Table 2 Parameter definitions

K₁

Rate constant, transfer of tracer from plasma to first tissue compartment

Modeled

\(\frac{{{\text{ml}}}_{{\text{blood}}}}{{{\text{ml}}}_{{\text{tissue}}}\cdot {\text{min}}}\)

k₂

Rate constant, transfer of tracer from first tissue compartment to plasma

Modeled

\({{\text{min}}}^{-1}\)

k₃

Rate constant, transfer of tracer from first tissue compartment to second tissue compartment

Modeled

\({{\text{min}}}^{-1}\)

k₄

Rate constant, transfer of tracer from second tissue compartment to first tissue compartment

Modeled

\({{\text{min}}}^{-1}\)

K_i

Net tracer influx rate

\({K}_{i}=\frac{{K}_{1}{k}_{3}}{({k}_{2}+{k}_{3})}\)

\(\frac{{{\text{ml}}}_{{\text{blood}}}}{{{\text{ml}}}_{{\text{tissue}}}\cdot {\text{min}}}\)

V_d

Distribution volume of tracer

\({V}_{d}=\frac{{K}_{1}}{({k}_{2}+{k}_{3})}\)

\(\frac{{{\text{ml}}}_{{\text{blood}}}}{{{\text{ml}}}_{{\text{tissue}}}}\)

SUV

Standardized uptake value

\({\text{SUV}}=\frac{{C}_{{\text{PET}}}\left(t\right)}{{\text{Dose}}/{\text{BodyMass}}}\)

\(-\)

%ID/kg

Percentage of total injected dose per kilogram of tissue

\(\%{\text{ID}}/{\text{kg}}=\frac{{C}_{{\text{PET}}}\left(t\right)}{{\text{Dose}}}\)

\(-\)