Table 1 Different parameters during renal [99mTc]Tc-MAG3 scintigraphy in single mouse bed examinations as influenced by the depth of anaesthesia controlled by respiratory rate
Low anaesthesia Respiratory rate: 80–90/min (n = 7) | Deep anaesthesia Respiratory rate: 40–45/min (n = 7) | p value | |
|---|---|---|---|
Isoflurane (%) | 1.3 [1.1–1.5] 0.8–1.5 | 1.5 [1.5–1.7] 1.2–1.9 | 0.078 |
Respiratory rate (breaths/min) | 89 [87–90] 81–92 | 47 [44–48] 43–51 | 0.018 |
Heart rate (beats/min) | 328 [326–336] 290–365 | 343 [307–356] 281–369 | 0.74 |
Relative renal tracer influx rate (MBq/ml/min) | 6.0 [5.1–6.2] 3.5–6.5 | 4.1 [3.4–4.3] 2.8–4.9 | 0.018 |
Aorta excretion (seconds) | |||
T50aorta | 29 [28-36] 25–40 | 35 [32-37] 28–42 | 0.091 |
Kidney uptake (min) | |||
Tmax | 1.5 [1.5–1.5] 1.3–1.8 | 1.8 [1.6–2.2] 1.4–2.9 | 0.063 |
T50 | 4.5 [4.1–4.7] 3.5–4.9 | 4.1 [4.0–5.8] 3.6–6.7 | 0.40 |
T25 | 7.0 [6.5–8.7] 6.1–9.2 | 8.6 [7.4–10.5] 7.2–12.1 | 0.24 |