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Table 1 68Ga-colloid content determined by ITLC, liver, and spleen uptake of unpurified, gel filtration, RP-HPLC- and SPE-purified 68Ga-DOTA-exendin-3 and 111In-DOTA-exendin-3 in BALB/c nude mice (n = 5 per group)

From: The effect of purification of Ga-68-labeled exendin on in vivo distribution

  68Ga-colloid content (%) Liver uptake (% ID/g) Spleen uptake (% ID/g)
111In-DOTA-exendin-3 <3 0.7 ± 0.1 0.3 ± 0.1
68Ga-DOTA-exendin-3 7 6.1 ± 1.0 4.5 ± 0.7
Gel filtration purified
68Ga-DOTA-exendin-3
9 3.0 ± 0.3 1.4 ± 0.3
Solid phase extraction purified 68Ga-DOTA-exendin-3 <3 0.8 ± 0.0 0.5 ± 0.1
RP-HPLC purified
68Ga-DOTA-exendin-3
<3 0.6 ± 0.1 0.4 ± 0.1