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EJNMMI Research

Table 1 Analytical data of PP4-WD, PP8-WD, and Flu-1

From: Exploring the impact of PEGylation on pharmacokinetics: a size-dependent effect of polyethylene glycol on prostate-specific membrane antigen inhibitors

Compound

Chemical formula

Calculated mass

m/z1

tr (min)2

Radiochemical purity (%)3

Log D7.4

PP4-WD

C54H79N9O20

1174.27

1174.55

8.01

97.98 ± 0.56

− 3.06 ± 0.15

PP8-WD

C62H95N9O24

1350.48

1350.66

8.09

96.56 ± 0.32

− 4.23 ± 0.26

Flu-14

C47H66N8O15

983.43

983.47

8.13

88.53 ± 1.21

− 2.64 ± 0.25

  1. 1Mass spectrometry data detected as [M + H]+. 2Retention times of the Ga-labeled compounds.3Values of radiochemical purity were measured by RP-HPLC. An Agilent analytical column (250 × 4.6 mm) was utilized with mobile phases consisting of 0.1% TFA in water (A) and ACN (B). A linear gradient of solvent A (90–10% in 15 min) in solvent B (10–90% in 15 min) at a flow rate of 1.0 mL/min. 4Data for [68Ga]Ga-Flu-1 was obtained from a previously published report [21]
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