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  1. The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosim...

    Authors: Guillaume Nodari, Romain Popoff, Jean Marc Riedinger, Olivier Lopez, Julie Pellegrinelli, Inna Dygai-Cochet, Claire Tabouret-Viaud, Benoit Presles, Olivier Chevallier, Sophie Gehin, Matthieu Gallet, Marianne Latournerie, Sylvain Manfredi, Romaric Loffroy, Jean Marc Vrigneaud and Alexandre Cochet
    Citation: EJNMMI Research 2021 11:24
    Content type: Original research Published on:

  2. To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target vol...

    Authors: Macarena Rodríguez-Fraile, Ana Ezponda, Fabiana Grisanti, Verónica Morán, Marta Calvo, Pablo Berián, Antonio Martínez de la Cuesta, Lidia Sancho, Mercedes Iñarrairaegui, Bruno Sangro and José Ignacio Bilbao
    Citation: EJNMMI Research 2021 11:23
    Content type: Original research Published on:

  3. Intraoperative identification of prostate cancer (PCa) lymph node (LN) metastases (LNM) detected by preoperative PSMA PET/CT may be facilitated by PSMA radio-guided surgery (RGS) with use of a γ-probe. Earlier...

    Authors: Michael Mix, Wolfgang Schultze-Seemann, Moritz von Büren, August Sigle, Mohamed A. Omrane, Markus T. Grabbert, Martin Werner, Christian Gratzke, Philipp T. Meyer and Cordula A. Jilg
    Citation: EJNMMI Research 2021 11:22
    Content type: Original research Published on:

  4. [68Ga]Ga-PSMA-11 PET/CT allows for a superior detection of prostate cancer tissue, especially in the context of a low tumor burden. Digital PET/CT bears the potential of reducing scan time duration/administered t...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Maurizio Conti, Axel Wetter, David Kersting, Christoph Rischpler and Pedro Fragoso Costa
    Citation: EJNMMI Research 2021 11:21
    Content type: Original research Published on:

  5. A major challenge to the long-term success of neuroblastoma therapy is widespread metastases that survive initial therapy as minimal residual disease (MRD). The SSTR2 receptor is expressed by most neuroblastom...

    Authors: Jason L. J. Dearling, Ellen M. van Dam, Matthew J. Harris and Alan B. Packard
    Citation: EJNMMI Research 2021 11:20
    Content type: Original research Published on:

  6. To develop and validate a machine learning model based on radiomic features derived from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) images to preoperatively predict...

    Authors: Haiqun Xing, Zhixin Hao, Wenjia Zhu, Dehui Sun, Jie Ding, Hui Zhang, Yu Liu and Li Huo
    Citation: EJNMMI Research 2021 11:19
    Content type: Original research Published on:

  7. Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. While most of the existing literature has been focussed on t...

    Authors: Paul Windisch, Daniel R. Zwahlen, Frederik L. Giesel, Eberhard Scholz, Patrick Lugenbiel, Jürgen Debus, Uwe Haberkorn and Sebastian Adeberg
    Citation: EJNMMI Research 2021 11:18
    Content type: Review Published on:

  8. Adrenocortical carcinoma (ACC) is an uncommon malignancy with an estimated 15,400 new cases annually across the globe. The prognosis is generally poor as the disease is often already advanced at initial diagno...

    Authors: Sen Lu, Jasreman Dhillon, Julie Hallanger Johnson and Ghassan El-Haddad
    Citation: EJNMMI Research 2021 11:17
    Content type: Case report Published on:

  9. The functional 6-[18F]FDOPA positron emission tomography (PET) can be a helpful tool in differentiating parkinsonism with dopaminergic deficiency from clinically similar differential diagnoses. Furthermore, in T2...

    Authors: Enrico Michler, Daniel Kaiser, Kiriaki Eleftheriadou, Björn Falkenburger, Jörg Kotzerke and Sebastian Hoberück
    Citation: EJNMMI Research 2021 11:16
    Content type: Original research Published on:

  10. The aim of this study was to assess the reader variability in quantitatively assessing pre- and post-treatment 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]FDG PET/CT) sc...

    Authors: Joo Hyun O, Su Jin Lim, Hao Wang, Jeffrey P. Leal, Hui-Kuo G. Shu and Richard L. Wahl
    Citation: EJNMMI Research 2021 11:15
    Content type: Original research Published on:

  11. RNA-based vaccination strategies tailoring immune response to specific reactions have become an important pillar for a broad range of applications. Recently, the use of lipid-based nanoparticles opened the pos...

    Authors: Matthias Miederer, Stefanie Pektor, Isabelle Miederer, Nicole Bausbacher, Isabell Sofia Keil, Hossam Hefesha, Heinrich Haas, Ugur Sahin and Mustafa Diken
    Citation: EJNMMI Research 2021 11:14
    Content type: Original research Published on:

  12. We investigated the potential of interim 4′-[methyl-11C]thiothymidine ([11C]4DST) PET for predicting the chemoradiotherapeutic response for head and neck squamous cell carcinoma (HNSCC), in comparison with 2-deox...

    Authors: Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto, Kengo Fujimoto, Yasukage Takami, Hiroshi Hoshikawa, Jun Toyohara and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2021 11:13
    Content type: Original research Published on:

  13. Both prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressive...

    Authors: Mads Ryø Jochumsen, Jens Sörensen, Lars Poulsen Tolbod, Bodil Ginnerup Pedersen, Jørgen Frøkiær, Michael Borre and Kirsten Bouchelouche
    Citation: EJNMMI Research 2021 11:12
    Content type: Original research Published on:

  14. Until now, results evaluating the expression of PSMA in ovarian cancer were sparse and contradictory. The aim was to reinvestigate the feasibility of a PSMA targeted theranostic approach in epithelial ovarian ...

    Authors: Nicolas Aide, Laurent Poulain, Nicolas Elie, Mélanie Briand, Florence Giffard, Cécile Blanc-Fournier, Florence Joly and Charline Lasnon
    Citation: EJNMMI Research 2021 11:11
    Content type: Short communication Published on:

  15. To improve the diagnostic accuracy of axillary lymph node (LN) metastasis in breast cancer patients using 2-[18F]FDG-PET/CT, we constructed an artificial intelligence (AI)-assisted diagnosis system that uses deep...

    Authors: Zongyao Li, Kazuhiro Kitajima, Kenji Hirata, Ren Togo, Junki Takenaka, Yasuo Miyoshi, Kohsuke Kudo, Takahiro Ogawa and Miki Haseyama
    Citation: EJNMMI Research 2021 11:10
    Content type: Original research Published on:

  16. [18F]Fluoromisonidazole ([18F]FMISO) is a PET imaging probe widely used for the detection of hypoxia. We previously reported that [18F]FMISO is metabolized to the glutathione conjugate of the reduced form in hypo...

    Authors: Yoichi Shimizu, Yukihiro Nakai, Hiroyuki Watanabe, Shimpei Iikuni, Masahiro Ono, Hideo Saji, Yuji Kuge, Tsuneo Saga and Yuji Nakamoto
    Citation: EJNMMI Research 2021 11:9
    Content type: Preliminary research Published on:

  17. The purpose of this study was to evaluate both the biodistribution and safety of 64Cu-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-Trastuzumab, a novel 64Cu-labeled positron emission tomography (PET) trace...

    Authors: Inki Lee, Ilhan Lim, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang-Keun Woo, Kwang Il Kim, Kyo Chul Lee, Joo Hyun Kang, Min-Ki Seong, Hyun-Ah Kim, Woo Chul Noh and Sang Moo Lim
    Citation: EJNMMI Research 2021 11:8
    Content type: Original research Published on:

  18. In this descriptive study of male and female mice at different weeks of age, we use serial non-invasive cardiac 18F-FDG-PET scans to follow up on metabolic alterations, heart function parameters, and the ECG o...

    Authors: Maximilian Fischer, Mathias J. Zacherl, Tobias Weinberger, Ludwig Weckbach, Bruno Huber, Christian Schulz, Steffen Massberg, Peter Bartenstein, Sebastian Lehner and Andrei Todica
    Citation: EJNMMI Research 2021 11:7
    Content type: Original research Published on:

  20. [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor r...

    Authors: Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher…
    Citation: EJNMMI Research 2021 11:5
    Content type: Original research Published on:

  21. Positron emission tomography (PET) is routinely used for cancer staging and treatment follow-up. Metabolic active tumor volume (MATV) as well as total MATV (TMATV—including primary tumor, lymph nodes and metas...

    Authors: Elisabeth Pfaehler, Liesbet Mesotten, Gem Kramer, Michiel Thomeer, Karolien Vanhove, Johan de Jong, Peter Adriaensens, Otto S. Hoekstra and Ronald Boellaard
    Citation: EJNMMI Research 2021 11:4
    Content type: Original research Published on:

  22. Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)–targeted positron emission...

    Authors: Jonathan Kuten, Snir Dekalo, Ishai Mintz, Ofer Yossepowitch, Roy Mano and Einat Even-Sapir
    Citation: EJNMMI Research 2021 11:3
    Content type: Original research Published on:

  23. Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [18F]DCFPyL (2-(3-{1-carboxy-5-[(6-...

    Authors: Dae-Myoung Yang, Fiona Li, Glenn Bauman, Joseph Chin, Stephen Pautler, Madeleine Moussa, Irina Rachinsky, John Valliant and Ting-Yim Lee
    Citation: EJNMMI Research 2021 11:2
    Content type: Original research Published on:

  24. The aim of this study was to compare a commercial dosimetry workstation (PLANET® Dose) and the dosimetry approach (GE Dosimetry Toolkit® and OLINDA/EXM® V1.0) currently used in our department for quantificatio...

    Authors: Lore Santoro, L. Pitalot, D. Trauchessec, E. Mora-Ramirez, P. O. Kotzki, M. Bardiès and E. Deshayes
    Citation: EJNMMI Research 2021 11:1
    Content type: Original research Published on:

  25. We investigated the image quality of 11C, 68Ga, 18F and 89Zr, which have different positron fractions, physical half-lifes and positron ranges. Three small animal positron emission tomography/computed tomography ...

    Authors: Jarmo Teuho, Leon Riehakainen, Aake Honkaniemi, Olli Moisio, Chunlei Han, Marko Tirri, Shihao Liu, Tove J. Grönroos, Jie Liu, Lin Wan, Xiao Liang, Yiqing Ling, Yuexuan Hua, Anne Roivainen, Juhani Knuuti, Qingguo Xie…
    Citation: EJNMMI Research 2020 10:155
    Content type: Original research Published on:

  26. 2-deoxy-2-[18F]fluoro-d-glucose’s (FDG) biodistribution limits the evaluation of cardiac sarcoidosis (CS) and neurosarcoidosis (NS). While protocols for cardiac suppression exist, they can be inconvenient for pat...

    Authors: Patrick Martineau, Matthieu Pelletier-Galarneau, Daniel Juneau, Eugene Leung, Pablo Nery, Rob deKemp, Rob Beanlands and David Birnie
    Citation: EJNMMI Research 2020 10:154
    Content type: Original research Published on:

  27. The efficiency of [18F]FDG PET/CT using volume-based indices was evaluated to assess the disease activity and response to therapy in patients with immunoglobulin G4-related disease (IgG4-RD).

    Authors: Katsuya Mitamura, Hanae Arai-Okuda, Yuka Yamamoto, Takashi Norikane, Yasukage Takami, Kengo Fujimoto, Risa Wakiya, Hiroki Ozaki, Hiroaki Dobashi and Yoshihiro Nishiyama
    Citation: EJNMMI Research 2020 10:153
    Content type: Original research Published on:

  28. Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype ...

    Authors: Mohammed Shahid, Juha O. Rinne, Mika Scheinin, Jere Virta, Päivi Marjamäki, Olof Solin, Eveliina Arponen, Jukka Sallinen, Katja Kuokkanen and Juha Rouru
    Citation: EJNMMI Research 2020 10:152
    Content type: Original research Published on:

  29. Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treat...

    Authors: Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian. J. Leeper, Kevin M. Brindle and André A. Neves
    Citation: EJNMMI Research 2020 10:151
    Content type: Original research Published on:

  30. Deriving links between imaging and genomic markers is an evolving field. 2-[18F]FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography–computed tomography) is commonly used for cancer imaging, with maxim...

    Authors: Amin Haghighat Jahromi, Donald A. Barkauskas, Matthew Zabel, Aaron M. Goodman, Garret Frampton, Mina Nikanjam, Carl K. Hoh and Razelle Kurzrock
    Citation: EJNMMI Research 2020 10:150
    Content type: Original research Published on:

  31. Radiohybrid (rh) ligands, a novel class of prostate-specific membrane antigen (PSMA)-targeted radiopharmaceuticals, can be labeled either with [18F]fluorine via isotopic exchange or with radiometals (such as [68G...

    Authors: Alexander Wurzer, Mara Parzinger, Matthias Konrad, Roswitha Beck, Thomas Günther, Veronika Felber, Stefanie Färber, Daniel Di Carlo and Hans-Jürgen Wester
    Citation: EJNMMI Research 2020 10:149
    Content type: Original research Published on:

  32. Stereotactic radiosurgery (SRS) is often the primary treatment modality for patients with intracranial metastatic disease. Despite advances in magnetic resonance imaging, including use of perfusion and diffusi...

    Authors: Ephraim E. Parent, Dhruv Patel, Jonathon A. Nye, Zhuo Li, Jeffrey J. Olson, David M. Schuster and Mark M. Goodman
    Citation: EJNMMI Research 2020 10:148
    Content type: Original research Published on:

  33. Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity...

    Authors: Yusuf Helo, Graham E. Searle, Federica Borghese, Sonya Abraham and Azeem Saleem
    Citation: EJNMMI Research 2020 10:147
    Content type: Short communication Published on:

  34. The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalys...

    Authors: Alice Egerton, Joel T. Dunn, Nisha Singh, Zilin Yu, Jim O’Doherty, Ivan Koychev, Jessica Webb, Simon Claridge, Federico E. Turkheimer, Paul K. Marsden, Alexander Hammers and Antony Gee
    Citation: EJNMMI Research 2020 10:146
    Content type: Original research Published on:

  35. Checkpoint inhibition therapy using monoclonal antibodies against programmed cell death protein 1 (PD-1) or its ligand (PD-L1) is now standard management of non-small cell lung cancer (NSCLC). PD-L1 expression...

    Authors: Daniel Johnathan Hughes, Gitasha Chand, Vicky Goh and Gary J. R. Cook
    Citation: EJNMMI Research 2020 10:145
    Content type: Original research Published on:

  36. Digital PET cameras markedly improve sensitivity and spatial resolution of brain 18F-FDG PET images compared to conventional cameras. Our study aimed to assess whether specific control databases are required to i...

    Authors: Elise Mairal, Matthieu Doyen, Thérèse Rivasseau-Jonveaux, Catherine Malaplate, Eric Guedj and Antoine Verger
    Citation: EJNMMI Research 2020 10:144
    Content type: Original research Published on:

  37. Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following AD...

    Authors: Gaurav Malviya, Rachana Patel, Mark Salji, Rafael S. Martinez, Peter Repiscak, Ernest Mui, Susan Champion, Agata Mrowinska, Emma Johnson, Maha AlRasheedi, Sally Pimlott, David Lewis and Hing Y. Leung
    Citation: EJNMMI Research 2020 10:143
    Content type: Original research Published on:

  38. Deriving individual tumor genomic characteristics from patient imaging analysis is desirable. We explore the predictive value of 2-[18F]FDG uptake with regard to the KRAS mutational status of colorectal adenocarc...

    Authors: M. Popovic, O. Talarico, J. van den Hoff, H. Kunin, Z. Zhang, D. Lafontaine, S. Dogan, J. Leung, E. Kaye, C. Czmielewski, M. E. Mayerhoefer, P. Zanzonico, R. Yaeger, H. Schöder, J. L. Humm, S. B. Solomon…
    Citation: EJNMMI Research 2020 10:142
    Content type: Original research Published on:

  39. In molecular imaging with dynamic PET, the binding and dissociation of a targeted tracer is characterized by kinetics modeling which requires the arterial concentration of the tracer to be measured accurately....

    Authors: Fiona Li, Justin W. Hicks, Lihai Yu, Lise Desjardin, Laura Morrison, Jennifer Hadway and Ting-Yim Lee
    Citation: EJNMMI Research 2020 10:141
    Content type: Original research Published on:

  40. Currently, the evidence on synaptic abnormalities in neuropsychiatric disorders—including obsessive–compulsive disorder (OCD)—is emerging. The newly established positron emission tomography (PET) ligand ((R)-1...

    Authors: Dorien Glorie, Jeroen Verhaeghe, Alan Miranda, Stef De Lombaerde, Sigrid Stroobants and Steven Staelens
    Citation: EJNMMI Research 2020 10:140
    Content type: Original research Published on:

  41. Assessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part of melanoma surgical oncology. The most common technique for sentinel node mapping is preoperative planar sci...

    Authors: Annie K. Kogler, Andrew M. Polemi, Surabhi Nair, Stanislaw Majewski, Lynn T. Dengel, Craig L. Slingluff Jr, Brian Kross, S. J. Lee, J. E. McKisson, John McKisson, Andrew G. Weisenberger, Benjamin L. Welch, Thomas Wendler, Philipp Matthies, Joerg Traub, Michael Witt…
    Citation: EJNMMI Research 2020 10:139
    Content type: Original research Published on:

  42. Clinical management decisions on prostate cancer (PCa) are often based on a determination of risk. 68Ga-prostate-specific membrane antigen (PSMA)-11-positron emission tomography (PET)/computer tomography (CT) is ...

    Authors: Jun-jie Hong, Bo-le Liu, Zhi-qiang Wang, Kun Tang, Xiao-wei Ji, Wei-wei Yin, Jie Lin and Xiang-wu Zheng
    Citation: EJNMMI Research 2020 10:138
    Content type: Original research Published on:

  43. Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts.

    Authors: Silvia Morbelli, Dario Arnaldi, Eugenia Cella, Stefano Raffa, Maria Isabella Donegani, Selene Capitanio, Federico Massa, Alberto Miceli, Laura Filippi, Andrea Chincarini and Flavio Nobili
    Citation: EJNMMI Research 2020 10:137
    Content type: Short communication Published on:

  44. Brown adipose tissue (BAT) is a fat tissue found in most mammals that helps regulate energy balance and core body temperature through a sympathetic process known as non-shivering thermogenesis. BAT activity is...

    Authors: Christian T. McHugh, John Garside, Jared Barkes, Jonathan Frank, Constance Dragicevich, Hong Yuan and Rosa T. Branca
    Citation: EJNMMI Research 2020 10:136
    Content type: Original research Published on:

  45. The study aimed to evaluate the effect of androgen deprivation therapy (ADT) on PSMA imaging and its correlation to the PSA concentration by comparing qualitative and quantitative parameters: SUVmax, SUVmean, PSM...

    Authors: Sebastian Hoberück, Steffen Löck, Robert Winzer, Klaus Zöphel, Michael Froehner, Dieter Fedders, Jörg Kotzerke and Tobias Hölscher
    Citation: EJNMMI Research 2020 10:135
    Content type: Original research Published on:

  46. Asphericity (ASP) of the primary tumor’s metabolic tumor volume (MTV) in FDG-PET/CT is independently predictive for survival in patients with non-small cell lung cancer (NSCLC). However, comparability between ...

    Authors: Julian M. M. Rogasch, Christian Furth, Stephanie Bluemel, Piotr Radojewski, Holger Amthauer and Frank Hofheinz
    Citation: EJNMMI Research 2020 10:134
    Content type: Original research Published on:

  47. As a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemore...

    Authors: Neil Gerard Quigley, Katja Steiger, Frauke Richter, Wilko Weichert, Sebastian Hoberück, Jörg Kotzerke and Johannes Notni
    Citation: EJNMMI Research 2020 10:133
    Content type: Original research Published on:

  48. Prostate-specific membrane antigen (PSMA) agents, such as [68Ga]Ga-PSMA-11, have an unprecedented accuracy in staging prostate cancer (PCa) and detecting disease recurrence. PSMA PET/CT may also be used for respo...

    Authors: Judith olde Heuvel, Berlinda J. de Wit-van der Veen, Maarten L. Donswijk, Cornelis H. Slump and Marcel P. M. Stokkel
    Citation: EJNMMI Research 2020 10:132
    Content type: Original research Published on:

  49. With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson’s disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. ...

    Authors: Jingjie Ge, Min Wang, Wei Lin, Ping Wu, Yihui Guan, Huiwei Zhang, Zhemin Huang, Likun Yang, Chuantao Zuo, Jiehui Jiang, Axel Rominger and Kuangyu Shi
    Citation: EJNMMI Research 2020 10:131
    Content type: Original research Published on:

  50. [177Lu]Lu-DOTA-ZOL has shown promising results from the dosimetry and preclinical aspects, but data on its role in the clinical efficacy are limited. The objective of this study is to evaluate the efficacy and sa...

    Authors: Madhav Prasad Yadav, Sanjana Ballal, Marian Meckel, Frank Roesch and Chandrasekhar Bal
    Citation: EJNMMI Research 2020 10:130
    Content type: Original research Published on:

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