Fig. 3

In vivo PET imaging using [¹¹C]SMW139 and [¹⁸F]F-DPA in the same APP/PS1-21 transgenic (TG) and age-matched wild type (WT) mice at 14 months. a and c Representative coronal and axial brain PET/CT images of TG (n = 1) and WT (n = 1) mice at 14 months imaged with [¹¹C]SMW139 (a) and [¹⁸F]F-DPA (c). [¹¹C]SMW139 images were summed over 3–15 min and adjusted to the same color scale. [¹⁸F]F-DPA were summed over 25–50 min and scaled to the same color scale. b and d Averaged [¹¹C]SMW139 (b) and [¹⁸F]F-DPA (d) time-activity curves in the neocortex of the same TG (n = 3) and WT (n = 4) mice at 14 months. Error bars indicate standard deviation