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EJNMMI Research

Table 1 Plasma parameters in mice fed control or methionine- and choline-deficient (MCD) diet for 1 and 2 weeks

From: [18F]-BMS-747158-02PET imaging for evaluating hepatic mitochondrial complex 1dysfunction in a mouse model of non-alcoholic fatty liver disease

Parameter

Control

MCD 1 week

MCD 2 weeks

TC (mg/dL)

91.1 ± 2.60

66.5** ± 3.85

52.3** ± 2.23

TG (mg/dL)

99.9 ± 15.6

31.6** ± 2.67

7.43** ± 1.71

AST (IU/L)

59.4 ± 18.6

367** ± 45.9

393** ± 108

ALT (IU/L)

25.1 ± 7.16

405** ± 67.1

256** ± 83.0

HDLC (mg/dL)

50.6 ± 1.61

36.1** ± 3.59

27.9** ± 2.08

  1. Data are expressed as the mean ± SEM of six mice per group. Statistical differences were assessed using Dunnett’s test
  2. TC total cholesterol, TG triglyceride, AST aspartate transaminase, ALT alanine aminotransferase, HDLC high-density lipoprotein cholesterol
  3. **p < 0.01 compared with the control mice
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