Fig. 1

Schematic overview of the binding of [¹¹¹In]In-FnBPA5 to fibronectin (Fn) depending on the mechanical conformation. a In the pathological ECM a high abundance of relaxed Fn can be detected. If Fn fibers are relaxed, [¹¹¹In]In-FnBPA5 binds with nM affinity to Fn. b In healthy tissues Fn fibers are predominantly stretched. Due to structural mismatch [¹¹¹In]In-FnBPA5 loses affinity to stretched Fn. Figure components adapted from Arnoldini et al. [35] CC by 4.0