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EJNMMI Research
Fig. 3 | EJNMMI Research

Fig. 3

From: Targeted imaging of very late antigen-4 for noninvasive assessment of lung inflammation-fibrosis axis

Fig. 3

Prognostication of bleomycin-induced lung injury by 64Cu-LLP2A PET. High lung uptake of 64Cu-LLP2A at 1-week post-bleomycin, defined as the uptake above the median %ID/mLmean (left panel) or %ID/mLmax (right panel), predicts a significantly worse survival over the course of 4 weeks (A). Similarly, both %ID/mLmean (left panel) and %ID/mLmax (right panel) of 64Cu-LLP2A uptake at 1-week post-bleomycin strongly predict fatal lung injury as assessed by ROC curve analysis (B). The progressive increase in lung uptake of 64Cu-LLP2A from week-1 to week-4 post-bleomycin correlates with the severity of fibrosis and ECM remodeling as determined by the hydroxyproline content of the lungs and mRNA expression of markers of matrix remodeling at week-4, including collagen 1 (Col1a1), fibronectin (Fn1), lysyl oxidase (Lox) and lysyl oxidase-like 2 (Loxl2) (C). N = 21 for panels A and B, N = 8 for panel C

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