Articles

Carotid atherosclerotic plaques standardised uptake values: software challenges and reproducibility

Positron emission tomography–computed tomography (PET-CT) carotid standardised uptake values (SUV) of ¹⁸F-fluorodeoxyglucose (¹⁸FDG) have been proposed as an inflammatory biomarker for determining cerebrovascular...

Authors: Nicola Giannotti, Martin J. O’Connell, Shane J. Foley, Peter J. Kelly and Jonathan P. McNulty

Therapeutic efficacy of α-radioimmunotherapy with different activity levels of the ²¹³Bi-labeled monoclonal antibody MX35 in an ovarian cancer model

The aim of this study was to compare the therapeutic efficacy of two different activity levels of the ²¹³Bi-labeled monoclonal antibody MX35 in an ovarian cancer model. Sixty female BALB/c (nu/nu) mice were inocu...

Authors: Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Alfred Morgenstern, Frank Bruchertseifer, Per Albertsson and Sture Lindegren

Effective dose estimation for oncological and neurological PET/CT procedures

The aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety of PET radiopharmaceutical compounds.

Authors: Josep M. Martí-Climent, Elena Prieto, Verónica Morán, Lidia Sancho, Macarena Rodríguez-Fraile, Javier Arbizu, María J. García-Velloso and José A. Richter

Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising

Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have...

Authors: Sandeep S. V. Golla, Mark Lubberink, Bart N. M. van Berckel, Adriaan A. Lammertsma and Ronald Boellaard

The effect of post-injection ¹⁸F-FDG PET scanning time on texture analysis of peripheral nerve sheath tumours in neurofibromatosis-1

Texture features are being increasingly evaluated in ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) as adjunctive imaging biomarkers in a number of different cancers. Whilst studies have report...

Authors: Eitan Lovat, Musib Siddique, Vicky Goh, Rosalie E. Ferner, Gary J. R. Cook and Victoria S. Warbey

Characterization of indeterminate renal masses with molecular imaging: how do we turn potential into reality?

Authors: Steven P. Rowe, Mehrbod S. Javadi, Mohamad E. Allaf and Michael A. Gorin

High-throughput high-volume nuclear imaging for preclinical in vivo compound screening^§

Preclinical single-photon emission computed tomography (SPECT)/CT imaging studies are hampered by low throughput, hence are found typically within small volume feasibility studies. Here, imaging and image anal...

Authors: Sven Macholl, Ciara M. Finucane, Jacob Hesterman, Stephen J. Mather, Rachel Pauplis, Deirdre Scully, Jane K. Sosabowski and Erwan Jouannot

Tracking dendritic cell migration into lymph nodes by using a novel PET probe ¹⁸F-tetrafluoroborate for sodium/iodide symporter

Recently, ¹⁸F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the ...

Authors: Sang Bong Lee, Ho Won Lee, Hongje Lee, Yong Hyun Jeon, Sang-Woo Lee, Byeong-Cheol Ahn, Jaetae Lee and Shin Young Jeong

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel ¹⁸F-labelled PET tracer targeting P2X7

The P2X7 receptor has been shown to play a fundamental role in the initiation and sustenance of the inflammatory cascade. The development of a novel fluorine-18 PET tracer superior and with a longer half-life ...

Authors: Enrico Raffaele Fantoni, Diego Dal Ben, Simonetta Falzoni, Francesco Di Virgilio, Simon Lovestone and Antony Gee

Impact of the EARL harmonization program on automatic delineation of metabolic active tumour volumes (MATVs)

The clinical validation of the EARL harmonization program for standardised uptake value (SUV) metrics is well documented; however, its potential for defining metabolic active tumour volume (MATV) has not yet b...

Authors: Charline Lasnon, Blandine Enilorac, Hosni Popotte and Nicolas Aide

Visual evaluation and differentiation of renal oncocytomas from renal cell carcinomas by means of ^99mTc-sestamibi SPECT/CT

Despite the progress in the quality of multiphasic CT and MRI scans, it is still difficult to fully characterize a solid kidney lesion. Approximately 10% of all solid renal tumours turn out to be oncocytomas. ...

Authors: Antonios Tzortzakakis, Ove Gustafsson, Mattias Karlsson, Linnea Ekström-Ehn, Rammin Ghaffarpour and Rimma Axelsson

I-123 iomazenil single photon emission computed tomography for detecting loss of neuronal integrity in patients with traumatic brain injury

Traumatic brain injury (TBI) causes brain dysfunction in many patients. Using C-11 flumazenil (FMZ) positron emission tomography (PET), we have detected and reported the loss of neuronal integrity, leading to ...

Authors: Kagari Abiko, Katsunori Ikoma, Tohru Shiga, Chietsugu Katoh, Kenji Hirata, Yuji Kuge, Kentaro Kobayashi and Nagara Tamaki

Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT

Phase analysis of gated myocardial perfusion single-photon emission computed tomography (SPECT) for assessment of left ventricular (LV) dyssynchrony was investigated using the following dedicated software pack...

Authors: Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Soichiro Kashiwaya, Hiroto Yoneyama, Takayuki Shibutani, Masahisa Onoguchi, Mitsumasa Hashimoto and Seigo Kinuya

Assessment of safety, efficacy, and dosimetry of a novel 18-kDa translocator protein ligand, [¹¹C]CB184, in healthy human volunteers

N,N-di-n-propyl-2-[2-(4-[¹¹C]methoxyphenyl)-6,8-dichloroimidazol[1,2-a]pyridine-3-yl]acetamide ([¹¹C]CB184) is a novel selective radioligand for the 18-kD translocator protein (TSPO), ...

Authors: Muneyuki Sakata, Kenji Ishibashi, Masamichi Imai, Kei Wagatsuma, Kenji Ishii, Kentaro Hatano, Kiichi Ishiwata and Jun Toyohara

Quantitative ¹⁸F-fluorocholine positron emission tomography for prostate cancer: correlation between kinetic parameters and Gleason scoring

The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflictin...

Authors: Joshua D. Schaefferkoetter, Ziting Wang, Mary C. Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W. Townsend, Thomas Thamboo and Edmund Chiong

Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study

Lack of treatment response in patients with late-life depression is common. The role of brain beta-amyloid (Aβ) deposition in treatment outcome in subjects with late-life depression remains unclear. The presen...

Authors: Peng Li, Ing-Tsung Hsiao, Chia-Yih Liu, Chia-Hsiang Chen, She-Yao Huang, Tzu-Chen Yen, Kuan-Yi Wu and Kun-Ju Lin

Reproducibility of 18F-fluoromisonidazole intratumour distribution in non-small cell lung cancer; methodological issues to avoid mismanagement of the patients

Authors: Siamak Sabour

New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics

Resolving the kinetic mechanisms of biomolecular interactions have become increasingly important in early-phase drug development. Since traditional in vitro methods belong to dose-dependent assessments, bindin...

Authors: Markus Zeilinger, Florian Pichler, Lukas Nics, Wolfgang Wadsak, Helmut Spreitzer, Marcus Hacker and Markus Mitterhauser

Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unc...

Authors: M-S. Buhour, F. Doidy, A. Mondou, A. Pélerin, L. Carluer, F. Eustache, F. Viader and B. Desgranges

Characteristics of immunoglobulin G4-related aortitis/periaortitis and periarteritis on fluorodeoxyglucose positron emission tomography/computed tomography co-registered with contrast-enhanced computed tomography

We aimed to assess the positivity, distribution, quantitative degree of vessel inflammation, and clinical characteristics of IgG4-related aortitis/periarteritis and periarteritis (IgG4-aortitis), and to examin...

Authors: Satoshi Yabusaki, Noriko Oyama-Manabe, Osamu Manabe, Kenji Hirata, Fumi Kato, Noriyuki Miyamoto, Yoshihiro Matsuno, Kohsuke Kudo, Nagara Tamaki and Hiroki Shirato

¹⁸F-FDG-labeled red blood cell PET for blood-pool imaging: preclinical evaluation in rats

Red blood cells (RBCs) labeled with single-photon emitters have been clinically used for blood-pool imaging. Although some PET tracers have been introduced for blood-pool imaging, they have not yet been widely...

Authors: Yohji Matsusaka, Tadaki Nakahara, Kazuhiro Takahashi, Yu Iwabuchi, Chiyoko Nishime, Mayumi Kajimura and Masahiro Jinzaki

SPECT image segmentation for estimation of tumour volume and activity concentration in ¹⁷⁷Lu-DOTATATE radionuclide therapy

Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is ¹⁷⁷Lu-DOTATATE,...

Authors: Johan Gustafsson, Anna Sundlöv and Katarina Sjögreen Gleisner

Pharmacokinetic modeling of [¹¹C]flumazenil kinetics in the rat brain

Preferred models for the pharmacokinetic analysis of [¹¹C]flumazenil human studies have been previously established. However, direct translation of these models and settings to animal studies might be sub-optimal...

Authors: Isadora Lopes Alves, David Vállez García, Andrea Parente, Janine Doorduin, Rudi Dierckx, Ana Maria Marques da Silva, Michel Koole, Antoon Willemsen and Ronald Boellaard

Quantitative evaluation of oxygen metabolism in the intratumoral hypoxia: ¹⁸F-fluoromisonidazole and ¹⁵O-labelled gases inhalation PET

Intratumoral hypoxia is one of the resistant factors in radiotherapy and chemotherapy for cancer. Although it is detected by ¹⁸F-fluoromisonidazole (FMISO) PET, the relationship between intratumoral hypoxia and o...

Authors: Tadashi Watabe, Yasukazu Kanai, Hayato Ikeda, Genki Horitsugi, Keiko Matsunaga, Hiroki Kato, Kayako Isohashi, Kohji Abe, Eku Shimosegawa and Jun Hatazawa

3D skeletal uptake of ¹⁸F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer

Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases ...

Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh

Erratum to: Test-retest analysis of a non-invasive method of quantifying [(11)C]-PBR28 binding in Alzheimer's disease

Authors: Akshay Nair, Mattia Veronese, Xiaohui Xu, Charles Curtis, Federico Turkheimer, Robert Howard and Suzanne Reeves

The extent to which standardized uptake values reflect FDG phosphorylation in the liver and spleen as functions of time after injection of ¹⁸F-fluorodeoxyglucose

In FDG PET/CT, standardized uptake value (SUV) is used to measure metabolic activity but detects un-phosphorylated FDG as well as phosphorylated FDG (FDG6P). Our aim was to determine the proportions of intrahe...

Authors: Georgia Keramida, Constantinos D. Anagnostopoulos and A. Michael Peters

Impact of PET acquisition durations on image quality and lesion detectability in whole-body ⁶⁸Ga-PSMA PET-MRI

While ⁶⁸Ga-PSMA PET-MRI might be superior to PET-CT with regard to soft tissue assessment in prostate cancer evaluation, it is also known to potentially introduce additional PET image artefacts. Therefore, the im...

Authors: Benjamin Noto, Florian Büther, Katharina Auf der Springe, Nemanja Avramovic, Walter Heindel, Michael Schäfers, Thomas Allkemper and Lars Stegger

Comparison of machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer from ¹⁸F-FDG PET/CT images

This study aimed to compare one state-of-the-art deep learning method and four classical machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer (NSCLC) from ¹⁸F-F...

Authors: Hongkai Wang, Zongwei Zhou, Yingci Li, Zhonghua Chen, Peiou Lu, Wenzhi Wang, Wanyu Liu and Lijuan Yu

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [¹²³I]FP-CIT SPECT imaging

The use of a normal database for [¹²³I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretatio...

Authors: John C. Dickson, Livia Tossici-Bolt, Terez Sera, Jan Booij, Morten Ziebell, Silvia Morbelli, Susanne Assenbaum-Nan, Thierry Vander Borght, Marco Pagani, Ozlem L. Kapucu, Swen Hesse, Koen Van Laere, Jacques Darcourt, Andrea Varrone and Klaus Tatsch

⁴⁴Sc-PSMA-617 for radiotheragnostics in tandem with ¹⁷⁷Lu-PSMA-617—preclinical investigations in comparison with ⁶⁸Ga-PSMA-11 and ⁶⁸Ga-PSMA-617

The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-te...

Authors: Christoph A. Umbricht, Martina Benešová, Raffaella M. Schmid, Andreas Türler, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

A comparison of FLT to FDG PET/CT in the early assessment of chemotherapy response in stages IB–IIIA resectable NSCLC

The aim of this study was to compare the percentage change in ¹⁸F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 compu...

Authors: John P. Crandall, Abdel K. Tahari, Rosalyn A. Juergens, Julie R. Brahmer, Charles M. Rudin, Giuseppe Esposito, Deepa S. Subramaniam, Michael V. Knopp, Nathan C. Hall, Prateek Gajwani, Jeffrey P. Leal, Martin A. Lodge, Joo H. O., Edward W. Gabrielson, Lalitha K. Shankar and Richard L. Wahl

Assessment of regional pulmonary blood flow using ⁶⁸Ga-DOTA PET

In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of ⁶⁸Ga-DOTA PET for the in vivo quantitative determination of regi...

Authors: Carlos Velasco, Jesus Mateo, Arnoldo Santos, Adriana Mota-Cobian, Fernando Herranz, Juan Pellico, Ruben A. Mota, Samuel España and Jesus Ruiz-Cabello

Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer

Molecular breast imaging (MBI) performed with ^99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as ^99mTc maraciclatide may offer improved ...

Authors: Michael K. O’Connor, Melissa M. B. Morrow, Katie N. Hunt, Judy C. Boughey, Dietlind L. Wahner-Roedler, Amy Lynn Conners, Deborah J. Rhodes and Carrie B. Hruska

Blood perfusion in osteomyelitis studied with [¹⁵O]water PET in a juvenile porcine model

Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (O...

Authors: Lars Jødal, Ole L. Nielsen, Pia Afzelius, Aage K. O. Alstrup and Søren B. Hansen

Patient-specific optimisation of administered activity and acquisition times for ¹⁸F-FDG PET imaging

The purpose of this study is to identify a method for optimising the administered activity and acquisition time for ¹⁸F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes ...

Authors: Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen and Thomas Wagner

Priming increases the anti-tumor effect and therapeutic window of ¹⁷⁷Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

¹⁷⁷Lu-[DOTA⁰, Tyr³]-octreotate (¹⁷⁷Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remissio...

Authors: Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z. Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg and Eva Forssell-Aronsson

Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients

Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pre...

Authors: Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

Three-minute SPECT/CT is sufficient for the assessment of bone metastasis as add-on to planar bone scintigraphy: prospective head-to-head comparison to 11-min SPECT/CT

The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as “add-on” to whole-body bone scintigraphy (WB-BS) for the investigation o...

Authors: Helle D. Zacho, José A. Biurrun Manresa, Ramune Aleksyniene, June A. Ejlersen, Joan Fledelius, Henrik Bertelsen and Lars J. Petersen

Yttrium-90 radioembolization for colorectal cancer liver metastases: a prospective cohort study on circulating angiogenic factors and treatment response

Yttrium-90 radioembolization (⁹⁰Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimula...

Authors: C. E. N. M. Rosenbaum, A. F. van den Hoven, M. N. G. J. A. Braat, M. Koopman, M. G. E. H. Lam, B. A. Zonnenberg, H. M. Verkooijen and M. A. A. J. van den Bosch

Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, ¹⁸F-labeled [Nle¹⁴,Lys⁴⁰]exendin-4 analog, shows promise for clinical imaging

Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer ...

Authors: Kirsi Mikkola, Cheng-Bin Yim, Paula Lehtiniemi, Saila Kauhanen, Miikka Tarkia, Tuula Tolvanen, Pirjo Nuutila and Olof Solin

Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft

Sorafenib, an oral multikinase inhibitor, has anti-proliferative and anti-angiogenic activities and is therapeutically effective against renal cell carcinoma (RCC). Recently, we have evaluated the tumor respon...

Authors: Naoyuki Ukon, Songji Zhao, Wenwen Yu, Yoichi Shimizu, Ken-ichi Nishijima, Naoki Kubo, Yoshimasa Kitagawa, Nagara Tamaki, Kei Higashikawa, Hironobu Yasui and Yuji Kuge

Computational simulation of the predicted dosimetric impact of adjuvant yttrium-90 PET/CT-guided percutaneous ablation following radioembolization

⁹⁰Y PET/CT post-radioembolization imaging has demonstrated that the distribution of ⁹⁰Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact ...

Authors: Alexander S. Pasciak, Abigail Lin, Christos Georgiades, Laura K. Findeiss, Shannon Kauffman and Yong C. Bradley

^99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study

Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (C...

Authors: Bieke Lambert, Philippe Carron, Yves D’Asseler, Klaus Bacher, Filip Van den Bosch, Dirk Elewaut, Gust Verbruggen, Rudi Beyaert, Caroline Dumolyn and Filip De Vos

The clinical safety, biodistribution and internal radiation dosimetry of [¹⁸F]AH113804 in healthy adult volunteers

Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (¹⁸F) Injection in six healthy volunteers (HVs), four males and two females, ...

Authors: E. J. Somer, R. Owenius, A. Wall, G. Antoni, A. Thibblin and J. Sörensen

The effect of isoflurane on ¹⁸F-FDG uptake in the rat brain: a fully conscious dynamic PET study using motion compensation

In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer...

Authors: Matthew G. Spangler-Bickell, Bart de Laat, Roger Fulton, Guy Bormans and Johan Nuyts

Pre-clinical quantitative imaging and mouse-specific dosimetry for ¹¹¹In-labelled radiotracers

Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study...

Authors: Ana M. Denis-Bacelar, Sarah E. Cronin, Chiara Da Pieve, Rowena L. Paul, Sue A. Eccles, Terence J. Spinks, Carol Box, Adrian Hall, Jane K. Sosabowski, Gabriela Kramer-Marek and Glenn D. Flux

Predictive factors of ¹⁸F-choline PET/CT positivity in patients with prostate cancer recurrence after radiation therapy: is the impact of PSA nadir underestimated?

The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with ¹⁸F-choline (CH) PET/CT after external beam radiation therapy (EBRT).

Authors: Alison C. Johnson, Audrey Emmanuelle Dugué, Marlon Silva, Laura Moise, Xavier Tillou, Florence Joly and Nicolas Aide

Improved safety and efficacy of ²¹³Bi-DOTATATE-targeted alpha therapy of somatostatin receptor-expressing neuroendocrine tumors in mice pre-treated with l-lysine

Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with ¹⁷⁷Lu-DOTATATE or ⁹⁰Y-DOTATOC has shown dose-...

Authors: Ho Sze Chan, Mark W. Konijnenberg, Tamara Daniels, Monique Nysus, Mehran Makvandi, Erik de Blois, Wouter A. Breeman, Robert W. Atcher, Marion de Jong and Jeffrey P. Norenberg

Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with ¹⁸F-BCPP-BF

In the present study, 2-tert-butyl-4-chloro-5-[6-(4-¹⁸F-fluorobutoxy)-pyridin-3-ylmethoxy]-2H-pyridazin-3-one (¹⁸F-BCPP-BF), a PET probe for mitochondrial complex I (MC-I), was used to validate whether MC-I is a ...

Authors: Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi and Hideo Tsukada