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  1. Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbid...

    Authors: Ralf Bergmann, Marian Meckel, Vojtěch Kubíček, Jens Pietzsch, Jörg Steinbach, Petr Hermann and Frank Rösch
    Citation: EJNMMI Research 2016 6:5
    Content type: Original research Published on:

  2. scVEGF/177Lu is a novel radiopharmaceutical targeted by recombinant single-chain (sc) derivative of vascular endothelial growth factor (VEGF) that binds to and is internalized by vascular endothelial growth facto...

    Authors: Mary Rusckowski, Yuzhen Wang, Francis G. Blankenberg, Zoia Levashova, Marina V. Backer and Joseph M. Backer
    Citation: EJNMMI Research 2016 6:4
    Content type: Original research Published on:

  3. As model system, a solid-tumor patient-derived xenograft (PDX) model characterized by high peptide receptor expression and histological tissue homogeneity was used to study radiopeptide targeting. In this soli...

    Authors: J. C. Haeck, K. Bol, C. M. A. de Ridder, L. Brunel, J. A. Fehrentz, J. Martinez, W. M. van Weerden, M. R. Bernsen, M. de Jong and J. F. Veenland
    Citation: EJNMMI Research 2016 6:3
    Content type: Original research Published on:

  4. 18F-fluorocholine PET/CT is used to detect lymph node metastases in prostate cancer patients. Physiological 18F-fluorocholine in the gastrointestinal tract, especially in the intestine...

    Authors: Maurits Wondergem, Friso M. van der Zant, Remco J. J. Knol, Jan Pruim and Igle J. de Jong
    Citation: EJNMMI Research 2016 6:2
    Content type: Short communication Published on:

  5. The inflammatory nature of atherosclerosis provides a broad range of potential molecular targets for atherosclerosis imaging. Growing interest is focused on targets related to plaque vulnerability such as the ...

    Authors: Romana Meletta, Adrienne Müller Herde, Patrick Dennler, Eliane Fischer, Roger Schibli and Stefanie D. Krämer
    Citation: EJNMMI Research 2016 6:1
    Content type: Original research Published on:

  6. Clinical applicability of newly discovered reagents for molecular imaging is hampered by the lack of translational models. As the dog prostate cancer (DPC-1) model recapitulates in dogs the natural history of ...

    Authors: Simone Chevalier, Serge Moffett, Eric Turcotte, Murillo Luz, Lyne Chauvette, Vilma Derbekyan, Eleonora Scarlata, Fatima Zouanat, Armen G. Aprikian and Maurice Anidjar
    Citation: EJNMMI Research 2015 5:77
    Content type: Original research Published on:

  7. The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 (18F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on mo...

    Authors: U. T. Timur, J. A. van Herwaarden, D. Mihajlovic, P. De Jong, W. Mali and F. L. Moll
    Citation: EJNMMI Research 2015 5:76
    Content type: Review Published on:

  8. Circadian variation of gene expression is often neglected when ionizing radiation-induced effects are studied, whether in animal models or in cell culture. This study characterized diurnal variation of genome-...

    Authors: Britta Langen, Nils Rudqvist, Toshima Z. Parris, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2015 5:75
    Content type: Original research Published on:

  9. 6-[Bis(carboxymethyl)amino]-1,4-bis(carboxymethyl)-6-methyl-1,4-diazepane (AAZTA ) is a promising chelator with potential advantages over 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) for rad...

    Authors: Joachim Pfister, Dominik Summer, Christine Rangger, Milos Petrik, Elisabeth von Guggenberg, Paolo Minazzi, Giovanni B. Giovenzana, Luigi Aloj and Clemens Decristoforo
    Citation: EJNMMI Research 2015 5:74
    Content type: Original research Published on:

  10. The objective of this study is to determine the radiation dosimetry of a novel radiotracer for vesicular acetylcholine transporter (−)-(1-((2R,3R)-8-(2-[18F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2...

    Authors: Morvarid Karimi, Zhude Tu, Xuyi Yue, Xiang Zhang, Hongjun Jin, Joel S. Perlmutter and Richard Laforest
    Citation: EJNMMI Research 2015 5:73
    Content type: Original research Published on:

  11. To investigate whether an apoptotic process demonstrated by 99mTc-annexin-V (99mTc-AV) uptake correlates with left ventricular remodeling (LVR) after myocardial infarction, we assessed 99mTc-AV uptake in rat mode...

    Authors: Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Kazuhiro Shiba, Ichiro Matsunari and Seigo Kinuya
    Citation: EJNMMI Research 2015 5:72
    Content type: Original research Published on:

  13. [18F]-tetrafluoroborate is a PET radiotracer taken up by the sodium/iodide symporter (NIS). Albeit the in vivo behavior in rodents is similar to the 99mTc-pertechnetate, no studies exist in primates or in humans....

    Authors: J. M. Marti-Climent, M. Collantes, M. Jauregui-Osoro, G. Quincoces, E. Prieto, I. Bilbao, M. Ecay, J. A. Richter and I. Peñuelas
    Citation: EJNMMI Research 2015 5:70
    Content type: Original research Published on:

  14. Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an addi...

    Authors: Alexander S. G. O’Neill, Samantha Y. A. Terry, Kathryn Brown, Lucy Meader, Andrew M. S. Wong, Jonathan D. Cooper, Paul R. Crocker, Wilson Wong and Gregory E. D. Mullen
    Citation: EJNMMI Research 2015 5:69
    Content type: Original research Published on:

  15. The relevance of prostate-specific membrane antigen (PSMA) targeting in the clinical management of prostate cancer (PCa) is continually increasing, entailing the development of PSMA-targeted molecular probes. ...

    Authors: Margret Schottelius, Martina Wirtz, Matthias Eiber, Tobias Maurer and Hans-Jürgen Wester
    Citation: EJNMMI Research 2015 5:68
    Content type: Short communication Published on:

  17. Prostate-specific membrane antigen (PSMA) is a promising target for diagnostics and therapy of prostate carcinoma (PCa). Based on the hypothesis that PSMA expression can be modulated by variations in androgen ...

    Authors: B. Meller, F. Bremmer, C. O. Sahlmann, S. Hijazi, C. Bouter, L. Trojan, J. Meller and P. Thelen
    Citation: EJNMMI Research 2015 5:66
    Content type: Original research Published on:

  18. The pathogenesis and immune response to Middle East respiratory syndrome (MERS) caused by a recently discovered coronavirus, MERS-CoV, have not been fully characterized because a suitable animal model is curre...

    Authors: Svetlana Chefer, David Thomasson, Jurgen Seidel, Richard C. Reba, J. Kyle Bohannon, Mathew G. Lackemeyer, Chris Bartos, Philip J. Sayre, Laura Bollinger, Lisa E. Hensley, Peter B. Jahrling and Reed F. Johnson
    Citation: EJNMMI Research 2015 5:65
    Content type: Original research Published on:

  19. Accurate alignment between histopathology slices and positron emission tomography (PET) images is important for radiopharmaceutical validation studies. Limited data is available on the registration accuracy th...

    Authors: Tanuj Puri, Anastasia Chalkidou, Rhonda Henley-Smith, Arunabha Roy, Paul R. Barber, Teresa Guerrero-Urbano, Richard Oakley, Ricard Simo, Jean-Pierre Jeannon, Mark McGurk, Edward W. Odell, Michael J. O’Doherty and Paul K. Marsden
    Citation: EJNMMI Research 2015 5:64
    Content type: Original research Published on:

  20. Cadmium zinc telluride (CZT) solid-state detectors have been recently introduced in the field of nuclear medicine in cardiology and breast imaging. The aim of the current study was to evaluate the performance ...

    Authors: Victoria Koulikov, Hedva Lerman, Mikhail Kesler and Einat Even-Sapir
    Citation: EJNMMI Research 2015 5:63
    Content type: Original research Published on:

  21. Successful treatments of patients with somatostatin receptor (SSTR)-overexpressing neuroendocrine tumours (NET) comprise somatostatin-analogue lutetium-177-labelled octreotate (177Lu-TATE) treatment, also referre...

    Authors: Sander M. Bison, Joost C. Haeck, K. Bol, S. J. Koelewijn, H. C. Groen, M. Melis, J. F. Veenland, M. R. Bernsen and M. de Jong
    Citation: EJNMMI Research 2015 5:62
    Content type: Original research Published on:

  22. Tail vein injection under short anesthesia is the most commonly used route for administering radiopharmaceuticals. However, the small caliber of the vein in rodents may lead to tracer extravasation and thereby...

    Authors: Charline Lasnon, Audrey Emmanuelle Dugué, Mélanie Briand, Soizic Dutoit and Nicolas Aide
    Citation: EJNMMI Research 2015 5:61
    Content type: Original research Published on:

  23. Hybrid PET/optical imaging provides quantitative and complementary information for diagnosis of tumors. Herein, we developed a 64Cu-labeled AlexaFluor 680-streptavidin ((AF)SAv)/biotin-based dimeric cyclic RGD pe...

    Authors: Choong Mo Kang, Hyun-Jung Koo, Gwang Il An, Yearn Seong Choe, Joon Young Choi, Kyung-Han Lee and Byung-Tae Kim
    Citation: EJNMMI Research 2015 5:60
    Content type: Original research Published on:

  24. 131I and 211At are used in nuclear medicine and accumulate in the thyroid gland and may impact normal thyroid function. The aim of this study was to determine transcriptional profile v...

    Authors: Nils Rudqvist, Johan Spetz, Emil Schüler, Britta Langen, Toshima Z. Parris, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2015 5:59
    Content type: Original research Published on:

  25. The goal of the study is to investigate 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET)’s ability to delineate the viable portion of a tumor in an animal model using cross-sectional histology as...

    Authors: Ingrid Wu, Hao Wang, David Huso and Richard L. Wahl
    Citation: EJNMMI Research 2015 5:58
    Content type: Original research Published on:

  26. Non-invasive measurement of tumor hypoxia has demonstrated potential for the evaluation of disease progression, as well as prediction and assessment of treatment outcome. [18F]fluoroazomycin arabinoside (FAZA) po...

    Authors: Jinzi Zheng, Stephan G. Klinz, Raquel De Souza, Jonathan Fitzgerald and David A. Jaffray
    Citation: EJNMMI Research 2015 5:57
    Content type: Original research Published on:

  27. Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-asso...

    Authors: Edit Bosnyák, David O. Kamson, Michael E. Behen, Geoffrey R. Barger, Sandeep Mittal and Csaba Juhász
    Citation: EJNMMI Research 2015 5:56
    Content type: Original research Published on:

  28. This feasibility study established an experimental protocol to evaluate brain activation patterns using fluorodeoxyglucose positron emission tomography ((18F)FDG-PET) during volume-induced voiding and isovolum...

    Authors: Yves Deruyver, Roma Rietjens, Jan Franken, Silvia Pinto, Ann Van Santvoort, Cindy Casteels, Thomas Voets and Dirk De Ridder
    Citation: EJNMMI Research 2015 5:55
    Content type: Original research Published on:

  29. The purpose of this study is to evaluate the impact of switching from sterile water to 5 % glucose (G5W) for the administration of yttrium-90 (90Y)-resin microspheres on the total activity of 90Y administered (ex...

    Authors: Hojjat Ahmadzadehfar, Carsten Meyer, Claus Christian Pieper, Ralph Bundschuh, Marianne Muckle, Florian Gärtner, Hans Heinz Schild and Markus Essler
    Citation: EJNMMI Research 2015 5:54
    Content type: Original research Published on:

  30. To assess the role of somatostatin receptor (SR) PET/CT using Ga-68 DOTATOC or DOTATATE in staging and restaging of typical (TC) and atypical (AC) lung carcinoids.

    Authors: Vikas Prasad, Ingo G. Steffen, Marianne Pavel, Timm Denecke, Elisabeth Tischer, Konstantina Apostolopoulou, Andreas Pascher, Ruza Arsenic and Winfried Brenner
    Citation: EJNMMI Research 2015 5:53
    Content type: Original research Published on:

  31. Ge/68Ga generators provide an inexpensive source of a PET isotope to hospitals without cyclotron facilities. The development of new 68Ga-based molecular imaging agents and subsequent clinical translation would be...

    Authors: Michelle T. Ma, Carleen Cullinane, Kelly Waldeck, Peter Roselt, Rodney J. Hicks and Philip J. Blower
    Citation: EJNMMI Research 2015 5:52
    Content type: Preliminary research Published on:

  32. Myocardial perfusion gated single photon emission computed tomography (SPECT) can be used for non-invasive detection of coronary artery stenosis and cardiac allograft vasculopathy (CAV), which is a crucial fac...

    Authors: Christian Wenning, Alexis Vrachimis, Angelo Dell´Aquila, Alvyda Penning, Jörg Stypmann and Michael Schäfers
    Citation: EJNMMI Research 2015 5:51
    Content type: Original research Published on:

  33. We found that 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) uptake in malignant lesion was enhanced, and it was decreased in the inflammatory lesion after the use of peroxisome proliferator activated receptor-γ (PPAR-...

    Authors: Yeon-Hee Han, Seong Young Kwon, Jeonghun Kim, Chang Ju Na, Sehun Choi, Jung-Joon Min, Hee-Seung Bom, Young-Chul Kim, In-Jae Oh, Han-Jung Chae, Seok Tae Lim, Myung-Hee Sohn and Hwan-Jeong Jeong
    Citation: EJNMMI Research 2015 5:50
    Content type: Original research Published on:

  34. This study aims to further evaluate the specificity and selectivity of [18F]FTC-146 and obtain additional data to support its clinical translation.

    Authors: Bin Shen, Michelle L. James, Lauren Andrews, Christopher Lau, Stephanie Chen, Mikael Palner, Zheng Miao, Natasha C. Arksey, Adam J. Shuhendler, Shawn Scatliffe, Kota Kaneshige, Stanley M. Parsons, Christopher R. McCurdy, Ahmad Salehi, Sanjiv S. Gambhir and Frederick T. Chin
    Citation: EJNMMI Research 2015 5:49
    Content type: Original research Published on:

  35. Reducing scan-time while maintaining sufficient image quality is a common issue in nuclear medicine diagnostics. This matter can be addressed by different post-processing methods such as Pixon® image processin...

    Authors: Oscar Ardenfors, Ulrika Svanholm, Hans Jacobsson, Patricia Sandqvist, Per Grybäck and Cathrine Jonsson
    Citation: EJNMMI Research 2015 5:48
    Content type: Original research Published on:

  36. Immune cells within the tumor can act either to promote growth or rejection of tumor cells. The aim of the present study was to evaluate immune cell markers (number and localization) within the tumor before an...

    Authors: Erika Elgström, Sophie E. Eriksson, Otto Ljungberg, Pär-Ola Bendahl, Tomas G. Ohlsson, Rune Nilsson and Jan Tennvall
    Citation: EJNMMI Research 2015 5:47
    Content type: Original research Published on:

  37. Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited ...

    Authors: Beatriz Salinas, Christopher P. Irwin, Susanne Kossatz, Alexander Bolaender, Gabriela Chiosis, Nagavarakishore Pillarsetty, Wolfgang A. Weber and Thomas Reiner
    Citation: EJNMMI Research 2015 5:46
    Content type: Original research Published on:

  38. Nucleoside analogs labeled with positrons, such as 11C and 18F, are considered valuable in visualizing the proliferative activity of tumor cells in vivo using positron emission tomography (PET). We recently devel...

    Authors: Tsuyoshi Tahara, Zhouen Zhang, Masahiro Ohno, Yukako Hirao, Nami Hosaka, Hisashi Doi, Masaaki Suzuki and Hirotaka Onoe
    Citation: EJNMMI Research 2015 5:45
    Content type: Research Article Published on:

  39. Non-invasive imaging of peritoneal carcinomatosis remains challenging. The aim of this study was to compare positron emission tomography (PET) and bioluminescence imaging (BLI) for the early detection of perit...

    Authors: J. Stollfuss, N. Landvogt, M. Abenstein, S. Ziegler, M. Schwaiger, R. Senekowitsch-Schmidtke and H. Wieder
    Citation: EJNMMI Research 2015 5:44
    Content type: Original research Published on:

  40. Fluorescent imaging agents are becoming evermore important in preclinical and clinical research. They do, however, suffer from poor tissue penetration, which makes optical fluorescence imaging incompatible wit...

    Authors: Andreas Paulus, Pooja Desai, Brandon Carney, Giuseppe Carlucci, Thomas Reiner, Christian Brand and Wolfgang A Weber
    Citation: EJNMMI Research 2015 5:43
    Content type: Original research Published on:

  41. The interpretation of myocardial perfusion scintigraphy (MPS) largely relies on visual assessment by the physician of the localization and extent of a perfusion defect. The aim of this study was to introduce t...

    Authors: David Minarik, Martin Senneby, Per Wollmer, Alva Mansten, Karl Sjöstrand, Lars Edenbrandt and Elin Trägårdh
    Citation: EJNMMI Research 2015 5:42
    Content type: Original research Published on:

  42. Agonist positron emission tomography (PET) tracers for dopamine D2/3 receptors (D2/3Rs) offer greater sensitivity to changes in endogenous dopamine levels than D2/3R antagonist tracers. D2/3R agonist tracers curr...

    Authors: Vladimir Shalgunov, Jan-Peter van Wieringen, Henk M. Janssen, P. Michel Fransen, Rudi A.J.O. Dierckx, Martin C. Michel, Jan Booij and Philip H. Elsinga
    Citation: EJNMMI Research 2015 5:41
    Content type: Original research Published on:

  43. This study evaluated the absorption, distribution, and excretion of Gallium-68 (68Ga) radionuclide after a single intravenous (i.v.) injection of 68Ge/68Ga generator eluate in healthy rats. Additionally, human ra...

    Authors: Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs and Anne Roivainen
    Citation: EJNMMI Research 2015 5:40
    Content type: Original research Published on:

    The Erratum to this article has been published in EJNMMI Research 2016 6:51

  44. We aimed to evaluate and define the general clinical applicability and impact of pulmonary radioaerosol mucociliary clearance (PRMC) on the work up of patients suspected of having primary ciliary dyskinesia (P...

    Authors: Mathias Munkholm, Kim Gjerum Nielsen and Jann Mortensen
    Citation: EJNMMI Research 2015 5:39
    Content type: Original research Published on:

  45. Reactive oxygen species (ROS) have been implicated in cisplatin-induced nephrotoxicity. The aim of this study was to investigate the potential of using [3H]-labeled N-methyl-2,3-diamino-6-phenyl-dihydrophenanthri...

    Authors: Nozomi Takai, Kohji Abe, Misato Tonomura, Natsumi Imamoto, Kazumi Fukumoto, Miwa Ito, Sotaro Momosaki, Kae Fujisawa, Kenji Morimoto, Nobuo Takasu and Osamu Inoue
    Citation: EJNMMI Research 2015 5:38
    Content type: Research Article Published on:

  46. Reactive oxygen species (ROS) have been implicated in the pathophysiology of the brain after ischemic stroke. In this study, we investigate the generation of brain ROS after transient focal ischemia in mice us...

    Authors: Kohji Abe, Misato Tonomura, Miwa Ito, Nozomi Takai, Natsumi Imamoto, Takemi Rokugawa, Sotaro Momosaki, Kazumi Fukumoto, Kenji Morimoto and Osamu Inoue
    Citation: EJNMMI Research 2015 5:37
    Content type: Original research Published on:

  47. Radioligand therapy (RLT) with 177Lu-DKFZ-617 PSMA (Lu-PSMA) (prostate-specific membrane antigen) is a novel targeted therapy of metastatic prostate cancer. We analysed retrospectively the early side effects and ...

    Authors: Hojjat Ahmadzadehfar, Kambiz Rahbar, Stefan Kürpig, Martin Bögemann, Michael Claesener, Elisabeth Eppard, Florian Gärtner, Sebastian Rogenhofer, Michael Schäfers and Markus Essler
    Citation: EJNMMI Research 2015 5:36
    Content type: Research Article Published on:

  48. Compartmental analysis is a standard method to quantify metabolic processes using fluorodeoxyglucose-positron emission tomography (FDG-PET). For liver studies, this analysis is complex due to the hepatocyte ca...

    Authors: Sara Garbarino, Valentina Vivaldi, Fabrice Delbary, Giacomo Caviglia, Michele Piana, Cecilia Marini, Selene Capitanio, Iolanda Calamia, Ambra Buschiazzo and Gianmario Sambuceti
    Citation: EJNMMI Research 2015 5:35
    Content type: Original research Published on:

  49. The norepinephrine transporter (NET) has been demonstrated to be relevant to a multitude of neurological, psychiatric and cardiovascular pathologies. Due to the wide range of possible applications for PET imag...

    Authors: Christina Rami-Mark, Neydher Berroterán-Infante, Cecile Philippe, Stefanie Foltin, Chrysoula Vraka, Alexander Hoepping, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser and Wolfgang Wadsak
    Citation: EJNMMI Research 2015 5:34
    Content type: Original research Published on:

  50. PET radiopharmaceuticals capable of imaging β-amyloid (Aβ) plaque burden in the brain could offer highly valuable diagnostic tools for clinical studies of Alzheimer’s disease. To further supplement existing ar...

    Authors: Guruswami SM Sundaram, Dhruva Dhavale, Julie L Prior, Jothilingam Sivapackiam, Richard Laforest, Paul Kotzbauer and Vijay Sharma
    Citation: EJNMMI Research 2015 5:33
    Content type: Original research Published on:

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