Fig. 2
Affinity (apparent IC50) data (depicted in bars) and lipophilicity (logD7.4) data (depicted in purple dots) of the PEG4 containing compounds, [nat/177Lu]Lu-DOTA-rhCCK-67 -68, -90 and -91 (red), the PEG7 containing compounds, [nat/177Lu]Lu-DOTA-rhCCK-70 to -73 (blue), as well as the PEG11 containing compounds, [nat/177Lu]Lu-DOTA-rhCCK-74 to -76 and -69 (orange), compared to the reference [nat/177Lu]Lu-DOTA-rhCCK-18 (grey, [20]). All novel compounds comprise a [177/natLu]Lu-DOTA complex as well as a D-γ-Glu-(PEG)3-Trp-(N-Me)Nle-Asp-1-Nal-NH2 binding unit linked together by a spacer sequence X (defined on the X-axis). * data taken from Günther et al. [20]. These data have been determined in our lab under identical conditions