Table 3 Iterative n.i. RCY optimisation of compound [18F]5. Values derived from TLC chromatogram analysis
Entry | Scale (μmol precursor) | Time (min) | Temperature (°C) | RCY (% ± SEM) |
|---|---|---|---|---|
1 | 3.2 | 15 | 95 | 63.0 ± 4.1 (n = 8) |
2 | 3.2 | 20–25 | 95 | 65.2 ± 7.4 (n = 3) |
3 | 3.2 | 15 | 110 | 42.9 ± 3.7 (n = 2) |
4 | 6.4 | 15 | 95 | 68.0 ± 17 (n = 2) |
5 | 6.4 | 15 | 110 | 75.9 ± 4.7 (n = 4) |
6 | 6.4 | 20 | 110 | 66.9 ± 3.2 (n = 2) |