Skip to main content

Table 2 Comparison of the regional VT values obtained with different kinetic methods at region and voxel levels

From: Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase

  2TCM Region level Voxel level
Logan MA1 SA Logan MA1 SA
Whole brain 13.2 ± 2.4 12.7 ± 2.4 (− 4.8) 12.2 ± 2.2 (− 8.3) 14.9 ± 2.7 (11.6) 12.3 ± 2.0 (− 7.3) 13.0 ± 2.6 (− 2.4) 15.4 ± 2.7 (15.5)
Temporal 15.0 ± 2.8 14.2 ± 2.9 (− 5.6) 13.6 ± 2.6 (− 9.7) 16.8 ± 2.6 (12.4) 13.6 ± 2.4 (− 9.4) 14.7 ± 3.3 (− 2.5) 17.4 ± 2.9 (15.6)
Frontal 14.1 ± 2.5 13.5 ± 2.6 (− 4.8) 13.0 ± 2.3 (− 8.3) 15.9 ± 3.0 (11.8) 13 ± 2.2 (− 8.0) 13.7 ± 2.9 (− 3.4) 16.4 ± 3.0 (15.0)
Striatum 15.6 ± 3.2 14.7 ± 3.2 (− 5.8) 14.2 ± 3.0 (− 9.2) 17.8 ± 3.4 (13.9) 14 ± 2.5 (− 10.2) 14.7 ± 3.1 (− 5.8) 17.6 ± 3.3 (12.8)
Cerebellum 14.1 ± 2.2 13.4 ± 2.3 (− 5.1) 12.9 ± 2.0 (− 8.9) 15.4 ± 2.3 (9.3) 12.9 ± 2.1 (− 9.1) 13.5 ± 2.7 (− 4.7) 16.1 ± 2.7 (13.0)
Brainstem 12.2 ± 2.3 11.7 ± 2.3 (− 4.1) 11.3 ± 2.1 (− 7.3) 13.2 ± 2.7 (7.7) 11.5 ± 2.0 (− 5.6) 12.0 ± 2.4 (− 1.5) 14.0 ± 2.5 (14.5)
  1. VT is presented as a mean ± SD (mL∙cm−3) and a bias (%) in parentheses; bias was calculated as the percentage ratio of the difference in VT between 2TCM and each quantification method to their average. VT, total distribution volume; 2TCM, two-tissue compartment model; MA1, Ichise’s multilinear analysis-1; SA, standard spectral analysis