Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410(6824):50–6.
Article
PubMed
Google Scholar
Oda Y, Tateishi N, Matono H, Matsuura S, Yamamaoto H, Tamiya S, et al. Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcoma. Int J Cancer. 2009;124(8):1852–9. doi:10.1002/ijc.24128.
Article
CAS
PubMed
Google Scholar
Balkwill F. The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol. 2004;14(3):171–9. doi:10.1016/j.semcancer.2003.10.003.
Article
CAS
PubMed
Google Scholar
George GP, Pisaneschi F, Nguyen QD, Aboagye EO. Positron emission tomographic imaging of CXCR4 in cancer: challenges and promises. Mol Imaging. 2014;13:1–19.
Google Scholar
Gourni E, Demmer O, Schottelius M, D'Alessandria C, Schulz S, Dijkgraaf I, et al. PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. J Nucl Med. 2011;52(11):1803–10. doi:10.2967/jnumed.111.098798.
Article
CAS
PubMed
Google Scholar
Demmer O, Gourni E, Schumacher U, Kessler H, Wester HJ. PET imaging of CXCR4 receptors in cancer by a new optimized ligand. Chemmedchem. 2011;6(10):1789–91. doi:10.1002/Cmdc.201100320.
Article
CAS
PubMed
PubMed Central
Google Scholar
Herrmann K, Lapa C, Wester HJ, Schottelius M, Schiepers C, Eberlein U, et al. Biodistribution and radiation dosimetry for the chemokine receptor CXCR4-targeting probe 68Ga-pentixafor. J Nucl Med. 2015;56(3):410–6. doi:10.2967/jnumed.114.151647.
Article
CAS
PubMed
Google Scholar
Vag T, Gerngross C, Herhaus P, Eiber M, Philipp-Abbrederis K, Graner FP, et al. First experience on chemokine receptor CXCR4 targeted positron emission tomography (PET) imaging in patients with solid cancers. J Nucl Med. 2016;57(5):741–6. doi:10.2967/jnumed.115.161034.
Article
PubMed
Google Scholar
Lapa C, Luckerath K, Rudelius M, Schmid JS, Schoene A, Schirbel A, et al. [68Ga]Pentixafor-PET/CT for imaging of chemokine receptor 4 expression in small cell lung cancer - initial experience. Oncotarget. 2016;7(8):9288–95. doi:10.18632/oncotarget.7063.
PubMed
PubMed Central
Google Scholar
Lapa C, Lückerath K, Kleinlein I, Monoranu CM, Linsenmann T, Kessler AF, et al. 68Ga-Pentixafor-PET/CT for imaging of chemokine receptor 4 expression in glioblastoma. Theranostics. 2016;6(3):428–34. doi:10.7150/thno.13986.
Article
CAS
PubMed
PubMed Central
Google Scholar
Derlin T, Jonigk D, Bauersachs J, Bengel FM. Molecular imaging of chemokine ceceptor CXCR4 in non-small cell lung cancer using 68Ga-Pentixafor PET/CT: comparison with 18F-FDG. Clin Nucl Med. 2016;41(4):e204–5. doi:10.1097/RLU.0000000000001092.
Article
PubMed
Google Scholar
Wester HJ, Keller U, Schottelius M, Beer A, Philipp-Abbrederis K, Hoffmann F, et al. Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging. Theranostics. 2015;5(6):618–30. doi:10.7150/thno.11251.
Article
CAS
PubMed
PubMed Central
Google Scholar
Philipp-Abbrederis K, Herrmann K, Knop S, Schottelius M, Eiber M, Luckerath K, et al. In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma. EMBO Mol Med. 2015;7(4):477–87. doi:10.15252/emmm.201404698.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rischpler C, Nekolla SG, Kossmann H, Dirschinger RJ, Schottelius M, Hyafil F, et al. Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET/MRI. J Nucl Cardiol. 2016;23(1):131–3. doi:10.1007/s12350-015-0347-5.
Article
PubMed
Google Scholar
Thackeray JT, Derlin T, Haghikia A, Napp LC, Wang Y, Ross TL, et al. Molecular imaging of the chemokine receptor CXCR4 after acute myocardial infarction. JACC Cardiovasc Imaging. 2015;8(12):1417–26. doi:10.1016/j.jcmg.2015.09.008.
Article
PubMed
Google Scholar
Lapa C, Reiter T, Werner RA, Ertl G, Wester HJ, Buck AK, et al. [(68)Ga]Pentixafor-PET/CT for imaging of chemokine receptor 4 expression after myocardial infarction. JACC Cardiovasc Imaging. 2015;8(12):1466–8. doi:10.1016/j.jcmg.2015.09.007.
Article
PubMed
Google Scholar
Viola NA, Rarig RS, Ouellette W, Doyle RP. Synthesis, structure and thermal analysis of the gallium complex of 1,4,7,10-tetraazacyclo-dodecane-N, N ', N '', N '''-tetraacetic acid (DOTA). Polyhedron. 2006;25(18):3457–62. doi:10.1016/j.poly.2006.06.039.
Article
CAS
Google Scholar
Price EW, Orvig C. Matching chelators to radiometals for radiopharmaceuticals. Chem Soc Rev. 2014;43(1):260–90. doi:10.1039/c3cs60304k.
Article
CAS
PubMed
Google Scholar
Simecek J, Schulz M, Notni J, Plutnar J, Kubicek V, Havlickova J, et al. Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium. Inorg Chem. 2012;51(1):577–90. doi:10.1021/ic202103v.
Article
CAS
PubMed
Google Scholar
Notni J, Hermann P, Havlickova J, Kotek J, Kubicek V, Plutnar J, et al. A triazacyclononane-based bifunctional phosphinate ligand for the preparation of multimeric Ga-68 tracers for positron emission tomography. Chem-Eur J. 2010;16(24):7174–85. doi:10.1002/chem.200903281.
Article
CAS
PubMed
Google Scholar
Poschenrieder A, Schottelius M, Schwaiger M, Kessler H, Wester H-J. The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity. EJNMMI Res. 2016;6(1):1–8. doi:10.1186/s13550-016-0193-8.
Article
CAS
Google Scholar
Schottelius M, Poethko T, Herz M, Reubi JC, Kessler H, Schwaiger M, et al. First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography. Clin Cancer Res. 2004;10(11):3593–606. doi:10.1158/1078-0432.CCR-03-0359.
Article
CAS
PubMed
Google Scholar
Poschenrieder A, Osl T, Schottelius M, Hoffmann F, Wirtz M, Schwaiger M, et al. First 18F-labeled pentixafor-based imaging agent for PET imaging of CXCR4 expression in vivo. Tomography. 2016;2(2):85–93. doi:10.18383/j.tom.2016.00130.
Article
Google Scholar
Weineisen M, Simecek J, Schottelius M, Schwaiger M, Wester HJ. Synthesis and preclinical evaluation of DOTAGAconjugated PSMA ligands for functional imaging and endoradiotherapy of prostate cancer. EJNMMI Res. 2014;4(63):1–15.
CAS
Google Scholar
Lin M, Welch MJ, Lapi SE. Effects of chelator modifications on (68)Ga-labeled [Tyr (3)]octreotide conjugates. Mol Imaging Biol. 2013;15(5):606–13. doi:10.1007/s11307-013-0627-x.
Article
PubMed
PubMed Central
Google Scholar
Fani M, Del Pozzo L, Abiraj K, Mansi R, Tamma ML, Cescato R, et al. PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference. J Nucl Med. 2011;52(7):1110–8. doi:10.2967/jnumed.111.087999.
Article
CAS
PubMed
Google Scholar
García Garayoa E, Schweinsberg C, Maes V, Brans L, Bläuenstein P, Tourwé DA, et al. Influence of the molecular charge on the biodistribution of bombesin analogues labeled with the [99mTc(CO)3]-core. Bioconjugate Chem. 2008;19(12):2409–16. doi:10.1021/bc800262m.
Article
Google Scholar
Strand J, Honarvar H, Perols A, Orlova A, Selvaraju RK, Karlstrom AE, et al. Influence of macrocyclic chelators on the targeting properties of (68)Ga-labeled synthetic affibody molecules: comparison with (111)In-labeled counterparts. PLoS ONE. 2013;8(8):e70028. doi:10.1371/journal.pone.0070028.
Article
CAS
PubMed
PubMed Central
Google Scholar