Fig. 4

a Illustration of the estimated AIF for participant 6, b extrapolated gray matter and c white matter TACs for the six participants (P1-P6). a Data points denoted by the ‘ + ’ and ‘●’ symbols are measurements taken from the LV in the validation and the 39-48-min windows, respectively. Measurements from the 39-48min window (red shaded area) were used to estimate the entire AIF (the red dashed line). b–c The TAC measurements averaged over gray and white matter ROIs for the six participants (P1-P6). Data from 36-60min (blue shaded area) were used to estimate the kinetic parameters and recover the entire TAC (red dashed line). Measurements outside the 36-60min window were used for validation