Table 1 Target blocking drugs, P-gp inhibitors and PET image summation timespan for rat PET experiments
From: Blocking of efflux transporters in rats improves translational validation of brain radioligands
Tracer | Target blocking drug | Dose (mg/kg) | P-gp inhibitor | Dose | Time span for image summation (min) |
|---|---|---|---|---|---|
[18F]MH.MZ | Ketanserin | 3 | Elacridar | 5 | 5–90 |
[18F]Altanserin | Ketanserin | 3 | Cyclosporin A | 22.5a | 5–90 |
[11C]Pimavanserin | Ketanserin | 3 | Elacridar | 5 | 5–60 |
[11C]Cimbi-36 | Ketanserin | 3 | Elacridar | 5 | 5–60 |
[11C]Cimbi-717 | SB269970 | 3 | Elacridar | 5 | 2–60 |
[11C]Cimbi-701 | SB269970 | 3 | Elacridar | 5 | 2–60 |
[11C]BA-10 | SB269970 | 3 | Elacridar | 5 | 30–60 |
[18F]Fallypride | Haloperidol | 1 | Elacridar | 5 | 5–90 |