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  1. Positron emission tomography (PET) imaging with 68Gallium labeled somatostatin analogues (68Ga-DOTA-SSA) plays a key role in neuroendocrine tumor management. The impact of patient size on PET image quality is not...

    Authors: Christina P. W. Cox, Marcel Segbers, Laura H. Graven, Tessa Brabander and Daniëlle M. E. van Assema
    Citation: EJNMMI Research 2020 10:27
  2. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease leading to neuromuscular palsy and death. We propose a computational approach to [18F]-fluorodeoxyglucose (FDG) PET/CT images to analyze the s...

    Authors: Matteo Bauckneht, Rita Lai, Alberto Miceli, Daniela Schenone, Vanessa Cossu, Maria Isabella Donegani, Stefano Raffa, Anna Borra, Stefano Marra, Cristina Campi, Annamaria Orengo, Anna Maria Massone, Alberto Tagliafico, Claudia Caponnetto, Corrado Cabona, Angelina Cistaro…
    Citation: EJNMMI Research 2020 10:23
  3. High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high recepto...

    Authors: Ali Alhuseinalkhudhur, Mark Lubberink, Henrik Lindman, Vladimir Tolmachev, Fredrik Y. Frejd, Joachim Feldwisch, Irina Velikyan and Jens Sörensen
    Citation: EJNMMI Research 2020 10:21
  4. Functional somatic syndrome (FSS) is a disorder characterized by clusters of medically unexplained symptoms. Some women suffer from persistent FSS after human papillomavirus (HPV) vaccination. However, a causa...

    Authors: Takashi Matsudaira, Tatsuhiro Terada, Tomokazu Obi, Masamichi Yokokura, Yukitoshi Takahashi and Yasuomi Ouchi
    Citation: EJNMMI Research 2020 10:29
  5. Anal cancer is a relatively rare tumor of which incidence increases in developed countries. 18F-FDG PET has been increasingly used for its post radio-chemotherapy evaluation. However, several authors have reporte...

    Authors: Nicolas Aide, Laure-Eugénie Tainturier, Cathy Nganoa, Benjamin Houdu, Jennifer Kammerer, Marie-Pierre Galais, Renaud Ciappuccini and Charline Lasnon
    Citation: EJNMMI Research 2020 10:28
  6. Dosimetry for diagnostic agents is performed to assess the risk of radiation detriment (e.g., cancer) associated with the imaging agent and the risk is assessed by computing the effective dose coefficient, e. Sty...

    Authors: Anders Josefsson, Klaikangwol Siritantikorn, Sagar Ranka, Jose Willegaignon de Amorim de Carvalho, Carlos Alberto Buchpiguel, Marcelo Tatit Sapienza, Wesley E. Bolch and George Sgouros
    Citation: EJNMMI Research 2020 10:26
  7. [18F]AmBF3-TATE is a somatostatin agonist that selectively binds to somatostatin receptor subtype 2 (SSTR2). For clinical translation, pharmacokinetics, radiation dosimetry, and acute toxicity of [18F]AmBF3-TATE ...

    Authors: Joseph Lau, Jinhe Pan, Etienne Rousseau, Carlos F. Uribe, Sudhakara Reddy Seelam, Brent W. Sutherland, David M. Perrin, Kuo-Shyan Lin and François Bénard
    Citation: EJNMMI Research 2020 10:25
  8. Anti-programmed cell death 1 (PD-1) antibody is an immune checkpoint inhibitor, and anti-PD-1 therapy improves the anti-tumor functions of T cells and affects tumor microenvironment. We previously reported tha...

    Authors: Mayu Tomita, Motofumi Suzuki, Yusuke Kono, Kohei Nakajima, Takuma Matsuda, Yuji Kuge and Mikako Ogawa
    Citation: EJNMMI Research 2020 10:24
  9. It is well known that a severe cell injury after exposure to ionizing radiation is the induction of DNA double-strand breaks (DSBs). After exposure, an early response to DSBs is the phosphorylation of the hist...

    Authors: Anna Stenvall, Erik Larsson, Bo Holmqvist, Sven-Erik Strand and Bo-Anders Jönsson
    Citation: EJNMMI Research 2020 10:22
  10. Previous studies found that [18F]LSN3316612 was a promising positron emission tomography (PET) radioligand for imaging O-GlcNAcase in nonhuman primates and human volunteers. This study sought to further evaluate ...

    Authors: Jae-Hoon Lee, Jeih-San Liow, Soumen Paul, Cheryl L. Morse, Mohammad B. Haskali, Lester Manly, Sergey Shcherbinin, J. Craig Ruble, Nancy Kant, Emily C. Collins, Hugh N. Nuthall, Paolo Zanotti-Fregonara, Sami S. Zoghbi, Victor W. Pike and Robert B. Innis
    Citation: EJNMMI Research 2020 10:20
  11. Lipopolysaccharide (LPS) is a classic immune stimulus. LPS combined with positron emission tomography (PET) 18 kDa translocator protein (TSPO) brain imaging provides a robust human laboratory model to study ne...

    Authors: Eric A. Woodcock, Martin Schain, Kelly P. Cosgrove and Ansel T. Hillmer
    Citation: EJNMMI Research 2020 10:19
  12. Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients be...

    Authors: Lisa H. de Vries, Lutske Lodewijk, Arthur J. A. T. Braat, Gerard C. Krijger, Gerlof D. Valk, Marnix G. E. H. Lam, Inne H. M. Borel Rinkes, Menno R. Vriens and Bart de Keizer
    Citation: EJNMMI Research 2020 10:18
  13. Identification of suspicious PSMA-PET/CT-positive lymph node (LN) metastases (LNM) from prostate cancer (PCa) during lymphadenectomy (LA) is challenging. We evaluated an 111In-labelled PSMA ligand (DKFZ-617, refe...

    Authors: Cordula A. Jilg, Kathrin Reichel, Christian Stoykow, H. Christian Rischke, Mark Bartholomä, Vanessa Drendel, Moritz von Büren, Wolfgang Schultze-Seemann, Philipp T. Meyer and Michael Mix
    Citation: EJNMMI Research 2020 10:17
  14. Targeting G protein-coupled receptors on the surface of cancer cells with peptide ligands is a promising concept for the selective tumor delivery of therapeutically active cargos, including radiometals for tar...

    Authors: Adrien Chastel, Dennis J. Worm, Isabel D. Alves, Delphine Vimont, Melina Petrel, Samantha Fernandez, Philippe Garrigue, Philippe Fernandez, Elif Hindié, Annette G. Beck-Sickinger and Clément Morgat
    Citation: EJNMMI Research 2020 10:16
  15. Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aim...

    Authors: Céline Derwael, Olivier Lavergne, Pierre Lovinfosse, Vlad Nechifor, Mallory Salvé, David Waltregny, Roland Hustinx and Nadia Withofs
    Citation: EJNMMI Research 2020 10:15
  16. Several scan parameters for PET imaging with 18F-PSMA-11 such as dosage, acquisition time and scan duration were evaluated to determine the most appropriate scan protocol, as well as the effect of furosemide admi...

    Authors: Sarah Piron, Kathia De Man, Vanessa Schelfhout, Nick Van Laeken, Ken Kersemans, Eric Achten, Filip De Vos and Piet Ost
    Citation: EJNMMI Research 2020 10:14
  17. Cancer stem cells (CSCs) are involved in drug resistance, metastasis, and relapse of cancers, which can significantly affect tumor therapy. Hence, to develop specifically therapeutic target probe at CSCs for i...

    Authors: Siao-Syun Guan, Cheng-Tien Wu, Tse-Zung Liao, Tsai-Yueh Luo, Kun-Liang Lin and Shing-Hwa Liu
    Citation: EJNMMI Research 2020 10:13
  18. The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET i...

    Authors: Anna Ringheim, Guilherme de Carvalho Campos Neto, Udunna Anazodo, Lumeng Cui, Marcelo Livorsi da Cunha, Taise Vitor, Karine Minaif Martins, Ana Cláudia Camargo Miranda, Marycel Figols de Barboza, Leonardo Lima Fuscaldi, Gustavo Caserta Lemos, José Roberto Colombo Junior and Ronaldo Hueb Baroni
    Citation: EJNMMI Research 2020 10:12
  19. The undifferentiated embryonic sarcoma of the liver (UESL) is a rare, aggressive tumor mainly affecting children. Since UESL has no specific clinical symptoms or imaging characteristics, many cases of UESL are...

    Authors: Regine Mariette Perl, Almut Häring, Marius Stefan Horger, Christina Pfannenberg and Sergios Gatidis
    Citation: EJNMMI Research 2020 10:11
  20. Targeted alpha therapy (TAT) is a promising treatment for micrometastatic and minimal residual cancer. We evaluated systemic α-radioimmunotherapy (α-RIT) of metastatic castration-resistant prostate cancer (mCR...

    Authors: Tom A. Bäck, Karin Jennbacken, Malin Hagberg Thulin, Sture Lindegren, Holger Jensen, Tove Olafsen, Paul J. Yazaki, Stig Palm, Per Albertsson, Jan-Erik Damber, Anna M. Wu and Karin Welén
    Citation: EJNMMI Research 2020 10:10
  21. Chronic kidney disease (CKD) is associated with endothelial dysfunction and increased cardiovascular mortality. Endothelial dysfunction can be studied measuring myocardial perfusion reserve (MPR). MPR is the r...

    Authors: Johanna Päivärinta, Kaj Metsärinne, Eliisa Löyttyniemi, Jarmo Teuho, Tuula Tolvanen, Juhani Knuuti and Niina Koivuviita
    Citation: EJNMMI Research 2020 10:9
  22. There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and per...

    Authors: Stephanus T. Malherbe, Ray Y. Chen, Patrick Dupont, Ilse Kant, Magdalena Kriel, André G. Loxton, Bronwyn Smith, Caroline G. G. Beltran, Susan van Zyl, Shirely McAnda, Charmaine Abrahams, Elizna Maasdorp, Alex Doruyter, Laura E. Via, Clifton E. Barry III, David Alland…
    Citation: EJNMMI Research 2020 10:8
  23. Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of ...

    Authors: Mohamed Altai, Javad Garousi, Sara S. Rinne, Alexey Schulga, Sergey Deyev and Anzhelika Vorobyeva
    Citation: EJNMMI Research 2020 10:7
  24. The aim of this study was the validation of a recently established comprehensive and compact prediction model for 68Ga-PSMA-11-ligand positron-emission tomography (PET) positivity with an independent subsequent p...

    Authors: Pia Kraft, Tobias Maurer, Andrei Gafita, Markus Krönke, Bernhard Haller, Wolfgang A. Weber, Matthias Eiber and Isabel Rauscher
    Citation: EJNMMI Research 2020 10:6
  25. Positron emission tomography (PET) is increasingly applied for in vivo brown adipose tissue (BAT) research in healthy volunteers. To limit the radiation exposure, the injected 18F-FDG tracer dose should be as low...

    Authors: Edwin E. G. W. ter Voert, Hanna Svirydenka, Julian Müller, Anton S. Becker, Miroslav Balaz, Vissarion Efthymiou, Claudia Irene Maushart, Gani Gashi, Christian Wolfrum, Matthias J. Betz and Irene A. Burger
    Citation: EJNMMI Research 2020 10:5
  26. 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated at the γ-glutamyl residue with fluorophores and radio-isotopes is able to image dead and dying cells in vitro and in vivo by binding...

    Authors: Ivan Ho Shon, Divesh Kumar, Chithradevi Sathiakumar, Paula Berghofer, Khang Van, Andrew Chicco and Philip J. Hogg
    Citation: EJNMMI Research 2020 10:4
  27. Patients with atrial fibrillation (AF) and dementia experience reduced quality of life and increased mortality. Technetium 99m ECD brain perfusion single-photon emission computed tomography (99mTc-ECD brain perfu...

    Authors: Hidenobu Hashimoto, Rine Nakanishi, Sunao Mizumura, Yukiko Hashimoto, Yuriko Okamura, Kyoko Yamanaka and Takanori Ikeda
    Citation: EJNMMI Research 2020 10:3
  28. Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still ne...

    Authors: Elodie Jouberton, Sébastien Schmitt, Emmanuel Chautard, Aurélie Maisonial-Besset, Marie Roy, Nina Radosevic-Robin, Jean-Michel Chezal, Elisabeth Miot-Noirault, Yann Bouvet and Florent Cachin
    Citation: EJNMMI Research 2020 10:2
  29. To propose a personalized therapeutic approach in osteosarcoma treatment, we assessed whether sequential [18F]FDG PET/CT (PET/CT) could predict the outcome of patients with osteosarcoma of the extremities after o...

    Authors: Inki Lee, Byung Hyun Byun, Ilhan Lim, Byung Il Kim, Chang Woon Choi, Jae-Soo Koh, Won Seok Song, Wan Hyeong Cho, Chang-Bae Kong and Sang Moo Lim
    Citation: EJNMMI Research 2020 10:1
  30. The aim of this study was to evaluate the diagnostic efficacy of 18F-fluorocholine (18F-FCH) PET/CT for uremic hyperparathyroidism (uHPT) compared to 99mTc-sestaMIBI SPECT/CT and ultrasonography (US).

    Authors: Yu Xue, Wenbo Li, Zhu Xia, Chengming Lei, Yiyi Cao, Zhengjie Wang and Hua Pang
    Citation: EJNMMI Research 2019 9:118
  31. We aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR).

    Authors: Alain Manrique, David Dudoignon, Stéphanie Brun, Catherine N’Ganoa, Emmanuelle Cassol, Damien Legallois, Yoan Lavie-Badie, Denis Agostini and Olivier Lairez
    Citation: EJNMMI Research 2019 9:117
  32. Predicting the aggressive behavior of non-functional pancreatic neuroendocrine tumors (NF-PNET) remains controversial. We wanted to explore, in a prospective setting, whether the diagnostic accuracy can be imp...

    Authors: Susanna Majala, Hanna Seppänen, Jukka Kemppainen, Jari Sundström, Camilla Schalin-Jäntti, Risto Gullichsen, Jukka Schildt, Harri Mustonen, Tiina Vesterinen, Johanna Arola and Saila Kauhanen
    Citation: EJNMMI Research 2019 9:116
  33. In clinical routine, SUVmax and SUVpeak are most often used to determine the glucose metabolism in tumours by 18F-FDG PET/CT. Both metrics can be further normalised to SUVs in reference regions resulting in a SUV...

    Authors: Janusch Blautzik, Leonie Grelich, Nicolai Schramm, Rebecca Henkel, Peter Bartenstein and Thomas Pfluger
    Citation: EJNMMI Research 2019 9:115
  34. Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may...

    Authors: Elodie A. Pérès, Jérôme Toutain, Louis-Paul Paty, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Louisa Barré, Aurélien Vidal, Michel Cherel, Mickaël Bourgeois, Myriam Bernaudin and Samuel Valable
    Citation: EJNMMI Research 2019 9:114
  35. While the aetiology of rheumatoid arthritis (RA) remains unclear, many of the inflammatory components are well characterised. For diagnosis and therapy evaluation, in vivo insight into these processes would be...

    Authors: Marius de Groot, Neel Patel, Roido Manavaki, Robert L. Janiczek, Mats Bergstrom, Andrew Östör, Danielle Gerlag, Alexandra Roberts, Martin J. Graves, Yakshitha Karkera, Disala Fernando, Prafull Mistry, Adam Walker, Nicolas Wisniacki, Tim D. Fryer and Pilar Jimenez-Royo
    Citation: EJNMMI Research 2019 9:113
  36. Radiation pneumonitis is a common and potentially fatal complication of radiotherapy (RT). Some patients with radiation pneumonitis show increases in uptake of fluorodeoxyglucose (FDG) on positron emission tom...

    Authors: Meiying Guo, Liang Qi, Yun Zhang, Dongping Shang, Jinming Yu and Jinbo Yue
    Citation: EJNMMI Research 2019 9:112
  37. Decreased cerebral glucose metabolism has been reported in idiopathic normal pressure hydrocephalus (iNPH). However, the timing of appearance in the preclinical stage of iNPH remains unknown. Herein, we evalua...

    Authors: Koichi Miyazaki, Kohei Hanaoka, Hayato Kaida, Yasutaka Chiba and Kazunari Ishii
    Citation: EJNMMI Research 2019 9:111
  38. P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which effectively restrict the brain distribution of the majority of current...

    Authors: Beatrix Wulkersdorfer, Martin Bauer, Rudolf Karch, Harald Stefanits, Cécile Philippe, Maria Weber, Thomas Czech, Marie-Claude Menet, Xavier Declèves, Johannes A. Hainfellner, Matthias Preusser, Marcus Hacker, Markus Zeitlinger, Markus Müller and Oliver Langer
    Citation: EJNMMI Research 2019 9:110
  39. For differentiating tumor from inflammation and normal tissues, fluorodeoxyglucose ([18F]FDG) dual time point PET could be helpful. Albeit [18F]FLT is more specific for tumors than [18F]FDG; we explored the role ...

    Authors: Pierre Lovinfosse, Caroline Rousseau, Jean-Yves Pierga, Francis Bouchet, Alexandre Cochet, Jean-Louis Alberini, Sylvie Girault, Pierre Vera, Pierre Olivier, Lionel Uwer, Florent Cachin, Benoit Scarwell, Jérome Lemonnier, Emmanuelle Fourme, Christel Mesleard, Anne-Laure Martin…
    Citation: EJNMMI Research 2019 9:109
  40. In colorectal cancer, survival of patients is drastically reduced when complete resection is hampered by involvement of critical structures. Targeted photodynamic therapy (tPDT) is a local and targeted therapy...

    Authors: Fortuné M. K. Elekonawo, Desirée L. Bos, David M. Goldenberg, Otto C. Boerman and Mark Rijpkema
    Citation: EJNMMI Research 2019 9:108
  41. Following publication of the original article [1], the authors have reported an error in the ‘Histopathology’ (under ‘Materials and methods’) section of the article that compromises the reproducibility of the ...

    Authors: Johannes Notni, Florian T. Gassert, Katja Steiger, Peter Sommer, Wilko Weichert, Ernst J. Rummeny, Markus Schwaiger, Horst Kessler, Reinhard Meier and Melanie A. Kimm
    Citation: EJNMMI Research 2019 9:107

    The original article was published in EJNMMI Research 2019 9:87

  42. A high SUV-reproducibility is crucial when different PET scanners are in use. We evaluated the SUV variability in whole-body FDG-PET scans of patients with suspected or proven cancer using an EARL-accredited c...

    Authors: Daniëlle Koopman, Pieter L. Jager, Cornelis H. Slump, Siert Knollema and Jorn A. van Dalen
    Citation: EJNMMI Research 2019 9:106
  43. In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and ...

    Authors: Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Marta Cvijic, Georg Schramm, Johan Nuyts, Jens-Uwe Voigt and Olivier Gheysens
    Citation: EJNMMI Research 2019 9:105
  44. We investigated the prognostic predictive value of the combination of fluorodeoxyglucose (FDG)- and fluoromisonidazole (FMISO)-PET in patients with non-small cell lung carcinoma (NSCLC) treated with stereotact...

    Authors: Shiro Watanabe, Tetsuya Inoue, Shozo Okamoto, Keiichi Magota, Ayumi Takayanagi, Jun Sakakibara-Konishi, Norio Katoh, Kenji Hirata, Osamu Manabe, Takuya Toyonaga, Yuji Kuge, Hiroki Shirato, Nagara Tamaki and Tohru Shiga
    Citation: EJNMMI Research 2019 9:104
  45. The aim of this analysis was to investigate whether the standardized uptake value (SUV) normalized by lean body mass (SUL) is a more appropriate quantitative parameter compared to the commonly used SUV normali...

    Authors: Andrei Gafita, Jeremie Calais, Charlott Franz, Isabel Rauscher, Hui Wang, Andrew Roberstson, Johannes Czernin, Wolfgang A. Weber and Matthias Eiber
    Citation: EJNMMI Research 2019 9:103
  46. Preclinical biodistribution and dosimetric analysis of [177Lu]Lu-DOTAZOL suggest the bisphosphonate zoledronate as a promising new radiopharmaceutical for therapy of bone metastases. We evaluated biodistribution ...

    Authors: Ambreen Khawar, Elisabeth Eppard, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian. C. Gaertner, Markus Essler and Ralph. A. Bundschuh
    Citation: EJNMMI Research 2019 9:102
  47. Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake.

    Authors: Ellen Boswijk, Renee Franssen, Guy H. E. J. Vijgen, Roel Wierts, Jochem A. J. van der Pol, Alma M. A. Mingels, Erwin M. J. Cornips, Marian H. J. M. Majoie, Wouter D. van Marken Lichtenbelt, Felix M. Mottaghy, Joachim E. Wildberger and Jan Bucerius
    Citation: EJNMMI Research 2019 9:101
  48. Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity sta...

    Authors: Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike and Christer Halldin
    Citation: EJNMMI Research 2019 9:100
  49. Despite the widespread use of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the diagnosis and response assessment of patients with lymphoma, few studies have assessed...

    Authors: Hye Lim Park, Joo Hyun O, Sonya Youngju Park, Seung-Eun Jung, Gyeongsin Park, Byung-Ock Choi, Sung Hoon Kim, Young-Woo Jeon, Seok-Goo Cho and Suk-Woo Yang
    Citation: EJNMMI Research 2019 9:99
  50. The linkage between the genetic and phenotypic heterogeneity of the tumor has not been thoroughly evaluated. Herein, we investigated how the genetic and metabolic heterogeneity features of the tumor are associ...

    Authors: Jinyeong Choi, Jeong-An Gim, Chiwoo Oh, Seunggyun Ha, Howard Lee, Hongyoon Choi and Hyung-Jun Im
    Citation: EJNMMI Research 2019 9:97

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