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Table 2 [99mTc]Tc-MAG3 kidney kinetics compared between single mouse bed and 3-mouse bed hotel examinations

From: Effects of isoflurane anaesthesia depth and duration on renal function measured with [99mTc]Tc-mercaptoacetyltriglycine SPECT in mice

 

Single

Position 1

Position 2

Position 3

Aorta excretion (seconds)

    

  T50aorta

64.9 #

28.2#

31.4

44.2

[32.1–179.6]

[21.2–53.1]

[22.9–61.0]

[25.8–66.4]

21.5–246.9

10.7–68.5

10.3–237.1

17.1–111.1

  No. of animals

12

22

24

21

Kidney uptake (min)

    

  Tmax

1.4 #

1.8 # ♦

1.5

1.4 ♦

[1.3–1.5]

[1.6–2.1]

[1.3–1.9]

[1.1–2.2]

1.2–5.6

1.3–5.6

1.2–2.3

1.1–2.9

  T50

3.8 #

5.3 # + ♦

3.7 + 

4.1 ♦

[3.5–4.3]

[4.1–7.1]

[3.3–4.7]

[3.2–5.1]

3.1–4.9

3.3–15.3

2.3–7.9

2.3–6.9

  T25

6.5 #

9.2 # + ♦

5.9 + 

6.6 ♦

[5.8–7.3]

[6.8–11.3]

[5.2–7.8]

[5.1–8.5]

4.9–7.8

5.3–26.3

3.6–13.2

2.5–10.9

  No. of animals

12

22

24

21

  1. Aorta tracer excretion half-life is expressed as T50aorta in seconds and kidney uptake as time-to-peak (Tmax), T50 (50% clearance) and T25 (75% clearance) in minutes. Each set of data includes the median, interquartile range [IQR], min–max and number of animals
  2. #p < 0.05 between single versus position 1
  3. +p < 0.01 between position 1 versus 2
  4. p < 0.05 between position 1 versus 3