The effects of novel macrocyclic chelates on the targeting properties of the 68Ga-labeled Gastrin releasing peptide receptor antagonist RM2

EJNMMI Research

Table 2 Quantitative analysis of tumor-to-background ratios

Tumour/organ ratio	DATA^5m-RM2			AAZTA⁵-RM2			DOTA-RM2
Tumour/organ ratio	30 min	60 min	120 min	30 min	60 min	120 min	30 min	60 min	120 min
Tumour/liver	5.86	7.57	6.09	6.04	7.55	5.92	3.19	3.40	4.00
Tumour/kidneys	1.73	2.20	2.41	1.20	1.41	1.31	1.53	1.89	2.05
Tumour/muscle	25.42	56.83	62.23	10.33	37.63	60.70	14.41	21.80	31.73
Tumour/blood	4.23	14.56	18.21	3.53	8.38	15.64	2.35	3.88	4.58
Tumour/pancereas	0.65	0.87	2.60	0.66	1.33	3.78	0.17	0.32	0.96
Tumour/bone	16.17	29.29	50.21	21.84	36.04	57.53	11.16	8.99	8.60