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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer

Fig. 5

A Bar chart for quantitative signal in ARG (SUVARG) for normal tissue and prostate cancer containing grids. High uptake of 99mTc-PSMA was present in grids with prostate cancer (SUVARG, ***Mann–Whitney U test, p < 0.001). B Significantly higher SUVARG was observed in the Gleason Score ≥ 8 compared to normal prostate tissue and Gleason Score < 8 groups (***ANOVA, p < 0.001). C Receiver-operating-curve analysis. A cutoff of 6.2 for SUVARG discriminated best between normal tissue and prostate cancer and yields a sensitivity of 77.7% and specificity of 76.8% (area under curve, 0.848). ARG = autoradiography, PSMA = prostate-specific membrane antigen, SUV = standardized uptake value

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