OP01 Ultra-Fast Wholebody Oncologic FDG PET/CT: A new capability enabled by digital photon counting PET/CT technology
K. Binzel1, A. Adelaja1, C. L. Wright1, D. Scharre2, J. Zhang1, M. V. Knopp1
1Wright Center of Innovation in Biomedical Imaging, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; 2Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Correspondence: K. Binzel
Aim: To demonstrate the clinical capability of ultra-fast whole body PET acquisition enabled by digital photon counting PET (dPET) and to assess and compare its diagnostic and quantitative characteristics to current clinical PET acquisition.
Methods: Twenty-five patients scheduled for FDG whole body PET/CT were imaged using three separate acquisitions as part of intra-individual comparison study with a pre-commercial release dPET/CT (Vereos) and cPET/CT (Gemini, Philips, Cleveland). Standard cPET imaging was performed at ~75 min p.i. of ~ 450 MBq FDG with investigational dPET imaged at ~55 min p.i. The first dPET acquisition was performed using 90s/bed position, immediately followed by a 9s/bed position.
Acquisition which lead to average table times of ~15 and ~2 min. These were compared with standard-of-care 90s/bed position cPET. The 9s/bed dPET listmode data were reconstructed using a previously optimized methodology. All other aspects of image acquisition were kept identical. Three blinded reviewers evaluated the data sets regarding visual characteristics, diagnostic confidence and semi-quantitative readouts.
Results: Visual assessment scores were significantly higher for 90s/bed dPET whole body (p<0.01) with no difference between 9s/bed dPET and 90s/bed cPET. Quantitatively, the 9s/bed dPET images presented slightly increased background noise, however there was no significant impact on diagnostic confidence or SUV measures of FDG-avid lesions.
Conclusion: Next generation digital photon counting PET detector technology enables a new capability of Ultra-Fast (~2min) wholebody acquisition with comparable diagnostic confidence and quantitative precision to current generation cPET acquisitions taking 10 times longer. This allows for new PET workflow concepts, improved patient comfort, minimized patient motion and whole-body pseudo-dynamic imaging of tracer uptake.
1. Wright CL, Binzel K, Zhang J, Knopp MV. Advanced Functional Tumor Imaging and Precision Nuclear Medicine Enabled by Digital PET Technologies. Contrast Media & Molecular Imaging. 2017;2017:5260305. https://doi.org/10.1155/2017/5260305.