Fig. 3

^99mTc-IgG and ^99mTc-SER-4 nanoSPECT/CT imaging and biodistribution in C57Bl/6 wild-type (WT) and Sn^-/- (KO) mice. Imaging was performed 3 h post injection on C57Bl/6 WT mice with a ^99mTc-IgG isotype control or b ^99mTc-SER-4 or c Sn^-/- mice with ^99mTc-SER-4. Arrows indicate signal arising from carotid arteries (CA), heart (H), aorta (A) and bladder (B). Maximum intensity projections are shown. d Biodistribution of ^99mTc-SER-4 in C57Bl/6 wild-type, Sn^-/- and ^99mTc-IgG isotype control in C57Bl/6 wild-type mice were expressed as percentage injected dose per gram of tissue (%ID/g). Error bars represent the standard error of the mean of n = 5