EJNMMI Research

Table 1 Influence of eluent additives in the synthesis of the intermediate product [¹⁸F]11

From: [¹⁸F]Atorvastatin: synthesis of a potential molecular imaging tool for the assessment of statin-related mechanisms of action

Eluent additive	Elution efficiency^a	TLC conversion	HPLC purity	[¹⁸F]11 yield^b
Bis(trimethylneopentylammonium) oxalate	75%	83%	80%	50%
Kryptofix 222, K₂C₂O₄	86%	59%	48%	24%
Tetraethylammonium bicarbonate	54%	34%	50%	9%
Tetrabutylammonium chloride	62%	91%	82%	46%
Sodium acetate	12%	10%	15%	0.2%
Silver acetate	67%	29%	82%	16%
Silver triflate	65%	69%	36%	16%
Sodium oxalate	54%	52%	71%	20%
None	42%	85%	90%	32%

^aCalculated by the ratio between the [¹⁸F]fluoride trapped in the anion exchange cartridge (45-PS-HCO₃⁻) and the radioactivity recovered (without reversing the cartridge) in the reaction vial
^bNon-isolated ¹⁸F-deoxyfluorination yield based on radio-TLC and radio-HPLC analysis of the crude product and having in consideration the elution efficiency resulting from the salt additive used in relation to the starting radioactivity. The final percentage of [¹⁸F]11 yield was determined by multiplying the elution efficiency with radio-TLC conversion of the starting [¹⁸F]fluoride and with radio-HPLC purity (n ≥ 2)

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