Region- and voxel-based quantification in human brain of [18F]LSN3316612, a radioligand for O-GlcNAcase

EJNMMI Research

Table 1 Correlation (Pearson's coefficient, r) of different binding parameters with V_T values calculated from the two-tissue compartment model in the representative regions

Model	Pseudo-reference	Region level				Voxel level
Model	Pseudo-reference	Logan	MA1	SA	IRF	Logan	MA1	SA	IRF
Parameter	SUVR	V_T	V_T	V_T	IRF₁₂₀	V_T	V_T	V_T	IRF₁₂₀
Whole brain	− 0.244^ns	0.979	0.986	0.903	0.960	0.983	0.955	0.980	0.955
Temporal	− 0.236^ns	0.965	0.979	0.922	0.970	0.979	0.923	0.990	0.970
Frontal	− 0.261^ns	0.976	0.986	0.889*	0.967	0.982	0.938	0.958	0.957
Cerebellum	0.163^ns	0.983	0.993	0.939	0.942	0.985	0.958	0.989	0.944

ns, not significant; *, P < 0.01; otherwise, P < 0.001
SUVR, ratio of standardized uptake value (SUV) of each region measured from the time-averaged PET images of 100 to 120 min to that of the pseudo-reference region (the corpus callosum); MA1, Ichise’s multilinear analysis-1; SA, standard spectral analysis; V_T, total distribution volume (mL∙cm⁻³); IRF₁₂₀, impulse response function (IRF) calculated at 120 min. Regional V_T estimates from parametric mapping methods were calculated as the mean of V_T voxel estimates in the region