitative 18F-fluorocholine positron emission tomography for prostate cancer: correlation between kinetic parameters and Gleason scoring

    The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflictin...

    Joshua J. D. Schaefferkoetter, Ziting Wang, Mary C. Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W. Townsend, Thomas Thamboo and Edmund Chiong

    EJNMMI Research 2017 7:25

    Published on: 21 March 2017

  14. Original research

    New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics

    Resolving the kinetic mechanisms of biomolecular interactions have become increasingly important in early-phase drug development. Since traditional in vitro methods belong to dose-dependent assessments, bindin...

    Markus Zeilinger, Florian Pichler, Lukas Nics, Wolfgang Wadsak, Helmut Spreitzer, Marcus Hacker and Markus Mitterhauser

    EJNMMI Research 2017 7:22

    Published on: 7 March 2017

  15. Original research

    Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unc...

    M-S. Buhour, F. Doidy, A. Mondou, A. Pélerin, L. Carluer, F. Eustache, F. Viader and B. Desgranges

    EJNMMI Research 2017 7:21

    Published on: 6 March 2017

  16. Original research

    18F-FDG-labeled red blood cell PET for blood-pool imaging: preclinical evaluation in rats

    Red blood cells (RBCs) labeled with single-photon emitters have been clinically used for blood-pool imaging. Although some PET tracers have been introduced for blood-pool imaging, they have not yet been widely...

    Yohji Matsusaka, Tadaki Nakahara, Kazuhiro Takahashi, Yu Iwabuchi, Chiyoko Nishime, Mayumi Kajimura and Masahiro Jinzaki

    EJNMMI Research 2017 7:19

    Published on: 27 February 2017

  17. Original research

    Characteristics of immunoglobulin G4-related aortitis/periaortitis and periarteritis on fluorodeoxyglucose positron emission tomography/computed tomography co-registered with contrast-enhanced computed tomography

    We aimed to assess the positivity, distribution, quantitative degree of vessel inflammation, and clinical characteristics of IgG4-related aortitis/periarteritis and periarteritis (IgG4-aortitis), and to examin...

    Satoshi Yabusaki, Noriko Oyama-Manabe, Osamu Manabe, Kenji Hirata, Fumi Kato, Noriyuki Miyamoto, Yoshihiro Matsuno, Kohsuke Kudo, Nagara Tamaki and Hiroki Shirato

    EJNMMI Research 2017 7:20

    Published on: 27 February 2017

  18. Original research

    Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

    Preferred models for the pharmacokinetic analysis of [11C]flumazenil human studies have been previously established. However, direct translation of these models and settings to animal studies might be sub-optimal...

    Isadora Lopes Alves, David Vállez García, Andrea Parente, Janine Doorduin, Rudi Dierckx, Ana Maria Marques da Silva, Michel Koole, Antoon Willemsen and Ronald Boellaard

    EJNMMI Research 2017 7:17

    Published on: 22 February 2017

  19. Original research

    3D skeletal uptake of 18F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer

    Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases ...

    Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh

    EJNMMI Research 2017 7:15

    Published on: 16 February 2017

  20. Original research

    Quantitative evaluation of oxygen metabolism in the intratumoral hypoxia: 18F-fluoromisonidazole and 15O-labelled gases inhalation PET

    Intratumoral hypoxia is one of the resistant factors in radiotherapy and chemotherapy for cancer. Although it is detected by 18F-fluoromisonidazole (FMISO) PET, the relationship between intratumoral hypoxia and o...

    Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Genki Horitsugi, Keiko Matsunaga, Hiroki Kato, Kayako Isohashi, Kohji Abe, Eku Shimosegawa and Jun Hatazawa

    EJNMMI Research 2017 7:16

    Published on: 16 February 2017

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