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Table 3 Iterative n.i. RCY optimisation of compound [18F]5. Values derived from TLC chromatogram analysis

From: Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

Entry Scale (μmol precursor) Time (min) Temperature (°C) RCY (% ± SEM)
1 3.2 15 95 63.0 ± 4.1 (n = 8)
2 3.2 20–25 95 65.2 ± 7.4 (n = 3)
3 3.2 15 110 42.9 ± 3.7 (n = 2)
4 6.4 15 95 68.0 ± 17 (n = 2)
5 6.4 15 110 75.9 ± 4.7 (n = 4)
6 6.4 20 110 66.9 ± 3.2 (n = 2)