Fig. 1
From: Longitudinal [18F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice
a Schematic illustration of the experimental design. Body weight, blood glucose levels as well as cerebral [18F]FDG-PET/CT and MRI/MRS measurement were evaluated at the age of 15, 29, 41, and 55 weeks (w) in wild type (wt, n = 8) and Apolipoprotein E-deficient (ApoE−/−, n = 8) mice. b, c Transversal T2 weighted TurboRARE (in-plane resolution: 65 × 65 µm, slice thickness 500 µm) and transversal T1 weighted isotropic 3D Flash (resolution: 120 × 120 × 120 µm) with M. Mirrione based mouse VOI template overlay (cortex—blue, striatum—red, thalamus—light green, hippocampus—dark green, cerebellum—yellow, brain stem—brown) of a wild type mouse. d Transversal [18F]FDG-PET/CT and MRI with M. Mirrione VOI template fusion. e Body weights were measured directly before [18F]FDG-PET/CT and MRI/MRS measurements. Values are given as mean ± SD; ANOVA for repeated measurements followed by Holm-Sidak comparison test: *p < 0.05 versus wt, #p < 0.05 versus 15 weeks, and p < 0.05 versus 29 weeks