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Fig. 6 | EJNMMI Research

Fig. 6

From: Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer

Fig. 6

SdAb-mediated SPECT/CT imaging in TC-1-huLAG-3 tumor bearing mice shows that sdAb 3187 generates high signal-to-background ratios enabling detection of huLAG-3 in the tumor. A Results of ex vivo γ-counting analysis of uptake in isolated organs (expressed in %IA/g and as mean ± SD (n = 3)). B The graph shows the ratio in uptake in the TC-1-huLAG-3 positive tumor compared to the indicated organs. C The table shows the statistical results of comparing TC-1-huLAG-3 positive tumor/organ ratio values between control sdAb and huLAG-3 targeting sdAbs, confirming significant differences for sdAbs 3187 and 3202

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