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  1. Content type: Original research

    Sigma receptors are highly expressed in human tumors and should be appropriate targets for developing tumor imaging agents. Previously, we synthesized a vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino]cycl...

    Authors: Kazuma Ogawa, Hiroya Kanbara, Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Tatsuto Kiwada and Akira Odani

    Citation: EJNMMI Research 2012 2:54

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  2. Content type: Preliminary research

    Ga-[1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″- tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positi...

    Authors: Xiang Li, Samuel Samnick, Constantin Lapa, Ina Israel, Andreas K Buck, Michael C Kreissl and Wolfgang Bauer

    Citation: EJNMMI Research 2012 2:52

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  3. Content type: Preliminary research

    Freehand single photon emission computed tomography (fSPECT) is a three-dimensional (3-D) tomographic imaging modality based on data acquisition with a handheld detector that is moved freely, in contrast to co...

    Authors: Kambiz Rahbar, Mario Colombo-Benkmann, Christina Haane, Christian Wenning, Alexis Vrachimis, Matthias Weckesser and Otmar Schober

    Citation: EJNMMI Research 2012 2:51

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  4. Content type: Original research

    We describe a new method for biodistribution studies with IRDye800CW fluorescent antibody probes. This method allows the quantification of the IRDye800CW fluorescent tracer in percentage of injected dose per g...

    Authors: Sabrina Oliveira, Ruth Cohen, Marijke Stigter-van Walsum, Guus AMS van Dongen, Sjoerd G Elias, Paul J van Diest, Willem Mali and Paul MP van Bergen en Henegouwen

    Citation: EJNMMI Research 2012 2:50

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  5. Content type: Original research

    Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used to treat neuroendocrine tumors with high somatostatin-receptor expression. 177Lu-octreotate is mainly excreted via the kidneys, but to some extent, accumulat...

    Authors: Maria Larsson, Peter Bernhardt, Johanna B Svensson, Bo Wängberg, Håkan Ahlman and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2012 2:49

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  6. Content type: Original research

    An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. Th...

    Authors: Barry C Gibney, Mi-Ae Park, Kenji Chamoto, Alexandra Ysasi, Moritz A Konerding, Akira Tsuda and Steven J Mentzer

    Citation: EJNMMI Research 2012 2:48

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  7. Content type: Original research

    Arterial spin labeling magnetic resonance imaging (ASL-MRI) has been recognised as a valuable method for non-invasive assessment of cerebral blood flow but validation studies regarding quantification accuracy ...

    Authors: Agnieszka Boś, Ralf Bergmann, Klaus Strobel, Frank Hofheinz, Jörg Steinbach and Jörg van den Hoff

    Citation: EJNMMI Research 2012 2:47

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  8. Content type: Original research

    We aimed to develop a mouse spontaneous liver metastasis model from an orthotopically implanted human colon cancer cell line stably expressing a human sodium/iodide symporter (NIS) reporter gene, which can be ...

    Authors: Masayuki Inubushi, Yong-Nan Jin, Chika Murai, Hironobu Hata, Yoshimasa Kitagawa and Tsuneo Saga

    Citation: EJNMMI Research 2012 2:46

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  9. Content type: Review

    The implementation of imaging technologies has dramatically increased the efficiency of preclinical studies, enabling a powerful, non-invasive and clinically translatable way for monitoring disease progression...

    Authors: Jordi L Tremoleda, Angela Kerton and Willy Gsell

    Citation: EJNMMI Research 2012 2:44

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  10. Content type: Original research

    We performed an initial evaluation of non-invasive ECG-gated [18 F]FDG-positron emission tomography (FDG-PET) for serial measurements of left ventricular volumes and function in murine models of dilated (DCM) and...

    Authors: Stefan Brunner, Andrei Todica, Guido Böning, Stefan G Nekolla, Moritz Wildgruber, Sebastian Lehner, Martina Sauter, Christopher Übleis, Karin Klingel, Paul Cumming, Wolfgang Michael Franz and Marcus Hacker

    Citation: EJNMMI Research 2012 2:43

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  11. Content type: Preliminary research

    Posterior lumbar interbody fusion (PLIF) is a method that allows decompression of the spinal canal and nerve roots by laminectomy combined with fusion by means of intervertebral cages filled with bone graft an...

    Authors: Boudewijn Brans, Rene Weijers, Serve Halders, Roel Wierts, Marloes Peters, Ilona Punt and Paul Willems

    Citation: EJNMMI Research 2012 2:42

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  12. Content type: Original research

    18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infe...

    Authors: Petteri Lankinen, Kaisa Lehtimäki, Antti J Hakanen, Anne Roivainen and Hannu T Aro

    Citation: EJNMMI Research 2012 2:41

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  13. Content type: Review

    Nanomedicine is emerging as a promising approach for diagnostic applications. Nanoparticles are structures in the nanometer size range, which can present different shapes, compositions, charges, surface modifi...

    Authors: AndréLuís Branco de Barros, Andrew Tsourkas, Babak Saboury, Valbert Nascimento Cardoso and Abass Alavi

    Citation: EJNMMI Research 2012 2:39

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  14. Content type: Original research

    This study compares the frequency and distribution of increased activity on 18 F-fluoride PET/CT with the presence of bone marrow edema on whole-body MR imaging in the spine and sacroiliac joints (SIJ) of pati...

    Authors: Dorothee R Fischer, Christian W A Pfirrmann, Veronika Zubler, Katrin D M Stumpe, Burkhardt Seifert, Klaus Strobel, Giorgio Tamborrini, Gustav K von Schulthess, Beat A Michel and Adrian Ciurea

    Citation: EJNMMI Research 2012 2:38

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  15. Content type: Original research

    Dysfunction of the glycine transporter 1 (GlyT1) has been suggested to be involved in psychiatric disorders such as schizophrenia. GlyT1 inhibitors have therefore been considered to have antipsychotic therapeu...

    Authors: Takeshi Fuchigami, Akihiro Takano, Balázs Gulyás, Zhisheng Jia, Sjoerd J Finnema, Jan D Andersson, Ryuji Nakao, Yasuhiro Magata, Mamoru Haratake, Morio Nakayama and Christer Halldin

    Citation: EJNMMI Research 2012 2:37

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  16. Content type: Original research

    At present, several positron emission tomography (PET) tracers are in use for imaging P-glycoprotein (P-gp) function in man. At baseline, substrate tracers such as R-[11C]verapamil display low brain concentration...

    Authors: Joost Verbeek, Jonas Eriksson, Stina Syvänen, Maaike Labots, Elizabeth C M de Lange, Rob A Voskuyl, Martinus P J Mooijer, Marissa Rongen, Adriaan A Lammertsma and Albert D Windhorst

    Citation: EJNMMI Research 2012 2:36

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  17. Content type: Original research

    We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor ...

    Authors: Simon-Peter Williams, Judith E Flores-Mercado, Andreas R Baudy, Ruediger E Port and Thomas Bengtsson

    Citation: EJNMMI Research 2012 2:35

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  18. Content type: Original research

    In breast cancer endocrine therapy, post-therapy Ki-67 assay of biopsy material predicts recurrence-free survival but is invasive and prone to sampling error. [18F]Fluorodeoxyglucose (FDG) positron emission tomog...

    Authors: Brenda F Kurland, Vijayakrishna K Gadi, Jennifer M Specht, Kimberly H Allison, Robert B Livingston, Eve T Rodler, Lanell M Peterson, Erin K Schubert, Xiaoyu Chai, David A Mankoff and Hannah M Linden

    Citation: EJNMMI Research 2012 2:34

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  19. Content type: Original research

    Attenuation correction of a single photon emission computed tomography (SPECT) image is possible using computed tomography (CT)-based attenuation maps with hybrid SPECT/CT. CT attenuation maps acquired during ...

    Authors: Kazuhiro Koshino, Kazuhito Fukushima, Masaji Fukumoto, Kazunari Sasaki, Tetsuaki Moriguchi, Yuki Hori, Tsutomu Zeniya, Yoshihiro Nishimura, Keisuke Kiso and Hidehiro Iida

    Citation: EJNMMI Research 2012 2:33

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  20. Content type: Original research

    Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer for creating DNA double-strand breaks and is thus proposed for radionuclide therapy when bound to tumor-seekin...

    Authors: Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou and Eva Forssell-Aronsson

    Citation: EJNMMI Research 2012 2:32

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  21. Content type: Original research

    We evaluated pharmacodynamic changes in tumour perfusion using positron emission tomography (PET) imaging with 15O-water to assess biological response to sunitinib, a multitargeted tyrosine kinase inhibitor.

    Authors: Andrew M Scott, Paul L Mitchell, Graeme O'Keefe, Timothy Saunder, Rodney J Hicks, Aurora Poon, Charles Baum, Nicoletta Brega, Timothy J McCarthy and Guy C Toner

    Citation: EJNMMI Research 2012 2:31

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  22. Content type: Original research

    Transcranial Doppler (TCD) CO2-reactivity and oxygen-15 positron emission tomography (PET) have both been used to measure the cerebral haemodynamic state in patients who may have a compromised blood flow. Our pur...

    Authors: Suzanne Persoon, L Jaap Kappelle, Bart N M van Berckel, Ronald Boellaard, Cyrille H Ferrier, Adriaan A Lammertsma and Catharina J M Klijn

    Citation: EJNMMI Research 2012 2:30

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  23. Content type: Short communication

    Currently, 68Ga-labeled 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA)-peptides are the most widely used class of 68Ga radiotracers for PET, although DOTA is not optimal for 68Ga complexation. More recent...

    Authors: Johannes Notni, Karolin Pohle and Hans-Jürgen Wester

    Citation: EJNMMI Research 2012 2:28

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  24. Content type: Original research

    It is important that referring physicians and other treating clinicians properly understand the final reports from diagnostic tests. The aim of the study was to investigate whether referring physicians interpr...

    Authors: Elin Trägårdh, Peter Höglund, Mattias Ohlsson, Mattias Wieloch and Lars Edenbrandt

    Citation: EJNMMI Research 2012 2:27

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  25. Content type: Original research

    Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of ...

    Authors: Marianne Isabelle Martic-Kehl, Simon Mensah Ametamey, Malte Frederick Alf, Pius August Schubiger and Michael Honer

    Citation: EJNMMI Research 2012 2:26

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  26. Content type: Original research

    In this study, we report on the synthesis, radiolabeling, and biological evaluation of two new somatostatin-14 (SS14) analogs, modified with the universal chelator DOTA. We were interested to investigate if an...

    Authors: Aikaterini Tatsi, Theodosia Maina, Renzo Cescato, Beatrice Waser, Eric P Krenning, Marion de Jong, Paul Cordopatis, Jean Claude Reubi and Berthold A Nock

    Citation: EJNMMI Research 2012 2:25

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  27. Content type: Original research

    Radiolabelled bombesin (BN) conjugates are promising radiotracers for imaging and therapy of breast and prostate tumours, in which BN2/gastrin-releasing peptide receptors are overexpressed. We describe the influe...

    Authors: Simone Däpp, Cristina Müller, Elisa García Garayoa, Peter Bläuenstein, Veronique Maes, Luc Brans, Dirk A Tourwé and Roger Schibli

    Citation: EJNMMI Research 2012 2:24

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  28. Content type: Original research

    Alternative positron-emission tomography (PET) probes like labeled inhibitors of the prostate-specific membrane antigen (PSMA) are of emerging clinical impact as they show the ability to image small lesions of...

    Authors: Martin Schäfer, Ulrike Bauder-Wüst, Karin Leotta, Frederic Zoller, Walter Mier, Uwe Haberkorn, Michael Eisenhut and Matthias Eder

    Citation: EJNMMI Research 2012 2:23

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  29. Content type: Original research

    The BRAF inhibitor, vemurafenib, has recently been approved for the treatment of metastatic melanoma in patients harboring BRAFV600 mutations. Currently, dual BRAF and MEK inhibition are ongoing in clinical trial...

    Authors: Andreas R Baudy, Taner Dogan, Judith E Flores-Mercado, Klaus P Hoeflich, Fei Su, Nicholas van Bruggen and Simon-Peter Williams

    Citation: EJNMMI Research 2012 2:22

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  30. Content type: Original research

    The “back-translation” of clinically available protocols to measure myocardial perfusion to preclinical imaging in mouse models of human disease is attractive for basic biomedical research. With respect to sin...

    Authors: Alexis Vrachimis, Sven Hermann, Domokos Máthé, Otmar Schober and Michael Schäfers

    Citation: EJNMMI Research 2012 2:21

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  31. Content type: Original research

    Anemia is usually not taken into account in internal radiotherapy. We investigated whether the hemoglobin (Hb) level could have an impact on the tumor response, as observed in external beam radiotherapy (EBRT).

    Authors: Stephan Walrand, Renaud Lhommel, Pierre Goffette, Marc Van den Eynde, Stanislas Pauwels and FranÇois Jamar

    Citation: EJNMMI Research 2012 2:20

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  32. Content type: Original research

    Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors. The objective of...

    Authors: Xiao Tong, Anikitos Garofalakis, Albertine Dubois, Raphaël Boisgard, Frédéric Ducongé, Régine Trébossen and Bertrand Tavitian

    Citation: EJNMMI Research 2012 2:19

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  33. Content type: Original research

    As is well known, limited spatial resolution leads to partial volume effects (PVE) and consequently to limited signal recovery. Determination of the mean activity concentration of a target structure is thus co...

    Authors: Frank Hofheinz, Jens Langner, Jan Petr, Bettina Beuthien-Baumann, Liane Oehme, Jörg Steinbach, Jörg Kotzerke and Jörg van den Hoff

    Citation: EJNMMI Research 2012 2:16

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  34. Content type: Original research

    Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [

    Authors: Aurelija Jučaite, Zsolt Cselényi, Annie Arvidsson, Gabrielle Åhlberg, Per Julin, Katarina Varnäs, Per Stenkrona, Jan Andersson, Christer Halldin and Lars Farde

    Citation: EJNMMI Research 2012 2:15

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  35. Content type: Preliminary research

    Tumor targeting is of high clinical and biological relevance, and major efforts have been made to develop molecular imaging technologies for visualization of the disease markers in tissue. Of particular intere...

    Authors: Andreas Buehler, Eva Herzog, Angelica Ale, Bradley D Smith, Vasilis Ntziachristos and Daniel Razansky

    Citation: EJNMMI Research 2012 2:14

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  36. Content type: Short communication

    Bisphosphonates possess strong affinity to bone. 99mTc bisphosphonate complexes are widely used for bone scintigraphy. For positron emission tomography (PET) bone imaging, Ga-68-based PET tracers based on bisphos...

    Authors: Johannes Notni, Jan Plutnar and Hans-Jürgen Wester

    Citation: EJNMMI Research 2012 2:13

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  37. Content type: Original research

    [11C]Flumazenil and positron emission tomography (PET) are used clinically to assess gamma-aminobutyric acid (GABA)-ergic function and to localize epileptic foci prior to resective surgery. Enhanced P-glycoprotei...

    Authors: Femke E Froklage, Stina Syvänen, N Harry Hendrikse, Marc C Huisman, Carla FM Molthoff, Yoshihiko Tagawa, Jaap C Reijneveld, Jan J Heimans, Adriaan A Lammertsma, Jonas Eriksson, Elizabeth CM de Lange and Rob A Voskuyl

    Citation: EJNMMI Research 2012 2:12

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  38. Content type: Original research

    Quantification of kinetic parameters of positron emission tomography (PET) imaging agents normally requires collecting arterial blood samples which is inconvenient for patients and difficult to implement in ro...

    Authors: Kaiyumars B Contractor, Laura M Kenny, Charles R Coombes, Federico E Turkheimer, Eric O Aboagye and Lula Rosso

    Citation: EJNMMI Research 2012 2:11

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  39. Content type: Original research

    [18F]fluoro-2-deoxy-D-glucose ([18F]FDG) positron emission tomography (PET) is a valuable tool for monitoring response to therapy in oncology. In longitudinal studies, however, patients are not scanned in exactly...

    Authors: Floris HP van Velden, Paul van Beers, Johan Nuyts, Linda M Velasquez, Wendy Hayes, Adriaan A Lammertsma, Ronald Boellaard and Dirk Loeckx

    Citation: EJNMMI Research 2012 2:10

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  40. Content type: Original research

    The F3 peptide (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK), a fragment of the human high mobility group protein 2, binds nucleolin. Nucleolin is expressed in the nuclei of normal cells but is also expressed on the membr...

    Authors: Bart Cornelissen, Andrew Waller, Carol Target, Veerle Kersemans, Sean Smart and Katherine A Vallis

    Citation: EJNMMI Research 2012 2:9

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  41. Content type: Original research

    Gastrin-releasing peptide receptors [GRPR] are highly over-expressed in multiple cancers and have been studied as a diagnostic target. Multimeric gastrin-releasing peptides are expected to have enhanced tumor ...

    Authors: Patrick Fournier, Véronique Dumulon-Perreault, Samia Ait-Mohand, Réjean Langlois, François Bénard, Roger Lecomte and Brigitte Guérin

    Citation: EJNMMI Research 2012 2:8

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  42. Content type: Original research

    Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positro...

    Authors: Nadège Anizan, Thomas Carlier, Cecilia Hindorf, Jacques Barbet and Manuel Bardiès

    Citation: EJNMMI Research 2012 2:7

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  43. Content type: Original research

    A retrospective analysis of estimates of tumor glucose uptake from 1,192 dynamic 2-deoxy-2-(18F)fluoro-D-glucose-positron-emission tomography [ FDG-PET] scans showed strong correlations between blood glucose and ...

    Authors: Simon-Peter Williams, Judith E Flores-Mercado, Ruediger E Port and Thomas Bengtsson

    Citation: EJNMMI Research 2012 2:6

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  44. Content type: Original research

    In this study, pretargeted immuno-positron-emission tomography [PET] with a bispecific monoclonal anti-carcinoembryonic antigen [CEA] (CEACAM5) × anti-hapten antibody (bispecific monoclonal antibody [bsmAb]) a...

    Authors: Rafke Schoffelen, Winette TA van der Graaf, Robert M Sharkey, Gerben M Franssen, William J McBride, Chien-Hsing Chang, Peter Laverman, David M Goldenberg, Wim JG Oyen and Otto C Boerman

    Citation: EJNMMI Research 2012 2:5

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  45. Content type: Original research

    In single photon emission computed tomography [SPECT], high specific activity of 111In-labelled tracers will allow administration of low amounts of tracer to prevent receptor saturation and/or side effects. To in...

    Authors: Maarten Brom, Lieke Joosten, Wim JG Oyen, Martin Gotthardt and Otto C Boerman

    Citation: EJNMMI Research 2012 2:4

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