Fig. 2

Transversal (a), sagittal (b) and coronal (c) T1 weighted MRI images including the position of the spectroscopy voxel (black dashed box) of a wild type (wt) mouse. An example of a MRS spectrum of a wt (upper) and an Apolipoprotein E-deficient (ApoE−/−) mouse (lower) as derived from the voxel of interest is shown in (d). Two prominent metabolites, e.g. N-Acetylaspartate (NAA resonates at 2.0 ppm) and creatine (Cr at 3.0 ppm) are evident and were further evaluated. e Diagram of the NAA/Cr ratio in wt and ApoE−/− mice. Values are given as mean ± SD