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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: A near-infrared probe for non-invasively monitoring cerebrospinal fluid flow by 18F-positron emitting tomography and fluorescence

Fig. 1

PET/MRI, PET/CT, and fluorescent visualization of IR783-AMBF3 distribution in the CNS after intrathecal injection. a A PET/MR scan of a rat following intrathecal introduction of [18F]-IR783-AMBF3 shows contrast that is clearly visible in the spine, pineal recess, pituitary recess, and olfactory bulb. b Maximum intensity projection PET/CT image of intrathecally injected [18F]-IR783-AMBF3 at 5 min post injection. IR783-AMBF3 distributes to the CSF-containing space similarly in a PET/MRI and b PET/CT. c After PET/CT imaging, the rat brain was collected for fluorescent imaging. d Ex vivo fluorescent histology of a coronal section of the brain in a healthy rat that has been injected with IR783-AMBF3 (10 μM) after 20 min. DAPI (blue) and IR783-AMBF3 fluorescent signal (red) show IR783-AMBF3 in the ventricles where CSF is normally present at quantity

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