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  1. The widespread use of 68Ga for positron emission tomography (PET) relies on the development of radiopharmaceutical precursors that can be radiolabelled and dispensed in a simple, quick, and convenient manner. The...

    Authors: Jean-Philippe Sinnes, Johannes Nagel, Bradley P. Waldron, Theodosia Maina, Berthold A. Nock, Ralf K. Bergmann, Martin Ullrich, Jens Pietzsch, Michael Bachmann, Richard P. Baum and Frank Rösch
    Citation: EJNMMI Research 2019 9:48
    Content type: Original research Published on:

  2. [11C]methionine ([11C]Met) was used for cancer imaging based on upregulated amino acid transport and protein synthesis in different tumor types. However, the short half-life of 11C decay limited further clinical ...

    Authors: Olga Sergeeva, Yifan Zhang, Jonathan D. Kenyon, Galen A. Miller-Atkins, Chunying Wu, Renuka Iyer, Sandra Sexton, Patrick Wojtylak, Amad Awadallah, Wei Xin, E. Ricky Chan, James K. O’Donnel and Zhenghong Lee
    Citation: EJNMMI Research 2019 9:47
    Content type: Original research Published on:

  3. Liposomes are drug nano-carriers that are capable of targeting therapeutics to tumor sites because of enhanced permeability retention (EPR). In several preclinical studies with various tumor-bearing mice models,

    Authors: Shyh-Jen Wang, Wen-Sheng Huang, Chi-Mu Chuang, Chih-Hsien Chang, Te-Wei Lee, Gann Ting, Ming-Huang Chen, Peter Mu-Hsin Chang, Ta-Chung Chao, Hao-Wei Teng, Yee Chao, Yuh-Min Chen, Tzu-Ping Lin, Ya-Jen Chang, Su-Jung Chen, Yuan-Ruei Huang…
    Citation: EJNMMI Research 2019 9:46
    Content type: Original research Published on:

  4. Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. To understand...

    Authors: Kevin S. Thorneloe, Armin Sepp, Sean Zhang, Laura Galinanes-Garcia, Paul Galette, Wasfi Al-Azzam, Danielle J. Vugts, Guus van Dongen, Phillip Elsinga, Johan Wiegers, Andor W. J. M. Glaudemans, Veena Vincent, Jessica Renaux, Matt Szapacs, Mary Birchler, Matthew Cleveland…
    Citation: EJNMMI Research 2019 9:45
    Content type: Original research Published on:

  5. Following publication of the original article [1], the authors flagged the that the Kaplan-Meier curve in Fig. 6 is a duplication of the Kaplan-Meier curve in Fig. 5, which is not correct.

    Authors: Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H. Poulsen, Mattias Ohlsson, Poul F. Høilund-Carlsen, Lars Edenbrandt and Elin Trägårdh
    Citation: EJNMMI Research 2019 9:44
    Content type: Correction Published on:

    The original article was published in EJNMMI Research 2017 7:15

  6. Reactive oxygen species (ROS)-induced oxidative stress damages many cellular components such as fatty acids, DNA, and proteins. This damage is implicated in many disease pathologies including cancer and neurod...

    Authors: Kiran Kumar Solingapuram Sai, Nagaraju Bashetti, Xiaofei Chen, Skylar Norman, Justin W. Hines, Omsai Meka, J. V. Shanmukha Kumar, Sriram Devanathan, Gagan Deep, Cristina M. Furdui and Akiva Mintz
    Citation: EJNMMI Research 2019 9:43
    Content type: Preliminary research Published on:

  7. In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued...

    Authors: C. Shaun Loveless, Lauren L. Radford, Samuel J. Ferran, Stacy L. Queern, Matthew R. Shepherd and Suzanne E. Lapi
    Citation: EJNMMI Research 2019 9:42
    Content type: Original research Published on:

  8. Acute allograft rejection is one of the major complications after lung transplantation, and adequate and early recognition is important. Till now, the reference standard to detect acute rejection is the histop...

    Authors: Eef D. Telenga, Wim van der Bij, Erik F. J. de Vries, Erik A. M. Verschuuren, Wim Timens, Gert Luurtsema, Riemer H. J. A. Slart, Alberto Signore and Andor W. J. M. Glaudemans
    Citation: EJNMMI Research 2019 9:41
    Content type: Preliminary research Published on:

  9. Positron emission tomography (PET) imaging of 90Y following selective internal radiation therapy (SIRT) is possible, but image quality is poor, and therefore, accurate quantification and dosimetry are challenging...

    Authors: Nathaniel P. Scott and Daniel R. McGowan
    Citation: EJNMMI Research 2019 9:40
    Content type: Original research Published on:

  10. While [18F]fluoromisonidazole (FMISO), a representative PET tracer to detect hypoxia, is reported to be able to prospect the prognosis after treatment for various types of cancers, the relation is unclear for pan...

    Authors: Tomohiko Yamane, Masayasu Aikawa, Masanori Yasuda, Kenji Fukushima, Akira Seto, Koujun Okamoto, Isamu Koyama and Ichiei Kuji
    Citation: EJNMMI Research 2019 9:39
    Content type: Original research Published on:

  11. Positron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protei...

    Authors: S. K. Vainio, A. M. Dickens, J. Tuisku, O. Eskola, O. Solin, E. Löyttyniemi, D. C. Anthony, J. O. Rinne, L. Airas and M. Haaparanta-Solin
    Citation: EJNMMI Research 2019 9:38
    Content type: Original research Published on:

  12. The specific uptake size index (SUSI) of striatal FP-CIT uptake is independent of spatial resolution in the SPECT image, in contrast to the specific binding ratio (SBR). This suggests that the SUSI is particul...

    Authors: Ralph Buchert, Catharina Lange, Timo S. Spehl, Ivayla Apostolova, Lars Frings, Cathrine Jonsson, Philipp T. Meyer and Sabine Hellwig
    Citation: EJNMMI Research 2019 9:37
    Content type: Original research Published on:

  13. Semi-automated quantitative measurement of metabolic tumor volume (MTV) for prognosis in diffuse large B-Cell lymphoma (DLBCL) has gained considerable interest lately. However, simple tumor volume measures may...

    Authors: Lars C. Gormsen, Mikkel H. Vendelbo, Mette Abildgaard Pedersen, Ate Haraldsen, Karin Hjorthaug, Trond Velde Bogsrud, Lars J. Petersen, Karen Juul Jensen, Rasmus Brøndum and Tarec C. El-Galaly
    Citation: EJNMMI Research 2019 9:36
    Content type: Original research Published on:

  15. The goal of targeted radiotherapy (TRT) is to administer radionuclides to tumor cells, while limiting radiation exposure to normal tissues. 3′-Deoxy-3′-[18F]-fluorothymidine (18F-FLT) is able to target tumor cell...

    Authors: Thititip Tippayamontri, Brigitte Guérin, René Ouellet, Otman Sarrhini, Jacques Rousseau, Roger Lecomte, Benoit Paquette and Léon Sanche
    Citation: EJNMMI Research 2019 9:33
    Content type: Original research Published on:

  16. A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to stat...

    Authors: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley and Adriaan A. Lammertsma
    Citation: EJNMMI Research 2019 9:32
    Content type: Original research Published on:

  17. [11C]-acetate positron emission tomography is used to assess oxidative metabolism in various tissues including the heart, tumor, and brown adipose tissue. For brown adipose tissue, a monoexponential decay model i...

    Authors: Marie Anne Richard, Denis P. Blondin, Christophe Noll, Réjean Lebel, Martin Lepage and André C. Carpentier
    Citation: EJNMMI Research 2019 9:31
    Content type: Original research Published on:

  18. Following publication of the original article [1], the authors flagged that the author affiliations detailed in the article are incorrect for the authors M. L. Calcagni and A. Giordano.

    Authors: E. Laffon, M. L. Calcagni, G. Galli, A. Giordano, A. Capotosti, R. Marthan and L. Indovina
    Citation: EJNMMI Research 2019 9:30
    Content type: Correction Published on:

    The original article was published in EJNMMI Research 2018 8:24

  20. 177Lu-octreotate is used for therapy of somatostatin receptor expressing neuroendocrine tumors with promising results, although complete tumor remission is rarely seen. Previous studies on nude mice bearing the h...

    Authors: Johan Spetz, Britta Langen, Nils-Petter Rudqvist, Toshima Z. Parris, Emman Shubbar, Johanna Dalmo, Bo Wängberg, Ola Nilsson, Khalil Helou and Eva Forssell-Aronsson
    Citation: EJNMMI Research 2019 9:28
    Content type: Original research Published on:

  21. Evidence has shown the clinical usefulness of measuring the metastatic tumor burden of bone for prognostic assessment especially in prostate cancer; quantitative evaluation by dedicated SPECT is difficult due ...

    Authors: Tadaki Nakahara, Yoshiki Owaki, Tsubasa Shindou, Kiyotaka Nakajima and Masahiro Jinzaki
    Citation: EJNMMI Research 2019 9:27
    Content type: Original research Published on:

  22. Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been us...

    Authors: Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino, Ken-Ichiro Kikuta, Tetsuya Mori, Akira Makino and Yasushi Kiyono
    Citation: EJNMMI Research 2019 9:26
    Content type: Original research Published on:

  23. Among the many peptide receptor systems, gastrin-releasing-peptide (GRP) receptors, the mammalian equivalent of bombesin (BN) receptors, are potential targets for diagnosis and therapy of breast tumors due to ...

    Authors: Kakali De, Dibyanti Mukherjee, Samarendu Sinha and Shantanu Ganguly
    Citation: EJNMMI Research 2019 9:25
    Content type: Original research Published on:

  24. Metabolic parameters are increasingly being used to characterize tumors. Motion artifacts due to patient respiration introduce uncertainties in quantification of metabolic parameters during positron emission t...

    Authors: Esther M. M. Smeets, Dominique S. Withaar, Willem Grootjans, John J. Hermans, Kees van Laarhoven, Lioe-Fee de Geus-Oei, Martin Gotthardt and Erik H. J. G. Aarntzen
    Citation: EJNMMI Research 2019 9:24
    Content type: Original research Published on:

  25. Today, the standardized uptake value (SUV) is essentially the only means for quantitative evaluation of static [18F-]fluorodeoxyglucose (FDG) positron emission tomography (PET) investigations. However, the SUV ap...

    Authors: Frank Hofheinz, Jens Maus, Sebastian Zschaeck, Julian Rogasch, Georg Schramm, Liane Oehme, Ivayla Apostolova, Jörg Kotzerke and Jörg van den Hoff
    Citation: EJNMMI Research 2019 9:23
    Content type: Original research Published on:

  26. The heart-to-mediastinum ratio (HMR) obtained in myocardial sympathetic innervation imaging using 123I-metaiodobenzylguanidine (MIBG) is used for heart failure or Lewy body diseases (LBD). Discovery NM/CT 670 CZT...

    Authors: Nanami Okano, Iichiro Osawa, Saki Tsuchihashi, Masafumi Takahashi, Mamoru Niitsu and Ichiro Matsunari
    Citation: EJNMMI Research 2019 9:22
    Content type: Original research Published on:

  27. Hybrid positron emission tomography and magnetic resonance imaging (PET/MRI) scanners are increasingly used for both clinical and preclinical imaging. Especially functional MRI sequences such as diffusion-weig...

    Authors: Jakob Albrecht, Dietrich Polenz, Anja A. Kühl, Julian M. M. Rogasch, Annekatrin Leder, Igor M. Sauer, Magor Babos, Gabor Mócsai, Nicola Beindorff, Ingo G. Steffen, Winfried Brenner and Eva J. Koziolek
    Citation: EJNMMI Research 2019 9:21
    Content type: Original research Published on:

  28. 223Ra imaging is crucial to evaluate the successfulness of the therapy of bone metastasis of castration-resistant prostate cancer (CRPC). The goals of this study were to establish a quantitative tomographic 223Ra...

    Authors: Nadia Benabdallah, Michela Bernardini, Marta Bianciardi, Claire de Labriolle-Vaylet, Didier Franck and Aurélie Desbrée
    Citation: EJNMMI Research 2019 9:20
    Content type: Original research Published on:

  29. We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and v...

    Authors: Esmaeel Jafargholi Rangraz, Walter Coudyzer, Geert Maleux, Kristof Baete, Christophe M. Deroose and Johan Nuyts
    Citation: EJNMMI Research 2019 9:19
    Content type: Original research Published on:

  30. We have previously developed the caspase-based radiotracer, 18F-ICMT-11, for PET imaging to monitor treatment response. We further validated 18F-ICMT-11 specificity in a murine melanoma death-switch tumour model ...

    Authors: Vessela Vassileva, Stephen M. Stribbling, Chris Barnes, Laurence Carroll, Marta Braga, Joel Abrahams, Kathrin Heinzmann, Caroline Haegeman, Marion MacFarlane, Kathryn L. Simpson, Caroline Dive, Jamie Honeychurch, Timothy M. Illidge and Eric O. Aboagye
    Citation: EJNMMI Research 2019 9:18
    Content type: Original research Published on:

  31. The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However,...

    Authors: Irina Velikyan, Torsten Haack, Martin Bossart, Andreas Evers, Iina Laitinen, Philip Larsen, Oliver Plettenburg, Lars Johansson, Stefan Pierrou, Michael Wagner and Olof Eriksson
    Citation: EJNMMI Research 2019 9:17
    Content type: Original research Published on:

  32. Bone marrow failure syndrome (BMFS) is a heterogeneous group of disorders associated with single- or multiple-lineage cytopenia and failure of normal hematopoiesis. We assessed the feasibility of integrated PE...

    Authors: Tetsuya Tsujikawa, Toshiki Tasaki, Naoko Hosono, Tetsuya Mori, Akira Makino, Yasushi Kiyono, Paolo Zanotti-Fregonara, Takahiro Yamauchi and Hidehiko Okazawa
    Citation: EJNMMI Research 2019 9:16
    Content type: Original research Published on:

  33. Hyperglycaemia can influence 18F-fluorodeoxyglucose (FDG) uptake due to competition for glucose transport and phosphorylation by hexokinase. Major international nuclear medicine societies recommend blood glucose ...

    Authors: David A. Pattison, Lisa L. MacFarlane, Jason Callahan, Emma L. Kane, Timothy Akhurst and Rodney J. Hicks
    Citation: EJNMMI Research 2019 9:15
    Content type: Original research Published on:

  34. Total metabolic active tumour volume (TMATV) and total tumour burden (TTB) are increasingly studied as prognostic and predictive factors in non-small cell lung cancer (NSCLC) patients. In this study, we invest...

    Authors: Guilherme D. Kolinger, David Vállez García, Gerbrand M. Kramer, Virginie Frings, Egbert F. Smit, Adrianus J. de Langen, Rudi A. J. O. Dierckx, Otto S. Hoekstra and Ronald Boellaard
    Citation: EJNMMI Research 2019 9:14
    Content type: Original research Published on:

  36. Partial-volume effects generally result in an underestimation of tumor tracer uptake on PET-CT for small lesions, necessitating partial-volume correction (PVC) for accurate quantification. However, investigati...

    Authors: M. C. F. Cysouw, S. V. S. Golla, V. Frings, E. F. Smit, O. S. Hoekstra, G. M. Kramer and R. Boellaard
    Citation: EJNMMI Research 2019 9:12
    Content type: Original research Published on:

  37. Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is commonly used to assess patients with cardiovascular disease. However, in certain scenarios, it may have limited sp...

    Authors: John P. Bois, Chris Scott, Panithaya Chareonthaitawee, Raymond J. Gibbons and Martin Rodriguez-Porcel
    Citation: EJNMMI Research 2019 9:11
    Content type: Original research Published on:

  38. 4′-[Methyl-11C] thiothymidine (4DST) has been introduced as a new cell proliferation imaging PET tracer that incorporates into DNA directly. The aim of this prospective study was to evaluate the efficacy of 4D...

    Authors: Masatoshi Hotta, Ryogo Minamimoto, Kazuhiko Yamada, Kyoko Nohara, Daisuke Soma, Kazuhiko Nakajima, Jun Toyohara and Kei Takase
    Citation: EJNMMI Research 2019 9:10
    Content type: Original research Published on:

  39. Positron emission tomography (PET) is a non-invasive molecular imaging technique that traces the distribution of radiolabeled molecules in experimental animals and human subjects. We hypothesized that PET coul...

    Authors: Magnus Schou, Pär Ewing, Zsolt Cselenyi, Markus Fridén, Akihiro Takano, Christer Halldin and Lars Farde
    Citation: EJNMMI Research 2019 9:9
    Content type: Original research Published on:

  40. Immunotherapy represents a new therapeutic approach in non-small cell lung carcinoma (NSCLC) with the potential for prolonged benefits. Because of the systemic nature and heterogeneity of tumoral diseases, as ...

    Authors: Lucas Goldfarb, Boris Duchemann, Kader Chouahnia, Laurent Zelek and Michael Soussan
    Citation: EJNMMI Research 2019 9:8
    Content type: Original research Published on:

  41. We sought to assess the machine learning-based combined diagnostic accuracy of three types of quantitative indices obtained using dopamine transporter single-photon emission computed tomography (DAT SPECT)—spe...

    Authors: Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yoshitake Yamada, Masahiro Hashimoto, Yohji Matsusaka, Takashi Osada, Daisuke Ito, Hajime Tabuchi and Masahiro Jinzaki
    Citation: EJNMMI Research 2019 9:7
    Content type: Original research Published on:

  42. Despite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), quantitative SPECT has not been widely used in the clinical practice. The aim of this study i...

    Authors: Samuli Arvola, Ivan Jambor, Anna Kuisma, Jukka Kemppainen, Sami Kajander, Marko Seppänen and Tommi Noponen
    Citation: EJNMMI Research 2019 9:6
    Content type: Original research Published on:

  43. Rupture-prone atherosclerotic plaques are characterized by heavy macrophage infiltration, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR, CD20...

    Authors: Zohreh Varasteh, Sarajo Mohanta, Yuanfang Li, Nicolás López Armbruster, Miriam Braeuer, Stephan G. Nekolla, Andreas Habenicht, Hendrik B. Sager, Geert Raes, Wolfgang Weber, Sophie Hernot and Markus Schwaiger
    Citation: EJNMMI Research 2019 9:5
    Content type: Original research Published on:

  44. 4′-[Methyl-11C] thiothymidine (4DST) PET/CT provides DNA synthesis imaging, which represented a higher correlation with the proliferation in advanced non-small cell lung cancer (NSCLC) than that from imaging with...

    Authors: Ryogo Minamimoto, Yuichiro Takeda, Masatoshi Hotta, Jun Toyohara, Kazuhiko Nakajima, Go Naka and Haruhito Sugiyama
    Citation: EJNMMI Research 2019 9:4
    Content type: Original research Published on:

  45. 18F-GP1 is a novel positron emission tomography (PET) tracer that targets glycoprotein IIb/IIIa receptors on activated platelets. The study objective was to explore the feasibility of directly imaging acute arte....

    Authors: Sun Young Chae, Tae-Won Kwon, Soyoung Jin, Sun U. Kwon, Changhwan Sung, Seung Jun Oh, Sang Ju Lee, Jungsu S. Oh, Youngjin Han, Yong-Pil Cho, Narae Lee, Ji Young Kim, Norman Koglin, Mathias Berndt, Andrew W. Stephens and Dae Hyuk Moon
    Citation: EJNMMI Research 2019 9:3
    Content type: Original research Published on:

  46. Prosthetic joint infections may lead to failures of total joint arthroplasty. Radionuclide imaging can play a diagnostic role in identifying such infections, which require two-stage exchange arthroplasty (inst...

    Authors: Jing-Ren Tseng, Yu-Han Chang, Lan-Yan Yang, Chen-Te Wu, Szu-Yuan Chen, Chih-Hsing Wan, Ing-Tsung Hsiao and Tzu-Chen Yen
    Citation: EJNMMI Research 2019 9:2
    Content type: Original research Published on:

  48. The aim of this study is to determine if the choice of the 18F-FDG-PET protocol, especially matrix size and reconstruction algorithm, is of importance to discriminate between immunohistochemical subtypes (luminal...

    Authors: Nicolas Aide, Thibault Salomon, Cécile Blanc-Fournier, Jean-Michel Grellard, Christelle Levy and Charline Lasnon
    Citation: EJNMMI Research 2018 8:114
    Content type: Original research Published on:

  49. The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand.

    Authors: Mahabuba Jahan, Peter Johnström, Ram K. Selvaraju, Marie Svedberg, Maria Sörhede Winzell, Jenny Bernström, Lee Kingston, Magnus Schou, Zhisheng Jia, Stanko Skrtic, Lars Johansson, Olle Korsgren, Lars Farde, Christer Halldin and Olof Eriksson
    Citation: EJNMMI Research 2018 8:113
    Content type: Original research Published on:

  50. Aim of this study was to automatically select a suitable pseudo-reference brain region for the accurate, non-invasive quantification of neuroinflammation in a rat brain using dynamic [18F]DPA-714 PET imaging.

    Authors: Igor Fagner Vieira, Dieter Ory, Cindy Casteels, Fernando R. A. Lima, Koen Van Laere, Guy Bormans and Michel Koole
    Citation: EJNMMI Research 2018 8:112
    Content type: Original research Published on:

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