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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Heterogeneity of prostate-specific membrane antigen (PSMA) and PSMA-ligand uptake detection combining autoradiography and postoperative pathology in primary prostate cancer

Fig. 2

PSMA protein expression and PSMA-ligand uptake are heterogeneous. Expression of PSMA protein quantified by IRS (A) was presented in order of increasing score. PSMA-ligand uptake quantified by ARS (B) was presented in the corresponding order. Degrees of heterogeneity in PSMA protein expression and PSMA-ligand uptake were measured by Shannon–Wiener Index and depicted as heat map ranging from low heterogeneity (white) to high heterogeneity (green). Correlation between (C) Shannon–Wiener Index of ARG and IHC (Pearson, r = 0.009, p = 0.974), (D) ARS and IRS (Pearson, r = 0.604, p = 0.013). ARS = autoradiographic-reactive score, IHC = immunohistochemistry, IRS = immunoreactive score, PSMA = prostate-specific membrane antigen. Patients were renumbered in the current study: P18 = 1; P10 = 2; P11 = 3; P17 = 4; P20 = 5; P9 = 6; P13 = 7; P12 = 8; P15 = 9; P3 = 10; P7 = 11; P8 = 12; P16 = 13; P19 = 14; P4 = 15; P5 = 16

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