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EJNMMI Research

Table 2 Group differences in rCBF relative to the putamen

From: Comparison of 18F-FDG PET and arterial spin labeling MRI in evaluating Alzheimer’s disease and amnestic mild cognitive impairment using integrated PET/MR

 

Relative CBF (rCBF)

P value

Parameter

NC

aMCI

AD

NC vs. aMCI

NC vs. AD

aMCI vs. AD

Orbitofrontal cortex

1.18 (0.16)

1.15 (0.21)

1.06 (0.17)

0.411

0.001

0.029

Prefrontal cortex

1.27 (0.11)

1.23 (0.16)

1.16(0.14)

0.234

 < 0.001

0.027

Superior frontal cortex

1.19 (0.10)

1.17 (0.11)

1.05 (0.13)

0.371

 < 0.001

 < 0.001

Lateral temporal

1.35 (0.15)

1.31 (0.17)

1.11 (0.18)

0.283

 < 0.001

 < 0.001

Medial temporal

1.02 (0.12)

0.99 (0.10)

0.91 (0.11)

0.193

 < 0.001

0.001

Inferior temporal

1.24 (0.15)

1.20 (0.14)

1.03 (0.18)

0.258

 < 0.001

 < 0.001

Parietal

1.32 (0.16)

1.27 (0.19)

1.02 (0.25)

0.166

 < 0.001

 < 0.001

Posterior precuneus

1.51 (0.17)

1.44 (0.21)

1.17 (0.28)

0.089

 < 0.001

 < 0.001

Posterior cingulate

1.65 (0.20)

1.59 (0.21)

1.27 (0.27)

0.134

 < 0.001

 < 0.001

Hippocampus

1.10 (0.12)

1.07 (0.11)

0.99 (0.14)

0.253

 < 0.001

0.003

Parahippocampus

1.06 (0.13)

1.01 (0.12)

0.95(0.13)

0.053

 < 0.001

0.036

  1. Data were presented with mean (standard deviation). There was a significantly decreased rCBF in AD compared to NC, and AD compared to aMCI. There were no significant differences between aMCI and NC in rCBF (P value ranged from 0.053 to 0.898). P < 0.05 indicate statistical significance
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