The effects of novel macrocyclic chelates on the targeting properties of the 68Ga-labeled Gastrin releasing peptide receptor antagonist RM2

EJNMMI Research

Table 1 Physical properties of X-RM2

Compound	Chemical formula	MW (g/mol)	m/z	Chemical purity (%)	Radiochemcial purity (%)^a	Log P
DOTA-RM2	C₇₈H₁₁₈N₂₀O₁₉	1639.92	[M + H]⁺ 1640.80	> 95	98.00 ± 0.67	− 2.49 ± 0.17
DATA^5m-RM2	C₇₉H₁₁₉N₁₉O₁₉	1638.94	[M + 2H]²⁺ 820.93	> 95	99.36 ± 0.58	− 2.29 ± 0.11
AAZTA⁵-RM2	C₈₀H₁₁₉N₁₉O₂₁	1682.94	[M − 2H]²⁻ 840.96	> 95	99.26 ± 0.90	− 2.69 ± 0.10