Table 1 68Ga-colloid content determined by ITLC, liver, and spleen uptake of unpurified, gel filtration, RP-HPLC- and SPE-purified 68Ga-DOTA-exendin-3 and 111In-DOTA-exendin-3 in BALB/c nude mice (n = 5 per group)
From: The effect of purification of Ga-68-labeled exendin on in vivo distribution
68Ga-colloid content (%) | Liver uptake (% ID/g) | Spleen uptake (% ID/g) | |
|---|---|---|---|
111In-DOTA-exendin-3 | <3 | 0.7 ± 0.1 | 0.3 ± 0.1 |
68Ga-DOTA-exendin-3 | 7 | 6.1 ± 1.0 | 4.5 ± 0.7 |
Gel filtration purified 68Ga-DOTA-exendin-3 | 9 | 3.0 ± 0.3 | 1.4 ± 0.3 |
Solid phase extraction purified 68Ga-DOTA-exendin-3 | <3 | 0.8 ± 0.0 | 0.5 ± 0.1 |
RP-HPLC purified 68Ga-DOTA-exendin-3 | <3 | 0.6 ± 0.1 | 0.4 ± 0.1 |