Fig. 4

(A) Regional K1 values for cortical regions: cortical regions: anterior cingulate (AC), entorhinal (E), lateral frontal (LF), lateral parietal (LP), lateral temporal (LT), medial frontal (MF), medial temporal (MT), precuneus (P), posterior cingulate (PC), temporal sulci (TS), and for cerebellar reference region (C). Amyloid-positive individuals showed significantly lower perfusion in all entorhinal (P = 0.01) and temporal sulci (P = 0.0005) compared to amyloid-negative cohorts. (B) Regional K1 values for composite of cortical index regions excluding the cerebellar reference region. Amyloid-positive individuals showed significantly higher perfusion compared to amyloid-negative (P = 0.0283)