Skip to main content

Table 2 Comparison of the regional VT values obtained with different kinetic methods at region and voxel levels

From: Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase

 

2TCM

Region level

Voxel level

Logan

MA1

SA

Logan

MA1

SA

Whole brain

13.2 ± 2.4

12.7 ± 2.4 (− 4.8)

12.2 ± 2.2 (− 8.3)

14.9 ± 2.7 (11.6)

12.3 ± 2.0 (− 7.3)

13.0 ± 2.6 (− 2.4)

15.4 ± 2.7 (15.5)

Temporal

15.0 ± 2.8

14.2 ± 2.9 (− 5.6)

13.6 ± 2.6 (− 9.7)

16.8 ± 2.6 (12.4)

13.6 ± 2.4 (− 9.4)

14.7 ± 3.3 (− 2.5)

17.4 ± 2.9 (15.6)

Frontal

14.1 ± 2.5

13.5 ± 2.6 (− 4.8)

13.0 ± 2.3 (− 8.3)

15.9 ± 3.0 (11.8)

13 ± 2.2 (− 8.0)

13.7 ± 2.9 (− 3.4)

16.4 ± 3.0 (15.0)

Striatum

15.6 ± 3.2

14.7 ± 3.2 (− 5.8)

14.2 ± 3.0 (− 9.2)

17.8 ± 3.4 (13.9)

14 ± 2.5 (− 10.2)

14.7 ± 3.1 (− 5.8)

17.6 ± 3.3 (12.8)

Cerebellum

14.1 ± 2.2

13.4 ± 2.3 (− 5.1)

12.9 ± 2.0 (− 8.9)

15.4 ± 2.3 (9.3)

12.9 ± 2.1 (− 9.1)

13.5 ± 2.7 (− 4.7)

16.1 ± 2.7 (13.0)

Brainstem

12.2 ± 2.3

11.7 ± 2.3 (− 4.1)

11.3 ± 2.1 (− 7.3)

13.2 ± 2.7 (7.7)

11.5 ± 2.0 (− 5.6)

12.0 ± 2.4 (− 1.5)

14.0 ± 2.5 (14.5)

  1. VT is presented as a mean ± SD (mL∙cm−3) and a bias (%) in parentheses; bias was calculated as the percentage ratio of the difference in VT between 2TCM and each quantification method to their average. VT, total distribution volume; 2TCM, two-tissue compartment model; MA1, Ichise’s multilinear analysis-1; SA, standard spectral analysis