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Table 1 Correlation (Pearson's coefficient, r) of different binding parameters with VT values calculated from the two-tissue compartment model in the representative regions

From: Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase

Model Pseudo-reference Region level Voxel level
Logan MA1 SA IRF Logan MA1 SA IRF
Parameter SUVR VT VT VT IRF120 VT VT VT IRF120
Whole brain − 0.244ns 0.979 0.986 0.903 0.960 0.983 0.955 0.980 0.955
Temporal − 0.236ns 0.965 0.979 0.922 0.970 0.979 0.923 0.990 0.970
Frontal − 0.261ns 0.976 0.986 0.889* 0.967 0.982 0.938 0.958 0.957
Cerebellum 0.163ns 0.983 0.993 0.939 0.942 0.985 0.958 0.989 0.944
  1. ns, not significant; *, P < 0.01; otherwise, P < 0.001
  2. SUVR, ratio of standardized uptake value (SUV) of each region measured from the time-averaged PET images of 100 to 120 min to that of the pseudo-reference region (the corpus callosum); MA1, Ichise’s multilinear analysis-1; SA, standard spectral analysis; VT, total distribution volume (mL∙cm−3); IRF120, impulse response function (IRF) calculated at 120 min. Regional VT estimates from parametric mapping methods were calculated as the mean of VT voxel estimates in the region