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Table 1 Target blocking drugs, P-gp inhibitors and PET image summation timespan for rat PET experiments

From: Blocking of efflux transporters in rats improves translational validation of brain radioligands

Tracer Target blocking drug Dose (mg/kg) P-gp inhibitor Dose Time span for image summation (min)
[18F]MH.MZ Ketanserin 3 Elacridar 5 5–90
[18F]Altanserin Ketanserin 3 Cyclosporin A 22.5a 5–90
[11C]Pimavanserin Ketanserin 3 Elacridar 5 5–60
[11C]Cimbi-36 Ketanserin 3 Elacridar 5 5–60
[11C]Cimbi-717 SB269970 3 Elacridar 5 2–60
[11C]Cimbi-701 SB269970 3 Elacridar 5 2–60
[11C]BA-10 SB269970 3 Elacridar 5 30–60
[18F]Fallypride Haloperidol 1 Elacridar 5 5–90
  1. aAfter bolus injection of 22.5 mg/kg cyclosporin A, rats received constant infusion of 7.5 mg/kg/h
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